JP2017055774A5 - - Google Patents
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- JP2017055774A5 JP2017055774A5 JP2016255720A JP2016255720A JP2017055774A5 JP 2017055774 A5 JP2017055774 A5 JP 2017055774A5 JP 2016255720 A JP2016255720 A JP 2016255720A JP 2016255720 A JP2016255720 A JP 2016255720A JP 2017055774 A5 JP2017055774 A5 JP 2017055774A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical formulation
- administration
- binding fragment
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims description 4
- 102000058223 human VEGFA Human genes 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000003163 Cavernous Hemangioma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010010071 Coma Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000008808 Fibrosarcoma Diseases 0.000 claims 1
- 208000000527 Germinoma Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000007256 Nevus Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010038933 Retinopathy of prematurity Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 201000006828 endometrial hyperplasia Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000003115 germ cell cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000002222 hemangioblastoma Diseases 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 208000006359 hepatoblastoma Diseases 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000003142 neovascular glaucoma Diseases 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 238000002649 immunization Methods 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000010799 Receptor Interactions Effects 0.000 description 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7569208P | 2008-06-25 | 2008-06-25 | |
| US13321208P | 2008-06-25 | 2008-06-25 | |
| US7569708P | 2008-06-25 | 2008-06-25 | |
| US61/075,697 | 2008-06-25 | ||
| US61/075,692 | 2008-06-25 | ||
| US61/133,212 | 2008-06-25 | ||
| US15504109P | 2009-02-24 | 2009-02-24 | |
| US61/155,041 | 2009-02-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087194A Division JP6100199B2 (ja) | 2008-06-25 | 2014-04-21 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018018375A Division JP6821612B2 (ja) | 2008-06-25 | 2018-02-05 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017055774A JP2017055774A (ja) | 2017-03-23 |
| JP2017055774A5 true JP2017055774A5 (enExample) | 2019-01-31 |
| JP6527128B2 JP6527128B2 (ja) | 2019-06-05 |
Family
ID=41209803
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515049A Active JP5956752B2 (ja) | 2008-06-25 | 2009-06-25 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2014087194A Active JP6100199B2 (ja) | 2008-06-25 | 2014-04-21 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2015037794A Pending JP2015134792A (ja) | 2008-06-25 | 2015-02-27 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2016255720A Active JP6527128B2 (ja) | 2008-06-25 | 2016-12-28 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2018018375A Active JP6821612B2 (ja) | 2008-06-25 | 2018-02-05 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2019090735A Active JP6978468B2 (ja) | 2008-06-25 | 2019-05-13 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2021184262A Active JP7171877B6 (ja) | 2008-06-25 | 2021-11-11 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515049A Active JP5956752B2 (ja) | 2008-06-25 | 2009-06-25 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2014087194A Active JP6100199B2 (ja) | 2008-06-25 | 2014-04-21 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2015037794A Pending JP2015134792A (ja) | 2008-06-25 | 2015-02-27 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018018375A Active JP6821612B2 (ja) | 2008-06-25 | 2018-02-05 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2019090735A Active JP6978468B2 (ja) | 2008-06-25 | 2019-05-13 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
| JP2021184262A Active JP7171877B6 (ja) | 2008-06-25 | 2021-11-11 | Ｖｅｇｆを阻害する安定かつ可溶性の抗体 |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US8349322B2 (enExample) |
| EP (3) | EP3722310B1 (enExample) |
| JP (7) | JP5956752B2 (enExample) |
| KR (8) | KR101737466B1 (enExample) |
| CN (3) | CN102143976B (enExample) |
| AU (1) | AU2009264565C1 (enExample) |
| BR (1) | BRPI0914251B1 (enExample) |
| CA (2) | CA3020290A1 (enExample) |
| CL (1) | CL2010001544A1 (enExample) |
| CY (3) | CY1118829T1 (enExample) |
| DK (3) | DK3722310T3 (enExample) |
| ES (3) | ES2793008T3 (enExample) |
| FI (1) | FI3722310T3 (enExample) |
| HR (3) | HRP20241467T1 (enExample) |
| HU (4) | HUE032894T2 (enExample) |
| LT (4) | LT3216803T (enExample) |
| MX (3) | MX2011000011A (enExample) |
| NL (1) | NL301058I2 (enExample) |
| NO (1) | NO2020021I1 (enExample) |
| PH (1) | PH12015501593A1 (enExample) |
| PL (3) | PL3722310T3 (enExample) |
| PT (3) | PT3216803T (enExample) |
| RU (6) | RU2531523C3 (enExample) |
| SI (3) | SI3216803T1 (enExample) |
| WO (1) | WO2009155724A2 (enExample) |
| ZA (1) | ZA201008594B (enExample) |
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| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint Pharmaceuticals, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| MX345395B (es) | 2008-06-25 | 2017-01-30 | Esbatech Alcon Biomed Res Unit | Humanizacion de anticuerpos de conejos usando una estructura de anticuerpos universal. |
| KR101737466B1 (ko) | 2008-06-25 | 2017-05-18 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체 |
| WO2009155723A2 (en) | 2008-06-25 | 2009-12-30 | Esbatech, An Alcon Biomedical Research Unit Llc | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFα |
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| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| CA2744103C (en) | 2009-02-24 | 2018-01-02 | Esbatech, An Alcon Biomedical Research Unit Llc | Methods for identifying immunobinders of cell-surface antigens |
| US8952138B2 (en) | 2009-06-22 | 2015-02-10 | Amgen Inc. | Refolding proteins using a chemically controlled redox state |
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| ES2604837T3 (es) | 2012-02-02 | 2017-03-09 | Esbatech - A Novartis Company Llc | Formulación de liberación sostenida que contiene anticuerpos para administración ocular |
| UA120029C2 (uk) | 2012-07-13 | 2019-09-25 | Рош Глікарт Аг | Спосіб зниження в'язкості біспецифічного антитіла до vegf/ang-2 та застосування такого антитіла для лікування судинних очних захворювань |
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