JP6050822B2 - ナノ粒子、ナノ粒子の調製のための処理、および癌治療および食品関連化合物を含む医療分野における両親媒性分子または疎水性分子ための担体としてのナノ粒子の使用 - Google Patents
ナノ粒子、ナノ粒子の調製のための処理、および癌治療および食品関連化合物を含む医療分野における両親媒性分子または疎水性分子ための担体としてのナノ粒子の使用 Download PDFInfo
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Description
・エスケープ変異体(ヒトインフルエンザウイルス、ニワトリにおけるコロナウイルス(伝染性気管支炎ウィルス[IBR])、C型肝炎ウィルス(HCV)
・抗原決定基を明らかにしない
・アクセス不能に隠れている(黄色ブドウ球菌[SA]、ストレプトコッカスエクイ)
・ヒトにおけるインフルエンザウイルスによって代表される微生物における他の抗原決定基、ミンクにおいてパルボウイルスが引き起こすalution病、ヒトにおけるC型肝炎ウィルス(HCV)
・病気を悪化させる免疫応答を誘導する(パルボウイルス[alution病]ミンク)
・多くのほぼ無数の変異体を有する病原菌の種に対して意図されたワクチンが、難しく/高価であり、代わりに例えばヒトにおけるHIVおよびC型肝炎に対して十分にカバーするワクチンなどを製造することをより経済的にする。いくつかの、さらに株変異体、例えば様々なカプセル抗原を有する炭水化物変異体(複合ワクチン例えばインフルエンザ菌、Meningococus miningitides、肺炎連鎖球菌、化膿連鎖球菌、肺炎球菌肺炎、および黄色ブドウ球菌)と同じ数の株変異体からの最大23のワクチン成分を必要とする多くのワクチンがまた周知である。
・様々なグラム陽性球菌、例えば動物におけるブドウ球菌に対して他のニーズが満たされていないことが支配的であり、特に、馬(Str.Equi,Str.Zooepidemicus)および牛(Str.agalacti,Str.dysgalacti and Str.Uberis)における黄色ブドウ球菌、連鎖球菌種によって引き起こされる、反芻動物における乳腺炎から守るワクチンに対する必要性がある。
・抗原原罪(インフルエンザ)または担体誘導エピトープ抑制抗原(CIES)
・高速複製薬、例えばヒトの免疫不全ウイルス(HIV)は、ワクチンによって誘導されたものを含む今後の新しい亜種による宿主のエスケープ免疫保護機構を複雑にする
・DNAおよびRNAワクチンは、多くの場合、アジュバントを欠く
キラヤサポニン、またはキラヤ酸とも呼ばれる共通のトリテルペノイド骨格を有するキラヤサポニン画分を使用してもよい。これまでに4形態(form)のキラヤ酸が記載されている。キラヤサポニンは、例えばHuらによって記載されるように、アシル基すなわちアシルサポニン(ASAP)を有する、またはアシル鎖すなわちデスアシル‐サポニン(DSAP)を有しない多くの糖を有する鎖を形成する。
このような標的分子は、インフルエンザや、気道(例えば、Lyckeらによって記載されるように、肺癌の標的形態またはCTA1DDがKGIまたはBBE製剤に組み込まれたコレラ毒素のAサブユニットのA1の部分である)に親和性を有する呼吸器合胞体ウィルスといったウィルスからのエンベロープタンパク質を含む。CTA1DDは、3つの主要な成分であって、各々が相補効果に寄与するように合理的に設計されている。CTA1は、A2およびBサブユニットから分離することによって、非毒性に変換されたコレラ毒素の酵素的に活性なサブユニットである。黄色ブドウ球菌由来のたんぱく質AからのDDに融合することは、B細胞を標的とする。より一般的には、モノおよびポリクローナル抗体は、EP 0 109 942 B1、EP 0 242 380 B1およびEP 0 180 564 B1に記載されるように粒子に組み込むことができる。
・前記患者からの癌細胞を、インビトロで請求項1〜7のいずれか1つに記載のナノ粒子または請求項8または9に記載の医薬組成物と接触させる工程と、
・前記癌細胞に対する前記ナノ粒子または医薬組成物の治療効果を示す少なくとも1つの効果を測定する工程と
を包含し、
請求項10または11に記載の方法は、前記ナノ粒子または医薬組成物が前記癌細胞に対する治療効果を示す有意な効果を示す場合には前記個々の患者に適用可能なものとして評価される。
チミジンキナーゼ(TK)のダウンレギュレーションおよび細胞分化を促進する分子、例えば細胞周期からの出口も示すIL‐8、FOXC1およびHDAC5のアップレギュレーションにおいて重要である。レギュレーション因子は例であり、より多くの、すなわち制限を結論付けない多くの例がある。
a)疎水性表面またはリポソームの懸濁液を提供する工程と、
b)前記疎水性表面または前記リポソームの懸濁液を、ステロールの溶液、好ましくはコレステロールが有機溶媒または界面活性剤中にモノマーとして溶解した溶液と接触させる工程と、
c)前記溶媒または界面活性剤を除去して前記表面にステロール膜を形成する工程と、
d)キラヤサポニンミセルの水溶液を提供する工程と、
e)サポニンミセルを含む前記水溶液を前記ステロール膜に添加する工程とを包含し、前記サポニンと前記ステロールと間に複合体が形成され、前記複合体は前記水溶液中に懸濁される。
実施例
材料と方法
化学物質と化合物
細胞株
ヒト樹状細胞(DC)
癌細胞殺傷効果の測定
G3製剤用いて刺激されたU937細胞についてのサイトカインIL‐8判定
G3製剤によって刺激されたヒト単球のサイトカインIL‐12遺伝子発現
チミジンキナーゼ(TK)活性
TK活性をBiovica(ウプサラ、スウェーデン)から入手したキットを用いて判定した。簡単に述べると、様々な時点でKGIまたはG3製剤に曝露させた後、0.1〜1×106細胞/mlの濃度の100μlの細胞懸濁液をエッペンドルフ管に移し、200gで10分間、遠心分離した。細胞ペレットを100μlの冷PBSに再懸濁し、2〜3回凍結/解凍した。5分間最大速度で遠心分離した後、次いで、細胞を回収した。細胞間TK活性は、製造業者のプロトコルにしたがって測定された。
ビタミンD3の検出
G3粒子に組み込まれたコレカルシフェロール(ビタミンD3)を有するサンプルが、University Hospital Laboratoryのリエゾン自動機器(Liaison automatic instrument)で分析された。アッセイ(DiaSorin Liaison)は、25‐HO‐D3を測定するように設計されているが、非ヒドロキシル化ビタミンD3と約1%の交差反応性を有する。
インフルエンザウイルス株とワクチン
ワクチン接種
赤血球凝集(HA)試験
赤血球凝集抑制(HI)試験
た。最終的な血清希釈1:5だった。HI試験をV型マイクロプレートおよびHA‐16ユニット/50μlを用いて行った。血清試料25μlを等量のPBS‐BSAを用いて2倍に希釈した。希釈した血清を、25μlのウィルス懸濁液とともにRT℃で1時間、インキュベートし、その後、混合物を4℃で1時間、インキュベートした。赤血球凝集を100%阻害する最高血清希釈が、サンプルの抗体値と考えられた。
リンパ球の調製
酵素結合免疫スポットアッセイ(ELISPOT)
データ分析と統計
Part I.製剤化および特性化
実施例1
実験の設定
工程2において
・A.工程1に記載されたように処理された2μLのコレステロール原液と、工程2の10μlのQHCとを用いて、1:1のモル比を与えるこのG3製剤を生成した。
・B.別のモル比もまた、つまり2モルのコレステロール対1モルのQHCを用いた。それ以外は、実験はAと同じであった。
・C.1モルのコレステロールおよび1モルのホスファチジルコリン(P‐5763は、Sigma‐Aldrich Sweden AB,Stockholm,スウェーデンからのものである)の比率を用いて工程1において膜を形成する。工程2では、2モルのQHCを使用した。
結果
結論と考察
実施例2
実験の設定
結果
結論
実施例3
実験の設定
結果
実施例4
実験の設定
結果
考察と結論
実施例5
実験レイアウト
結果
結論
Part II.抗癌剤としてのG3
実施例6
実験の設定
結果
結論と考察
実施例7
実験の設定
結果
結論と考察
実施例8
実験の設定
結果
結論と考察
実施例9
実験の設定
結果
結論と考察
実施例10
実験の設定
結果
結論と考察
実施例11
実験の設定
結果
結論と考察
実施例12
実験レイアウト
結果
結論と考察
Part III.アジュバントとしてのG3
実施例13
実験レイアウト
結果
結論
Part IV.薬物送達システムとしてのG3
実施例14
実験の設定
上記のように同じ濃度から連続的に希釈した後、VLX40‐DMSO対照群(2)およびG3‐VLX40懸濁液/溶液(3)を収集し、U937‐GTB細胞に対して試験を行い、IC50を回帰曲線から計算した。
結果
これらの実験を3回繰り返した。
結論と考察
実施例15
実験の設定
結果
考察
実施例16
実験の設定
結果
結論と考察
参照
1 Kefei Hu, Saideh Berenjian, Rolf Larsson, Joachim Gullbo, Peter Nygren, Tanja Loevgren, Bror Morein Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index. International Journal of Nanomedicine, January 2010 Volume 2010:5 Pages 51‐62
2 Loevgren & Morein (2000) ISCOM Technology in Methods in Molecular Medicine, Vol 42: 239‐258, Vaccine adjuvants: Preparation Methods and Research Protocols, Edited by D.T.O O’Hagen, Humana Press, Inc., Titawa, N.J.
3 Morein B, Hu K, Lovgren K and D’Hondt E. New ISCOMs meet unsettled vaccine demands in Vaccine Adjuvants and Delivery Systems, Ed. by Singh M. A John Wiley & Sons, Inc., Publication, Hoboken, New Jersey. 2007, p 191‐222.
4 Lycke, N. From toxin to adjuvant: The rational design of a vaccine adjuvant vector, CTA1‐DD/ISCOM. Cell Microbiol 2004, 6(1), 23‐32, and by Mowat et al. (2001)
5 Mowat, A.M., Donachie, A.M., Jagewalll, S., Schon, K., Lowenadler, B., Dalsgaard, K., et al. CTA1‐DD‐immune stimulating complex: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen. J. Immunol 2001, 167(6), 3398‐3405
6 Blair AH, Ghose TI. Linkage of cytotoxic agents to immunoglobulins. J Immunol Methods. 1983 Apr 29;59(2): 129‐43.
7 Ghose TI, Blair AH, Kulkarni PN. Preparation of antibody‐linked cytotoxic agents. Methods Enzymol. 1983;93:280‐333.
8 Davis MT, Preston JF. A simple modified carbodiimide method for conjugation of small‐molecular‐weight compounds to immunoglobulin G with minimal protein crosslinking. Anal Biochem. 1981 Sep 15;116(2):402‐7.
9 Eliasson DG, El Bakkouri K, Schon K, Ramne A, Festjens E, Lowenadler B, Fiers W. Saelens X, Lycke N.CTA1‐M2e‐DD: a novel mucosal adjuvant targeted influenza vaccine. Vaccine. 2008 Feb 26;26(9): 1243‐52. Epub 2008 Jan 10.
10 A. Esmat Abou‐Arab, Azza Abou‐Arab and M.Ferial Abu−Salem, Physico‐chmical assessment of natural sweeteners steviosides produced from Stevia rebaudiana bertoni, African Journal of Food Science,Vol4 (5) pp 269‐281, May 2010.
11Chaiwat Boonkaewwant, Chaivat Toskulkao, and Molvibha Vongsakul. Anti‐Inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP‐1 Cells, J. Agric. Food Chem. 2006, 54, 785789 7)
13 Kersten, G.F.A., Spiekstra, A., Beuvery, E.C. and Cromelin D.J.A. (1991) On the structure of immune‐stimulating saponin lipid complexes (ISCOMs). BBA 1062, 165‐171.
Claims (24)
- ステロールと、キラヤ酸およびキラヤサポニンから選択されるキラヤサポナリアモリナからの成分とを含むナノ粒子であって、
リン脂質を含有せず、
15〜25ナノメートルの範囲の粒径を有することを特徴とする水溶性ナノ粒子。 - ステロールはコレステロールである、請求項1に記載の水溶性ナノ粒子。
- キラヤサポナリアモリナからの成分は、キラヤサポニンであり、好ましくはキラヤサポニン画分QHA、QHBおよび/またはQHCである、請求項1または2に記載の水溶性ナノ粒子。
- コレステロールとキラヤサポニンとの比は、1:10〜10:1である、請求項1〜3のいずれかに記載の水溶性ナノ粒子。
- コレステロールとキラヤサポニンとの比は、1:2〜2:1である、請求項1〜3のいずれかに記載の水溶性ナノ粒子。
- 少なくとも1つの両親媒性または疎水性分子をさらに含む、請求項1〜5のいずれかに記載の水溶性ナノ粒子。
- 前記両親媒性または疎水性分子は、抗原、アジュバント、標的分子、医薬化合物および食品関連化合物から選択される少なくとも1つのメンバーである、請求項6に記載の水溶性ナノ粒子。
- 前記両親媒性または疎水性分子はジテルペンである、請求項7に記載の水溶性ナノ粒子。
- 請求項1〜8のいずれかに記載の1つ以上の水溶性ナノ粒子を含む組成物。
- 異なるキラヤサポニン画分はそれぞれ、異なるナノ粒子に組み込まれる、請求項9に記載の組成物。
- 薬学的に許容される緩衝剤、希釈剤、賦形剤、アジュバントおよび/または担体をさらに含む医薬組成物において任意に医薬として使用される、請求項1〜8のいずれか1つに記載の水溶性ナノ粒子または請求項9または10に記載の組成物。
- アジュバントとして使用される請求項11に記載の組成物。
- ワクチンと組み合わせて使用される、請求項12に記載の医薬アジュバント製剤。
- 癌の治療のための薬剤の製造における、請求項1〜8のいずれかに記載の水溶性ナノ粒子、又は請求項9または10に記載の組成物の使用。
- リン脂質を含有しない水溶性ナノ粒子を製造するための方法であって、前記方法は、
a)疎水性表面またはリポソームの懸濁液を提供する工程と、
b)前記疎水性表面または前記リポソームの懸濁液を、ステロールの溶液、好ましくはコレステロールが有機溶媒または界面活性剤中にモノマーとして溶解した溶液と接触させる工程と、
c)有機溶媒または界面活性剤を除去して前記表面にステロール膜を形成する工程と、
d)キラヤサポニンミセルの水溶液を提供する工程と、
e)サポニンミセルを含む水溶液を前記ステロール膜に添加する工程と
を包含し、
サポニンとステロールとの間には複合体が形成され、前記複合体は前記水溶液中に懸濁される、方法。 - 両親媒性または疎水性分子が添加されることによってさらに特徴付けられる、請求項15に記載の方法。
- 前記両親媒性または疎水性分子はジテルペンである、請求項16に記載の方法。
- アジュバントとしての、ワクチンと組み合わせたアジュバントとしての、あるいは癌の治療のための薬剤の製造における、請求項15〜17のいずれか1つに記載の方法によって製造される水溶性ナノ粒子の使用。
- 個々の患者への請求項14または18に記載の使用の適用性を評価するための方法であって、
・前記患者からの癌細胞を、インビトロで請求項1〜8のいずれか1つに記載の水溶性ナノ粒子と接触させる工程と、
・前記癌細胞に対する前記水溶性ナノ粒子の治療効果を示す少なくとも1つの効果を測定する工程と
を包含し、
請求項12に記載の組成物は、前記水溶性ナノ粒子が前記癌細胞に対する治療効果を示す有意な効果を示す場合には前記個々の患者に適用可能なものとして評価される、方法。 - 個々の患者への請求項14または18に記載の使用の適用性を評価するための方法であって、
・前記患者からの癌細胞を、インビトロで請求項1〜8のいずれか1つに記載の水溶性ナノ粒子と接触させる工程と、
・前記癌細胞に対する前記水溶性ナノ粒子の治療効果を示す少なくとも1つの効果を測定する工程と
を包含し、
請求項13に記載の医薬アジュバント製剤は、前記水溶性ナノ粒子が前記癌細胞に対する治療効果を示す有意な効果を示す場合には前記個々の患者に適用可能なものとして評価される、方法。 - 個々の患者への請求項14または18に記載の使用の適用性を評価するための方法であって、
・前記患者からの癌細胞を、インビトロで請求項9または10に記載の組成物と接触させる工程と、
・前記癌細胞に対する前記組成物の治療効果を示す少なくとも1つの効果を測定する工程と
を包含し、
請求項12に記載の組成物は、前記組成物が前記癌細胞に対する治療効果を示す有意な効果を示す場合には前記個々の患者に適用可能なものとして評価される、方法。 - 個々の患者への請求項14または18に記載の使用の適用性を評価するための方法であって、
・前記患者からの癌細胞を、インビトロで請求項9または10に記載の組成物と接触させる工程と、
・前記癌細胞に対する前記組成物の治療効果を示す少なくとも1つの効果を測定する工程と
を包含し、
請求項13に記載の医薬アジュバント製剤は、前記組成物が前記癌細胞に対する治療効果を示す有意な効果を示す場合には前記個々の患者に適用可能なものとして評価される、方法。 - 請求項1〜8のいずれかに記載の水溶性ナノ粒子を含むワクチン。
- 請求項1〜8のいずれかに記載の水溶性ナノ粒子を含む抗癌剤。
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