EA202191565A1 - Способ получения циклического динуклеотида - Google Patents

Способ получения циклического динуклеотида

Info

Publication number
EA202191565A1
EA202191565A1 EA202191565A EA202191565A EA202191565A1 EA 202191565 A1 EA202191565 A1 EA 202191565A1 EA 202191565 A EA202191565 A EA 202191565A EA 202191565 A EA202191565 A EA 202191565A EA 202191565 A1 EA202191565 A1 EA 202191565A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyclic dinucleotide
producing cyclic
producing
dinucleotide
useful
Prior art date
Application number
EA202191565A
Other languages
English (en)
Inventor
Майкл Энтони Шмидт
Бин Чжэнг
Бенджамин М. Коэн
Аманда Дж. Роджерс
Чанся Юань
Джейсон Дж. Чжу
Чао Хан
Дэниэл С. Трейтлер
Адам Джозеф Фрайтаг
Джеффри Юджин Пурдум
Миао Ю
Мелда Сезен Эдмондс
Сивей Гуо
Original Assignee
Бристол-Маерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA202191565A1 publication Critical patent/EA202191565A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретение в целом относится к улучшенным способам получения циклического динуклеотида, который является полезным в качестве агониста STING.
EA202191565A 2018-12-04 2019-12-03 Способ получения циклического динуклеотида EA202191565A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862775094P 2018-12-04 2018-12-04
PCT/US2019/064137 WO2020117739A1 (en) 2018-12-04 2019-12-03 Process for the preparation of a cyclic dinucleotide

Publications (1)

Publication Number Publication Date
EA202191565A1 true EA202191565A1 (ru) 2021-12-02

Family

ID=69024628

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202191565A EA202191565A1 (ru) 2018-12-04 2019-12-03 Способ получения циклического динуклеотида

Country Status (13)

Country Link
US (1) US20220064205A1 (ru)
EP (1) EP3891160A1 (ru)
JP (1) JP2022513712A (ru)
KR (1) KR20210099065A (ru)
CN (1) CN113166184A (ru)
AU (1) AU2019391012A1 (ru)
BR (1) BR112021010466A2 (ru)
CA (1) CA3122027A1 (ru)
EA (1) EA202191565A1 (ru)
IL (1) IL283633A (ru)
MX (1) MX2021006498A (ru)
SG (1) SG11202105807XA (ru)
WO (1) WO2020117739A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253766A (zh) * 2023-03-27 2023-06-13 瑞阳（上海）新药研发有限公司 一种环二核苷酸2’,3’-cGAMP的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10604542B2 (en) * 2016-01-11 2020-03-31 Innate Tumor Immunity, Inc. Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
SG11202008827XA (en) * 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Also Published As

Publication number Publication date
WO2020117739A1 (en) 2020-06-11
IL283633A (en) 2021-07-29
BR112021010466A2 (pt) 2021-08-24
KR20210099065A (ko) 2021-08-11
CN113166184A (zh) 2021-07-23
AU2019391012A1 (en) 2021-07-22
MX2021006498A (es) 2021-07-06
US20220064205A1 (en) 2022-03-03
JP2022513712A (ja) 2022-02-09
CA3122027A1 (en) 2020-06-11
SG11202105807XA (en) 2021-06-29
EP3891160A1 (en) 2021-10-13

Similar Documents

Publication Publication Date Title
CL2019002793A1 (es) Composición para producir tagatosa y procedimiento de producción de tagatosa usando la misma.
MY190659A (en) Method for producing biohydrocarbons
PH12019500493A1 (en) Solvate form of (r)-2-amino-3-phenylpropyl carbamate
MY195408A (en) Novel Aspartokinase Variant and Method for Producing L- Amino Acid Using the Same
TW201612153A (en) Producing method of (R)-1,1,3-trimethyl-4-aminoindane
MX2022000893A (es) Metodo de obtencion de mitocondrias de celulas y mitocondrias obtenidas.
UA117127C2 (uk) Спосіб одержання збагаченої вуглецем біомаси
MX2019001465A (es) Metodo de produccion de cetoenoles ciclicos sustituidos con espirocetales.
BR112016025024A2 (pt) ?processo para preparar compostos ceto, e, uso de farnesil acetona?
MY176584A (en) Gluconate repressor variant, microorganism containing the same producing l-lysine, and method for producing l-lysine
GB2548308A (en) Visualization of wellbore cleaning performance
MX2019004182A (es) Proceso para la fabricacion de 2,6-dimetil-5-hepten-1-al.
MX2019004024A (es) Metodo para preparar acetofenonas sustituidas con ciclopropilo.
EA201990270A1 (ru) Смеси, содержащие defi и тауратамиды, и способы их получения
EA202191565A1 (ru) Способ получения циклического динуклеотида
MX2023009431A (es) Metodo para crear un compuesto a base de mercurio, compuesto a base de mercurio, metodos de uso del compuesto a base de mercurio y usos del compuesto a base de mercurio.
EA201692246A1 (ru) Способ получения 2,6-диметилбензохинона
CO2020002617A2 (es) Método para la producción de plántulas de caña de azúcar
EA202092707A1 (ru) Огнеупор, шихта для его получения, способ его получения, а также применение такого огнеупора
MX2018013334A (es) Metodo para producir derivados de espirociclicos cis-alcoxi-sustituidos 1-h-pirrolidina-2,4-diona.
BR112015027977A2 (pt) método para a produção de formulações de óleo, formulações de óleo, e uso das formulações de óleo
PH12020550958A1 (en) Method for producing carbodiimides
EA201791620A1 (ru) Способ разложения материала биомассы, содержащего лигноцеллюлозу
MY177218A (en) Method for producing specific ?,?-unsaturated aldehydes by rearrangement process
EA201992726A1 (ru) Способ получения (s,s)-секоизоларицирезинола диглюкозида и (r,r)-секоизоларицирезинола диглюкозида