JP2016534094A5 - - Google Patents
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- Publication number
- JP2016534094A5 JP2016534094A5 JP2016530087A JP2016530087A JP2016534094A5 JP 2016534094 A5 JP2016534094 A5 JP 2016534094A5 JP 2016530087 A JP2016530087 A JP 2016530087A JP 2016530087 A JP2016530087 A JP 2016530087A JP 2016534094 A5 JP2016534094 A5 JP 2016534094A5
- Authority
- JP
- Japan
- Prior art keywords
- average diameter
- nanoscale construct
- nanoscale
- nucleic acid
- antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005557 antagonist Substances 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 230000003993 interaction Effects 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 102000053602 DNA Human genes 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910017052 cobalt Inorganic materials 0.000 claims 1
- 239000010941 cobalt Substances 0.000 claims 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 239000011162 core material Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 230000004957 immunoregulator effect Effects 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361858584P | 2013-07-25 | 2013-07-25 | |
| US61/858,584 | 2013-07-25 | ||
| PCT/US2014/048294 WO2015013675A1 (en) | 2013-07-25 | 2014-07-25 | Spherical nucleic acid-based constructs as immunoregulatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016534094A JP2016534094A (ja) | 2016-11-04 |
| JP2016534094A5 true JP2016534094A5 (enExample) | 2017-09-07 |
Family
ID=51422128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016530087A Pending JP2016534094A (ja) | 2013-07-25 | 2014-07-25 | 免疫調節剤としての球状核酸に基づくコンストラクト |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20160194642A1 (enExample) |
| EP (1) | EP3024494A1 (enExample) |
| JP (1) | JP2016534094A (enExample) |
| KR (1) | KR20160045726A (enExample) |
| CN (1) | CN105658241A (enExample) |
| AU (1) | AU2014292928A1 (enExample) |
| CA (1) | CA2919273A1 (enExample) |
| WO (1) | WO2015013675A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| JP5863670B2 (ja) | 2010-01-19 | 2016-02-17 | ノースウェスタン ユニバーシティ | 核酸および／または他の構成要素を含有している合成ナノ構造体 |
| CN105579582A (zh) | 2013-07-25 | 2016-05-11 | 埃克西奎雷股份有限公司 | 用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体 |
| WO2015023797A1 (en) | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| CN112107693B (zh) | 2013-12-03 | 2023-05-26 | 西北大学 | 脂质体颗粒、制备所述脂质体颗粒的方法以及其用途 |
| US10413565B2 (en) | 2014-04-30 | 2019-09-17 | Northwestern University | Nanostructures for modulating intercellular communication and uses thereof |
| CA2953216C (en) * | 2014-06-04 | 2020-12-22 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| BR112017007012A2 (pt) | 2014-10-06 | 2018-03-06 | Exicure Inc | compostos anti-tnf |
| AU2015349680A1 (en) | 2014-11-21 | 2017-06-08 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| WO2016085986A1 (en) | 2014-11-24 | 2016-06-02 | Northwestern University | High density lipoprptein nanoparticles for inflammation |
| US10704043B2 (en) * | 2015-01-14 | 2020-07-07 | Exicure, Inc. | Nucleic acid nanostructures with core motifs |
| WO2016134104A1 (en) * | 2015-02-18 | 2016-08-25 | Exicure, Inc. | Immuno-regulatory lipid containing spherical nucleic acids |
| WO2016149323A1 (en) * | 2015-03-16 | 2016-09-22 | Exicure, Inc. | Immunomodulatory spherical nucleic acids |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| EP3322407A4 (en) * | 2015-07-14 | 2019-07-10 | Exicure, Inc. | RELOCATION OF LIPID COMPLEXES IN CELLS INDUCED BY SPINICAL NUCLEIC ACIDS (SNA) |
| AU2017261360A1 (en) | 2016-05-06 | 2018-11-29 | Exicure Operating Company | Liposomal Spherical Nucleic Acid (SNA) constructs presenting Antisense Oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor MRNA |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2018213585A1 (en) * | 2017-05-17 | 2018-11-22 | Northwestern University | Conjugation of peptides to spherical nucleic acids (snas) using tracelless linkers |
| MX2020000387A (es) | 2017-07-13 | 2020-08-17 | Univ Northwestern | Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos. |
| JP7023460B2 (ja) * | 2017-10-26 | 2022-02-22 | 国立大学法人 鹿児島大学 | Ｔｌｒリガンド固定化ナノ粒子 |
| US20210189397A1 (en) * | 2018-05-10 | 2021-06-24 | Northwestern University | Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology |
| US20210269806A1 (en) * | 2018-06-20 | 2021-09-02 | Exicure, Inc. | Il-1 beta targeting spherical nucleic acids |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| US11951211B2 (en) * | 2020-01-31 | 2024-04-09 | Yale University | DNA brick-assisted liposome sorting |
| CN120615126A (zh) * | 2022-12-09 | 2025-09-09 | 武田药品工业株式会社 | 经修饰的免疫调节剂 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5472881A (en) | 1992-11-12 | 1995-12-05 | University Of Utah Research Foundation | Thiol labeling of DNA for attachment to gold surfaces |
| CA2262018C (en) | 1996-07-29 | 2007-10-02 | Nanosphere Llc | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US6506569B1 (en) | 1997-05-30 | 2003-01-14 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor TR10 |
| AU784040B2 (en) | 1999-06-25 | 2006-01-19 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| WO2001051665A2 (en) | 2000-01-13 | 2001-07-19 | Nanosphere Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| ATE487136T1 (de) | 2000-03-28 | 2010-11-15 | Nanosphere Inc | Nanopartikel mit gebundenen oligonukleotiden und verwendungen derselben |
| US7238472B2 (en) | 2001-05-25 | 2007-07-03 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
| JP2005511761A (ja) | 2001-07-10 | 2005-04-28 | ノース・キャロライナ・ステイト・ユニヴァーシティ | ナノ粒子送達ビヒクル |
| US8252756B2 (en) | 2005-06-14 | 2012-08-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| AU2008212820B2 (en) | 2007-02-09 | 2014-01-30 | Northwestern University | Particles for detecting intracellular targets |
| WO2008127789A2 (en) | 2007-02-27 | 2008-10-23 | Northwestern University | Molecule attachment to nanoparticles |
| DK2160464T3 (da) | 2007-05-30 | 2014-08-04 | Univ Northwestern | Nukleinsyrefunktionaliserede nanopartikler til terapeutiske anvendelser |
| CA2732142A1 (en) * | 2008-07-28 | 2010-02-04 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 9 expression by antisense oligonucleotides |
| EP2365803B1 (en) | 2008-11-24 | 2017-11-01 | Northwestern University | Polyvalent rna-nanoparticle compositions |
| CN102307470B (zh) | 2009-01-08 | 2015-05-20 | 西北大学 | 通过多价寡核苷酸修饰的纳米颗粒缀合物抑制细菌蛋白的产生 |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| US20100294952A1 (en) | 2009-01-15 | 2010-11-25 | Northwestern University | Controlled agent release and sequestration |
| US20120277283A1 (en) | 2009-08-04 | 2012-11-01 | Mirkin Chad A | Localized Delivery of Gold Nanoparticles for Therapeutic and Diagnostic Applications |
| US20120269730A1 (en) | 2009-08-07 | 2012-10-25 | Northwestern University | Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles |
| US20110111974A1 (en) | 2009-10-23 | 2011-05-12 | Northwestern University | Short Duplex Probes for Enhanced Target Hybridization |
| US9376690B2 (en) | 2009-10-30 | 2016-06-28 | Northwestern University | Templated nanoconjugates |
| US20130178610A1 (en) | 2009-12-24 | 2013-07-11 | Chad A. Mirkin | Oligonucleotide specific uptake of nanoconjugates |
| EP2399608B1 (en) * | 2010-03-05 | 2020-07-08 | Sebastian Fuchs | Immunomodulating nanoparticulate composition for use in inhalation therapy |
-
2014
- 2014-07-25 AU AU2014292928A patent/AU2014292928A1/en not_active Abandoned
- 2014-07-25 WO PCT/US2014/048294 patent/WO2015013675A1/en not_active Ceased
- 2014-07-25 JP JP2016530087A patent/JP2016534094A/ja active Pending
- 2014-07-25 KR KR1020167004851A patent/KR20160045726A/ko not_active Withdrawn
- 2014-07-25 EP EP14756142.7A patent/EP3024494A1/en not_active Withdrawn
- 2014-07-25 CN CN201480052513.5A patent/CN105658241A/zh active Pending
- 2014-07-25 CA CA2919273A patent/CA2919273A1/en not_active Abandoned
- 2014-07-25 US US14/907,455 patent/US20160194642A1/en not_active Abandoned
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