WO2016079757A3 - Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives - Google Patents

Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives Download PDF

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Publication number
WO2016079757A3
WO2016079757A3 PCT/IN2015/000430 IN2015000430W WO2016079757A3 WO 2016079757 A3 WO2016079757 A3 WO 2016079757A3 IN 2015000430 W IN2015000430 W IN 2015000430W WO 2016079757 A3 WO2016079757 A3 WO 2016079757A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxazolidin
hydroxymethyl
derivatives
preparing
novel processes
Prior art date
Application number
PCT/IN2015/000430
Other languages
French (fr)
Other versions
WO2016079757A2 (en
Inventor
Rao Dodda Mohan
Reddy Vanga Malla
Aadepu Jithender
Original Assignee
Symed Labs Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symed Labs Limited filed Critical Symed Labs Limited
Publication of WO2016079757A2 publication Critical patent/WO2016079757A2/en
Publication of WO2016079757A3 publication Critical patent/WO2016079757A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to improved, commercially viable and industrially advantageous processes for the preparation of 5-Hydroxymethyl-oxazolidin-2-one derivatives or a pharmaceutically acceptable salt thereof using novel intermediates, in high yield and purity.
PCT/IN2015/000430 2014-11-19 2015-11-19 Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives WO2016079757A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5809CH2014 2014-11-19
IN5809/CHE/2014 2014-11-19

Publications (2)

Publication Number Publication Date
WO2016079757A2 WO2016079757A2 (en) 2016-05-26
WO2016079757A3 true WO2016079757A3 (en) 2018-12-27

Family

ID=56014648

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000430 WO2016079757A2 (en) 2014-11-19 2015-11-19 Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives

Country Status (1)

Country Link
WO (1) WO2016079757A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
CN113957441B (en) * 2021-10-29 2024-01-02 光华科学技术研究院(广东)有限公司 Etching solution and preparation method and application thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784551A (en) * 1971-07-08 1974-01-08 Yoshitomi Pharmaceutical 2-oxo-1,4-dioxa-8-azaspiro (4.5) decanes and related compounds
US20050143421A1 (en) * 2003-09-08 2005-06-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
WO2008056335A1 (en) * 2006-11-10 2008-05-15 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20120322766A1 (en) * 2003-04-30 2012-12-20 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
US20130324719A1 (en) * 2011-02-24 2013-12-05 Lee Pharma Limited Novel process for preparation of linezolid and its novel intermediates
WO2014174522A1 (en) * 2013-04-25 2014-10-30 Symed Labs Limited Improved processes for the preparation of linezolid using novel intermediates

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3784551A (en) * 1971-07-08 1974-01-08 Yoshitomi Pharmaceutical 2-oxo-1,4-dioxa-8-azaspiro (4.5) decanes and related compounds
US20120322766A1 (en) * 2003-04-30 2012-12-20 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
US20050143421A1 (en) * 2003-09-08 2005-06-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
WO2008056335A1 (en) * 2006-11-10 2008-05-15 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives
US20130324719A1 (en) * 2011-02-24 2013-12-05 Lee Pharma Limited Novel process for preparation of linezolid and its novel intermediates
WO2014174522A1 (en) * 2013-04-25 2014-10-30 Symed Labs Limited Improved processes for the preparation of linezolid using novel intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAKRABORTI ET AL.: "Chemoselective Protection of Carboxylic Acid as Methyl Ester: A Practical Alternative to Diazomethane Protocol", J. ORG. CHEM., vol. 64, 1999, pages 8014 - 8017, XP055556806 *

Also Published As

Publication number Publication date
WO2016079757A2 (en) 2016-05-26

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