WO2016104960A3 - 결정성 페북소스타트 피돌레이트 염 및 이의 제조 방법 - Google Patents

결정성 페북소스타트 피돌레이트 염 및 이의 제조 방법 Download PDF

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Publication number
WO2016104960A3
WO2016104960A3 PCT/KR2015/012595 KR2015012595W WO2016104960A3 WO 2016104960 A3 WO2016104960 A3 WO 2016104960A3 KR 2015012595 W KR2015012595 W KR 2015012595W WO 2016104960 A3 WO2016104960 A3 WO 2016104960A3
Authority
WO
WIPO (PCT)
Prior art keywords
febuxostat
pidolate
salt
free base
present
Prior art date
Application number
PCT/KR2015/012595
Other languages
English (en)
French (fr)
Other versions
WO2016104960A2 (ko
Inventor
유형철
Original Assignee
제이투에이치바이오텍 (주)
주식회사 휴온스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제이투에이치바이오텍 (주), 주식회사 휴온스 filed Critical 제이투에이치바이오텍 (주)
Publication of WO2016104960A2 publication Critical patent/WO2016104960A2/ko
Publication of WO2016104960A3 publication Critical patent/WO2016104960A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 통풍 치료제로 이용되는 신규 페북소스타트 피돌레이트 염 및 이의 제조 방법에 관한 것이다. 본 발명의 페북소스타트 피돌레이트 염은 그 제조에 있어 특수한 용매 환경에서 피돌레이트의 당량 및 교반 시간을 조절함으로써, 최적 비율의 신규한 결정성 염을 우수한 순도 및 수율로 수득할 수 있다. 본 발명의 신규 페북소스타트 피돌레이트 염은 화학적 순도와 제조 수율이 기존 페북소스타트 유리염기 보다 우수하고, 산, 염기, 열안정성 및 광안정성이 우수하며, 기존 페북소스타트 유리염기 보다 용해도가 우수하고, 입자의 크기가 기존 페북소스타트 유리염기 보다 미세하고 균질하여 제제학적으로 매우 유용하다.
PCT/KR2015/012595 2014-12-22 2015-11-23 결정성 페북소스타트 피돌레이트 염 및 이의 제조 방법 WO2016104960A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2014-0185702 2014-12-22
KR20140185702A KR101501253B1 (ko) 2014-12-22 2014-12-22 결정성 페북소스타트 피돌레이트 염 및 이의 제조 방법

Publications (2)

Publication Number Publication Date
WO2016104960A2 WO2016104960A2 (ko) 2016-06-30
WO2016104960A3 true WO2016104960A3 (ko) 2016-09-15

Family

ID=53027143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2015/012595 WO2016104960A2 (ko) 2014-12-22 2015-11-23 결정성 페북소스타트 피돌레이트 염 및 이의 제조 방법

Country Status (2)

Country Link
KR (1) KR101501253B1 (ko)
WO (1) WO2016104960A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180013563A (ko) * 2016-07-29 2018-02-07 한미정밀화학주식회사 고순도 결정형 페북소스타트의 개선된 제조 방법
CN106749091A (zh) * 2017-03-08 2017-05-31 广州奈米微晶生物科技有限公司 非布索坦2‑甲基咪唑盐及其制备方法和包含其的药物组合物
KR102398639B1 (ko) * 2017-06-20 2022-05-17 (주) 성운파마코피아 아미드 유도체의 염 및 그 제조방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070105354A (ko) * 2005-02-24 2007-10-30 얀센 파마슈티카 엔.브이. 오카페리돈 염 및 이를 함유한 약제학적 조성물
JP4319491B2 (ja) * 2002-08-21 2009-08-26 シージェイ チェイルジェダン コーポレイション アムロジピンの有機酸塩
WO2012020272A2 (en) * 2010-08-13 2012-02-16 EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság New salts, polymorphs and solvates of a pharmaceutical active ingredient
CN102372679A (zh) * 2010-08-27 2012-03-14 北京润德康医药技术有限公司 一种非布司他水溶性衍生物及其制备方法
US20130190366A1 (en) * 2010-02-19 2013-07-25 Cadila Healthcare Limited Substantially pure salts of febuxostat and processes for preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4319491B2 (ja) * 2002-08-21 2009-08-26 シージェイ チェイルジェダン コーポレイション アムロジピンの有機酸塩
KR20070105354A (ko) * 2005-02-24 2007-10-30 얀센 파마슈티카 엔.브이. 오카페리돈 염 및 이를 함유한 약제학적 조성물
US20130190366A1 (en) * 2010-02-19 2013-07-25 Cadila Healthcare Limited Substantially pure salts of febuxostat and processes for preparation thereof
WO2012020272A2 (en) * 2010-08-13 2012-02-16 EGIS GYÓGYSZERGYÁR Nyilvánosan Müködö Részvénytársaság New salts, polymorphs and solvates of a pharmaceutical active ingredient
CN102372679A (zh) * 2010-08-27 2012-03-14 北京润德康医药技术有限公司 一种非布司他水溶性衍生物及其制备方法

Also Published As

Publication number Publication date
WO2016104960A2 (ko) 2016-06-30
KR101501253B1 (ko) 2015-03-12

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