JP2011525477A5 - - Google Patents
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- Publication number
- JP2011525477A5 JP2011525477A5 JP2010549861A JP2010549861A JP2011525477A5 JP 2011525477 A5 JP2011525477 A5 JP 2011525477A5 JP 2010549861 A JP2010549861 A JP 2010549861A JP 2010549861 A JP2010549861 A JP 2010549861A JP 2011525477 A5 JP2011525477 A5 JP 2011525477A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine composition
- particles
- aspect ratio
- antigen
- immunostimulatory agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 claims 22
- 229960005486 vaccine Drugs 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000003308 immunostimulating effect Effects 0.000 claims 8
- 230000005847 immunogenicity Effects 0.000 claims 4
- 230000002596 correlated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 125000002091 cationic group Chemical group 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6822708P | 2008-03-04 | 2008-03-04 | |
| US61/068,227 | 2008-03-04 | ||
| PCT/US2009/036068 WO2009111588A1 (en) | 2008-03-04 | 2009-03-04 | Immunomodulator particles and methods of treating |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238952A Division JP2015078204A (ja) | 2008-03-04 | 2014-11-26 | 免疫調節剤粒子および処置方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525477A JP2011525477A (ja) | 2011-09-22 |
| JP2011525477A5 true JP2011525477A5 (enExample) | 2012-04-26 |
Family
ID=41056361
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549861A Pending JP2011525477A (ja) | 2008-03-04 | 2009-03-04 | 免疫調節剤粒子および処置方法 |
| JP2014238952A Pending JP2015078204A (ja) | 2008-03-04 | 2014-11-26 | 免疫調節剤粒子および処置方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238952A Pending JP2015078204A (ja) | 2008-03-04 | 2014-11-26 | 免疫調節剤粒子および処置方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110151015A1 (enExample) |
| EP (1) | EP2262480B1 (enExample) |
| JP (2) | JP2011525477A (enExample) |
| CN (1) | CN102014874A (enExample) |
| WO (1) | WO2009111588A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100055459A1 (en) * | 2006-08-30 | 2010-03-04 | Liquidia Technologies, Inc. | Nanoparticles Having Functional Additives for Self and Directed Assembly and Methods of Fabricating Same |
| US20100190654A1 (en) * | 2006-12-05 | 2010-07-29 | Liquidia Technologies , Inc. | Nanoarrays and methods and materials for fabricating same |
| AU2008222678B2 (en) | 2007-03-07 | 2013-01-17 | The General Hospital Corporation | Compositions and methods for the prevention and treatment of autoimmune conditions |
| WO2010138192A2 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| EP2538969A4 (en) * | 2010-02-22 | 2013-11-27 | Liquidia Technologies Inc | VACCINES FROM POLYSACCHARIDE PARTICLES |
| CN102905728B (zh) | 2010-05-26 | 2015-11-25 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| US20130203675A1 (en) | 2010-09-16 | 2013-08-08 | Joseph M. DeSimone | Asymmetric biofunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents |
| EP2640190A4 (en) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | MODIFIED NICOTINIC COMPOUNDS AND ASSOCIATED METHODS |
| US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
| KR20140041505A (ko) | 2011-04-29 | 2014-04-04 | 셀렉타 바이오사이언시즈, 인크. | 조절 b 세포 유도를 위한 관용원성 합성 나노운반체 |
| US20130028857A1 (en) | 2011-07-29 | 2013-01-31 | Selecta Biosciences, Inc. | Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents |
| US20150037428A1 (en) | 2011-11-29 | 2015-02-05 | The University Of North Carolina At Chapel Hill | Geometrically engineered particles and methods for modulating macrophage or immune responses |
| US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
| US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
| WO2014165728A1 (en) * | 2013-04-05 | 2014-10-09 | The University Of North Carolina At Chapel Hill | Particles having peg-ylated surfaces modified for lymphatic trafficking |
| JP2017500285A (ja) | 2013-11-04 | 2017-01-05 | ユーティーアイ リミテッド パートナーシップ | 持続的免疫療法のための方法および組成物 |
| SG10201913957PA (en) | 2015-05-06 | 2020-03-30 | Uti Lp | Nanoparticle compositions for sustained therapy |
| US20190298854A1 (en) | 2016-03-07 | 2019-10-03 | Glaxosmithkline Biologicals, Sa | Drug delivery particles |
| US10898494B2 (en) | 2016-05-05 | 2021-01-26 | Liquidia Technologies, Inc. | Dry powder treprostinil for the treatment of pulmonary hypertension |
| JP7436372B2 (ja) | 2017-11-29 | 2024-02-21 | ユーティアイ・リミテッド・パートナーシップ | 自己免疫性疾患を治療する方法 |
| US20230241237A1 (en) * | 2020-04-16 | 2023-08-03 | Emory University | Immune Cell Redirecting Compositions and Therapeutic Uses Thereof |
| CN116407624B (zh) * | 2023-04-14 | 2024-04-09 | 吉林省农业科学院(中国农业科技东北创新中心) | 一种鸡传染性支气管炎细菌样颗粒疫苗的制备方法和应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090406A (en) * | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5709879A (en) * | 1990-06-29 | 1998-01-20 | Chiron Corporation | Vaccine compositions containing liposomes |
| GB9227068D0 (en) | 1992-12-29 | 1993-02-24 | British Bio Technology | Novel proteinaceous particles |
| FR2723849B1 (fr) | 1994-08-31 | 1997-04-11 | Biovector Therapeutics Sa | Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique |
| US5686113A (en) * | 1995-03-21 | 1997-11-11 | Temple University Of The Commonwealth System Of Higher Education | Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses |
| ATE215385T1 (de) * | 1997-12-16 | 2002-04-15 | Chiron Corp | Verwendung von mikropartikeln mit submikron öl/wasser emulsionen |
| US6086881A (en) | 1998-05-15 | 2000-07-11 | Children's Medical Center Corp. | Spatially aligned conjugated composition having a thioether bond linkage |
| CA2351593C (en) * | 1998-11-11 | 2012-02-21 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
| US6326021B1 (en) | 1999-06-18 | 2001-12-04 | The Ohio State University Research Foundation | Biocompatible polymeric delivery systems having functional groups attached to the surface thereof |
| JP4658423B2 (ja) | 1999-08-03 | 2011-03-23 | ザ オハイオ ステイト ユニバーシティ | Her−2タンパク質に対する免疫反応性を増強するためのポリペプチドおよびポリヌクレオチド |
| US20020061312A1 (en) | 2000-07-31 | 2002-05-23 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US20030232055A1 (en) * | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
| US20030175287A1 (en) * | 2001-01-03 | 2003-09-18 | Yale University | Innate immune system-directed vaccines |
| AU2002305539A1 (en) | 2001-05-09 | 2002-11-18 | Yale University | Toll/interleukin-1 receptor adaptor protein (tirap) |
| AU2003235685A1 (en) | 2002-01-09 | 2003-07-30 | Ruslan M. Medzhitov | Rip2: a method of signaling in the innate and adaptive immune systems |
| US20030157539A1 (en) | 2002-01-09 | 2003-08-21 | Yale University | IRAK-M is a negative regulator of toll-like receptor signaling |
| CA2481980A1 (en) * | 2002-04-05 | 2003-10-23 | Progenics Pharmaceuticals, Inc. | Particle-bound human immunodeficiency virus envelope glycoproteins and related compositions and methods |
| AU2003225054A1 (en) | 2002-04-19 | 2003-11-03 | Yale University | Toll-like receptor 11 and toll-like receptor 12 |
| US20040009943A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Pathogen vaccines and methods for using the same |
| US7393493B2 (en) * | 2003-02-27 | 2008-07-01 | A Enterprises, Inc. | Crosslinkable polymeric materials and their applications |
| US20050163764A1 (en) | 2003-09-22 | 2005-07-28 | Yale University | Treatment with agonists of toll-like receptors |
| US20050118199A1 (en) * | 2003-10-07 | 2005-06-02 | Esser Mark T. | Process for covalently conjugating polysaccharides to microspheres or biomolecules |
| EP1687024B1 (en) * | 2003-11-05 | 2011-10-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer |
| US8263129B2 (en) * | 2003-12-19 | 2012-09-11 | The University Of North Carolina At Chapel Hill | Methods for fabricating isolated micro-and nano-structures using soft or imprint lithography |
| US9040090B2 (en) * | 2003-12-19 | 2015-05-26 | The University Of North Carolina At Chapel Hill | Isolated and fixed micro and nano structures and methods thereof |
| CA2556169C (en) * | 2004-01-29 | 2011-11-22 | Andrew Lees | Use of amino-oxy functional groups in the preparation of vaccines |
| CA2595783A1 (en) * | 2005-02-01 | 2006-08-10 | Medivas, Llc | Vaccine delivery compositions and methods of use |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| MX2007016039A (es) | 2005-06-17 | 2008-10-27 | Univ North Carolina | Metodos, sistemas y materiales de fabricacion de nanoparticulas. |
| EP1951202A4 (en) | 2005-11-07 | 2013-03-06 | Univ North Carolina | ISOLATED AND SOLID MICRO AND NANO STRUCTURES AND METHOD THEREFOR |
| WO2007081876A2 (en) * | 2006-01-04 | 2007-07-19 | Liquidia Technologies, Inc. | Nanostructured surfaces for biomedical/biomaterial applications and processes thereof |
| WO2008063204A2 (en) | 2006-01-27 | 2008-05-29 | The University Of North Carolina At Chapel Hill | Taggants and methods and systems for fabricating |
| CN101405028B (zh) * | 2006-03-17 | 2015-08-19 | 美国政府健康及人类服务部 | 制备复合的多价免疫原性结合物的方法 |
| US20080181958A1 (en) * | 2006-06-19 | 2008-07-31 | Rothrock Ginger D | Nanoparticle fabrication methods, systems, and materials |
| US20100055459A1 (en) * | 2006-08-30 | 2010-03-04 | Liquidia Technologies, Inc. | Nanoparticles Having Functional Additives for Self and Directed Assembly and Methods of Fabricating Same |
| ES2517869T3 (es) * | 2006-09-12 | 2014-11-04 | Alphavax, Inc. | Partículas de replicones de alfavirus emparejadas con antígenos proteicos como adyuvantes inmunológicos |
| WO2008045486A2 (en) | 2006-10-09 | 2008-04-17 | The University Of North Carolina At Chapel Hill | Nanoparticle compositions for controlled delivery of nucleic acids |
| EP2146689B1 (en) * | 2007-04-16 | 2020-08-12 | Corium, Inc. | Solvent-cast microneedle arrays containing active |
-
2009
- 2009-03-04 JP JP2010549861A patent/JP2011525477A/ja active Pending
- 2009-03-04 EP EP09717401.5A patent/EP2262480B1/en not_active Not-in-force
- 2009-03-04 CN CN2009801168810A patent/CN102014874A/zh active Pending
- 2009-03-04 WO PCT/US2009/036068 patent/WO2009111588A1/en not_active Ceased
- 2009-03-04 US US12/920,944 patent/US20110151015A1/en not_active Abandoned
-
2014
- 2014-11-26 JP JP2014238952A patent/JP2015078204A/ja active Pending
-
2015
- 2015-06-11 US US14/737,180 patent/US20150273079A1/en not_active Abandoned
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