JP2012191939A5 - - Google Patents
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- Publication number
- JP2012191939A5 JP2012191939A5 JP2012129374A JP2012129374A JP2012191939A5 JP 2012191939 A5 JP2012191939 A5 JP 2012191939A5 JP 2012129374 A JP2012129374 A JP 2012129374A JP 2012129374 A JP2012129374 A JP 2012129374A JP 2012191939 A5 JP2012191939 A5 JP 2012191939A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- oligonucleotide
- heg
- immune response
- ggttgt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091034117 Oligonucleotide Proteins 0.000 claims 24
- 230000028993 immune response Effects 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 2
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 1
- 229930024421 Adenine Natural products 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 229960000643 adenine Drugs 0.000 claims 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 125000005642 phosphothioate group Chemical group 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229940113082 thymine Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60683304P | 2004-09-01 | 2004-09-01 | |
| US60/606,833 | 2004-09-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Division JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012191939A JP2012191939A (ja) | 2012-10-11 |
| JP2012191939A5 true JP2012191939A5 (enExample) | 2013-01-24 |
| JP5775024B2 JP5775024B2 (ja) | 2015-09-09 |
Family
ID=36036819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Pending JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| JP2012129374A Expired - Fee Related JP5775024B2 (ja) | 2004-09-01 | 2012-06-06 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530180A Pending JP2008514187A (ja) | 2004-09-01 | 2005-08-24 | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8759305B2 (enExample) |
| EP (2) | EP1794174B1 (enExample) |
| JP (2) | JP2008514187A (enExample) |
| KR (1) | KR101268877B1 (enExample) |
| CN (1) | CN101052643B (enExample) |
| AU (2) | AU2005282889B2 (enExample) |
| CA (1) | CA2578775C (enExample) |
| DK (1) | DK1794174T3 (enExample) |
| ES (2) | ES2385657T3 (enExample) |
| NZ (1) | NZ553581A (enExample) |
| PL (1) | PL1794174T3 (enExample) |
| PT (1) | PT1794174E (enExample) |
| SI (1) | SI1794174T1 (enExample) |
| WO (1) | WO2006028742A2 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008514187A (ja) | 2004-09-01 | 2008-05-08 | ダイナバックス テクノロジーズ コーポレイション | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| CA2591582A1 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| DE102005005642A1 (de) * | 2005-02-06 | 2006-08-10 | Phenion Gmbh & Co. Kg | Kosmetische oder pharmazeutische Zubereitungen enthaltend Nukleinsäuren, die zur Ausbildung von stem-loop-Sekundärstrukturen geeignete Sequenzen umfassen |
| CN101171033A (zh) | 2005-03-04 | 2008-04-30 | 戴纳瓦克斯技术公司 | 包含具免疫刺激序列iss之寡核苷酸的疫苗：其中iss与抗原缀合并通过缓冲条件和其他赋形剂稳定 |
| AU2006266503B2 (en) | 2005-07-01 | 2011-12-08 | Index Pharmaceuticals Ab | Immunostimulatory method |
| ATE439135T1 (de) | 2005-07-01 | 2009-08-15 | Index Pharmaceuticals Ab | Modulierung der reaktion auf steroide |
| EP2982679A1 (en) | 2005-10-12 | 2016-02-10 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| AU2006306805A1 (en) | 2005-10-28 | 2007-05-03 | Index Pharmaceuticals Ab | Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease |
| JP2010536787A (ja) * | 2007-08-15 | 2010-12-02 | イデラ ファーマシューティカルズ インコーポレイテッド | Ｔｏｌｌ様受容体モジュレータ |
| EP2209896B1 (en) | 2007-10-26 | 2017-03-01 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| US8030289B2 (en) | 2008-08-06 | 2011-10-04 | Changchun Huapu Biotechnology Co., Ltd. | Oligonucleotide and use thereof |
| ES2478012T3 (es) * | 2008-08-06 | 2014-07-18 | Changchun Huapu Biotechnology Co., Ltd. | Oligonucleótidos y uso de los mismos |
| WO2010042543A2 (en) * | 2008-10-06 | 2010-04-15 | Idera Pharmaceuticals, Inc. | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto |
| EP2451974A2 (en) * | 2009-07-08 | 2012-05-16 | Idera Pharmaceuticals, Inc. | Oligonucleotide-based compounds as inhibitors of toll-like receptors |
| EP2582398B1 (en) | 2010-06-16 | 2016-04-13 | Dynavax Technologies Corporation | Methods of treatment using tlr7 and/or tlr9 inhibitors |
| JP5921535B2 (ja) * | 2010-06-16 | 2016-05-24 | ディナバックス テクノロジーズ コーポレイション | Ｔｌｒ７および／またはｔｌｒ９阻害剤を用いる治療の方法 |
| NZ607996A (en) | 2010-09-22 | 2014-07-25 | Alios Biopharma Inc | Substituted nucleotide analogs |
| JP5813778B2 (ja) | 2010-11-19 | 2015-11-17 | イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | トール様受容体に基づく免疫反応を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物 |
| CA2860234A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
| HK1206362A1 (zh) | 2012-03-21 | 2016-01-08 | Alios Biopharma, Inc. | 硫代氨基磷酸酯核苷酸前藥的固體形式 |
| WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| EP2754714A1 (en) * | 2013-01-14 | 2014-07-16 | Sarepta Therapeutics, Inc. | Inhibitory oligonucleotides and their use in therapy |
| MA50829A (fr) | 2015-06-01 | 2018-04-11 | Sarepta Therapeutics Inc | Exclusion d'exon induite pat technologie antisens dans le collagène de type vii |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| JP7034951B2 (ja) | 2016-06-08 | 2022-03-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 操作されたウイルスベクターは炎症および免疫応答の誘導を低減する |
| US11370794B2 (en) | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| JP6886854B2 (ja) * | 2017-04-13 | 2021-06-16 | シスメックス株式会社 | 被検物質の情報取得方法 |
| JP2021502381A (ja) | 2017-11-08 | 2021-01-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ウイルスベクター誘発性炎症反応を阻害するための組成物および方法 |
| WO2019160866A2 (en) | 2018-02-13 | 2019-08-22 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| BR112020020479A2 (pt) | 2018-04-09 | 2021-01-12 | Checkmate Pharmaceuticals | Empacotamento de oligonucleotídeos em partículas similares a vírus |
| US11863189B2 (en) * | 2021-03-05 | 2024-01-02 | Taiwan Semiconductor Manufacturing Company, Ltd. | Input buffer circuit |
| US12110324B2 (en) | 2022-07-22 | 2024-10-08 | Flagship Pioneering Innovations Vi, Llc | Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP) |
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| JP2008514187A (ja) | 2004-09-01 | 2008-05-08 | ダイナバックス テクノロジーズ コーポレイション | 先天性免疫応答及び自己免疫疾患の阻害法及び阻害用組成物 |
| CA2591582A1 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| MX2008008279A (es) | 2005-12-20 | 2009-03-04 | Idera Pharmaceuticals Inc | Actividad inmunoestimuladora de oligonucleotidos inmunoestimuladores palindromicos que contienen diferentes longitudes de segmentos palindromicos. |
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| KR101221589B1 (ko) | 2006-04-07 | 2013-01-15 | 이데라 파마슈티칼즈, 인코포레이티드 | Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물 |
| EP2209896B1 (en) * | 2007-10-26 | 2017-03-01 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
-
2005
- 2005-08-24 JP JP2007530180A patent/JP2008514187A/ja active Pending
- 2005-08-24 NZ NZ553581A patent/NZ553581A/en not_active IP Right Cessation
- 2005-08-24 PT PT05792518T patent/PT1794174E/pt unknown
- 2005-08-24 DK DK05792518.2T patent/DK1794174T3/da active
- 2005-08-24 PL PL05792518T patent/PL1794174T3/pl unknown
- 2005-08-24 ES ES05792518T patent/ES2385657T3/es not_active Expired - Lifetime
- 2005-08-24 ES ES10011096.4T patent/ES2543207T3/es not_active Expired - Lifetime
- 2005-08-24 US US11/212,297 patent/US8759305B2/en active Active
- 2005-08-24 EP EP05792518A patent/EP1794174B1/en not_active Expired - Lifetime
- 2005-08-24 SI SI200531556T patent/SI1794174T1/sl unknown
- 2005-08-24 CN CN200580037417.4A patent/CN101052643B/zh not_active Expired - Fee Related
- 2005-08-24 WO PCT/US2005/030494 patent/WO2006028742A2/en not_active Ceased
- 2005-08-24 EP EP10011096.4A patent/EP2305693B1/en not_active Expired - Lifetime
- 2005-08-24 CA CA2578775A patent/CA2578775C/en not_active Expired - Lifetime
- 2005-08-24 KR KR1020077006947A patent/KR101268877B1/ko not_active Expired - Fee Related
- 2005-08-24 AU AU2005282889A patent/AU2005282889B2/en not_active Ceased
-
2012
- 2012-05-29 AU AU2012203156A patent/AU2012203156B2/en not_active Ceased
- 2012-06-06 JP JP2012129374A patent/JP5775024B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-23 US US14/312,533 patent/US20150050296A1/en not_active Abandoned
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