UA116991C2 - Способи синтезу аматоксинового структурного елемента та аматоксинів - Google Patents
Способи синтезу аматоксинового структурного елемента та аматоксинівInfo
- Publication number
- UA116991C2 UA116991C2 UAA201501155A UAA201501155A UA116991C2 UA 116991 C2 UA116991 C2 UA 116991C2 UA A201501155 A UAA201501155 A UA A201501155A UA A201501155 A UAA201501155 A UA A201501155A UA 116991 C2 UA116991 C2 UA 116991C2
- Authority
- UA
- Ukraine
- Prior art keywords
- amatoxins
- building block
- methods
- synthesizing
- amatoxin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Даний винахід стосується нових способів синтезу синтону для (,(-дигідроксіізолейцину 1 (№ згідно з С AS 55399-94-5) як структурного елемента для синтезу аматоксинів, а також нових способів синтезу аматоксинів за допомогою такого структурного елемента.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12005173.5A EP2684865A1 (en) | 2012-07-13 | 2012-07-13 | Methods for synthesizing amatoxin building block and amatoxins |
| PCT/EP2013/002084 WO2014009025A1 (en) | 2012-07-13 | 2013-07-12 | Methods for synthesizing amatoxin building block and amatoxins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA116991C2 true UA116991C2 (uk) | 2018-06-11 |
Family
ID=48793164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201501155A UA116991C2 (uk) | 2012-07-13 | 2013-07-12 | Способи синтезу аматоксинового структурного елемента та аматоксинів |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9676702B2 (uk) |
| EP (2) | EP2684865A1 (uk) |
| JP (2) | JP2015528799A (uk) |
| KR (1) | KR102122575B1 (uk) |
| CN (1) | CN104470891B (uk) |
| AU (1) | AU2013289555B2 (uk) |
| BR (1) | BR112015000232B1 (uk) |
| CA (1) | CA2878081C (uk) |
| CY (1) | CY1117950T1 (uk) |
| DK (1) | DK2872479T3 (uk) |
| ES (1) | ES2589306T3 (uk) |
| HK (1) | HK1209723A1 (uk) |
| HR (1) | HRP20160984T1 (uk) |
| HU (1) | HUE029538T2 (uk) |
| IL (1) | IL236129A (uk) |
| MX (1) | MX361116B (uk) |
| NZ (1) | NZ702752A (uk) |
| PL (1) | PL2872479T3 (uk) |
| PT (1) | PT2872479T (uk) |
| RU (1) | RU2637924C2 (uk) |
| SG (1) | SG11201500225WA (uk) |
| SI (1) | SI2872479T1 (uk) |
| UA (1) | UA116991C2 (uk) |
| WO (1) | WO2014009025A1 (uk) |
| ZA (1) | ZA201409384B (uk) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3215519A1 (en) | 2014-11-06 | 2017-09-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
| WO2017089607A1 (en) * | 2015-11-27 | 2017-06-01 | Heidelberg Pharma Gmbh | Derivatives of gamma-amanitin |
| EP3222292A1 (en) | 2016-03-03 | 2017-09-27 | Heidelberg Pharma GmbH | Amanitin conjugates |
| EP3452492A1 (en) | 2016-05-05 | 2019-03-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
| SG10202100726XA (en) * | 2016-06-17 | 2021-02-25 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd117+cells |
| JP2019522050A (ja) | 2016-06-17 | 2019-08-08 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 細胞の枯渇のための組成物および方法 |
| AU2017380099A1 (en) | 2016-12-23 | 2019-06-13 | Heidelberg Pharma Research Gmbh | Amanitin antibody conjugates |
| IL268058B2 (en) | 2017-01-20 | 2023-09-01 | Magenta Therapeutics Inc | Compositions and methods for depleting cd137 plus cells |
| EP3661938A1 (en) | 2017-08-07 | 2020-06-10 | Heidelberg Pharma Research GmbH | Novel method for synthesizing amanitins |
| AU2018314668B2 (en) | 2017-08-07 | 2022-06-02 | Heidelberg Pharma Research Gmbh | Novel method for synthesizing amanitins |
| SG11202008284XA (en) * | 2017-08-18 | 2020-09-29 | Sichuan Baili Pharm Co Ltd | Non-natural amatoxin-type antibody conjugate |
| SG11202008017UA (en) * | 2017-09-08 | 2020-09-29 | Sichuan Baili Pharm Co Ltd | Amanitin antibody conjugate |
| KR20190043031A (ko) * | 2017-10-17 | 2019-04-25 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
| EP3546447A1 (en) | 2018-03-29 | 2019-10-02 | Heidelberg Pharma GmbH | Synthesis of (2s,3r,4r)-4,5-dihydroxyisoleucine and derivatives |
| CN112739340A (zh) | 2018-07-23 | 2021-04-30 | 美真达治疗公司 | 抗cd5抗体药物缀合物(adc)在同种异体细胞疗法中的用途 |
| US20230135930A1 (en) | 2019-04-24 | 2023-05-04 | Heidelberg Pharma Research Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| JP2022538692A (ja) * | 2019-07-05 | 2022-09-05 | プーレ バイオオーガニクス エスアイエー | α－アマニチン及びその誘導体の合成 |
| EP3792250A1 (en) * | 2019-09-13 | 2021-03-17 | Pure Bioorganics SIA | Synthesis of alpha-amanitin and its derivatives |
| KR102092817B1 (ko) * | 2019-08-22 | 2020-03-24 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
| CN112552196B (zh) * | 2020-11-23 | 2024-02-02 | 蚌埠丰原医药科技发展有限公司 | 一种制备赖氨匹林的方法 |
| WO2024121632A1 (en) | 2022-12-09 | 2024-06-13 | Crispr Therapeutics Ag | Use of anti-cd117 antibody drug conjugate (adc) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1585076A (en) * | 1976-07-13 | 1981-02-25 | Roche Products Ltd | Peptides of phosphonic and phosphinic acids |
| DE4104024A1 (de) * | 1991-02-09 | 1992-08-13 | Merck Patent Gmbh | Aminosaeurederivate |
| JPH0959228A (ja) * | 1995-08-17 | 1997-03-04 | Hokuriku Seiyaku Co Ltd | 光学活性なアミノアルコール及びその製造方法 |
| ES2193398T3 (es) * | 1996-09-13 | 2003-11-01 | Nippon Kayaku Kk | Esteres eritro-3-amino-2-hidroxibutiricos opticamente activos y procedimiento para preparar dichos esteres. |
| JPH11137291A (ja) * | 1997-11-12 | 1999-05-25 | Mori Sangyo Kk | アマニチン類の製造法 |
| CA2332772A1 (en) * | 1998-05-22 | 1999-12-02 | Jack Henkin | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
| NZ521248A (en) * | 2000-03-17 | 2004-04-30 | Bristol Myers Squibb Pharma Co | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha |
| JP2004501085A (ja) * | 2000-04-18 | 2004-01-15 | イーライ・リリー・アンド・カンパニー | リピドｉｉの製造方法 |
| ATE521366T1 (de) | 2006-05-27 | 2011-09-15 | Faulstich Heinz Dr | Anwendung von amatoxin-konjugaten und phallotoxin-konjugaten mit makromolekülen zur krebstherapie und therapie von entzündungen |
| LT3192529T (lt) | 2009-04-08 | 2020-06-25 | Faulstich, Heinz, Dr. | Amatoksinu užtaisyti terapiniai su ląstelės paviršiumi susirišantys komponentai, sukonstruoti navikų terapijai |
| SG174328A1 (en) | 2009-04-08 | 2011-10-28 | Deutsches Krebsforsch | Amatoxin-armed target-binding moieties for the treatment of cancer |
-
2012
- 2012-07-13 EP EP12005173.5A patent/EP2684865A1/en not_active Withdrawn
-
2013
- 2013-07-12 NZ NZ702752A patent/NZ702752A/en unknown
- 2013-07-12 PL PL13737145.6T patent/PL2872479T3/pl unknown
- 2013-07-12 WO PCT/EP2013/002084 patent/WO2014009025A1/en active Application Filing
- 2013-07-12 DK DK13737145.6T patent/DK2872479T3/en active
- 2013-07-12 RU RU2015104802A patent/RU2637924C2/ru active
- 2013-07-12 KR KR1020157003282A patent/KR102122575B1/ko active IP Right Grant
- 2013-07-12 HU HUE13737145A patent/HUE029538T2/en unknown
- 2013-07-12 UA UAA201501155A patent/UA116991C2/uk unknown
- 2013-07-12 PT PT137371456T patent/PT2872479T/pt unknown
- 2013-07-12 SG SG11201500225WA patent/SG11201500225WA/en unknown
- 2013-07-12 EP EP13737145.6A patent/EP2872479B1/en active Active
- 2013-07-12 AU AU2013289555A patent/AU2013289555B2/en active Active
- 2013-07-12 US US14/414,143 patent/US9676702B2/en active Active
- 2013-07-12 BR BR112015000232-3A patent/BR112015000232B1/pt active IP Right Grant
- 2013-07-12 ES ES13737145.6T patent/ES2589306T3/es active Active
- 2013-07-12 CN CN201380037459.2A patent/CN104470891B/zh active Active
- 2013-07-12 MX MX2015000479A patent/MX361116B/es active IP Right Grant
- 2013-07-12 JP JP2015520852A patent/JP2015528799A/ja active Pending
- 2013-07-12 CA CA2878081A patent/CA2878081C/en active Active
- 2013-07-12 SI SI201330268A patent/SI2872479T1/sl unknown
-
2014
- 2014-12-08 IL IL236129A patent/IL236129A/en active IP Right Grant
- 2014-12-19 ZA ZA2014/09384A patent/ZA201409384B/en unknown
-
2015
- 2015-10-22 HK HK15110372.0A patent/HK1209723A1/xx unknown
-
2016
- 2016-08-02 HR HRP20160984TT patent/HRP20160984T1/hr unknown
- 2016-08-22 CY CY20161100827T patent/CY1117950T1/el unknown
-
2018
- 2018-02-16 JP JP2018025844A patent/JP6560382B2/ja active Active
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