MA31926B1 - Procédé pour la préparation de 1-(2h)-isoquinoléinones 6-substituées - Google Patents

Procédé pour la préparation de 1-(2h)-isoquinoléinones 6-substituées

Info

Publication number
MA31926B1
MA31926B1 MA32931A MA32931A MA31926B1 MA 31926 B1 MA31926 B1 MA 31926B1 MA 32931 A MA32931 A MA 32931A MA 32931 A MA32931 A MA 32931A MA 31926 B1 MA31926 B1 MA 31926B1
Authority
MA
Morocco
Prior art keywords
isocinolinone
substitute
preparation process
preparation
present
Prior art date
Application number
MA32931A
Other languages
Arabic (ar)
English (en)
Inventor
Kai Rossen
Hermut Wehlan
Oliver Plettenburg
Volker Kraft
Guenter Billen
Simon Gessler
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA31926B1 publication Critical patent/MA31926B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Abstract

La présente invention concerne un procédé de préparation de dérivés de 1-(2h)-isoquinolinones 6-substituées de formule (i) dans laquelle r1 et n sont tels que décrits dans la description. La présente invention concerne en outre de nouveaux intermédiaires qui sont utilisés dans le procédé selon l'invention, ainsi que des procédés de préparation de ces intermédiaires.
MA32931A 2007-12-26 2010-06-18 Procédé pour la préparation de 1-(2h)-isoquinoléinones 6-substituées MA31926B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07291622 2007-12-26
US5655008P 2008-05-28 2008-05-28
PCT/EP2008/010998 WO2009080335A1 (fr) 2007-12-26 2008-12-22 Procédé de préparation de 1-(2h)-isoquinolinones 6-substituées

Publications (1)

Publication Number Publication Date
MA31926B1 true MA31926B1 (fr) 2010-12-01

Family

ID=39410019

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32931A MA31926B1 (fr) 2007-12-26 2010-06-18 Procédé pour la préparation de 1-(2h)-isoquinoléinones 6-substituées

Country Status (19)

Country Link
US (1) US8716481B2 (fr)
EP (1) EP2240441B1 (fr)
JP (1) JP2011507921A (fr)
KR (1) KR20100103646A (fr)
CN (1) CN101910123A (fr)
AR (1) AR071744A1 (fr)
AU (1) AU2008340601A1 (fr)
BR (1) BRPI0821837A2 (fr)
CA (1) CA2710447A1 (fr)
CL (1) CL2008003897A1 (fr)
CO (1) CO6290756A2 (fr)
HU (1) HUE025985T2 (fr)
IL (1) IL206530A0 (fr)
MA (1) MA31926B1 (fr)
NZ (1) NZ586335A (fr)
RU (1) RU2010131010A (fr)
TW (1) TW200940525A (fr)
UY (1) UY31577A1 (fr)
WO (1) WO2009080335A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102013566B1 (ko) * 2011-07-08 2019-08-23 사노피 ６-(피페리딘-４-일옥시)-２ｈ-이소퀴놀린-１-온 하이드로클로라이드의 결정성 용매화물
BR112014000279B1 (pt) * 2011-07-08 2020-11-24 Sanofi composto de fenila substituído de fórmula (vi), seu processo de preparação, seu uso na preparação de um composto de fórmula (i) e processo de preparação de um composto de fórmula (i)
US8598201B2 (en) * 2011-07-08 2013-12-03 Sanofi Polymorphs of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride
US20140187777A1 (en) * 2012-03-26 2014-07-03 Dow Agrosciences Llc Materials and methods for the base-assisted synthesis of substituted heteroaromatic compounds
EP3141235A1 (fr) 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N- (6- ((2r, 3s) -3,4-dihydroxybutan-2-yloxy) -2- (4-fluorobenzylthio) pyrimidin-4-yl) -3-methylazetidine-l sulfonamide
AR107354A1 (es) * 2016-01-13 2018-04-18 Bristol Myers Squibb Co Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock
KR101700381B1 (ko) * 2016-06-27 2017-01-31 이에스콘트롤스(주) 와이파이를 이용한 무선 자동제어 장치 및 방법
WO2024030854A1 (fr) 2022-08-01 2024-02-08 Valo Health, Inc. Procédé de préparation de 1-(2h)-isoquinolinones substituées en position 6 et composé intermédiaire

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732245A (en) * 1970-11-04 1973-05-08 Hoffmann La Roche Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
PT1910333E (pt) * 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
TW200738682A (en) * 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives

Also Published As

Publication number Publication date
EP2240441A1 (fr) 2010-10-20
JP2011507921A (ja) 2011-03-10
CN101910123A (zh) 2010-12-08
US8716481B2 (en) 2014-05-06
IL206530A0 (en) 2010-12-30
BRPI0821837A2 (pt) 2015-06-16
CA2710447A1 (fr) 2009-07-02
EP2240441B1 (fr) 2015-06-03
WO2009080335A1 (fr) 2009-07-02
CO6290756A2 (es) 2011-06-20
AU2008340601A1 (en) 2009-07-02
KR20100103646A (ko) 2010-09-27
UY31577A1 (es) 2009-08-03
TW200940525A (en) 2009-10-01
HUE025985T2 (en) 2016-04-28
AR071744A1 (es) 2010-07-14
US20110021779A1 (en) 2011-01-27
NZ586335A (en) 2011-08-26
RU2010131010A (ru) 2012-02-10
CL2008003897A1 (es) 2009-05-22

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