EA032920B1 - Способы получения соединений бензохинолина - Google Patents

Способы получения соединений бензохинолина

Info

Publication number
EA032920B1
EA032920B1 EA201691162A EA201691162A EA032920B1 EA 032920 B1 EA032920 B1 EA 032920B1 EA 201691162 A EA201691162 A EA 201691162A EA 201691162 A EA201691162 A EA 201691162A EA 032920 B1 EA032920 B1 EA 032920B1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
manufacturing
benzoquinoline compounds
manufacturing benzoquinoline
compounds
Prior art date
Application number
EA201691162A
Other languages
English (en)
Other versions
EA201691162A1 (ru
Inventor
Чэнчжи Чжан
Original Assignee
Оспекс Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оспекс Фармасьютикалз, Инк. filed Critical Оспекс Фармасьютикалз, Инк.
Publication of EA201691162A1 publication Critical patent/EA201691162A1/ru
Publication of EA032920B1 publication Critical patent/EA032920B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001Acyclic or carbocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Данное изобретение относится к новым способам получения бензохинолиновых ингибиторов везикулярного моноаминного переносчика 2 (VMAT2) и его промежуточных соединений.
EA201691162A 2013-12-03 2014-11-24 Способы получения соединений бензохинолина EA032920B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361911214P 2013-12-03 2013-12-03
PCT/US2014/067117 WO2015084622A1 (en) 2013-12-03 2014-11-24 Methods of manufacturing benzoquinoline compounds

Publications (2)

Publication Number Publication Date
EA201691162A1 EA201691162A1 (ru) 2016-11-30
EA032920B1 true EA032920B1 (ru) 2019-08-30

Family

ID=53264424

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201691162A EA032920B1 (ru) 2013-12-03 2014-11-24 Способы получения соединений бензохинолина
EA201791466A EA201791466A1 (ru) 2013-12-03 2014-11-24 Способы получения соединений бензохинолина

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201791466A EA201791466A1 (ru) 2013-12-03 2014-11-24 Способы получения соединений бензохинолина

Country Status (14)

Country Link
US (8) US20150152099A1 (ru)
EP (2) EP3076970A4 (ru)
JP (1) JP6542222B2 (ru)
KR (1) KR102391134B1 (ru)
CN (1) CN105873589B (ru)
AU (4) AU2014357518A1 (ru)
BR (1) BR112016012747B1 (ru)
CA (1) CA2930744A1 (ru)
EA (2) EA032920B1 (ru)
HK (2) HK1223020A1 (ru)
IL (1) IL245539B (ru)
MX (1) MX369956B (ru)
NZ (1) NZ720301A (ru)
WO (1) WO2015084622A1 (ru)

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WO2014047167A1 (en) 2012-09-18 2014-03-27 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9550780B2 (en) 2012-09-18 2017-01-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
WO2015084622A1 (en) 2013-12-03 2015-06-11 Auspex Pharmaceuticals, Inc. Methods of manufacturing benzoquinoline compounds
CN107624067A (zh) 2015-03-06 2018-01-23 奥斯拜客斯制药有限公司 用于治疗异常不自主运动障碍的方法
WO2017182916A1 (en) 2016-04-22 2017-10-26 Lupin Limited Novel process for preparation of tetrabenazine and deutetrabenazine
US10703750B2 (en) 2017-01-10 2020-07-07 Sandoz Ag Crystalline valbenazine free base
US10954235B2 (en) 2017-02-27 2021-03-23 Sandoz Ag Crystalline forms of valbenazine salts
EA201992168A1 (ru) * 2017-03-15 2020-03-16 Ауспекс Фармасьютикалз, Инк. Аналоги деутетрабеназина, их получение и применение
WO2019130252A2 (en) * 2017-12-29 2019-07-04 Mylan Laboratories Ltd Methods and intermediates for preparing deutetrabenazine
US11505549B2 (en) * 2018-02-01 2022-11-22 Lakshmi Prasad ALAPARTHI Process for preparation of Deutetrabenazine
WO2020086765A1 (en) * 2018-10-24 2020-04-30 Neurocrine Biosciences, Inc. Processes for preparing a vmat2 inhibitor
CN111960999B (zh) * 2020-07-20 2021-11-02 暨明医药科技(苏州)有限公司 一种丁苯那嗪中间体的合成方法

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Also Published As

Publication number Publication date
EP3424504A1 (en) 2019-01-09
AU2020201091B2 (en) 2021-04-29
EA201691162A1 (ru) 2016-11-30
AU2023203246A1 (en) 2023-06-15
EP3076970A1 (en) 2016-10-12
AU2021209150A1 (en) 2021-08-19
US20190092719A1 (en) 2019-03-28
NZ720301A (en) 2022-01-28
US10513488B2 (en) 2019-12-24
BR112016012747B1 (pt) 2022-07-12
EA201791466A1 (ru) 2017-11-30
US12077487B2 (en) 2024-09-03
EP3076970A4 (en) 2017-07-26
US20200331846A1 (en) 2020-10-22
US20200347008A1 (en) 2020-11-05
CA2930744A1 (en) 2015-06-11
IL245539B (en) 2021-06-30
JP6542222B2 (ja) 2019-07-10
JP2017501141A (ja) 2017-01-12
US20230060294A1 (en) 2023-03-02
IL245539A0 (en) 2016-06-30
AU2020201091A1 (en) 2020-03-05
KR102391134B1 (ko) 2022-04-28
HK1223020A1 (zh) 2017-07-21
AU2014357518A1 (en) 2016-06-09
BR112016012747A2 (ru) 2017-08-08
US20170190654A1 (en) 2017-07-06
HK1224222A1 (zh) 2017-08-18
MX369956B (es) 2019-11-27
US20150152099A1 (en) 2015-06-04
MX2016007056A (es) 2017-01-06
US20170197957A1 (en) 2017-07-13
KR20160087904A (ko) 2016-07-22
WO2015084622A1 (en) 2015-06-11
CN105873589B (zh) 2019-11-01
CN105873589A (zh) 2016-08-17
US20180230083A1 (en) 2018-08-16

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