DE60229118D1 - Polynukleotide-bindende komplexe die sterolen und saponine enthalten - Google Patents
Polynukleotide-bindende komplexe die sterolen und saponine enthaltenInfo
- Publication number
- DE60229118D1 DE60229118D1 DE60229118T DE60229118T DE60229118D1 DE 60229118 D1 DE60229118 D1 DE 60229118D1 DE 60229118 T DE60229118 T DE 60229118T DE 60229118 T DE60229118 T DE 60229118T DE 60229118 D1 DE60229118 D1 DE 60229118D1
- Authority
- DE
- Germany
- Prior art keywords
- complexes
- saponins
- polynucleotide
- methods
- determinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100560 | 2001-04-04 | ||
US30860901P | 2001-07-31 | 2001-07-31 | |
PCT/DK2002/000229 WO2002080981A2 (en) | 2001-04-04 | 2002-04-04 | Polynucleotide binding complexes comprising sterols and saponins |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60229118D1 true DE60229118D1 (de) | 2008-11-13 |
Family
ID=26069002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60229118T Expired - Lifetime DE60229118D1 (de) | 2001-04-04 | 2002-04-04 | Polynukleotide-bindende komplexe die sterolen und saponine enthalten |
Country Status (7)
Country | Link |
---|---|
EP (2) | EP2011517A1 (de) |
JP (2) | JP2004528321A (de) |
AT (1) | ATE409495T1 (de) |
DE (1) | DE60229118D1 (de) |
DK (1) | DK1377320T3 (de) |
NZ (1) | NZ529347A (de) |
WO (1) | WO2002080981A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1545605B8 (de) * | 2002-10-02 | 2010-05-26 | Nordic Vaccine A/S | Zusammensetzung zur impfung |
WO2009106085A1 (en) * | 2008-02-28 | 2009-09-03 | Nordic Vaccine A/S | Vaccine compositions comprising saccharide antigens |
EP2750683B2 (de) | 2011-10-03 | 2021-01-06 | Croda International PLC | Nanopartikel, verfahren zu ihrer herstellung und ihre verwendung als träger für amphipatische oder hydrophobe moleküle in der medizin mit verbindungen zur krebsbehandlung und nahrungsmitteln |
WO2014163558A1 (en) | 2013-04-01 | 2014-10-09 | Moreinx Ab | Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds |
KR20200026908A (ko) * | 2017-07-11 | 2020-03-11 | 프라이 유니베르시탯 베를린 | 사포닌의 신규한 용도 및 이의 단리 방법 |
CN108498376B (zh) * | 2018-04-02 | 2020-11-13 | 榛硕(武汉)智能科技有限公司 | 一种甲基硅油乳液及其制备方法 |
CN109295080B (zh) * | 2018-09-19 | 2021-08-20 | 昆明理工大学 | 珠子参β-香树脂醇合成酶基因Pjβ-AS的用途 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4162282A (en) | 1976-04-22 | 1979-07-24 | Coulter Electronics, Inc. | Method for producing uniform particles |
GB2064320B (en) | 1979-10-13 | 1983-10-12 | Welsh Nat School Med | Intra-ocular irrigation fluid |
US4310505A (en) | 1979-11-08 | 1982-01-12 | California Institute Of Technology | Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances |
US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
US4550022A (en) | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
US4443432A (en) | 1981-10-05 | 1984-04-17 | Alcon Laboratories, Inc. | Ophthmalic irrigating solution |
US4526714A (en) | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
SE450674B (sv) | 1982-11-17 | 1987-07-13 | Volvo Ab | Kabelholje |
US4728575A (en) | 1984-04-27 | 1988-03-01 | Vestar, Inc. | Contrast agents for NMR imaging |
CA1264668C (en) | 1984-06-20 | 1990-01-23 | EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES | |
US4921706A (en) | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
NZ217844A (en) | 1985-10-11 | 1989-10-27 | Sumitomo Pharma | A sustained release pharmaceutical composition containing silicone elastomer and an albumin |
US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
IL79559A0 (en) | 1986-07-29 | 1986-10-31 | Univ Ramot | Contrast agents for nmr medical imaging |
US4728578A (en) | 1986-08-13 | 1988-03-01 | The Lubrizol Corporation | Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers |
US5554372A (en) | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
US4938970A (en) | 1987-02-06 | 1990-07-03 | Hustead Robert E | Painless electrolyte solutions |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US5583112A (en) | 1987-05-29 | 1996-12-10 | Cambridge Biotech Corporation | Saponin-antigen conjugates and the use thereof |
NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
DE68912139T2 (de) | 1988-11-09 | 1994-04-28 | Colin Tilcock | Liposomale radiologische kontrastmittel. |
FR2645866B1 (fr) | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
AU651319B2 (en) | 1989-07-27 | 1994-07-21 | Univax Biologics Incorporated | Lipid A analog/immunogenic carrier conjugates and the use thereof as vaccines |
NL9002314A (nl) * | 1990-10-23 | 1992-05-18 | Nederlanden Staat | Immunogene complexen, in het bijzonder iscoms. |
GB9106673D0 (en) | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
EP0594640A4 (en) | 1991-05-23 | 1998-06-03 | Evan C Unger | Liposoluble compounds for magnetic resonance imaging |
SE502569C2 (sv) * | 1991-05-31 | 1995-11-13 | British Tech Group | Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit |
US5273965A (en) | 1992-07-02 | 1993-12-28 | Cambridge Biotech Corporation | Methods for enhancing drug delivery with modified saponins |
US5650398A (en) | 1992-07-02 | 1997-07-22 | Cambridge Biotech Corporation | Drug delivery enhancement via modified saponins |
WO1995009179A1 (en) | 1993-09-30 | 1995-04-06 | Seed Capital Investments (Sci) B.V. | Compounds with adjuvant activity |
JP4512882B2 (ja) * | 1996-02-09 | 2010-07-28 | チェング ピー―ワン | 受容体リガンドにより促進される生物活性分子の送達 |
AU732085B2 (en) | 1996-06-25 | 2001-04-12 | Pepscan Systems B.V. | Vaccine comprising antigens bound to carriers through labile bonds |
JP3963506B2 (ja) * | 1996-08-26 | 2007-08-22 | 俊彦 松尾 | リポソーム点眼剤 |
AUPO517897A0 (en) * | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
JP2002505665A (ja) * | 1997-04-30 | 2002-02-19 | メリュー・オラバックス | Th1型アジュバントを含有する抗ヘリコバクターワクチン組成物 |
US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
AUPO732997A0 (en) * | 1997-06-12 | 1997-07-03 | Csl Limited | Ganglioside immunostimulating complexes and uses thereof |
DE19740092A1 (de) * | 1997-09-12 | 1999-03-18 | Ulrich Dr Med Hengge | Liposomen und Verfahren zur Transfektion von Zellen |
US6013258A (en) * | 1997-10-09 | 2000-01-11 | Zycos Inc. | Immunogenic peptides from the HPV E7 protein |
CZ20013103A3 (cs) * | 1999-03-02 | 2002-01-16 | The Liposome Company, Inc. | Způsob zapouzdřování bioaktivních komplexů do liposomů |
EP1292330A1 (de) | 2000-03-31 | 2003-03-19 | Vaccine Chip Technology APS | Immunostimulierende eigenschaften eines tgf-beta-fragmentes |
-
2002
- 2002-04-04 EP EP08159646A patent/EP2011517A1/de not_active Withdrawn
- 2002-04-04 NZ NZ529347A patent/NZ529347A/en unknown
- 2002-04-04 WO PCT/DK2002/000229 patent/WO2002080981A2/en active IP Right Grant
- 2002-04-04 DK DK02759762T patent/DK1377320T3/da active
- 2002-04-04 EP EP02759762A patent/EP1377320B1/de not_active Expired - Lifetime
- 2002-04-04 JP JP2002579019A patent/JP2004528321A/ja not_active Withdrawn
- 2002-04-04 DE DE60229118T patent/DE60229118D1/de not_active Expired - Lifetime
- 2002-04-04 AT AT02759762T patent/ATE409495T1/de not_active IP Right Cessation
-
2010
- 2010-05-26 JP JP2010120290A patent/JP2010180249A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK1377320T3 (da) | 2009-02-09 |
EP1377320A2 (de) | 2004-01-07 |
ATE409495T1 (de) | 2008-10-15 |
NZ529347A (en) | 2008-01-31 |
EP1377320B1 (de) | 2008-10-01 |
WO2002080981A2 (en) | 2002-10-17 |
JP2004528321A (ja) | 2004-09-16 |
JP2010180249A (ja) | 2010-08-19 |
EP2011517A1 (de) | 2009-01-07 |
WO2002080981A3 (en) | 2002-12-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R082 | Change of representative |
Ref document number: 1377320 Country of ref document: EP Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |