WO2020003272A8 - An improved process for the preparation of venetoclax - Google Patents

An improved process for the preparation of venetoclax Download PDF

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Publication number
WO2020003272A8
WO2020003272A8 PCT/IB2019/055578 IB2019055578W WO2020003272A8 WO 2020003272 A8 WO2020003272 A8 WO 2020003272A8 IB 2019055578 W IB2019055578 W IB 2019055578W WO 2020003272 A8 WO2020003272 A8 WO 2020003272A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
venetoclax
compound
formula
Prior art date
Application number
PCT/IB2019/055578
Other languages
French (fr)
Other versions
WO2020003272A1 (en
Inventor
Chandan Kumar Gupta
Navdeep DHIMAN
Sunil Sanghani
Govind Singh
Saswata Lahiri
Walter Cabri
Nitin Gupta
Original Assignee
Fresenius Kabi Oncology Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Oncology Ltd. filed Critical Fresenius Kabi Oncology Ltd.
Publication of WO2020003272A1 publication Critical patent/WO2020003272A1/en
Publication of WO2020003272A8 publication Critical patent/WO2020003272A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

An improved process for the preparation of Venetoclax. The present invention also relates to an improved process for the preparation of a compound of formula I or its salts, (I) wherein R is C1-4 alkyl; and its use for the preparation of the compound of formula V.
PCT/IB2019/055578 2018-06-29 2019-07-01 An improved process for the preparation of venetoclax WO2020003272A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201811024212 2018-06-29
ININ201811024212 2018-06-29

Publications (2)

Publication Number Publication Date
WO2020003272A1 WO2020003272A1 (en) 2020-01-02
WO2020003272A8 true WO2020003272A8 (en) 2020-08-13

Family

ID=67539541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2019/055578 WO2020003272A1 (en) 2018-06-29 2019-07-01 An improved process for the preparation of venetoclax

Country Status (1)

Country Link
WO (1) WO2020003272A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116496239A (en) * 2022-12-14 2023-07-28 南京哈柏医药科技有限公司 Synthesis method of key intermediate and bulk drug of vitamin Nadotox

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
EP2970263B1 (en) 2013-03-13 2018-05-09 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
WO2017156398A1 (en) 2016-03-10 2017-09-14 Assia Chemical Industries Ltd. Solid state forms of venetoclax and processes for preparation of venetoclax
WO2018029711A2 (en) 2016-08-12 2018-02-15 Mylan Laboratories Limited Process for the preparation of venetoclax
WO2018225043A1 (en) * 2017-06-10 2018-12-13 Lupin Limited Solid state forms of an apoptosis-inducing agent and processes thereof

Also Published As

Publication number Publication date
WO2020003272A1 (en) 2020-01-02

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