MX2015000479A - Metodos para sintetizar bloque de construccion de amatoxina y amatoxinas. - Google Patents

Metodos para sintetizar bloque de construccion de amatoxina y amatoxinas.

Info

Publication number
MX2015000479A
MX2015000479A MX2015000479A MX2015000479A MX2015000479A MX 2015000479 A MX2015000479 A MX 2015000479A MX 2015000479 A MX2015000479 A MX 2015000479A MX 2015000479 A MX2015000479 A MX 2015000479A MX 2015000479 A MX2015000479 A MX 2015000479A
Authority
MX
Mexico
Prior art keywords
amatoxins
building block
methods
synthesizing
amatoxin
Prior art date
Application number
MX2015000479A
Other languages
English (en)
Other versions
MX361116B (es
Inventor
Christoph Mueller
Werner Simon
Christian Lutz
Original Assignee
Heidelberg Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Gmbh filed Critical Heidelberg Pharma Gmbh
Publication of MX2015000479A publication Critical patent/MX2015000479A/es
Publication of MX361116B publication Critical patent/MX361116B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a nuevos métodos para sintetizar un sintón para ?,d-dihidroxiisoleucina 1 (CAS No. 55399-94-5) como bloque de construcción para la síntesis de amatoxinas y para nuevos métodos para sintetizar amatoxinas usando tal bloque de construcción.
MX2015000479A 2012-07-13 2013-07-12 Métodos para sintetizar bloque de construcción de amatoxina y amatoxinas. MX361116B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12005173.5A EP2684865A1 (en) 2012-07-13 2012-07-13 Methods for synthesizing amatoxin building block and amatoxins
PCT/EP2013/002084 WO2014009025A1 (en) 2012-07-13 2013-07-12 Methods for synthesizing amatoxin building block and amatoxins

Publications (2)

Publication Number Publication Date
MX2015000479A true MX2015000479A (es) 2015-04-08
MX361116B MX361116B (es) 2018-11-28

Family

ID=48793164

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000479A MX361116B (es) 2012-07-13 2013-07-12 Métodos para sintetizar bloque de construcción de amatoxina y amatoxinas.

Country Status (25)

Country Link
US (1) US9676702B2 (es)
EP (2) EP2684865A1 (es)
JP (2) JP2015528799A (es)
KR (1) KR102122575B1 (es)
CN (1) CN104470891B (es)
AU (1) AU2013289555B2 (es)
BR (1) BR112015000232B1 (es)
CA (1) CA2878081C (es)
CY (1) CY1117950T1 (es)
DK (1) DK2872479T3 (es)
ES (1) ES2589306T3 (es)
HK (1) HK1209723A1 (es)
HR (1) HRP20160984T1 (es)
HU (1) HUE029538T2 (es)
IL (1) IL236129A (es)
MX (1) MX361116B (es)
NZ (1) NZ702752A (es)
PL (1) PL2872479T3 (es)
PT (1) PT2872479T (es)
RU (1) RU2637924C2 (es)
SG (1) SG11201500225WA (es)
SI (1) SI2872479T1 (es)
UA (1) UA116991C2 (es)
WO (1) WO2014009025A1 (es)
ZA (1) ZA201409384B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016071856A1 (en) 2014-11-06 2016-05-12 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
CA3005683A1 (en) * 2015-11-27 2017-06-01 Heidelberg Pharma Research Gmbh Derivatives of gamma-amanitin
EP3222292A1 (en) 2016-03-03 2017-09-27 Heidelberg Pharma GmbH Amanitin conjugates
WO2017191579A1 (en) 2016-05-05 2017-11-09 Novartis Ag Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase
WO2017219025A1 (en) 2016-06-17 2017-12-21 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cells
US10111966B2 (en) * 2016-06-17 2018-10-30 Magenta Therapeutics, Inc. Methods for the depletion of CD117+ cells
AU2017380099A1 (en) 2016-12-23 2019-06-13 Heidelberg Pharma Research Gmbh Amanitin antibody conjugates
IL268058B2 (en) 2017-01-20 2023-09-01 Magenta Therapeutics Inc Compositions and methods for depleting cd137 plus cells
JP7220199B2 (ja) 2017-08-07 2023-02-09 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング アマニチンの新規な合成方法
EP3665173A1 (en) 2017-08-07 2020-06-17 Heidelberg Pharma Research GmbH Novel method for synthesizing amanitins
WO2019034175A1 (zh) * 2017-08-18 2019-02-21 四川百利药业有限责任公司 一种非天然鹅膏毒肽类抗体偶联物
SG11202008017UA (en) * 2017-09-08 2020-09-29 Sichuan Baili Pharm Co Ltd Amanitin antibody conjugate
KR20190043031A (ko) * 2017-10-17 2019-04-25 한국화학연구원 아마톡신 유도체 및 이의 제조방법
EP3546447A1 (en) 2018-03-29 2019-10-02 Heidelberg Pharma GmbH Synthesis of (2s,3r,4r)-4,5-dihydroxyisoleucine and derivatives
AU2020263959A1 (en) 2019-04-24 2021-11-25 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
WO2021004973A1 (en) * 2019-07-05 2021-01-14 Pure Bioorganics Sia Synthesis of a-amanitin and its derivatives
EP3792250A1 (en) * 2019-09-13 2021-03-17 Pure Bioorganics SIA Synthesis of alpha-amanitin and its derivatives
KR102092817B1 (ko) * 2019-08-22 2020-03-24 한국화학연구원 아마톡신 유도체 및 이의 제조방법
CN112552196B (zh) * 2020-11-23 2024-02-02 蚌埠丰原医药科技发展有限公司 一种制备赖氨匹林的方法

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GB1585076A (en) 1976-07-13 1981-02-25 Roche Products Ltd Peptides of phosphonic and phosphinic acids
DE4104024A1 (de) 1991-02-09 1992-08-13 Merck Patent Gmbh Aminosaeurederivate
JPH0959228A (ja) * 1995-08-17 1997-03-04 Hokuriku Seiyaku Co Ltd 光学活性なアミノアルコール及びその製造方法
KR100491748B1 (ko) * 1996-09-13 2005-05-27 니폰 가야꾸 가부시끼가이샤 광학활성 에리스로-3-아미노-2-히드록시부티르산에스테르류및 해당 부티르산류의 제조방법
JPH11137291A (ja) 1997-11-12 1999-05-25 Mori Sangyo Kk アマニチン類の製造法
CA2332772A1 (en) 1998-05-22 1999-12-02 Jack Henkin Antiangiogenic drug to treat cancer, arthritis and retinopathy
KR20030009391A (ko) 2000-03-17 2003-01-29 브리스톨-마이어스 스퀴브 파마 컴파니 기질 금속단백분해효소 및 ＴＮＦ-α의 억제제인 시클릭β-아미노산 유도체
JP2004501085A (ja) 2000-04-18 2004-01-15 イーライ・リリー・アンド・カンパニー リピドｉｉの製造方法
ES2371085T3 (es) 2006-05-27 2011-12-27 Faulstich, Heinz, Dr. Utilización de conjugados de amatoxinas o falotoxinas con macromoléculas para la terapia tumoral y de la inflamación.
KR20110140124A (ko) 2009-04-08 2011-12-30 하인즈 파울스티히 암치료용 아미톡신-활성 표적 결합 부위
EP3485912A1 (en) 2009-04-08 2019-05-22 Faulstich, Heinz, Dr. Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy

Also Published As

Publication number Publication date
US20150210628A1 (en) 2015-07-30
RU2637924C2 (ru) 2017-12-08
EP2684865A1 (en) 2014-01-15
AU2013289555A1 (en) 2015-01-22
MX361116B (es) 2018-11-28
ES2589306T3 (es) 2016-11-11
IL236129A0 (en) 2015-02-01
CN104470891A (zh) 2015-03-25
BR112015000232A8 (pt) 2022-08-23
HRP20160984T1 (hr) 2016-10-21
WO2014009025A1 (en) 2014-01-16
EP2872479B1 (en) 2016-06-08
KR102122575B1 (ko) 2020-06-12
PL2872479T3 (pl) 2016-12-30
KR20150036444A (ko) 2015-04-07
PT2872479T (pt) 2016-08-23
CA2878081A1 (en) 2014-01-16
HUE029538T2 (en) 2017-03-28
JP2018090610A (ja) 2018-06-14
AU2013289555B2 (en) 2017-10-05
HK1209723A1 (en) 2016-04-08
US9676702B2 (en) 2017-06-13
JP6560382B2 (ja) 2019-08-14
SG11201500225WA (en) 2015-02-27
CY1117950T1 (el) 2017-05-17
UA116991C2 (uk) 2018-06-11
CA2878081C (en) 2021-01-26
EP2872479A1 (en) 2015-05-20
IL236129A (en) 2017-10-31
DK2872479T3 (en) 2016-09-05
CN104470891B (zh) 2016-10-12
NZ702752A (en) 2017-04-28
JP2015528799A (ja) 2015-10-01
SI2872479T1 (sl) 2016-11-30
BR112015000232A2 (pt) 2017-06-27
RU2015104802A (ru) 2016-08-27
BR112015000232B1 (pt) 2022-09-06
ZA201409384B (en) 2015-12-23

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