SG11202105807XA - Process for the preparation of a cyclic dinucleotide - Google Patents

Process for the preparation of a cyclic dinucleotide

Info

Publication number
SG11202105807XA
SG11202105807XA SG11202105807XA SG11202105807XA SG11202105807XA SG 11202105807X A SG11202105807X A SG 11202105807XA SG 11202105807X A SG11202105807X A SG 11202105807XA SG 11202105807X A SG11202105807X A SG 11202105807XA SG 11202105807X A SG11202105807X A SG 11202105807XA
Authority
SG
Singapore
Prior art keywords
preparation
cyclic dinucleotide
dinucleotide
cyclic
Prior art date
Application number
SG11202105807XA
Other languages
English (en)
Inventor
Michael Anthony Schmidt
Bin Zheng
Benjamin M Cohen
Amanda J Rogers
Changxia Yuan
Jason J Zhu
Chao Hang
Daniel S Treitler
Adam Joseph Freitag
Geoffrey Eugene Purdum
Miao Yu
Edmonds Melda Sezen
Siwei Guo
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG11202105807XA publication Critical patent/SG11202105807XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/167Purine radicals with ribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
SG11202105807XA 2018-12-04 2019-12-03 Process for the preparation of a cyclic dinucleotide SG11202105807XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862775094P 2018-12-04 2018-12-04
PCT/US2019/064137 WO2020117739A1 (en) 2018-12-04 2019-12-03 Process for the preparation of a cyclic dinucleotide

Publications (1)

Publication Number Publication Date
SG11202105807XA true SG11202105807XA (en) 2021-06-29

Family

ID=69024628

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105807XA SG11202105807XA (en) 2018-12-04 2019-12-03 Process for the preparation of a cyclic dinucleotide

Country Status (13)

Country Link
US (1) US20220064205A1 (ru)
EP (1) EP3891160A1 (ru)
JP (1) JP2022513712A (ru)
KR (1) KR20210099065A (ru)
CN (1) CN113166184A (ru)
AU (1) AU2019391012A1 (ru)
BR (1) BR112021010466A2 (ru)
CA (1) CA3122027A1 (ru)
EA (1) EA202191565A1 (ru)
IL (1) IL283633A (ru)
MX (1) MX2021006498A (ru)
SG (1) SG11202105807XA (ru)
WO (1) WO2020117739A1 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253766A (zh) * 2023-03-27 2023-06-13 瑞阳(上海)新药研发有限公司 一种环二核苷酸2’,3’-cGAMP的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10604542B2 (en) * 2016-01-11 2020-03-31 Innate Tumor Immunity, Inc. Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
SG11202008827XA (en) * 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Also Published As

Publication number Publication date
WO2020117739A1 (en) 2020-06-11
IL283633A (en) 2021-07-29
BR112021010466A2 (pt) 2021-08-24
KR20210099065A (ko) 2021-08-11
CN113166184A (zh) 2021-07-23
AU2019391012A1 (en) 2021-07-22
MX2021006498A (es) 2021-07-06
US20220064205A1 (en) 2022-03-03
JP2022513712A (ja) 2022-02-09
CA3122027A1 (en) 2020-06-11
EA202191565A1 (ru) 2021-12-02
EP3891160A1 (en) 2021-10-13

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