JP2014530219A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014530219A5 JP2014530219A5 JP2014534512A JP2014534512A JP2014530219A5 JP 2014530219 A5 JP2014530219 A5 JP 2014530219A5 JP 2014534512 A JP2014534512 A JP 2014534512A JP 2014534512 A JP2014534512 A JP 2014534512A JP 2014530219 A5 JP2014530219 A5 JP 2014530219A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticles
- nanoparticle
- pharmaceutical composition
- sterol
- quillaja
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002105 nanoparticle Substances 0.000 claims 15
- PIGTXFOGKFOFTO-FVFWYJKVSA-N (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-carboxy-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O([C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)C[C@@H](O)[C@]1(CCC(C[C@H]14)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O PIGTXFOGKFOFTO-FVFWYJKVSA-N 0.000 claims 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229930182558 Sterol Natural products 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 150000003432 sterols Chemical class 0.000 claims 5
- 235000003702 sterols Nutrition 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 235000009001 Quillaja saponaria Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 230000005661 hydrophobic surface Effects 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 claims 1
- 241001092142 Molina Species 0.000 claims 1
- 241001092473 Quillaja Species 0.000 claims 1
- 241001454523 Quillaja saponaria Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 244000275904 brauner Senf Species 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542425P | 2011-10-03 | 2011-10-03 | |
| US61/542,425 | 2011-10-03 | ||
| PCT/SE2012/051048 WO2013051994A1 (en) | 2011-10-03 | 2012-10-01 | Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530219A JP2014530219A (ja) | 2014-11-17 |
| JP2014530219A5 true JP2014530219A5 (enExample) | 2015-11-19 |
| JP6050822B2 JP6050822B2 (ja) | 2016-12-21 |
Family
ID=47143250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534512A Active JP6050822B2 (ja) | 2011-10-03 | 2012-10-01 | ナノ粒子、ナノ粒子の調製のための処理、および癌治療および食品関連化合物を含む医療分野における両親媒性分子または疎水性分子ための担体としてのナノ粒子の使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10047116B2 (enExample) |
| EP (3) | EP4176871A1 (enExample) |
| JP (1) | JP6050822B2 (enExample) |
| KR (1) | KR102090740B1 (enExample) |
| CN (1) | CN103857403B (enExample) |
| AU (1) | AU2012319239B2 (enExample) |
| CA (1) | CA2850296C (enExample) |
| DK (2) | DK2750683T4 (enExample) |
| ES (1) | ES2673957T5 (enExample) |
| HR (1) | HRP20180956T1 (enExample) |
| IN (1) | IN2014DN03485A (enExample) |
| PL (1) | PL2750683T3 (enExample) |
| PT (1) | PT2750683T (enExample) |
| RS (1) | RS57350B1 (enExample) |
| TR (1) | TR201808733T4 (enExample) |
| WO (1) | WO2013051994A1 (enExample) |
| ZA (1) | ZA201402040B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201808733T4 (tr) | 2011-10-03 | 2018-07-23 | Mx Adjuvac Ab | Kanser tedavisini ve gıda ile ilgili bileşikleri içeren tıp alanlarında amfipatik veya hidrofobik moleküller için taşıyıcı olarak nano-parçacıklar, preparasyon için proses ve bunların kullanımı. |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| EP2777402A1 (en) | 2013-03-15 | 2014-09-17 | DSM IP Assets B.V. | Solid lipid nanoparticles (I) |
| AR095962A1 (es) | 2013-04-01 | 2015-11-25 | Moreinx Ab | Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| CN104382856B (zh) * | 2014-12-04 | 2017-11-14 | 中国药科大学 | 一种去氧鬼臼毒素长循环脂质体冻干制剂 |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| CN110494543A (zh) | 2016-10-19 | 2019-11-22 | 弗洛设计声能学公司 | 通过声学的亲和细胞提取 |
| WO2018237109A1 (en) * | 2017-06-23 | 2018-12-27 | Yale University | Nanomaterials with enhanced drug delivery efficiency |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| EP3669890A1 (en) * | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
| JP7597554B2 (ja) * | 2020-10-30 | 2024-12-10 | 株式会社ニップン | オキシトシン受容体作動性組成物 |
| CN116077639A (zh) * | 2023-01-05 | 2023-05-09 | 国药中生生物技术研究院有限公司 | 雷公藤红素或其可药用衍生物在制备疫苗佐剂中的用途 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2802005A (en) | 1957-08-06 | S-eluorourace | ||
| US3046301A (en) | 1959-10-29 | 1962-07-24 | Burroughs Wellcome Co | Method of making chlorambucil |
| US3803124A (en) | 1968-04-12 | 1974-04-09 | Farmaceutici It Soc | Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives |
| GB1235022A (en) | 1969-06-04 | 1971-06-09 | Laeaeke Ag | A new method for the production of cyclophosphamide |
| DE2124023C3 (de) | 1970-05-27 | 1980-07-10 | Richter Gedeon Vegyeszeti Gyar R.T., Budapest | Verfahren zur selektiven Gewinnung von Vinblastin, Vinleurosin und Vincristin oder von deren Sulfaten |
| US4020270A (en) | 1974-05-02 | 1977-04-26 | Societa' Farmaceutici Italia S.P.A. | L-lyxohex-1-enopyranose derivative |
| GB1467383A (en) | 1974-06-12 | 1977-03-16 | Farmaceutici Italia | Daunomycin analogues |
| US4307100A (en) | 1978-08-24 | 1981-12-22 | Agence Nationale De Valorisation De La Recherche (Anvar) | Nor bis-indole compounds usable as medicaments |
| DE2845574A1 (de) | 1978-10-19 | 1980-04-24 | Deutsches Krebsforsch | Durch heterocyclische ringe oder alkylreste substituierte analoga von ccnu und verfahren zu deren herstellung |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| EP0111058B1 (en) | 1982-11-26 | 1987-11-04 | Nippon Kayaku Kabushiki Kaisha | Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof |
| US4526988A (en) | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| SE8405493D0 (sv) | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| DK166762B1 (da) * | 1986-01-14 | 1993-07-12 | Nederlanden Staat | Fremgangsmaade til fremstilling af immunogenkomplekser og farmaceutisk sammensaetning indeholdende saadanne komplekser |
| FR2601675B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| US5004758A (en) | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| JPH0679958B2 (ja) | 1988-10-07 | 1994-10-12 | 東レ株式会社 | 糸条の巻取装置 |
| GB8919819D0 (en) | 1989-09-01 | 1989-10-18 | Coopers Animal Health | Complexes having adjuvant activity |
| NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| SE502569C2 (sv) * | 1991-05-31 | 1995-11-13 | British Tech Group | Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| IT1250692B (it) | 1991-07-23 | 1995-04-21 | Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. | |
| US5650398A (en) * | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
| US5476932A (en) | 1994-08-26 | 1995-12-19 | Hoffmann-La Roche Inc. | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US20010053365A1 (en) * | 1995-04-25 | 2001-12-20 | Smithkline Beecham Biologicals S.A. | Vaccines |
| SE9600647D0 (sv) | 1996-02-21 | 1996-02-21 | Bror Morein | Ny användning |
| GB9718901D0 (en) * | 1997-09-05 | 1997-11-12 | Smithkline Beecham Biolog | Vaccine |
| GB9719426D0 (en) | 1997-09-13 | 1997-11-12 | Johnson Matthey Plc | Novel process |
| GB9817052D0 (en) * | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| DE59903869D1 (de) * | 1998-10-14 | 2003-01-30 | Cognis Deutschland Gmbh | Verwendung von nanoskaligen sterolen und sterolestern |
| PL209127B1 (pl) * | 2000-02-23 | 2011-07-29 | Smithkline Beecham Biolog | Środek farmaceutyczny do stosowania w immunoterapeutycznym leczeniu raka i sposób diagnozowania u pacjenta obecności lub podatności na raka |
| EP1377320B1 (en) | 2001-04-04 | 2008-10-01 | Nordic Vaccine Technology A/S | Polynucleotide binding complexes comprising sterols and saponins |
| US7713942B2 (en) * | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| CA2449856C (en) * | 2001-06-15 | 2009-03-10 | Cornerstone Pharmaceuticals | Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells |
| GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| AU2002359855B2 (en) * | 2001-12-21 | 2008-08-21 | David S. Soane | Use of oligomers and polymers for drug solublization, stabilization, and delivery |
| US6861410B1 (en) * | 2002-03-21 | 2005-03-01 | Chiron Corporation | Immunological adjuvant compositions |
| SE0202110D0 (sv) | 2002-07-05 | 2002-07-05 | Isconova Ab | Iscom preparation and use thereof |
| AU2003269839B2 (en) | 2002-10-02 | 2006-07-27 | Nordic Vaccine A/S | Composition for vaccination |
| SE0301998D0 (sv) | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| US20050175623A1 (en) * | 2004-02-10 | 2005-08-11 | Zheng-Pin Wang | Saponins as anticancer agent |
| JP2008539255A (ja) * | 2005-04-26 | 2008-11-13 | マイクロビア インコーポレーテッド | 高コレステロール血症のための４−ビアリーリル−１−フェニルアゼチジン−２−オングルクロニド誘導体 |
| KR100641060B1 (ko) * | 2005-07-22 | 2006-11-01 | 삼성전자주식회사 | 게이트 구조물의 제조 방법 및 이를 이용하는 반도체장치의 제조 방법 |
| DE102006007903A1 (de) | 2005-12-21 | 2007-07-05 | VD-Werkstätten GmbH & Co KG | Verfahren für die Herstellung von Möbel-Formteilen |
| EP1974754A4 (en) * | 2006-01-18 | 2012-09-05 | Nat Univ Corp Tokyo Med & Dent | BIOMATERIAL FOR OSTEOGENESIS CONTAINING A PROMOTER OF OSTEOGENESIS AND A NANOGEL |
| US9040081B2 (en) * | 2006-11-20 | 2015-05-26 | Duecom | Use of lipid containing particles comprising Quillaja saponins for the treatment of cancer |
| EP2494958A1 (en) * | 2006-12-01 | 2012-09-05 | Anterios, Inc. | Amphiphilic Entity Nanoparticles |
| WO2008080900A2 (en) * | 2006-12-29 | 2008-07-10 | Evonik Degussa Gmbh | Methionine synthases with reduced product inhibition |
| US20080299177A1 (en) * | 2007-06-06 | 2008-12-04 | Biovaluation & Analysis, Inc. | Supramolecular Complexes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
| BRPI0817664A2 (pt) * | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| US8999353B2 (en) * | 2007-10-12 | 2015-04-07 | Csl Limited | Method of eliciting an immune response against pandemic influenza virus |
| SI3056214T1 (sl) * | 2008-06-27 | 2019-06-28 | Zoetis Services Llc | Nove pomožne sestavine |
| EP2328613A1 (en) * | 2008-08-28 | 2011-06-08 | GlaxoSmithKline Biologicals S.A. | Vaccine |
| JP5344558B2 (ja) * | 2008-10-31 | 2013-11-20 | 国立大学法人 東京医科歯科大学 | カチオン性ナノゲルを用いる粘膜ワクチン |
| AU2010264688A1 (en) * | 2009-06-24 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Recombinant RSV antigens |
| WO2010149743A2 (en) * | 2009-06-24 | 2010-12-29 | Id Biomedical Corporation Of Quebec | Vaccine |
| CN102470168A (zh) | 2009-07-10 | 2012-05-23 | 伊斯克诺瓦公司 | 新组合物 |
| US20130302369A1 (en) * | 2011-02-04 | 2013-11-14 | Omar Yousif Abdelmagid | Immunogenic Bordetella Bronchiseptica Compositions |
| AU2012253373A1 (en) * | 2011-05-11 | 2013-11-28 | Nanovalent Pharmaceuticals, Inc. | Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor |
| TR201808733T4 (tr) * | 2011-10-03 | 2018-07-23 | Mx Adjuvac Ab | Kanser tedavisini ve gıda ile ilgili bileşikleri içeren tıp alanlarında amfipatik veya hidrofobik moleküller için taşıyıcı olarak nano-parçacıklar, preparasyon için proses ve bunların kullanımı. |
| GB201119999D0 (en) * | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| AR095962A1 (es) | 2013-04-01 | 2015-11-25 | Moreinx Ab | Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos |
| US11390483B2 (en) | 2017-10-20 | 2022-07-19 | Corelex Shin-Ei Co., Ltd. | Log roll manufacturing apparatus |
-
2012
- 2012-10-01 TR TR2018/08733T patent/TR201808733T4/tr unknown
- 2012-10-01 EP EP22214948.6A patent/EP4176871A1/en not_active Withdrawn
- 2012-10-01 DK DK12781489.5T patent/DK2750683T4/da active
- 2012-10-01 DK DK17207322.3T patent/DK3311827T3/da active
- 2012-10-01 CN CN201280048961.9A patent/CN103857403B/zh active Active
- 2012-10-01 EP EP17207322.3A patent/EP3311827B1/en active Active
- 2012-10-01 PT PT127814895T patent/PT2750683T/pt unknown
- 2012-10-01 PL PL12781489T patent/PL2750683T3/pl unknown
- 2012-10-01 WO PCT/SE2012/051048 patent/WO2013051994A1/en not_active Ceased
- 2012-10-01 JP JP2014534512A patent/JP6050822B2/ja active Active
- 2012-10-01 IN IN3485DEN2014 patent/IN2014DN03485A/en unknown
- 2012-10-01 AU AU2012319239A patent/AU2012319239B2/en active Active
- 2012-10-01 CA CA2850296A patent/CA2850296C/en active Active
- 2012-10-01 HR HRP20180956TT patent/HRP20180956T1/hr unknown
- 2012-10-01 EP EP12781489.5A patent/EP2750683B2/en active Active
- 2012-10-01 US US14/349,142 patent/US10047116B2/en active Active
- 2012-10-01 KR KR1020147011942A patent/KR102090740B1/ko active Active
- 2012-10-01 ES ES12781489T patent/ES2673957T5/es active Active
- 2012-10-01 RS RS20180720A patent/RS57350B1/sr unknown
-
2014
- 2014-03-24 ZA ZA2014/02040A patent/ZA201402040B/en unknown
-
2017
- 2017-05-25 US US15/605,595 patent/US10100078B2/en active Active
- 2017-11-16 US US15/815,488 patent/US10487107B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014530219A5 (enExample) | ||
| Witika et al. | Current advances in specialised niosomal drug delivery: Manufacture, characterization and drug delivery applications | |
| Kyriakides et al. | Biocompatibility of nanomaterials and their immunological properties | |
| Yuan et al. | Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles | |
| HRP20180956T1 (hr) | Nanočestice, postupak dobivanja i njihova primjena kao nosača amfipatičnih ili hidrofobnih molekula u medicini, uključujući i terapiju karcinoma, kao i prehrambenih spojeva | |
| Chountoulesi et al. | Lyotropic liquid crystalline nanostructures as drug delivery systems and vaccine platforms | |
| Abbaraju et al. | Asymmetric silica nanoparticles with tunable head–tail structures enhance hemocompatibility and maturation of immune cells | |
| Juere et al. | In vitro dissolution, cellular membrane permeability, and anti-inflammatory response of resveratrol-encapsulated mesoporous silica nanoparticles | |
| Zhao et al. | Functionalized graphene oxide nanoparticles for cancer cell-specific delivery of antitumor drug | |
| Bi et al. | Layered double hydroxide-based nanocarriers for drug delivery | |
| Ding et al. | Theoretical and computational investigations of nanoparticle–biomembrane interactions in cellular delivery | |
| Kamboj et al. | Vesicular drug delivery systems: a novel approach for drug targeting | |
| Praphakar et al. | Targeted delivery of rifampicin to tuberculosis-infected macrophages: design, in-vitro, and in-vivo performance of rifampicin-loaded poly (ester amide) s nanocarriers | |
| JP2022003102A (ja) | 異なる医薬品の制御送達のためのビヒクル | |
| Kumar et al. | Nanomedicine in drug delivery | |
| Yan et al. | A novel type of aqueous dispersible ultrathin-layered double hydroxide nanosheets for in vivo bioimaging and drug delivery | |
| Ali et al. | Enhancing the solubility and oral bioavailability of poorly water-soluble drugs using monoolein cubosomes | |
| JP2012517987A5 (ja) | 吸入用の医薬組成物のｆｐｄ特性を設定する方法 | |
| Binaymotlagh et al. | Liposome–hydrogel composites for controlled drug delivery applications | |
| Leu et al. | Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems | |
| CN112074298B (zh) | Langerin+细胞靶向 | |
| Shi et al. | Optimization of process variables of zanamivir-loaded solid lipid nanoparticles and the prediction of their cellular transport in Caco-2 cell model | |
| JP2015515992A (ja) | 粘液内層を通過する迅速な透過のための脂質ベース薬物キャリア | |
| JP2015515992A5 (enExample) | ||
| Barros et al. | A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules |