|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4489055A
(en)
|
1978-07-19 |
1984-12-18 |
N.V. Sopar S.A. |
Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use
|
|
US4289872A
(en)
|
1979-04-06 |
1981-09-15 |
Allied Corporation |
Macromolecular highly branched homogeneous compound based on lysine units
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
US5008050A
(en)
|
1984-06-20 |
1991-04-16 |
The Liposome Company, Inc. |
Extrusion technique for producing unilamellar vesicles
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5229490A
(en)
|
1987-05-06 |
1993-07-20 |
The Rockefeller University |
Multiple antigen peptide system
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
CA1340032C
(en)
|
1987-06-24 |
1998-09-08 |
Jim Haralambidis |
Lucleoside derivatives
|
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
|
JPH03503894A
(ja)
|
1988-03-25 |
1991-08-29 |
ユニバーシィティ オブ バージニア アランミ パテンツ ファウンデイション |
オリゴヌクレオチド n‐アルキルホスホラミデート
|
|
US5216141A
(en)
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
|
US5457183A
(en)
|
1989-03-06 |
1995-10-10 |
Board Of Regents, The University Of Texas System |
Hydroxylated texaphyrins
|
|
US5256775A
(en)
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
US4958013A
(en)
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
|
DE69034150T2
(de)
|
1989-10-24 |
2005-08-25 |
Isis Pharmaceuticals, Inc., Carlsbad |
2'-Modifizierte Oligonukleotide
|
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5955589A
(en)
|
1991-12-24 |
1999-09-21 |
Isis Pharmaceuticals Inc. |
Gapped 2' modified oligonucleotides
|
|
US5578718A
(en)
|
1990-01-11 |
1996-11-26 |
Isis Pharmaceuticals, Inc. |
Thiol-derivatized nucleosides
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
PT98562B
(pt)
|
1990-08-03 |
1999-01-29 |
Sanofi Sa |
Processo para a preparacao de composicoes que compreendem sequencias de nucleo-sidos com cerca de 6 a cerca de 200 bases resistentes a nucleases
|
|
US5177196A
(en)
|
1990-08-16 |
1993-01-05 |
Microprobe Corporation |
Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
|
|
FR2677272B1
(fr)
|
1991-06-05 |
1995-03-03 |
Biovecteurs As |
Vecteur particulaire a tropisme selectif, procede de preparation et composition pharmaceutique.
|
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
US5792608A
(en)
|
1991-12-12 |
1998-08-11 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
FR2687679B1
(fr)
|
1992-02-05 |
1994-10-28 |
Centre Nat Rech Scient |
Oligothionucleotides.
|
|
US5814666A
(en)
|
1992-04-13 |
1998-09-29 |
The United States As Represented By The Department Of Health And Human Services |
Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
|
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
|
JPH07508342A
(ja)
|
1992-04-22 |
1995-09-14 |
エコール ポリテクニーク フェデラル ドゥ ローザンヌ(エーペーエフエル) |
脂質膜センサー
|
|
US5434257A
(en)
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
|
US5472881A
(en)
|
1992-11-12 |
1995-12-05 |
University Of Utah Research Foundation |
Thiol labeling of DNA for attachment to gold surfaces
|
|
EP0691968B1
(en)
|
1993-03-30 |
1997-07-16 |
Sanofi |
Acyclic nucleoside analogs and oligonucleotide sequences containing them
|
|
HU9501974D0
(en)
|
1993-03-31 |
1995-09-28 |
Sterling Winthrop Inc |
Oligonucleotides with amide linkages replacing phosphodiester linkages
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
US5519134A
(en)
|
1994-01-11 |
1996-05-21 |
Isis Pharmaceuticals, Inc. |
Pyrrolidine-containing monomers and oligomers
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US5646269A
(en)
|
1994-04-28 |
1997-07-08 |
Gilead Sciences, Inc. |
Method for oligonucleotide analog synthesis
|
|
US20030026782A1
(en)
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
ES2366201T3
(es)
|
1994-07-15 |
2011-10-18 |
University Of Iowa Research Foundation |
Oligonucleótidos inmunmoduladores.
|
|
ES2336857T3
(es)
|
1995-05-04 |
2010-04-16 |
Gilead Sciences, Inc. |
Complejos de ligandos de acido nucleico.
|
|
US5912340A
(en)
|
1995-10-04 |
1999-06-15 |
Epoch Pharmaceuticals, Inc. |
Selective binding complementary oligonucleotides
|
|
US5780448A
(en)
|
1995-11-07 |
1998-07-14 |
Ottawa Civic Hospital Loeb Research |
DNA-based vaccination of fish
|
|
US6361944B1
(en)
|
1996-07-29 |
2002-03-26 |
Nanosphere, Inc. |
Nanoparticles having oligonucleotides attached thereto and uses therefor
|
|
US6582921B2
(en)
|
1996-07-29 |
2003-06-24 |
Nanosphere, Inc. |
Nanoparticles having oligonucleotides attached thereto and uses thereof
|
|
US6506564B1
(en)
|
1996-07-29 |
2003-01-14 |
Nanosphere, Inc. |
Nanoparticles having oligonucleotides attached thereto and uses therefor
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
US6051698A
(en)
|
1997-06-06 |
2000-04-18 |
Janjic; Nebojsa |
Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
|
|
US20060002949A1
(en)
|
1996-11-14 |
2006-01-05 |
Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. |
Transcutaneous immunization without heterologous adjuvant
|
|
US6406705B1
(en)
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
JP2002514919A
(ja)
|
1997-04-04 |
2002-05-21 |
バイオサイト ダイアグノスティックス,インコーポレイテッド |
多価ライブラリーおよびポリクローナルライブラリー
|
|
DE69841002D1
(de)
|
1997-05-14 |
2009-09-03 |
Univ British Columbia |
Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
|
|
US20030104044A1
(en)
|
1997-05-14 |
2003-06-05 |
Semple Sean C. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
US6271209B1
(en)
|
1998-04-03 |
2001-08-07 |
Valentis, Inc. |
Cationic lipid formulation delivering nucleic acid to peritoneal tumors
|
|
US6287765B1
(en)
|
1998-05-20 |
2001-09-11 |
Molecular Machines, Inc. |
Methods for detecting and identifying single molecules
|
|
DE69932717T2
(de)
|
1998-05-22 |
2007-08-09 |
Ottawa Health Research Institute, Ottawa |
Methoden und produkte zur induzierung mukosaler immunität
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
FR2783170B1
(fr)
|
1998-09-11 |
2004-07-16 |
Pasteur Merieux Serums Vacc |
Emulsion immunostimulante
|
|
US6228642B1
(en)
|
1998-10-05 |
2001-05-08 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of tumor necrosis factor-(α) (TNF-α) expression
|
|
US6080580A
(en)
|
1998-10-05 |
2000-06-27 |
Isis Pharmaceuticals Inc. |
Antisense oligonucleotide modulation of tumor necrosis factor-α (TNF-α) expression
|
|
AR022404A1
(es)
|
1999-01-25 |
2002-09-04 |
Photogen Inc |
Metodo y agentes para la terapia de radiacion mejorada
|
|
AU784040B2
(en)
|
1999-06-25 |
2006-01-19 |
Nanosphere, Inc. |
Nanoparticles having oligonucleotides attached thereto and uses therefor
|
|
EP1210092B1
(en)
|
1999-07-08 |
2009-04-08 |
CAP Biotechnology, Inc. |
Calcium-containing structures and methods of making and using the same
|
|
EP1072679A3
(en)
|
1999-07-20 |
2002-07-31 |
Agilent Technologies, Inc. (a Delaware corporation) |
Method of producing nucleic acid molecules with reduced secondary structure
|
|
DE19935756A1
(de)
|
1999-07-27 |
2001-02-08 |
Mologen Forschungs Entwicklung |
Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
|
|
ATE419869T1
(de)
|
1999-08-19 |
2009-01-15 |
Dynavax Tech Corp |
Methode zur modulierung eines immunantwortes mit immunstimulierenden sequencen und zusammensetzungen dafür
|
|
US20050249794A1
(en)
|
1999-08-27 |
2005-11-10 |
Semple Sean C |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
DK1221955T3
(da)
|
1999-09-25 |
2006-01-30 |
Univ Iowa Res Found |
Immunstimulerende nukleinsyre
|
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
US6585947B1
(en)
|
1999-10-22 |
2003-07-01 |
The Board Of Trustess Of The University Of Illinois |
Method for producing silicon nanoparticles
|
|
US7223398B1
(en)
|
1999-11-15 |
2007-05-29 |
Dynavax Technologies Corporation |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
|
|
CA2392685C
(en)
|
1999-11-29 |
2011-02-22 |
Avi Biopharma, Inc. |
Antisense antibacterial method and composition
|
|
EP1246931A1
(fr)
|
1999-12-30 |
2002-10-09 |
Aventis Pharma S.A. |
Compositions comprenant des acides nucleiques incorpores dans des particules minerales bilamellaires
|
|
AT409085B
(de)
|
2000-01-28 |
2002-05-27 |
Cistem Biotechnologies Gmbh |
Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US20020156033A1
(en)
|
2000-03-03 |
2002-10-24 |
Bratzler Robert L. |
Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
|
|
US20040131628A1
(en)
|
2000-03-08 |
2004-07-08 |
Bratzler Robert L. |
Nucleic acids for the treatment of disorders associated with microorganisms
|
|
US20030129251A1
(en)
|
2000-03-10 |
2003-07-10 |
Gary Van Nest |
Biodegradable immunomodulatory formulations and methods for use thereof
|
|
US7129222B2
(en)
|
2000-03-10 |
2006-10-31 |
Dynavax Technologies Corporation |
Immunomodulatory formulations and methods for use thereof
|
|
CA2404041A1
(en)
|
2000-03-28 |
2001-10-04 |
The Regents Of The University Of California |
Methods for increasing a cytotoxic t lymphocyte response in vivo
|
|
US7291284B2
(en)
|
2000-05-26 |
2007-11-06 |
Northwestern University |
Fabrication of sub-50 nm solid-state nanostructures based on nanolithography
|
|
EP1360318B1
(en)
|
2000-07-11 |
2006-04-26 |
Northwestern University |
Method of detection by enhancement of silver staining
|
|
US7083958B2
(en)
|
2000-11-20 |
2006-08-01 |
The Board Of Trustees Of The University Of Illinois |
Membrane scaffold proteins
|
|
US7563618B2
(en)
|
2001-03-23 |
2009-07-21 |
Geron Corporation |
Oligonucleotide conjugates
|
|
GB0111279D0
(en)
|
2001-05-10 |
2001-06-27 |
Nycomed Imaging As |
Radiolabelled liposomes
|
|
US7238472B2
(en)
|
2001-05-25 |
2007-07-03 |
Nanosphere, Inc. |
Non-alloying core shell nanoparticles
|
|
US7514098B2
(en)
|
2001-05-30 |
2009-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Use of targeted cross-linked nanoparticles for in vivo gene delivery
|
|
EP2423335B1
(en)
|
2001-06-21 |
2014-05-14 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same
|
|
JP2005511761A
(ja)
|
2001-07-10 |
2005-04-28 |
ノース・キャロライナ・ステイト・ユニヴァーシティ |
ナノ粒子送達ビヒクル
|
|
US7666674B2
(en)
|
2001-07-27 |
2010-02-23 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
|
|
JP4607452B2
(ja)
|
2001-08-07 |
2011-01-05 |
ダイナバックス テクノロジーズ コーポレイション |
免疫調節性組成物、製剤およびその使用方法
|
|
CA2456201A1
(en)
|
2001-08-10 |
2003-02-27 |
Dynavax Technologies Corporation |
Immunomodulatory oligonucleotide formulations and methods for use thereof
|
|
US20030099668A1
(en)
|
2001-09-14 |
2003-05-29 |
Cytos Biotechnology Ag |
Packaging of immunostimulatory substances into virus-like particles: method of preparation and use
|
|
US7850990B2
(en)
|
2001-10-03 |
2010-12-14 |
Celator Pharmaceuticals, Inc. |
Compositions for delivery of drug combinations
|
|
US20030134810A1
(en)
|
2001-10-09 |
2003-07-17 |
Chris Springate |
Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents
|
|
TW200303759A
(en)
|
2001-11-27 |
2003-09-16 |
Schering Corp |
Methods for treating cancer
|
|
PL371746A1
(en)
|
2002-02-05 |
2005-06-27 |
Bristol-Myers Squibb Company |
N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
|
|
US8088388B2
(en)
|
2002-02-14 |
2012-01-03 |
United Biomedical, Inc. |
Stabilized synthetic immunogen delivery system
|
|
AU2003259827B2
(en)
|
2002-08-12 |
2008-09-04 |
Dynavax Technologies Corporation |
Immunomodulatory compositions, methods of making, and methods of use thereof
|
|
ATE544466T1
(de)
|
2002-10-29 |
2012-02-15 |
Coley Pharm Group Inc |
Verwendung von cpg oligonukleotide zur behandlung von hepatitis c virus infektion
|
|
US20040158051A1
(en)
|
2002-11-19 |
2004-08-12 |
Mihri Ozkan |
Mono and dual conjugation of nanostructures and methods of making and using thereof
|
|
GB0227738D0
(en)
|
2002-11-28 |
2003-01-08 |
Univ Liverpool |
Nanoparticle conjugates and method of production thereof
|
|
US8158768B2
(en)
|
2002-12-23 |
2012-04-17 |
Dynavax Technologies Corporation |
Immunostimulatory sequence oligonucleotides and methods of using the same
|
|
JP2006512391A
(ja)
|
2002-12-30 |
2006-04-13 |
スリーエム イノベイティブ プロパティズ カンパニー |
組み合わせ免疫賦活薬
|
|
US20060105343A1
(en)
|
2003-01-09 |
2006-05-18 |
Children's Medical Center Corporation |
Methods for diagnosis and prognosis of cancer
|
|
US7354907B2
(en)
|
2003-02-07 |
2008-04-08 |
Idera Pharmaceuticals, Inc. |
Short immunomodulatory oligonucleotides
|
|
CA2526212C
(en)
|
2003-05-16 |
2013-08-27 |
Hybridon, Inc. |
Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents
|
|
WO2005008222A2
(en)
|
2003-05-30 |
2005-01-27 |
Nanosphere, Inc. |
Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
|
|
US7727969B2
(en)
|
2003-06-06 |
2010-06-01 |
Massachusetts Institute Of Technology |
Controlled release nanoparticle having bound oligonucleotide for targeted delivery
|
|
GB0313259D0
(en)
|
2003-06-09 |
2003-07-16 |
Consejo Superior Investigacion |
Magnetic nanoparticles
|
|
JP4874801B2
(ja)
|
2003-06-11 |
2012-02-15 |
イデラ ファーマシューティカルズ インコーポレイテッド |
安定化免疫調節オリゴヌクレオチド
|
|
US20050096263A1
(en)
|
2003-10-30 |
2005-05-05 |
Keay Susan K. |
Novel antiproliferative factor and methods of use
|
|
AU2004255470B2
(en)
|
2003-07-10 |
2010-08-19 |
Cytos Biotechnology Ag |
Packaged virus-like particles
|
|
US20060074040A1
(en)
|
2003-07-15 |
2006-04-06 |
Hybridon, Inc. |
Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and/or immunomer compounds in conjunction with cytokines and/or chemotherapeutic agents or radiation therapy
|
|
US20080057128A1
(en)
|
2003-07-18 |
2008-03-06 |
Omeros Corporation |
Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from
|
|
DK3342425T3
(da)
|
2003-09-09 |
2020-03-16 |
Geron Corp |
Modificerede oligonukleotider til inhibering af telomerase
|
|
CA2536139A1
(en)
|
2003-09-25 |
2005-04-07 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid-lipophilic conjugates
|
|
US7846412B2
(en)
|
2003-12-22 |
2010-12-07 |
Emory University |
Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof
|
|
EP1547581A1
(en)
|
2003-12-23 |
2005-06-29 |
Vectron Therapeutics AG |
Liposomal vaccine for the treatment of human hematological malignancies
|
|
EP1550458A1
(en)
|
2003-12-23 |
2005-07-06 |
Vectron Therapeutics AG |
Synergistic liposomal adjuvants
|
|
JP2007517550A
(ja)
|
2004-01-02 |
2007-07-05 |
アドヴァンスド カーディオヴァスキュラー システムズ, インコーポレイテッド |
高比重リポ蛋白をコーティングした医療デバイス
|
|
DE602005025087D1
(de)
|
2004-02-26 |
2011-01-13 |
Layerlab Ab |
Mit lipidmembran attachments verwandte oligonukleotide
|
|
EP1730281A2
(en)
|
2004-04-02 |
2006-12-13 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for inducing il-10 responses
|
|
WO2005108614A2
(en)
|
2004-04-07 |
2005-11-17 |
Northwestern University |
Reversible and chemically programmable micelle assembly with dna block-copolymer amphiphiles
|
|
GB0409940D0
(en)
|
2004-05-04 |
2004-06-09 |
Glaxosmithkline Biolog Sa |
Vaccine
|
|
CA2562482A1
(en)
|
2004-05-12 |
2005-12-01 |
Genentech, Inc. |
Novel gene disruptions, compositions and methods relating thereto
|
|
GB0411537D0
(en)
|
2004-05-24 |
2004-06-23 |
Midatech Ltd |
Nanoparticles comprising rna ligands
|
|
US20080213177A1
(en)
|
2004-05-24 |
2008-09-04 |
Thomas William Rademacher |
Nanoparticles Comprising Rna Ligands
|
|
EP1773303A2
(en)
|
2004-05-25 |
2007-04-18 |
Chimeracore, Inc. |
Self-assembling nanoparticle drug delivery system
|
|
EP1604669A1
(en)
|
2004-06-10 |
2005-12-14 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Use of ATP analogues for treatment of cardiovascular diseases
|
|
EP1765417A4
(en)
|
2004-06-15 |
2009-03-25 |
Idera Pharmaceuticals Inc |
MULTIMERS OF OLIGONUCLEOTIDES IMMUNOSTIMULATORS
|
|
US7427405B2
(en)
|
2004-06-15 |
2008-09-23 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory oligonucleotide multimers
|
|
WO2006012695A1
(en)
|
2004-08-04 |
2006-02-09 |
Panvax Limited |
An immunogenic composition
|
|
WO2006015560A1
(de)
|
2004-08-09 |
2006-02-16 |
Mologen Ag |
Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen
|
|
US20060083781A1
(en)
|
2004-10-14 |
2006-04-20 |
Shastri V P |
Functionalized solid lipid nanoparticles and methods of making and using same
|
|
MY159370A
(en)
|
2004-10-20 |
2016-12-30 |
Coley Pharm Group Inc |
Semi-soft-class immunostimulatory oligonucleotides
|
|
CA2586913A1
(en)
|
2004-11-09 |
2006-05-18 |
University Of Southern California |
Targeted innate immunity
|
|
JP2008521385A
(ja)
|
2004-11-29 |
2008-06-26 |
長春華普生物技術有限公司 |
アジュバントとしてのCpG含有一本鎖デオキシヌクレオチド
|
|
EP1674128A1
(en)
|
2004-12-22 |
2006-06-28 |
Steinbeis-Transferzentrum für Herz-Kreislaufforschung |
Magnetic pole matrices useful for tissue engineering and treatment of disease
|
|
US8007829B2
(en)
|
2005-01-19 |
2011-08-30 |
William Marsh Rice University |
Method to fabricate inhomogeneous particles
|
|
KR100704011B1
(ko)
|
2005-02-16 |
2007-04-04 |
한국과학기술원 |
금속나노입자와 양자점의 fret에 의한 생체분자특이결합 검출 방법
|
|
NZ561144A
(en)
|
2005-03-04 |
2009-09-25 |
Dynavax Tech Corp |
Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients
|
|
US8211712B2
(en)
|
2005-03-29 |
2012-07-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of fabricating lipid bilayer membranes on solid supports
|
|
US8246995B2
(en)
|
2005-05-10 |
2012-08-21 |
The Board Of Trustees Of The Leland Stanford Junior University |
Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
|
|
US20090214618A1
(en)
|
2005-05-27 |
2009-08-27 |
Schoenfisch Mark H |
Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
|
|
US8252756B2
(en)
|
2005-06-14 |
2012-08-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
EA200800268A1
(ru)
|
2005-07-07 |
2008-06-30 |
Коли Фармасьютикал Груп, Инк. |
КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИТЕЛОМ ПРОТИВ CTLA-4 И СОДЕРЖАЩИМ CpG-МОТИВ СИНТЕТИЧЕСКИМ ОЛИГОДЕЗОКСИНУКЛЕОТИДОМ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
WO2007047455A2
(en)
|
2005-10-13 |
2007-04-26 |
Northwestern University |
Colorimetric screening of dna binding/intercalating agents with gold nanoparticle probes
|
|
FR2892819B1
(fr)
|
2005-10-28 |
2008-02-01 |
Centre Nat Rech Scient |
Nanoparticules a luminescence persistance pour leur utilisation en tant qu'agent de diagnostic destine a l'imagerie optique in vivo
|
|
GB2448255A
(en)
|
2005-12-01 |
2008-10-08 |
Trinity College Dublin |
Compositions and methods relating to treatment of cancer and infectious diseases
|
|
WO2007067733A2
(en)
|
2005-12-09 |
2007-06-14 |
Massachusetts Institute Of Technology |
Compositions and methods to monitor rna delivery to cells
|
|
US20070184068A1
(en)
|
2005-12-14 |
2007-08-09 |
Cytos Biotechnology Ag |
Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
|
|
US20070148251A1
(en)
|
2005-12-22 |
2007-06-28 |
Hossainy Syed F A |
Nanoparticle releasing medical devices
|
|
EP2441846A3
(en)
|
2006-01-09 |
2012-07-25 |
The Regents Of the University of California |
Immunostimulatory combinations of TNFRSF, TLR, NLR, RHR, purinergic receptor, and cytokine receptor agoinsts for vaccines and tumor immunotherapy
|
|
WO2007089607A2
(en)
|
2006-01-26 |
2007-08-09 |
University Of Massachusetts |
Rna silencing agents for use in therapy and nanotransporters for efficient delivery of same
|
|
US7723045B2
(en)
|
2006-02-10 |
2010-05-25 |
The Regents Of The University Of California |
Assays to predict atherosclerosis and dysfunctional high-density lipoprotein
|
|
WO2007095316A2
(en)
|
2006-02-15 |
2007-08-23 |
Coley Pharmaceutical Gmbh |
Compositions and methods for oligonucleotide formulations
|
|
EP1820804A1
(en)
|
2006-02-20 |
2007-08-22 |
Humboldt-Universität zu Berlin |
Lipidated oligonucleotides
|
|
US8361494B2
(en)
|
2006-03-10 |
2013-01-29 |
The Trustees Of The University Of Pennsylvania |
Biomimetic iron-oxide-containing lipoprotein and related materials
|
|
US20100167051A1
(en)
|
2006-03-31 |
2010-07-01 |
Goia Dan V |
Process for Manufacture of Silver-Based Particles and Electrical Contact Materials
|
|
GB0607866D0
(en)
|
2006-04-20 |
2006-05-31 |
Isis Innovation |
Nanostructures
|
|
MX2008014380A
(es)
|
2006-05-11 |
2009-03-02 |
Mologen Ag |
Multimero para inmunoestimulacion.
|
|
WO2007137117A2
(en)
|
2006-05-17 |
2007-11-29 |
Massachusetts Institute Of Technology |
Aptamer-directed drug delivery
|
|
US8748567B2
(en)
|
2006-05-22 |
2014-06-10 |
Children's Medical Center Corporation |
Method for delivery across the blood brain barrier
|
|
US8017237B2
(en)
|
2006-06-23 |
2011-09-13 |
Abbott Cardiovascular Systems, Inc. |
Nanoshells on polymers
|
|
WO2008097328A2
(en)
|
2006-06-23 |
2008-08-14 |
Northwestern University |
Asymmetric functionalized nanoparticles and methods of use
|
|
JP2010507361A
(ja)
|
2006-07-31 |
2010-03-11 |
キュアバック ゲーエムベーハー |
具体的には免疫刺激剤/アジュバントとしての、一般式(I):GlXmGn、または一般式(II):ClXmCnで表される核酸
|
|
US20080124366A1
(en)
|
2006-08-06 |
2008-05-29 |
Ohlfest John R |
Methods and Compositions for Treating Tumors
|
|
AU2007286203B2
(en)
|
2006-08-08 |
2013-05-02 |
Board Of Regents, The University Of Texas System |
Multistage delivery of active agents
|
|
WO2008030624A2
(en)
|
2006-09-08 |
2008-03-13 |
The Research Foundation Of State University Of New York |
Nanoparticles for two-photon activated photodynamic therapy and imaging
|
|
SI2068918T2
(sl)
|
2006-09-26 |
2024-10-30 |
Access To Advanced Health Institute |
Sestavek za cepljenje, ki vsebuje sintetična pomagala
|
|
WO2008042156A1
(en)
|
2006-09-28 |
2008-04-10 |
Northwestern University |
Maximizing oligonucleotide loading on gold nanoparticle
|
|
ITFI20060263A1
(it)
|
2006-10-27 |
2008-04-28 |
Saeco Ipr Ltd |
Dispositivo emulsionatore per la produzione di latte schiumato e simili e relativo metodo
|
|
US20080181928A1
(en)
|
2006-12-22 |
2008-07-31 |
Miv Therapeutics, Inc. |
Coatings for implantable medical devices for liposome delivery
|
|
US8415461B2
(en)
|
2007-01-19 |
2013-04-09 |
The Board Of Trustees Of The University Of Illinois |
Amphiphilic substances and functionalized lipid vesicles including the same
|
|
EP2111218B1
(en)
|
2007-01-24 |
2014-07-02 |
Syddansk Universitet |
Dna controlled assembly of lipid membranes
|
|
AU2008212820B2
(en)
|
2007-02-09 |
2014-01-30 |
Northwestern University |
Particles for detecting intracellular targets
|
|
WO2008127789A2
(en)
|
2007-02-27 |
2008-10-23 |
Northwestern University |
Molecule attachment to nanoparticles
|
|
NZ579881A
(en)
|
2007-03-30 |
2012-10-26 |
Hirofumi Takeuchi |
Transpulmonary liposome for controlling drug arrival
|
|
JP2010523595A
(ja)
|
2007-04-04 |
2010-07-15 |
マサチューセッツ インスティテュート オブ テクノロジー |
ポリ(アミノ酸)ターゲッティング部分
|
|
WO2008141289A1
(en)
|
2007-05-10 |
2008-11-20 |
Northwestern University |
Silver nanoparticle binding agent conjugates based on moieties with triple cyclic disulfide anchoring groups
|
|
DK2160464T3
(da)
|
2007-05-30 |
2014-08-04 |
Univ Northwestern |
Nukleinsyrefunktionaliserede nanopartikler til terapeutiske anvendelser
|
|
ES2660906T3
(es)
|
2007-05-31 |
2018-03-26 |
Anterios, Inc. |
Nanopartículas de ácido nucleico y usos de las mismas
|
|
WO2009045579A2
(en)
|
2007-06-14 |
2009-04-09 |
The Regents Of The University Of California |
Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics
|
|
US20080317768A1
(en)
|
2007-06-21 |
2008-12-25 |
Boeing Company |
Bioconjugated nanoparticles
|
|
ATE554170T1
(de)
|
2007-07-23 |
2012-05-15 |
Univ Aarhus |
Nanopartikel-vermittelte behandlung für entzündungskrankheiten
|
|
US8563527B2
(en)
|
2007-08-20 |
2013-10-22 |
Pharmain Corporation |
Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
|
|
PT2214646T
(pt)
|
2007-10-05 |
2021-09-29 |
Univ Wayne State |
Dendrímeros para libertação sustentada de compostos
|
|
WO2009049208A1
(en)
|
2007-10-12 |
2009-04-16 |
The University Of North Carolina At Chapel Hill |
Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
|
|
KR101198354B1
(ko)
|
2007-10-17 |
2013-03-14 |
주식회사 삼양바이오팜 |
핵산 전달용 저밀도 지단백질 유사(LDL-like) 양이온성 나노입자, 그의 제조방법 및 이를 이용한 핵산의 전달 방법
|
|
EP2207903A4
(en)
|
2007-11-09 |
2012-02-15 |
Univ Northeastern |
SELF-ASSEMBLING MICELLES NANOPARTICLES FOR SYSTEMIC GENE DELIVERY
|
|
WO2009072657A1
(ja)
|
2007-12-06 |
2009-06-11 |
The University Of Tokushima |
ナノ機能性シリカ粒子およびその製造方法
|
|
US20090148384A1
(en)
|
2007-12-10 |
2009-06-11 |
Fischer Katrin |
Functionalized, solid polymer nanoparticles comprising epothilones
|
|
CN102027019A
(zh)
|
2007-12-12 |
2011-04-20 |
大学健康网络 |
高密度脂蛋白样肽磷脂支架("hpps")纳米颗粒
|
|
WO2009089117A1
(en)
|
2008-01-04 |
2009-07-16 |
Hormel Foods Corporation |
Encapsulation of oxidatively unstable compounds
|
|
US8481508B2
(en)
|
2008-02-21 |
2013-07-09 |
University Of Kentucky Research Foundation |
Ultra-small RNAs as toll-like receptor-3 antagonists
|
|
EP2259798B1
(en)
|
2008-03-05 |
2013-12-11 |
Baxter International Inc. |
Surface-modified particles and methods for targeted drug delivery
|
|
EP2257306B1
(en)
|
2008-03-25 |
2014-05-07 |
Juvaris Biotherapeutics, Inc. |
Enhancement of an immune response by administration of a cationic lipid-dna complex (cldc)
|
|
EP2105145A1
(en)
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Method for muscle-specific delivery lipid-conjugated oligonucleotides
|
|
US20110151000A1
(en)
|
2008-04-21 |
2011-06-23 |
Schultz William J |
Nitric oxide-releasing compositions, devices and methods
|
|
KR20110042152A
(ko)
|
2008-04-25 |
2011-04-25 |
노쓰웨스턴유니버시티 |
콜레스테롤을 격리시키기에 적합한 나노구조
|
|
JP5721620B2
(ja)
|
2008-05-02 |
2015-05-20 |
キャンサー・リサーチ・テクノロジー・リミテッドCancer Research Technology Limited |
免疫応答を刺激するための作製物および方法
|
|
WO2009158678A1
(en)
|
2008-06-27 |
2009-12-30 |
Children's Hospital & Research Center At Oakland |
Lipophilic nucleic acid delivery vehicle and methods of use therefor
|
|
MX2011001317A
(es)
|
2008-08-04 |
2011-03-04 |
Idera Pharmaceuticals Inc |
Modulacion de la expresion del receptor de tipo toll 3 por medio de oligonucleotidos antisentido.
|
|
US20100047188A1
(en)
|
2008-08-04 |
2010-02-25 |
Idera Pharmaceuticals, Inc. |
Modulation of toll-like receptor 8 expression by antisense oligonucleotides
|
|
BRPI0916884A2
(pt)
|
2008-08-28 |
2016-06-14 |
Glaxosmithkline Biolog Sa |
composição imunogênica, processo para preparar uma composição imunogênica, uso de uma composição imunogênica, e, kit
|
|
US10369204B2
(en)
|
2008-10-02 |
2019-08-06 |
Dako Denmark A/S |
Molecular vaccines for infectious disease
|
|
NZ591925A
(en)
|
2008-10-16 |
2012-09-28 |
Internat Vaccine Inst |
Adjuvant composition comprising a host defense peptide, an immunostimulatory sequence and a polyanionic polymer
|
|
US8574582B2
(en)
|
2008-10-31 |
2013-11-05 |
Janssen Biotech, Inc. |
Methods for mediating fibrotic response
|
|
US20120093914A1
(en)
|
2008-11-24 |
2012-04-19 |
Moma Therapeutics |
Implantable liposome embedded matrix composition, uses thereof, and polycaprolactone particles as scaffolds for tissue regeneration
|
|
EP2365803B1
(en)
|
2008-11-24 |
2017-11-01 |
Northwestern University |
Polyvalent rna-nanoparticle compositions
|
|
ES2481040T3
(es)
|
2008-12-09 |
2014-07-29 |
Coley Pharmaceutical Group, Inc. |
Oligonucleótidos inmunoestimulantes
|
|
US8298765B2
(en)
|
2009-01-01 |
2012-10-30 |
Cornell University |
Multifunctional nucleic acid nano-structures
|
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
CN102307470B
(zh)
|
2009-01-08 |
2015-05-20 |
西北大学 |
通过多价寡核苷酸修饰的纳米颗粒缀合物抑制细菌蛋白的产生
|
|
CA2750499A1
(en)
|
2009-01-30 |
2010-08-05 |
Idera Pharmaceuticals, Inc. |
Novel synthetic agonists of tlr9
|
|
WO2010091293A1
(en)
|
2009-02-06 |
2010-08-12 |
The Regents Of The University Of California |
Plasmonic system for detecting binding of biological molecules
|
|
AR070368A2
(es)
|
2009-02-12 |
2010-03-31 |
Smithkline Beecham Biolog |
Procedimiento para la preparacion de una composicion de vacuna que comprende un inmunoestimulante un antigeno y una sal metalica y uso de dicha composicion para preparar un medicamento.composicion de vacuna
|
|
US20100267806A1
(en)
|
2009-03-12 |
2010-10-21 |
David Bumcrot |
LIPID FORMULATED COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF Eg5 AND VEGF GENES
|
|
JP2012520085A
(ja)
|
2009-03-13 |
2012-09-06 |
エーゲン、インコーポレイテッド |
生物活性rnaの送達のための組成物及び方法
|
|
KR102036676B1
(ko)
|
2009-04-15 |
2019-10-24 |
노오쓰웨스턴 유니버시티 |
올리고뉴클레오티드 관능화된 나노입자의 전달
|
|
BRPI1015408A2
(pt)
|
2009-05-29 |
2017-07-18 |
Envision Scient Private Limited |
restabelecimento do fluxo sanguíneo em artérias humanas bloqueadas por transferência de fármaco nanoencapsulado através de dispositivos médicos projetados para o mesmo e reliberação do fármaco nanoencapsulado na artéria humana com ph corporal
|
|
LT3305302T
(lt)
|
2009-06-17 |
2018-12-10 |
Biogen Ma Inc. |
Junginiai ir būdai smn2 splaisingo moduliavimui subjekte
|
|
KR101360432B1
(ko)
|
2009-06-18 |
2014-02-25 |
한림대학교 산학협력단 |
리포좀에 포집된 올리고뉴클레오타이드를 유효성분으로 하는 면역증강 조성물
|
|
US8889181B2
(en)
|
2009-07-17 |
2014-11-18 |
Industry Academic Cooperation Foundation, Hallym University |
Immunostimulatory compositions comprising liposome-encapsulated oligonucleotides and epitopes
|
|
WO2011017382A2
(en)
|
2009-08-03 |
2011-02-10 |
The Regents Of The University Of California |
Nanofibers and morphology shifting micelles
|
|
US20120277283A1
(en)
|
2009-08-04 |
2012-11-01 |
Mirkin Chad A |
Localized Delivery of Gold Nanoparticles for Therapeutic and Diagnostic Applications
|
|
US20120269730A1
(en)
|
2009-08-07 |
2012-10-25 |
Northwestern University |
Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles
|
|
US20120283316A1
(en)
|
2009-09-01 |
2012-11-08 |
Northwestern University |
Delivery of Therapeutic Agents Using Oligonucleotide-Modified Nanoparticles As Carriers
|
|
WO2011028847A1
(en)
|
2009-09-01 |
2011-03-10 |
Northwestern University |
Polyvalent polynucleotide nanoparticle conjugates as delivery vehicles for a chemotherapeutic agent
|
|
US20110053829A1
(en)
|
2009-09-03 |
2011-03-03 |
Curevac Gmbh |
Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
|
|
WO2011037973A1
(en)
|
2009-09-23 |
2011-03-31 |
Northwestern University |
"click" nanoparticle conjugates
|
|
US20110111974A1
(en)
|
2009-10-23 |
2011-05-12 |
Northwestern University |
Short Duplex Probes for Enhanced Target Hybridization
|
|
US9376690B2
(en)
|
2009-10-30 |
2016-06-28 |
Northwestern University |
Templated nanoconjugates
|
|
WO2011072133A1
(en)
|
2009-12-09 |
2011-06-16 |
William Marsh Rice University |
Therapeutic compositions and methods for delivery of active agents cleavably linked to nanoparticles
|
|
US8933046B2
(en)
|
2009-12-23 |
2015-01-13 |
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. |
Influenza targets
|
|
US20130178610A1
(en)
|
2009-12-24 |
2013-07-11 |
Chad A. Mirkin |
Oligonucleotide specific uptake of nanoconjugates
|
|
JP5863670B2
(ja)
|
2010-01-19 |
2016-02-17 |
ノースウェスタン ユニバーシティ |
核酸および/または他の構成要素を含有している合成ナノ構造体
|
|
EP2399608B1
(en)
|
2010-03-05 |
2020-07-08 |
Sebastian Fuchs |
Immunomodulating nanoparticulate composition for use in inhalation therapy
|
|
US20130101512A1
(en)
|
2010-03-12 |
2013-04-25 |
Chad A. Mirkin |
Crosslinked polynucleotide structure
|
|
US20110262347A1
(en)
|
2010-04-08 |
2011-10-27 |
The Salk Institute For Biological Studies |
Methods and compositions for enhanced delivery of compounds
|
|
ES2608475T3
(es)
|
2010-04-13 |
2017-04-11 |
Celldex Therapeutics, Inc. |
Anticuerpos que se unen a cd27 humana y usos de los mismos
|
|
CA2798074A1
(en)
|
2010-04-27 |
2011-11-03 |
The Johns Hopkins University |
Immunogenic compositions and methods for treating neoplasia
|
|
KR101198715B1
(ko)
|
2010-05-14 |
2012-11-13 |
한국생명공학연구원 |
핵산 및 친수성 음이온 화합물의 고효율 포획을 위한 비대칭 리포솜 및 이의 제조방법
|
|
WO2011150264A2
(en)
|
2010-05-26 |
2011-12-01 |
Selecta Biosciences, Inc. |
Synthetic nanocarrier combination vaccines
|
|
SI2575878T1
(sl)
|
2010-05-28 |
2018-12-31 |
Zoetis Belgium S.A. |
Cepiva, ki obsegajo holesterol in cpg kot edine molekule, ki nosijo adjuvans
|
|
US20130089614A1
(en)
|
2010-06-14 |
2013-04-11 |
Xuefeng Zhang |
Magnetic Nanoparticles and Uses Thereof
|
|
WO2012006634A2
(en)
|
2010-07-09 |
2012-01-12 |
The Board Of Trustees Of The University Of Illiniois |
Prostate specific antigen (psa) peptide therapy
|
|
SG186706A1
(en)
|
2010-07-30 |
2013-02-28 |
Curevac Gmbh |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
WO2012031205A2
(en)
|
2010-09-03 |
2012-03-08 |
The Brigham And Women's Hospital, Inc. |
Lipid-polymer hybrid particles
|
|
US20130095039A1
(en)
|
2010-09-30 |
2013-04-18 |
The Board Of Trustees Of The University Of Illinois |
Nucleic acid-mediated shape control of nanoparticles
|
|
AR083561A1
(es)
|
2010-10-26 |
2013-03-06 |
Ac Immune Sa |
Preparacion de una construccion antigenica
|
|
WO2012084991A1
(en)
|
2010-12-21 |
2012-06-28 |
Index Pharmaceuticals Ab |
Biologically active oligonucleotides capable of modulating the immune system ii
|
|
DK2663548T3
(en)
|
2011-01-11 |
2017-07-24 |
Alnylam Pharmaceuticals Inc |
PEGYLED LIPIDS AND THEIR USE FOR PHARMACEUTICAL SUPPLY
|
|
US9675561B2
(en)
|
2011-04-28 |
2017-06-13 |
President And Fellows Of Harvard College |
Injectable cryogel vaccine devices and methods of use thereof
|
|
EP2723381A4
(en)
|
2011-06-21 |
2015-03-18 |
Univ Johns Hopkins |
FOCUSED RADIATION FOR THE REINFORCEMENT OF IMMUNE TREATMENTS AGAINST NEOPLASMS
|
|
JP6049712B2
(ja)
|
2011-07-08 |
2016-12-21 |
ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill |
抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子
|
|
WO2013012628A2
(en)
*
|
2011-07-15 |
2013-01-24 |
The University Of Georgia Research Foundation, Inc. |
Immune-stimulating photoactive hybrid nanoparticles
|
|
EP2548571A1
(en)
|
2011-07-22 |
2013-01-23 |
Institut Curie |
Compositions having means for targeting at least one antigen to dendritic cells
|
|
CA2843274A1
(en)
|
2011-07-29 |
2013-02-07 |
Selecta Biosciences, Inc. |
Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses
|
|
EP2750662A4
(en)
|
2011-08-31 |
2015-06-24 |
Univ Georgia |
NANOPARTICLES OBTAINING APOPTOSIS
|
|
JP2014531898A
(ja)
*
|
2011-09-11 |
2014-12-04 |
オーラセンス, エルエルシーAurasense, Llc |
細胞取り込み制御システム
|
|
US9308253B2
(en)
|
2011-09-19 |
2016-04-12 |
The Johns Hopkins University |
Cancer immunotherapy
|
|
AU2013201121A1
(en)
|
2011-09-20 |
2013-04-04 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
|
IN2014CN02581A
(enExample)
|
2011-10-06 |
2015-08-07 |
Immunovaccine Technologies Inc |
|
|
CN104080480A
(zh)
|
2012-01-01 |
2014-10-01 |
奇比艾企业有限公司 |
用于选择性递送治疗剂和诊断剂的endo180靶向微粒
|
|
WO2013113326A1
(en)
|
2012-01-31 |
2013-08-08 |
Curevac Gmbh |
Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
|
|
CA2864841C
(en)
|
2012-02-17 |
2020-07-07 |
Keith L. Knutson |
Methods and materials for generating cd8+ t cells having the ability to recognize cancer cells expressing a her2/neu polypeptide
|
|
US20150064255A1
(en)
|
2012-02-22 |
2015-03-05 |
Northwestern University |
Nanostructures for treating cancers and other conditions
|
|
EP2833918B1
(en)
|
2012-04-05 |
2019-05-08 |
Massachusetts Institute of Technology |
Immunostimulatory compositions and methods of use thereof
|
|
KR20200075023A
(ko)
|
2012-05-04 |
2020-06-25 |
화이자 인코포레이티드 |
전립선 관련된 항원 및 백신 기재 면역치료 요법
|
|
US9750819B2
(en)
|
2012-05-23 |
2017-09-05 |
Ohio State Innovation Foundation |
Lipid nanoparticle compositions and methods of making and methods of using the same
|
|
AU2013287630B2
(en)
|
2012-07-13 |
2017-05-25 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant
|
|
CN112587658A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
WO2014025795A1
(en)
|
2012-08-07 |
2014-02-13 |
Northeastern University |
Compositions for the delivery of rna and drugs into cells
|
|
US9095625B2
(en)
|
2012-08-31 |
2015-08-04 |
University Of Massachusetts |
Graft-copolymer stabilized metal nanoparticles
|
|
US20150111790A1
(en)
|
2013-01-31 |
2015-04-23 |
Christopher Ategeka |
Testing device
|
|
MX2015010083A
(es)
|
2013-02-05 |
2016-04-26 |
1Globe Health Inst Llc |
Nanoparticulas biodegradables y clinicamente compatibles como portadores para administracion de farmacos.
|
|
US9968673B2
(en)
|
2013-02-26 |
2018-05-15 |
Commissariat á l'ènergie atomique et aux ènergies alternatives |
Immunogenic composition in emulsion form comprising two dispersed phases, one comprising an antigen and the other comprising an immunostimulating agent
|
|
EP2961395B1
(en)
|
2013-03-01 |
2024-06-19 |
California Institute Of Technology |
Targeted nanoparticles
|
|
WO2014152795A2
(en)
|
2013-03-14 |
2014-09-25 |
Schentag Jerome J |
Cholestosome vesicles for incorporation of molecules into chylomicrons
|
|
CN103212089B
(zh)
*
|
2013-04-07 |
2016-08-24 |
中国科学院上海应用物理研究所 |
一种碳纳米材料-免疫刺激序列复合物的制备方法及其应用
|
|
US9617544B2
(en)
|
2013-04-11 |
2017-04-11 |
The Board Of Trustees Of The University Of Illinois |
Nanoparticle mediated delivery of siRNA
|
|
AR095882A1
(es)
|
2013-04-22 |
2015-11-18 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
|
|
WO2014201245A1
(en)
|
2013-06-12 |
2014-12-18 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Tlr-9 agonist with tlr-7 and/or tlr-8 agonist for treating tumors
|
|
AU2014292928A1
(en)
|
2013-07-25 |
2016-03-03 |
Exicure, Inc. |
Spherical nucleic acid-based constructs as immunoregulatory agents
|
|
CN105579582A
(zh)
|
2013-07-25 |
2016-05-11 |
埃克西奎雷股份有限公司 |
用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体
|
|
CN112107693B
(zh)
|
2013-12-03 |
2023-05-26 |
西北大学 |
脂质体颗粒、制备所述脂质体颗粒的方法以及其用途
|
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
GB2523187A
(en)
|
2014-02-18 |
2015-08-19 |
Mologen Ag |
Covalently closed non-coding immunomodulatory DNA construct
|
|
EP3129391A4
(en)
|
2014-04-03 |
2017-12-20 |
Exicure, Inc. |
Self assembling nucleic acid nanostructures
|
|
CA2953216C
(en)
|
2014-06-04 |
2020-12-22 |
Exicure, Inc. |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
|
|
WO2016004168A1
(en)
|
2014-07-01 |
2016-01-07 |
Aurasense Therapeutics, Llc |
Spherical nanoparticles as antibacterial agents
|
|
BR112017007012A2
(pt)
|
2014-10-06 |
2018-03-06 |
Exicure Inc |
compostos anti-tnf
|
|
KR20170072244A
(ko)
|
2014-10-10 |
2017-06-26 |
이데라 파마슈티칼즈, 인코포레이티드 |
관문 억제제를 가지는 tlr9 효능제를 이용한 암 치료
|
|
US10704043B2
(en)
|
2015-01-14 |
2020-07-07 |
Exicure, Inc. |
Nucleic acid nanostructures with core motifs
|
|
WO2016134104A1
(en)
|
2015-02-18 |
2016-08-25 |
Exicure, Inc. |
Immuno-regulatory lipid containing spherical nucleic acids
|
|
WO2016149323A1
(en)
|
2015-03-16 |
2016-09-22 |
Exicure, Inc. |
Immunomodulatory spherical nucleic acids
|
|
US10078092B2
(en)
|
2015-03-18 |
2018-09-18 |
Northwestern University |
Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules
|
|
EP3322407A4
(en)
|
2015-07-14 |
2019-07-10 |
Exicure, Inc. |
RELOCATION OF LIPID COMPLEXES IN CELLS INDUCED BY SPINICAL NUCLEIC ACIDS (SNA)
|
|
WO2017011618A1
(en)
|
2015-07-15 |
2017-01-19 |
The Curators Of The University Of Missouri |
Targeted nanoparticle conjugate and method for co-delivery of sirna and drug
|
|
AU2016312530A1
(en)
|
2015-08-24 |
2018-03-01 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
|
|
LU92821B1
(en)
|
2015-09-09 |
2017-03-20 |
Mologen Ag |
Combination comprising immunostimulatory oligonucleotides
|
|
WO2017184427A1
(en)
|
2016-04-19 |
2017-10-26 |
Exicure, Inc. |
Topical administration of therapeutic agents and oligonucleotide formulations
|
|
CN109312348A
(zh)
|
2016-05-06 |
2019-02-05 |
埃克西奎雷股份有限公司 |
球形核酸tlr9激动剂
|
|
AU2017261360A1
(en)
|
2016-05-06 |
2018-11-29 |
Exicure Operating Company |
Liposomal Spherical Nucleic Acid (SNA) constructs presenting Antisense Oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor MRNA
|
|
EP3922279B8
(en)
|
2016-08-30 |
2025-02-12 |
Dana-Farber Cancer Institute, Inc. |
Drug delivery compositions and uses thereof
|
|
JP7200093B2
(ja)
|
2016-09-15 |
2023-01-06 |
アイデラ・ファーマシューティカルズ,インコーポレーテッド |
がん治療用tlr9アゴニストを用いた免疫調節
|
|
US20190374650A1
(en)
|
2017-02-22 |
2019-12-12 |
The Regents Of The University Of Michigan |
Compositions and methods for delivery of polymer/biomacromolecule conjugates
|
|
US11696954B2
(en)
|
2017-04-28 |
2023-07-11 |
Exicure Operating Company |
Synthesis of spherical nucleic acids using lipophilic moieties
|
|
WO2019169203A1
(en)
|
2018-02-28 |
2019-09-06 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs for survival of motor neuron (sma) inhibitors
|
|
WO2019168558A1
(en)
|
2018-02-28 |
2019-09-06 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs for survival of motor neuron (sma) inhibitors
|