WO2001038303A3 - Analogues de la vitamine d - Google Patents

Analogues de la vitamine d Download PDF

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Publication number
WO2001038303A3
WO2001038303A3 PCT/FR2000/003249 FR0003249W WO0138303A3 WO 2001038303 A3 WO2001038303 A3 WO 2001038303A3 FR 0003249 W FR0003249 W FR 0003249W WO 0138303 A3 WO0138303 A3 WO 0138303A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogues
vitamin
cancerology
dermatology
organ
Prior art date
Application number
PCT/FR2000/003249
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English (en)
Other versions
WO2001038303A2 (fr
Inventor
Jean-Michel Bernardon
Thibaud Biadatti
Original Assignee
Galderma Res & Dev
Bernardon Jean Michel
Thibaud Biadatti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev, Bernardon Jean Michel, Thibaud Biadatti filed Critical Galderma Res & Dev
Priority to CA002392165A priority Critical patent/CA2392165C/fr
Priority to BR0015924-7A priority patent/BR0015924A/pt
Priority to AT00988868T priority patent/ATE269289T1/de
Priority to MXPA02005175A priority patent/MXPA02005175A/es
Priority to US10/130,941 priority patent/US6831106B1/en
Priority to DE60011669T priority patent/DE60011669T2/de
Priority to AU25222/01A priority patent/AU767399B2/en
Priority to JP2001539859A priority patent/JP3822106B2/ja
Priority to PL364768A priority patent/PL207046B1/pl
Priority to EP00988868A priority patent/EP1235777B1/fr
Publication of WO2001038303A2 publication Critical patent/WO2001038303A2/fr
Publication of WO2001038303A3 publication Critical patent/WO2001038303A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Abstract

L'invention concerne de nouveaux composés tri-aromatiques qui présentent la formule générale (I) ainsi que leur méthode de préparation, et leur utilisation dans des compositions pharmaceutiques destinées à un usage en médecine humaine ou vétérinaire (en dermatologie, en cancérologie, ainsi que dans le domaine des maladies auto-immunes et celui des transplantations d'organes ou de tissus notamment), ou bien encore dans des compositions cosmétiques.
PCT/FR2000/003249 1999-11-24 2000-11-22 Analogues de la vitamine d WO2001038303A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA002392165A CA2392165C (fr) 1999-11-24 2000-11-22 Analogues de la vitamine d
BR0015924-7A BR0015924A (pt) 1999-11-24 2000-11-22 Compostos triaromáticos análogos de vitamina d, uso de um composto, composição farmacêutica, composição cosmética e uso de uma composição cosmética
AT00988868T ATE269289T1 (de) 1999-11-24 2000-11-22 Vitamin-d analoga
MXPA02005175A MXPA02005175A (es) 1999-11-24 2000-11-22 Analogos de vitamina d.
US10/130,941 US6831106B1 (en) 1999-11-24 2000-11-22 Vitamin D analogues
DE60011669T DE60011669T2 (de) 1999-11-24 2000-11-22 Vitamin-d analoga
AU25222/01A AU767399B2 (en) 1999-11-24 2000-11-22 Vitamin D analogues
JP2001539859A JP3822106B2 (ja) 1999-11-24 2000-11-22 ビタミンｄ類似体
PL364768A PL207046B1 (pl) 1999-11-24 2000-11-22 Triaromatyczne analogi witaminy D, ich zastosowanie i kompozycje farmaceutyczne je zawierające
EP00988868A EP1235777B1 (fr) 1999-11-24 2000-11-22 Analogues de la vitamine d

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/14781 1999-11-24
FR9914781A FR2801305B1 (fr) 1999-11-24 1999-11-24 Analogues de la vitamine d

Publications (2)

Publication Number Publication Date
WO2001038303A2 WO2001038303A2 (fr) 2001-05-31
WO2001038303A3 true WO2001038303A3 (fr) 2002-01-17

Family

ID=9552483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/003249 WO2001038303A2 (fr) 1999-11-24 2000-11-22 Analogues de la vitamine d

Country Status (22)

Country Link
US (1) US6831106B1 (fr)
EP (1) EP1235777B1 (fr)
JP (1) JP3822106B2 (fr)
KR (1) KR100599069B1 (fr)
CN (2) CN1213980C (fr)
AR (1) AR043279A1 (fr)
AT (1) ATE269289T1 (fr)
AU (1) AU767399B2 (fr)
BR (1) BR0015924A (fr)
CA (1) CA2392165C (fr)
DE (1) DE60011669T2 (fr)
DK (1) DK1235777T3 (fr)
ES (1) ES2223642T3 (fr)
FR (1) FR2801305B1 (fr)
MX (1) MXPA02005175A (fr)
PL (1) PL207046B1 (fr)
PT (1) PT1235777E (fr)
RU (1) RU2237651C2 (fr)
SE (1) SE1235777T5 (fr)
TR (1) TR200401603T4 (fr)
WO (1) WO2001038303A2 (fr)
ZA (1) ZA200203475B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833258B1 (fr) * 2001-12-10 2004-08-27 Galderma Res & Dev Analogues de la vitamine d
US6924400B2 (en) * 2001-12-10 2005-08-02 Galderma Research & Development, Snc Triaromatic vitamin D analogues
PT1511740E (pt) * 2002-05-29 2009-08-10 Lilly Co Eli Moduladores do receptor de vitamina d tipo fenil-tiofeno
FR2843962B1 (fr) * 2002-08-27 2005-12-02 Galderma Res & Dev Analogues de la vitamine d
RU2364584C2 (ru) * 2002-08-27 2009-08-20 Галдерма Ресерч Энд Девелопмент, Снс Аналоги витамина d
WO2005027930A1 (fr) * 2003-09-19 2005-03-31 Pfizer Products Inc. Derives de la 2-alkylidene-19-nor-vitamine d pour le traitement de l'osteosarcome
AU2004294728A1 (en) 2003-11-21 2005-06-16 Galderma Research & Development, S.N.C. Sprayable composition for the administration of vitamin D derivatives
DE602005021484D1 (de) 2004-05-14 2010-07-08 Galderma Res & Dev Neuartige 7,7-disubstituierte derivate von (5h,9h)-6,8-dioxabenzocyclohepten, herstellungsverfahren dafür und ihre verwendung in der synthese von nicht-steroidalen vitamin-d-analogen
FR2870238B1 (fr) * 2004-05-14 2008-07-04 Galderma Res & Dev Nouveaux derives 7,7-disubstitues du (5h,9h)-6,8- dioxabenzocycloheptene, leur preparation et leur utilisation dans la synthese d'analogues non steroidiens de la vitamine d
US20070299041A1 (en) * 2004-05-26 2007-12-27 Cedars-Sinai Medical Center Induction of innate immunity by vitamin d3 and its analogs
KR20150090263A (ko) * 2004-09-02 2015-08-05 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
JP2008540513A (ja) * 2005-05-10 2008-11-20 ダーミプソル リミテッド スキンケアのための組成物及び方法
NZ563270A (en) 2005-05-10 2010-11-26 Dermipsor Ltd Calcipotriol, polyethylene oxide topical compositions for the treatment of hyperproliferative epidermal diseases
JP5008928B2 (ja) * 2005-10-31 2012-08-22 三ツ星ベルト株式会社 プーリ構造体
WO2008083389A1 (fr) * 2006-12-29 2008-07-10 Moleculin, L.L.C. Procédés de traitement de troubles de la peau avec des analogues de l'acide caféique
US8450337B2 (en) * 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
EP2393494A1 (fr) 2009-01-27 2011-12-14 Berg Biosystems, LLC Vitamines d3 et analogues de celles-ci pour soulagement des effets secondaires associés à une chimiothérapie
US8470304B2 (en) * 2009-08-04 2013-06-25 Avidas Pharmaceuticals Llc Therapeutic vitamin D sun-protecting formulations and methods for their use
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
AU2014274099A1 (en) 2013-05-29 2015-12-24 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin D
GB201705686D0 (en) * 2017-04-07 2017-05-24 Centauri Therapeutics Ltd Novel compounds and therapeutic uses thereof
US11612580B2 (en) 2017-10-16 2023-03-28 The Board Of Regents Of The University Of Texas System Compositions for inhibiting 3′ repair exonuclease 2 and methods of screening for such compositions
CN109738252B (zh) * 2019-01-23 2021-03-09 深圳天辰医疗科技有限公司 25-羟基-维生素d解离液
CN109696435B (zh) * 2019-01-25 2021-03-09 深圳天辰医疗科技有限公司 维生素d的测定方法

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EP0661260A1 (fr) * 1993-12-15 1995-07-05 Centre International De Recherches Dermatologiques Galderma, ( Cird Galderma) Nouveaux composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations
WO1995027692A1 (fr) * 1994-04-08 1995-10-19 Smithkline Beecham Corporation Inhibiteurs du facteur de necrose tumorale a substitution biphenyle
JPH08188650A (ja) * 1995-01-13 1996-07-23 Idemitsu Kosan Co Ltd 液晶共重合体の製造方法
EP0728739A1 (fr) * 1995-02-23 1996-08-28 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations
WO1998020866A2 (fr) * 1996-11-13 1998-05-22 Gill Parkash S Procede de traitement du sarcome de kaposi par des agonistes des recepteurs de la vitamine-d¿3?
EP0879814A1 (fr) * 1997-05-23 1998-11-25 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Composés triaromatiques, compositions les contenant et utilisations
EP0947496A1 (fr) * 1998-03-31 1999-10-06 Galderma Research & Development, S.N.C. Composés bicycliques-aromatiques et leur utilisation en médecine humaine ou vétérinaire ainsi qu'en cosmétologie

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Publication number Priority date Publication date Assignee Title
EP0375368A2 (fr) * 1988-12-23 1990-06-27 Zeneca Limited Dérivés d'alcools et d'éthers
EP0661260A1 (fr) * 1993-12-15 1995-07-05 Centre International De Recherches Dermatologiques Galderma, ( Cird Galderma) Nouveaux composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations
WO1995027692A1 (fr) * 1994-04-08 1995-10-19 Smithkline Beecham Corporation Inhibiteurs du facteur de necrose tumorale a substitution biphenyle
JPH08188650A (ja) * 1995-01-13 1996-07-23 Idemitsu Kosan Co Ltd 液晶共重合体の製造方法
EP0728739A1 (fr) * 1995-02-23 1996-08-28 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Composés bi-aromatiques dérivés d'amide, compositions pharmaceutiques et cosmétiques les contenant et utilisations
WO1998020866A2 (fr) * 1996-11-13 1998-05-22 Gill Parkash S Procede de traitement du sarcome de kaposi par des agonistes des recepteurs de la vitamine-d¿3?
EP0879814A1 (fr) * 1997-05-23 1998-11-25 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Composés triaromatiques, compositions les contenant et utilisations
EP0947496A1 (fr) * 1998-03-31 1999-10-06 Galderma Research & Development, S.N.C. Composés bicycliques-aromatiques et leur utilisation en médecine humaine ou vétérinaire ainsi qu'en cosmétologie

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US6831106B1 (en) 2004-12-14
AU767399B2 (en) 2003-11-06
RU2237651C2 (ru) 2004-10-10
FR2801305A1 (fr) 2001-05-25
PT1235777E (pt) 2004-11-30
DK1235777T3 (da) 2004-09-20
PL207046B1 (pl) 2010-10-29
JP2003514892A (ja) 2003-04-22
AU2522201A (en) 2001-06-04
CA2392165C (fr) 2008-08-26
CN1616452A (zh) 2005-05-18
ZA200203475B (en) 2003-04-01
WO2001038303A2 (fr) 2001-05-31
ES2223642T3 (es) 2005-03-01
CN100522943C (zh) 2009-08-05
FR2801305B1 (fr) 2002-12-06
TR200401603T4 (tr) 2004-08-23
EP1235777A2 (fr) 2002-09-04
KR100599069B1 (ko) 2006-07-12
JP3822106B2 (ja) 2006-09-13
BR0015924A (pt) 2002-08-06
AR043279A1 (es) 2005-07-27
PL364768A1 (en) 2004-12-13
EP1235777B1 (fr) 2004-06-16
SE1235777T5 (fr) 2004-09-21
ATE269289T1 (de) 2004-07-15
MXPA02005175A (es) 2003-01-28
CN1423627A (zh) 2003-06-11
CA2392165A1 (fr) 2001-05-31
CN1213980C (zh) 2005-08-10
DE60011669T2 (de) 2005-06-30
DE60011669D1 (de) 2004-07-22

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