MX2019013816A - Compuesto usado como regulador de la autofagia, metodo de preparacion y sus usos. - Google Patents

Compuesto usado como regulador de la autofagia, metodo de preparacion y sus usos.

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Publication number
MX2019013816A
MX2019013816A MX2019013816A MX2019013816A MX2019013816A MX 2019013816 A MX2019013816 A MX 2019013816A MX 2019013816 A MX2019013816 A MX 2019013816A MX 2019013816 A MX2019013816 A MX 2019013816A MX 2019013816 A MX2019013816 A MX 2019013816A
Authority
MX
Mexico
Prior art keywords
preparation
method therefor
compound used
regulator
autophagy
Prior art date
Application number
MX2019013816A
Other languages
English (en)
Inventor
Luo Cheng
Zhou Bing
Xie Yuli
Yao Zhiyi
Yue Liyan
Wan Wei
Zhang Bidong
Zhang Yuanyuan
Jiang Hualiang
Chen Kaixian
Original Assignee
Wigen Biomedicine Tech (Shanghai) Co Ltd
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Publication date
Application filed by Wigen Biomedicine Tech (Shanghai) Co Ltd filed Critical Wigen Biomedicine Tech (Shanghai) Co Ltd
Publication of MX2019013816A publication Critical patent/MX2019013816A/es

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    • A61K31/12—Ketones
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

(ver formula) Se relaciona con compuestos usados como moduladores de la autofagia y un método para preparar y usar los mismos, específicamente para proporcionar un compuesto de fórmula general (I), o sales farmacéuticamente aceptables de este, que es un tipo de moduladores de la autofagia, particularmente moduladores de homólogos de ATG8 de mamífero.
MX2019013816A 2017-05-22 2018-05-18 Compuesto usado como regulador de la autofagia, metodo de preparacion y sus usos. MX2019013816A (es)

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CN116969904A (zh) 2023-10-31
JP7237017B2 (ja) 2023-03-10
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CA3061209A1 (en) 2019-10-23
US20200190066A1 (en) 2020-06-18
CN111148740A (zh) 2020-05-12
BR112019024376A2 (pt) 2020-07-14
EP3632903B1 (en) 2023-10-11
AU2018274378A1 (en) 2019-12-12
US11319303B2 (en) 2022-05-03
WO2018214812A1 (zh) 2018-11-29
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