JP2016538316A5 - - Google Patents
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- JP2016538316A5 JP2016538316A5 JP2016536372A JP2016536372A JP2016538316A5 JP 2016538316 A5 JP2016538316 A5 JP 2016538316A5 JP 2016536372 A JP2016536372 A JP 2016536372A JP 2016536372 A JP2016536372 A JP 2016536372A JP 2016538316 A5 JP2016538316 A5 JP 2016538316A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- compound
- unsubstituted
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 58
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 229910052739 hydrogen Inorganic materials 0.000 claims 32
- 239000001257 hydrogen Substances 0.000 claims 32
- 125000000623 heterocyclic group Chemical group 0.000 claims 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 125000003107 substituted aryl group Chemical group 0.000 claims 16
- -1 -O- carboxy Chemical group 0.000 claims 15
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 13
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
- 125000004429 atom Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000002619 bicyclic group Chemical group 0.000 claims 5
- 108010050904 Interferons Proteins 0.000 claims 4
- 102000014150 Interferons Human genes 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 229940079322 interferon Drugs 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 claims 3
- MTPVBMVUENFFLL-HXUWFJFHSA-N 1-(2-fluorophenyl)-3-[(3s)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea Chemical compound FC1=CC=CC=C1NC(=O)N[C@@H]1C(=O)NC2=CC=CC=C2C(C=2C=CC=CC=2)=N1 MTPVBMVUENFFLL-HXUWFJFHSA-N 0.000 claims 2
- SWQQELWGJDXCFT-PNHWDRBUSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylimidazole-4-carboxamide Chemical compound C#CC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 SWQQELWGJDXCFT-PNHWDRBUSA-N 0.000 claims 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 2
- KSHJXDWYTZJUEI-UHFFFAOYSA-N 1-cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one Chemical compound N=1C2=CC=CC=C2N(CCCCO)C=1CN(C1=O)C2=CN=CC=C2N1C1CC1 KSHJXDWYTZJUEI-UHFFFAOYSA-N 0.000 claims 2
- RDQSNNMSDOHAPG-UHFFFAOYSA-N 2-[[2-[[1-(2-aminoethyl)piperidin-4-yl]amino]-4-methylbenzimidazol-1-yl]methyl]-6-methylpyridin-3-ol Chemical compound CC1=CC=C(O)C(CN2C3=CC=CC(C)=C3N=C2NC2CCN(CCN)CC2)=N1 RDQSNNMSDOHAPG-UHFFFAOYSA-N 0.000 claims 2
- DKORMNNYNRPTBJ-UHFFFAOYSA-N 2-[[6-[[2-(3-hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol Chemical compound CC1=CC=C(CCCO)C(NCC=2C=C3N(CC=4C(=CC=C(C)N=4)O)C(NCCCN4CCOCC4)=NC3=CC=2)=C1 DKORMNNYNRPTBJ-UHFFFAOYSA-N 0.000 claims 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 claims 2
- ZETYKEPFFRMVBX-UHFFFAOYSA-N rfi 641 Chemical compound NC(=O)CN(CC(N)=O)S(=O)(=O)C1=CC=CC(NC=2N=C(NC=3C=C(C(C=4C(=CC(NC=5N=C(NC=6C=C(C=CC=6)S(=O)(=O)N(CC(N)=O)CC(N)=O)N=C(NC=6C=C(C=CC=6)S(=O)(=O)N(CC(N)=O)CC(N)=O)N=5)=CC=4)S(O)(=O)=O)=CC=3)S(O)(=O)=O)N=C(NC=3C=C(C=CC=3)S(=O)(=O)N(CC(N)=O)CC(N)=O)N=2)=C1 ZETYKEPFFRMVBX-UHFFFAOYSA-N 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 229950006081 taribavirin Drugs 0.000 claims 2
- BSDIOOGSAAJMSR-JOCHJYFZSA-N (9br)-9b-(4-chlorophenyl)-1-(4-fluorobenzoyl)-2,3-dihydroimidazo[5,6]pyrrolo[1,2-a]pyridin-5-one Chemical compound C1=CC(F)=CC=C1C(=O)N1[C@@]2(C=3C=CC(Cl)=CC=3)C3=CN=CC=C3C(=O)N2CC1 BSDIOOGSAAJMSR-JOCHJYFZSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 claims 1
- ASILHPOFVOONEE-UHFFFAOYSA-N 1,4-bis(3-methylpyridin-4-yl)-1,4-diazepane Chemical compound CC1=CN=CC=C1N1CCN(C=2C(=CN=CC=2)C)CCC1 ASILHPOFVOONEE-UHFFFAOYSA-N 0.000 claims 1
- GVVIAZOBDFNZPB-UHFFFAOYSA-N 1h-1-benzazepine-2-carboxamide Chemical compound N1C(C(=O)N)=CC=CC2=CC=CC=C21 GVVIAZOBDFNZPB-UHFFFAOYSA-N 0.000 claims 1
- BLUJRJMLDHEMRX-UHFFFAOYSA-N 2-[[2-hydroxy-5-[(5-methyltetrazol-1-yl)iminomethyl]phenyl]-(4-hydroxyphenyl)methyl]-4-[(5-methyltetrazol-1-yl)iminomethyl]phenol Chemical compound Cc1nnnn1N=Cc1ccc(O)c(c1)C(c1ccc(O)cc1)c1cc(C=Nn2nnnc2C)ccc1O BLUJRJMLDHEMRX-UHFFFAOYSA-N 0.000 claims 1
- BLUJRJMLDHEMRX-BMNRKXRESA-N 2-[[2-hydroxy-5-[(E)-(5-methyltetrazol-1-yl)iminomethyl]phenyl]-(4-hydroxyphenyl)methyl]-4-[(E)-(5-methyltetrazol-1-yl)iminomethyl]phenol Chemical compound Cc1nnnn1\N=C\c2ccc(O)c(c2)C(c3ccc(O)cc3)c4cc(\C=N\n5nnnc5C)ccc4O BLUJRJMLDHEMRX-BMNRKXRESA-N 0.000 claims 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
- LNZKOJMCKWERFO-UHFFFAOYSA-N 2H-thieno[2,3-d]azepine-2-carboxamide Chemical compound S1C(C=C2C1=CC=NC=C2)C(=O)N LNZKOJMCKWERFO-UHFFFAOYSA-N 0.000 claims 1
- OPRZZDKUMMSNLY-UHFFFAOYSA-N 4-amino-8-[3-[2-(3,4-dimethoxyphenyl)ethylamino]propyl]-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-3h-imidazo[4,5-h]isoquinoline-7,9-dione Chemical compound C1=C(OC)C(OC)=CC=C1CCNCCCN1C(=O)C(C)(C)C(C=C(N)C2=C3NC(=N2)C=2C=C(C(C)=CC=2)[N+]([O-])=O)=C3C1=O OPRZZDKUMMSNLY-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- 229940127513 Fusion Protein Inhibitors Drugs 0.000 claims 1
- 108091006027 G proteins Proteins 0.000 claims 1
- 102000030782 GTP binding Human genes 0.000 claims 1
- 108091000058 GTP-Binding Proteins 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 101000777301 Homo sapiens Uteroglobin Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 101710200424 Inosine-5'-monophosphate dehydrogenase Proteins 0.000 claims 1
- QDZAXMSTRRUTQH-UHFFFAOYSA-N NC1=NN=NN1N=CC1(C(C=CC=C1)C(C1=CC=C(C=C1)O)C1=C(C=CC=C1)O)O Chemical compound NC1=NN=NN1N=CC1(C(C=CC=C1)C(C1=CC=C(C=C1)O)C1=C(C=CC=C1)O)O QDZAXMSTRRUTQH-UHFFFAOYSA-N 0.000 claims 1
- 101710141454 Nucleoprotein Proteins 0.000 claims 1
- YDITYPFXLDVVDY-UHFFFAOYSA-N O=C(NC1CC1)C1=CC2=C(C1)c1ccccc1N(CC2)C(=O)c1ccc(NC(=O)c2ccccc2N2CCCC2)cc1 Chemical compound O=C(NC1CC1)C1=CC2=C(C1)c1ccccc1N(CC2)C(=O)c1ccc(NC(=O)c2ccccc2N2CCCC2)cc1 YDITYPFXLDVVDY-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- YUCHAYRHHXJNQK-UHFFFAOYSA-N amitivir Chemical compound N#CNC1=NN=CS1 YUCHAYRHHXJNQK-UHFFFAOYSA-N 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N benzofuran Natural products C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 1
- 150000001907 coumarones Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940125777 fusion inhibitor Drugs 0.000 claims 1
- 102000055576 human SCGB1A1 Human genes 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 150000002475 indoles Chemical class 0.000 claims 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims 1
- 229960001521 motavizumab Drugs 0.000 claims 1
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
- 229960000951 mycophenolic acid Drugs 0.000 claims 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229960000402 palivizumab Drugs 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- XESARGFCSKSFID-FLLFQEBCSA-N pirazofurin Chemical compound OC1=C(C(=O)N)NN=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 XESARGFCSKSFID-FLLFQEBCSA-N 0.000 claims 1
- QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- PMAKDNHZVBVWFM-UHFFFAOYSA-N sodium;cyano(1,3,4-thiadiazol-2-yl)azanide Chemical compound [Na+].N#C[N-]C1=NN=CS1 PMAKDNHZVBVWFM-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868519P | 2013-08-21 | 2013-08-21 | |
| US61/868,519 | 2013-08-21 | ||
| US201461945048P | 2014-02-26 | 2014-02-26 | |
| US61/945,048 | 2014-02-26 | ||
| PCT/US2014/051642 WO2015026792A1 (en) | 2013-08-21 | 2014-08-19 | Antiviral compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538316A JP2016538316A (ja) | 2016-12-08 |
| JP2016538316A5 true JP2016538316A5 (https=) | 2017-09-28 |
| JP6485817B2 JP6485817B2 (ja) | 2019-03-20 |
Family
ID=52484091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536372A Expired - Fee Related JP6485817B2 (ja) | 2013-08-21 | 2014-08-19 | 抗ウイルス化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20150065504A1 (https=) |
| EP (1) | EP3036220A4 (https=) |
| JP (1) | JP6485817B2 (https=) |
| KR (1) | KR102455034B1 (https=) |
| CN (2) | CN114716426A (https=) |
| AU (1) | AU2014308991B2 (https=) |
| BR (1) | BR112016003348B1 (https=) |
| CA (1) | CA2921294C (https=) |
| CL (1) | CL2016000381A1 (https=) |
| EA (1) | EA038819B1 (https=) |
| HK (1) | HK1225716A1 (https=) |
| IL (1) | IL244163A0 (https=) |
| MX (2) | MX2016002199A (https=) |
| NZ (1) | NZ716822A (https=) |
| PE (1) | PE20160547A1 (https=) |
| PH (2) | PH12021550330A1 (https=) |
| SG (1) | SG11201600977XA (https=) |
| TW (1) | TWI646080B (https=) |
| UA (1) | UA123854C2 (https=) |
| WO (1) | WO2015026792A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013305759C1 (en) * | 2012-08-23 | 2018-01-18 | Janssen Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
| GEP201706757B (en) | 2012-12-21 | 2017-10-25 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| NZ716822A (en) | 2013-08-21 | 2017-10-27 | Alios Biopharma Inc | Antiviral compounds |
| SG11201700851WA (en) * | 2014-08-05 | 2017-03-30 | Alios Biopharma Inc | Combination therapy for treating a paramyxovirus |
| MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| CN109734651A (zh) * | 2015-07-06 | 2019-05-10 | 江苏恩华药业股份有限公司 | 阿芬太尼、舒芬太尼的制备方法及用于制备阿芬太尼、舒芬太尼的化合物 |
| MY197231A (en) | 2015-07-22 | 2023-06-06 | Enanta Pharm Inc | Benzodiazepine derivatives as rsv inhibitors |
| EP4327809A3 (en) * | 2015-09-02 | 2024-04-17 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
| CN108699077B (zh) | 2016-01-15 | 2021-03-02 | 英安塔制药有限公司 | 作为rsv抑制剂的杂环化合物 |
| BR112018014958A2 (pt) * | 2016-02-03 | 2019-01-08 | Janssen Sciences Ireland Uc | produtos de combinação para o tratamento de rsv |
| ES2881776T3 (es) | 2016-03-08 | 2021-11-30 | Novartis Ag | Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus |
| JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
| MY199389A (en) * | 2016-10-05 | 2023-10-25 | Syngenta Participations Ag | Methods of preserving the biological activity or ribonucleic acids |
| US10398706B2 (en) | 2017-01-06 | 2019-09-03 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as RSV inhibitors |
| AU2018221820B2 (en) | 2017-02-16 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| US10752598B2 (en) | 2017-06-07 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as RSV inhibitors |
| WO2019006291A1 (en) * | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| WO2019006295A1 (en) * | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| CA3077309A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as rsv inhibitors |
| NZ764647A (en) | 2017-11-13 | 2025-12-19 | Enanta Pharm Inc | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| KR20230031990A (ko) | 2018-02-28 | 2023-03-07 | 노파르티스 아게 | 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물 |
| US10975094B2 (en) | 2018-04-11 | 2021-04-13 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| KR102926658B1 (ko) | 2019-03-18 | 2026-02-11 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
| WO2020210246A1 (en) | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| CN110105268A (zh) * | 2019-05-30 | 2019-08-09 | 西安交通大学 | 一种戊内酰胺生物碱类化合物的合成方法 |
| AU2020357452B2 (en) * | 2019-10-04 | 2026-01-29 | Enanta Pharmaceuticals, Inc | Antiviral heterocyclic compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| WO2021198981A1 (en) | 2020-04-01 | 2021-10-07 | Janssen Biopharma, Inc. | Antiviral compounds and uses thereof |
| JP2023522091A (ja) | 2020-04-21 | 2023-05-26 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｒｓｖ阻害性の３置換キノリン及びシンノリン誘導体 |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| US11945824B2 (en) | 2020-10-19 | 2024-04-02 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| CN116528850B (zh) | 2020-10-28 | 2025-08-22 | 盐野义制药株式会社 | 具有抗病毒活性的酰胺衍生物 |
| IL305189A (en) | 2021-02-26 | 2023-10-01 | Enanta Pharm Inc | Heterocyclic antiviral compounds |
| WO2022211812A1 (en) * | 2021-04-01 | 2022-10-06 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| WO2023052593A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Sciences Ireland Unlimited Company | Rsv inhibiting spiro bearing derivatives |
| CN113788764B (zh) * | 2021-10-20 | 2024-02-02 | 江苏弘和药物研发有限公司 | 一种坦伯酰胺的合成方法 |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| US12162857B2 (en) | 2022-04-27 | 2024-12-10 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2023237732A1 (en) | 2022-06-10 | 2023-12-14 | Janssen Sciences Ireland Unlimited Company | Rsv inhibiting triazolo bearing derivatives |
| WO2023237730A1 (en) | 2022-06-10 | 2023-12-14 | Janssen Sciences Ireland Unlimited Company | Rsv inhibiting triazolo and spiro bearing derivatives |
| EP4382529A1 (en) | 2022-12-07 | 2024-06-12 | Bayer Consumer Care AG | A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride |
| CN120476107A (zh) | 2022-12-15 | 2025-08-12 | 先正达农作物保护股份公司 | 可用作杀有害生物剂的新型的二环-甲酰胺化合物 |
| TW202521519A (zh) * | 2023-08-17 | 2025-06-01 | 美商默沙東有限責任公司 | 人類呼吸道融合病毒及間質肺病毒抑制劑 |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1276808A (en) * | 1916-12-07 | 1918-08-27 | Alexander N Pierman | Signal or alarm apparatus. |
| US2516098A (en) * | 1949-03-26 | 1950-07-25 | Parke Davis & Co | Biphenyl compounds |
| US4703056A (en) * | 1983-01-21 | 1987-10-27 | Alkaloida Vegyeszeti Gyar | New alkyl diamine derivatives |
| US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| MA26487A1 (fr) | 1997-04-29 | 2004-12-20 | Smithkline Beecham Corp | Heterocyclecetohydrazides inhibiteurs de proteases, procede pour leur preparation et compositions pharmaceutiques les contenant . |
| US6410585B1 (en) | 1997-08-28 | 2002-06-25 | Scott D. Larsen | Inhibitors of protein tyrosine phosphatase |
| CN1548436A (zh) * | 1998-05-22 | 2004-11-24 | ʷ��˿�������ȳ�ķ����˾ | 新的2-烷基取代咪唑化合物 |
| AR018915A1 (es) | 1998-06-24 | 2001-12-12 | Smithkline Beecham Corp | Inhibidores de proteasas diacilhidrazinicos, composicion farmaceutica que la comprenden, usos de los mismos para la manufactura de un medicamento, unprocedimiento de fabricacion de dichos compuestos |
| US6623741B1 (en) | 2000-02-29 | 2003-09-23 | Trimeris, Inc. | Methods and compositions for inhibition of membrane fusion-associated events including RSV transmission |
| PT1317451E (pt) | 2000-09-15 | 2006-12-29 | Anormed Inc | Compostos heterocíclicos que se ligam a receptores de quimioquinas |
| JP2002293764A (ja) * | 2001-01-26 | 2002-10-09 | Takeda Chem Ind Ltd | アミノエタノール誘導体 |
| EP1362846A4 (en) | 2001-01-26 | 2006-10-04 | Takeda Pharmaceutical | AMINOETHANOL DERIVATIVES |
| US6878743B2 (en) * | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| CA2462112A1 (en) * | 2001-10-01 | 2003-04-10 | Bristol-Myers Squibb Company | Spiro-hydantoin compounds useful as anti-inflammatory agents |
| GB0128415D0 (en) * | 2001-11-27 | 2002-01-16 | Univ Sheffield | Medicaments |
| WO2004039366A1 (en) | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| ES2323068T3 (es) * | 2003-08-08 | 2009-07-06 | Schering Corporation | Inhibidores de bace-1 de aminas ciclicas con un sustituyente de benzamida. |
| MXPA06001558A (es) | 2003-08-08 | 2006-05-15 | Schering Corp | Inhibidores de amina ciclica bace-1 que poseen un sustituyente heterociclico. |
| EP1680411A2 (en) * | 2003-10-08 | 2006-07-19 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters containing cycloalkyl or pyranyl groups |
| DE10348023A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
| WO2005042530A1 (en) | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
| EP1697343B1 (en) | 2003-12-18 | 2009-07-01 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
| US7825135B2 (en) * | 2004-03-24 | 2010-11-02 | Merck Sharp & Dohme Limited | Heteroaryl piperidine glycine transporter inhibitors |
| GB0425919D0 (en) | 2004-11-25 | 2004-12-29 | Prosidion Ltd | Indole-2-carboxylic acid amides |
| CA2612263C (en) | 2005-06-20 | 2015-04-14 | Tibotec Pharmaceuticals Ltd. | 1-(2-amino-3-(substituted alkyl)-3h-benzimidazolylmethyl)-3-subtituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
| MX2008015246A (es) * | 2006-06-08 | 2008-12-17 | Syngenta Participations Ag | Derivados de n-(1-alquil-2-feniletil)-carboxamida y uso de los mismos como fungicidas. |
| CN100509766C (zh) | 2006-06-19 | 2009-07-08 | 张文 | 羟基和氨基同时保护的手性非α-氨基酸衍生物的制备方法 |
| EP2422790A1 (en) | 2007-02-09 | 2012-02-29 | Emory University | Paramyxovirus family inhibitors and methods of use thereof |
| EP2594562B1 (en) * | 2007-05-31 | 2016-07-20 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| WO2009005638A2 (en) | 2007-06-27 | 2009-01-08 | Merck & Co., Inc. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
| BRPI0815042A2 (pt) | 2007-08-01 | 2015-02-10 | Pfizer | Compostos de pirazol |
| ES2660690T3 (es) * | 2007-10-05 | 2018-03-23 | Genzyme Corporation | Método para tratar poliquistosis renales con derivados de ceramida |
| CA2703477C (en) | 2007-10-25 | 2016-10-11 | Exelixis, Inc. | Pyridinyl substituted tropane compounds and uses thereof |
| AU2008334948B2 (en) | 2007-12-13 | 2014-11-20 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
| EP2719700A1 (en) * | 2008-01-09 | 2014-04-16 | Amura Therapeutics Limited | Tetrahydrofuro(3,2-b)pyrrol-3-one derivatives as inhibitors of cysteine proteinases |
| TW201000099A (en) | 2008-06-20 | 2010-01-01 | Amgen Inc | S1P1 receptor agonists and use thereof |
| WO2010103306A1 (en) | 2009-03-10 | 2010-09-16 | Astrazeneca Uk Limited | Benzimidazole derivatives and their use as antivaral agents |
| WO2010132992A1 (en) * | 2009-05-20 | 2010-11-25 | UNIVERSITé LAVAL | Compounds for the inhibition of herpesviruses |
| ES2643034T3 (es) | 2009-06-05 | 2017-11-21 | Ablynx N.V. | Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias |
| BR112012000657A2 (pt) * | 2009-06-26 | 2016-11-16 | Panacea Biotec Ltd | novos azabicilohexanos |
| WO2011005842A1 (en) * | 2009-07-09 | 2011-01-13 | Gilead Sciences, Inc. | Anti-rsv compounds |
| AR078793A1 (es) * | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
| CN103221047B (zh) * | 2010-01-13 | 2014-12-17 | 坦颇罗制药股份有限公司 | 化合物和方法 |
| WO2011091184A1 (en) * | 2010-01-20 | 2011-07-28 | New Hope Ventures, Lp | Tissue repair implant and delivery device and method |
| WO2011097607A1 (en) * | 2010-02-08 | 2011-08-11 | Southern Research Institute | Anti-viral treatment and assay to screen for anti-viral agent |
| MA34392B1 (fr) | 2010-06-24 | 2013-07-03 | Gilead Sciences Inc | Pyrimidines en tant qu'agents antiviraux |
| WO2012020786A1 (ja) | 2010-08-11 | 2012-02-16 | 日本新薬株式会社 | 医薬組成物 |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| US8796303B2 (en) | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| DE102011106990B3 (de) | 2011-07-08 | 2013-01-03 | Technische Universität Darmstadt | Verbindungen als Glykogen Synthase Kinase 3 (GSK-3) Inhibitoren für die Behandlung von GSK-3-vermittelten Erkrankungen |
| EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| EP2766370B1 (en) | 2011-10-11 | 2016-08-03 | F.Hoffmann-La Roche Ag | Compounds for the treatment and prophylaxis of respiratory syncytial virus disease |
| US20140228349A1 (en) | 2011-10-12 | 2014-08-14 | Array Biopharma Inc. | 5,7-substituted-imidazo[1,2-c]pyrimidines |
| WO2013059119A1 (en) * | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| US20140287916A1 (en) * | 2011-11-04 | 2014-09-25 | Syngenta Participations Ag | Pesticidal compounds |
| CA2858096C (en) | 2011-12-22 | 2020-06-23 | Gilead Sciences, Inc. | Pyrazolo[1,5-a]pyrimidines as antiviral agents |
| JP5348267B2 (ja) * | 2012-03-06 | 2013-11-20 | 住友金属鉱山株式会社 | 脱亜鉛処理プラント及び脱亜鉛プラントの操業方法、並びにニッケル酸化鉱石の湿式製錬方法 |
| CN106986869A (zh) | 2012-04-17 | 2017-07-28 | 吉利德科学公司 | 用于抗病毒治疗的化合物和方法 |
| WO2013186334A1 (en) | 2012-06-15 | 2013-12-19 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with benzimidazoles as respiratory syncytial virus antiviral agents |
| LT2864323T (lt) | 2012-06-15 | 2017-07-25 | Janssen Sciences Ireland Uc | 1,3-dihidro-2h-benzimidazol-2-ono dariniai, turintys heterociklų pakaitų, kaip antivirusiniai agentai prieš respiratorinį sincitinį virusą |
| KR20150032283A (ko) | 2012-06-15 | 2015-03-25 | 얀센 알 앤드 디 아일랜드 | 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체 |
| EA201590023A1 (ru) | 2012-06-15 | 2015-05-29 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса |
| RU2015102792A (ru) | 2012-07-10 | 2016-08-27 | Ф. Хоффманн-Ля Рош Аг | Новые индазолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
| AU2013305759C1 (en) * | 2012-08-23 | 2018-01-18 | Janssen Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
| NZ716822A (en) | 2013-08-21 | 2017-10-27 | Alios Biopharma Inc | Antiviral compounds |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
-
2014
- 2014-08-19 NZ NZ716822A patent/NZ716822A/en not_active IP Right Cessation
- 2014-08-19 CN CN202210267361.7A patent/CN114716426A/zh active Pending
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- 2014-08-19 PH PH1/2021/550330A patent/PH12021550330A1/en unknown
- 2014-08-19 EA EA201690224A patent/EA038819B1/ru unknown
- 2014-08-19 KR KR1020167007035A patent/KR102455034B1/ko active Active
- 2014-08-19 CN CN201480055176.5A patent/CN105636936B/zh not_active Expired - Fee Related
- 2014-08-19 SG SG11201600977XA patent/SG11201600977XA/en unknown
- 2014-08-19 AU AU2014308991A patent/AU2014308991B2/en not_active Ceased
- 2014-08-19 WO PCT/US2014/051642 patent/WO2015026792A1/en not_active Ceased
- 2014-08-19 EP EP14837913.4A patent/EP3036220A4/en not_active Withdrawn
- 2014-08-19 MX MX2016002199A patent/MX2016002199A/es unknown
- 2014-08-19 BR BR112016003348-5A patent/BR112016003348B1/pt not_active IP Right Cessation
- 2014-08-19 HK HK16113922.8A patent/HK1225716A1/zh unknown
- 2014-08-19 UA UAA201601391A patent/UA123854C2/uk unknown
- 2014-08-19 PE PE2016000288A patent/PE20160547A1/es not_active Application Discontinuation
- 2014-08-19 CA CA2921294A patent/CA2921294C/en active Active
- 2014-08-19 US US14/462,937 patent/US20150065504A1/en not_active Abandoned
- 2014-08-21 TW TW103128871A patent/TWI646080B/zh not_active IP Right Cessation
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2016
- 2016-02-17 IL IL244163A patent/IL244163A0/en unknown
- 2016-02-18 PH PH12016500332A patent/PH12016500332B1/en unknown
- 2016-02-19 MX MX2021002168A patent/MX2021002168A/es unknown
- 2016-02-19 CL CL2016000381A patent/CL2016000381A1/es unknown
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2017
- 2017-08-16 US US15/678,901 patent/US20180065932A1/en not_active Abandoned
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- 2018-10-19 US US16/165,865 patent/US11021444B2/en not_active Expired - Fee Related
-
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- 2021-03-22 US US17/208,964 patent/US20220363640A1/en not_active Abandoned
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