JP2017501141A5 - - Google Patents
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- Publication number
- JP2017501141A5 JP2017501141A5 JP2016536571A JP2016536571A JP2017501141A5 JP 2017501141 A5 JP2017501141 A5 JP 2017501141A5 JP 2016536571 A JP2016536571 A JP 2016536571A JP 2016536571 A JP2016536571 A JP 2016536571A JP 2017501141 A5 JP2017501141 A5 JP 2017501141A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethoxy
- hours
- dihydroisoquinoline
- water
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 229960005333 tetrabenazine Drugs 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011877 solvent mixture Substances 0.000 claims 2
- IOEPOEDBBPRAEI-UHFFFAOYSA-N 1,2-dihydroisoquinoline Chemical compound C1=CC=C2CNC=CC2=C1 IOEPOEDBBPRAEI-UHFFFAOYSA-N 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 claims 1
- 125000005910 alkyl carbonate group Chemical group 0.000 claims 1
- -1 alkyl phosphate Chemical compound 0.000 claims 1
- 150000008051 alkyl sulfates Chemical group 0.000 claims 1
- 150000008052 alkyl sulfonates Chemical group 0.000 claims 1
- 125000005228 aryl sulfonate group Chemical group 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- IAIYJIVHDZMNIP-UHFFFAOYSA-N trimethyl(4-methylpentyl)azanium Chemical compound CC(C)CCC[N+](C)(C)C IAIYJIVHDZMNIP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911214P | 2013-12-03 | 2013-12-03 | |
| US61/911,214 | 2013-12-03 | ||
| PCT/US2014/067117 WO2015084622A1 (en) | 2013-12-03 | 2014-11-24 | Methods of manufacturing benzoquinoline compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501141A JP2017501141A (ja) | 2017-01-12 |
| JP2017501141A5 true JP2017501141A5 (OSRAM) | 2018-01-11 |
| JP6542222B2 JP6542222B2 (ja) | 2019-07-10 |
Family
ID=53264424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536571A Active JP6542222B2 (ja) | 2013-12-03 | 2014-11-24 | ベンゾキノリン化合物の製造方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US20150152099A1 (OSRAM) |
| EP (2) | EP3076970A4 (OSRAM) |
| JP (1) | JP6542222B2 (OSRAM) |
| KR (1) | KR102391134B1 (OSRAM) |
| CN (1) | CN105873589B (OSRAM) |
| AU (4) | AU2014357518A1 (OSRAM) |
| BR (1) | BR112016012747B1 (OSRAM) |
| CA (1) | CA2930744A1 (OSRAM) |
| EA (2) | EA201791466A1 (OSRAM) |
| HK (1) | HK1224222A1 (OSRAM) |
| IL (1) | IL245539B (OSRAM) |
| MX (1) | MX369956B (OSRAM) |
| NZ (1) | NZ720301A (OSRAM) |
| WO (1) | WO2015084622A1 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6362601B2 (ja) | 2012-09-18 | 2018-07-25 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CA2930744A1 (en) | 2013-12-03 | 2015-06-11 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| IL288712B2 (en) | 2015-03-06 | 2024-01-01 | Auspex Pharmaceuticals Inc | Methods for the treatment of abnormal involuntary movement disorders |
| US10479787B2 (en) * | 2016-04-22 | 2019-11-19 | Lupin Limited | Process for preparation of tetrabenazine and deutetrabenazine |
| US10703750B2 (en) | 2017-01-10 | 2020-07-07 | Sandoz Ag | Crystalline valbenazine free base |
| US10954235B2 (en) | 2017-02-27 | 2021-03-23 | Sandoz Ag | Crystalline forms of valbenazine salts |
| WO2018170214A1 (en) | 2017-03-15 | 2018-09-20 | Zhang Chengzi | Analogs of deutetrabenazine, their preparation and use |
| WO2019130252A2 (en) * | 2017-12-29 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing deutetrabenazine |
| WO2019150387A1 (en) * | 2018-02-01 | 2019-08-08 | Alaparthi Lakshmi Prasad | A novel process for preparation of deutetrabenazine |
| MA53904A (fr) | 2018-10-18 | 2021-08-25 | Oncopeptides Ab | Composés contenant du deutérium |
| WO2020086765A1 (en) * | 2018-10-24 | 2020-04-30 | Neurocrine Biosciences, Inc. | Processes for preparing a vmat2 inhibitor |
| CN111960999B (zh) * | 2020-07-20 | 2021-11-02 | 暨明医药科技（苏州）有限公司 | 一种丁苯那嗪中间体的合成方法 |
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| CA2930167A1 (en) | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Methods of treating abnormal muscular activity |
| WO2015077521A1 (en) | 2013-11-22 | 2015-05-28 | Auspex Pharmaceuticals, Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CA2930744A1 (en) | 2013-12-03 | 2015-06-11 | Auspex Pharmaceuticals, Inc. | Methods of manufacturing benzoquinoline compounds |
| MX2016009817A (es) | 2014-01-27 | 2017-02-28 | Auspex Pharmaceuticals Inc | Inhibidores de benzoquinolina del transportador vesicular de monoaminas 2. |
-
2014
- 2014-11-24 CA CA2930744A patent/CA2930744A1/en not_active Abandoned
- 2014-11-24 BR BR112016012747-1A patent/BR112016012747B1/pt active IP Right Grant
- 2014-11-24 US US14/551,909 patent/US20150152099A1/en not_active Abandoned
- 2014-11-24 JP JP2016536571A patent/JP6542222B2/ja active Active
- 2014-11-24 NZ NZ720301A patent/NZ720301A/en unknown
- 2014-11-24 MX MX2016007056A patent/MX369956B/es active IP Right Grant
- 2014-11-24 KR KR1020167017402A patent/KR102391134B1/ko active Active
- 2014-11-24 HK HK16112664.2A patent/HK1224222A1/zh unknown
- 2014-11-24 EA EA201791466A patent/EA201791466A1/ru unknown
- 2014-11-24 EA EA201691162A patent/EA032920B1/ru not_active IP Right Cessation
- 2014-11-24 EP EP14867514.3A patent/EP3076970A4/en not_active Withdrawn
- 2014-11-24 CN CN201480066154.9A patent/CN105873589B/zh active Active
- 2014-11-24 WO PCT/US2014/067117 patent/WO2015084622A1/en not_active Ceased
- 2014-11-24 AU AU2014357518A patent/AU2014357518A1/en not_active Abandoned
- 2014-11-24 EP EP18179389.4A patent/EP3424504A1/en not_active Withdrawn
-
2016
- 2016-05-08 IL IL245539A patent/IL245539B/en active IP Right Grant
-
2017
- 2017-03-21 US US15/464,938 patent/US20170190654A1/en not_active Abandoned
- 2017-03-29 US US15/472,779 patent/US10513488B2/en active Active
-
2018
- 2018-04-12 US US15/952,031 patent/US20180230083A1/en not_active Abandoned
- 2018-11-30 US US16/205,525 patent/US20190092719A1/en not_active Abandoned
-
2019
- 2019-11-12 US US16/680,674 patent/US20200331846A1/en not_active Abandoned
-
2020
- 2020-02-14 AU AU2020201091A patent/AU2020201091B2/en active Active
- 2020-04-15 US US16/849,603 patent/US20200347008A1/en not_active Abandoned
-
2021
- 2021-07-26 AU AU2021209150A patent/AU2021209150A1/en not_active Abandoned
-
2022
- 2022-08-02 US US17/879,600 patent/US12077487B2/en active Active
-
2023
- 2023-05-23 AU AU2023203246A patent/AU2023203246B2/en active Active
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