AR071744A1 - Proceso para la preparacion de 6-sustituido-1-(2h)-isoquinolinonas, intermediarios para su sintesis y metodos de obtencion de estos intermediarios. - Google Patents

Proceso para la preparacion de 6-sustituido-1-(2h)-isoquinolinonas, intermediarios para su sintesis y metodos de obtencion de estos intermediarios.

Info

Publication number
AR071744A1
AR071744A1 ARP080105720A ARP080105720A AR071744A1 AR 071744 A1 AR071744 A1 AR 071744A1 AR P080105720 A ARP080105720 A AR P080105720A AR P080105720 A ARP080105720 A AR P080105720A AR 071744 A1 AR071744 A1 AR 071744A1
Authority
AR
Argentina
Prior art keywords
compound
formula
protecting group
intermediaries
give
Prior art date
Application number
ARP080105720A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR071744A1 publication Critical patent/AR071744A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Proceso para preparar derivados de 6-sustituidos-1-(2H)-isoquinolinona. Tambien se refiere a intermediarios que se usan en el proceso mencionado y a procesos para preparar tales intermedios. Reivindicacion 1: Un proceso para la preparacion de un compuesto de formula (1) o una sal del mismo, donde n es 1, 2, 3 o 4; y R1 es H o un grupo protector, que comprende las etapas de (A) hacer reaccionar un compuesto de formula (2) en el que X es halogeno, en un disolvente adecuado y en presencia de una base seleccionada de un alcoxido de metal alcalino terciario, hidruro de metal alcalino o metal alcalino con un compuesto de formula (3) donde R1 es H o un grupo protector y n es 1, 2, 3 o 4, para dar un compuesto de formula (4) donde R1 es H o un grupo protector y n es 1, 2, 3 o 4; y, s¡ R1 es H, protegiendo el grupo amino para dar un compuesto de formula (4) en el que R1 es un grupo protector de amino; (B) hacer reaccionar un compuesto de formula (4) con un compuesto de formula (5) R4-CH[N(R5)2]2 donde R4 es -O-alquilo C1-6, y R5 es alquilo C1-6, para proporcionar un compuesto de formula (6) en el que R1 es un grupo protector y n es 1, 2, 3 o 4; y (C) ciclar un compuesto de formula (6) y opcionalmente eliminar el grupo protector en un disolvente adecuado y en presencia de un  cido hidroh lico para dar un compuesto de formula (1) en el que R1 es H o un grupo protector; (D) opcionalmente eliminar el grupo protector a partir de un compuesto de formula (1) obtenido en la etapa (C), en el que R1 es un grupo protector, para dar el compuesto de formula (1) en el que R1 es H, y (E) opcionalmente convertir un compuesto de formula (1) en su sal. Reivindicacion 14: Un compuesto de formula (4) en el que R1 es H o un grupo protector y n es 1, 2, 3 o 4. Reivindicacion 16: Un compuesto de formula (6) en el que R1 es H o un grupo protector y n es 1, 2, 3 o 4.
ARP080105720A 2007-12-26 2008-12-23 Proceso para la preparacion de 6-sustituido-1-(2h)-isoquinolinonas, intermediarios para su sintesis y metodos de obtencion de estos intermediarios. AR071744A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07291622 2007-12-26

Publications (1)

Publication Number Publication Date
AR071744A1 true AR071744A1 (es) 2010-07-14

Family

ID=39410019

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105720A AR071744A1 (es) 2007-12-26 2008-12-23 Proceso para la preparacion de 6-sustituido-1-(2h)-isoquinolinonas, intermediarios para su sintesis y metodos de obtencion de estos intermediarios.

Country Status (19)

Country Link
US (1) US8716481B2 (es)
EP (1) EP2240441B1 (es)
JP (1) JP2011507921A (es)
KR (1) KR20100103646A (es)
CN (1) CN101910123A (es)
AR (1) AR071744A1 (es)
AU (1) AU2008340601A1 (es)
BR (1) BRPI0821837A2 (es)
CA (1) CA2710447A1 (es)
CL (1) CL2008003897A1 (es)
CO (1) CO6290756A2 (es)
HU (1) HUE025985T2 (es)
IL (1) IL206530A0 (es)
MA (1) MA31926B1 (es)
NZ (1) NZ586335A (es)
RU (1) RU2010131010A (es)
TW (1) TW200940525A (es)
UY (1) UY31577A1 (es)
WO (1) WO2009080335A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014000279B1 (pt) * 2011-07-08 2020-11-24 Sanofi composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)
EP2729461B1 (en) 2011-07-08 2016-01-20 Sanofi Polymorphs of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride
PL2729460T3 (pl) * 2011-07-08 2016-07-29 Sanofi Sa Krystaliczne solwaty chlorowodorku 6-(piperydyn-4-ylooksy)-2H-izochinolin-1-onu
US20140187777A1 (en) * 2012-03-26 2014-07-03 Dow Agrosciences Llc Materials and methods for the base-assisted synthesis of substituted heteroaromatic compounds
EP2740458B1 (en) 2012-12-06 2016-08-03 IP Gesellschaft für Management mbH Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide
AR107354A1 (es) * 2016-01-13 2018-04-18 Bristol Myers Squibb Co Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock
KR101700381B1 (ko) * 2016-06-27 2017-01-31 이에스콘트롤스(주) 와이파이를 이용한 무선 자동제어 장치 및 방법
WO2024030854A1 (en) 2022-08-01 2024-02-08 Valo Health, Inc. Process for preparing 6-substituted-1-(2h)-isoquinolinones and intermediate compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) * 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
AU2006274245B2 (en) * 2005-07-26 2011-11-24 Sanofi-Aventis Piperidinyl-substituted isoquinolone derivatives as Rho-kinase inhibitors
TW200738682A (en) * 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives

Also Published As

Publication number Publication date
WO2009080335A1 (en) 2009-07-02
EP2240441A1 (en) 2010-10-20
IL206530A0 (en) 2010-12-30
HUE025985T2 (en) 2016-04-28
JP2011507921A (ja) 2011-03-10
CA2710447A1 (en) 2009-07-02
KR20100103646A (ko) 2010-09-27
CL2008003897A1 (es) 2009-05-22
UY31577A1 (es) 2009-08-03
NZ586335A (en) 2011-08-26
CO6290756A2 (es) 2011-06-20
US20110021779A1 (en) 2011-01-27
EP2240441B1 (en) 2015-06-03
AU2008340601A1 (en) 2009-07-02
MA31926B1 (fr) 2010-12-01
RU2010131010A (ru) 2012-02-10
US8716481B2 (en) 2014-05-06
CN101910123A (zh) 2010-12-08
TW200940525A (en) 2009-10-01
BRPI0821837A2 (pt) 2015-06-16

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