WO2015104721A3 - An improved process for the preparation of tranexamic acid - Google Patents

An improved process for the preparation of tranexamic acid Download PDF

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Publication number
WO2015104721A3
WO2015104721A3 PCT/IN2015/050003 IN2015050003W WO2015104721A3 WO 2015104721 A3 WO2015104721 A3 WO 2015104721A3 IN 2015050003 W IN2015050003 W IN 2015050003W WO 2015104721 A3 WO2015104721 A3 WO 2015104721A3
Authority
WO
WIPO (PCT)
Prior art keywords
tranexamic acid
preparation
improved process
moderate
disclosed
Prior art date
Application number
PCT/IN2015/050003
Other languages
French (fr)
Other versions
WO2015104721A2 (en
Inventor
Ponnaiah Ravi
Praveen Kumar Neela
Nageswara Rao NIMMAKAYALA
Trinadha Rao AMPOLU
Ravinder TURKA
Mule VENKATESWARLU
Original Assignee
Davuluri, Ramamohan Rao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Davuluri, Ramamohan Rao filed Critical Davuluri, Ramamohan Rao
Publication of WO2015104721A2 publication Critical patent/WO2015104721A2/en
Publication of WO2015104721A3 publication Critical patent/WO2015104721A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/02—Formation of carboxyl groups in compounds containing amino groups, e.g. by oxidation of amino alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

An improved process for the preparation of Tranexamic acid is disclosed. The process can be performed at moderate reaction conditions such as at moderate temperatures and moderate pressure for large scale manufacture of Tranexamic acid.
PCT/IN2015/050003 2014-01-08 2015-01-07 An improved process for the preparation of tranexamic acid WO2015104721A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN90CH2014 2014-01-08
IN90/CHE/2014 2014-01-08

Publications (2)

Publication Number Publication Date
WO2015104721A2 WO2015104721A2 (en) 2015-07-16
WO2015104721A3 true WO2015104721A3 (en) 2016-03-03

Family

ID=53524449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/050003 WO2015104721A2 (en) 2014-01-08 2015-01-07 An improved process for the preparation of tranexamic acid

Country Status (1)

Country Link
WO (1) WO2015104721A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107954887B (en) * 2017-11-27 2020-02-21 常州寅盛药业有限公司 Method for preparing tranexamic acid
CN108752226A (en) * 2018-05-15 2018-11-06 常州兰陵制药有限公司 The preparation method of tranexamic acid
CN109959736B (en) * 2019-04-09 2021-08-17 北京市药品检验所 Method for determining tranexamic acid content by using amino acid analyzer
CN110483767B (en) * 2019-07-08 2021-10-15 华南师范大学 Degradable high-molecular hemostatic material and preparation method thereof
US20220402864A1 (en) * 2019-11-18 2022-12-22 Actera Ingredients, Inc. Salts of tranexamic acid esters
WO2021111475A1 (en) 2019-12-05 2021-06-10 Kawman Pharma Private Limited Process for preparing tranexamic acid
CN114436873B (en) * 2022-01-25 2023-08-22 上海巽田科技股份有限公司 Preparation method of tranexamic acid

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1440150A (en) * 1974-03-01 1976-06-23 Kureha Chemical Ind Co Ltd Process for preparing trans-4-amino-methylcyclohexane-1-carboxyl ic acid
GB1445636A (en) * 1972-09-07 1976-08-11 Teijin Ltd Isomerisation process
US4048222A (en) * 1974-03-04 1977-09-13 Kureha Kagaku Kogyo Kabushiki Kaisha Process for preparing trans-4-aminomethyl-cyclohexane-1-carboxylic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1445636A (en) * 1972-09-07 1976-08-11 Teijin Ltd Isomerisation process
GB1440150A (en) * 1974-03-01 1976-06-23 Kureha Chemical Ind Co Ltd Process for preparing trans-4-amino-methylcyclohexane-1-carboxyl ic acid
US4048222A (en) * 1974-03-04 1977-09-13 Kureha Kagaku Kogyo Kabushiki Kaisha Process for preparing trans-4-aminomethyl-cyclohexane-1-carboxylic acid

Also Published As

Publication number Publication date
WO2015104721A2 (en) 2015-07-16

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