CA2578775C - Methods and compositions for inhibition of innate immune responses and autoimmunity - Google Patents

Methods and compositions for inhibition of innate immune responses and autoimmunity Download PDF

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Publication number
CA2578775C
CA2578775C CA2578775A CA2578775A CA2578775C CA 2578775 C CA2578775 C CA 2578775C CA 2578775 A CA2578775 A CA 2578775A CA 2578775 A CA2578775 A CA 2578775A CA 2578775 C CA2578775 C CA 2578775C
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seq
oligonucleotide
irp
immune response
individual
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CA2578775A
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French (fr)
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CA2578775A1 (en
Inventor
Franck Barrat
Robert L. Coffman
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Dynavax Technologies Corp
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Dynavax Technologies Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3183—Diol linkers, e.g. glycols or propanediols
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G

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  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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CA2578775A 2004-09-01 2005-08-24 Methods and compositions for inhibition of innate immune responses and autoimmunity Expired - Lifetime CA2578775C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60683304P 2004-09-01 2004-09-01
US60/606,833 2004-09-01
PCT/US2005/030494 WO2006028742A2 (en) 2004-09-01 2005-08-24 Methods and conpositions for inhibition of innate immune responses and autoimmunity

Publications (2)

Publication Number Publication Date
CA2578775A1 CA2578775A1 (en) 2006-03-16
CA2578775C true CA2578775C (en) 2016-05-03

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CA2578775A Expired - Lifetime CA2578775C (en) 2004-09-01 2005-08-24 Methods and compositions for inhibition of innate immune responses and autoimmunity

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US (2) US8759305B2 (enExample)
EP (2) EP1794174B1 (enExample)
JP (2) JP2008514187A (enExample)
KR (1) KR101268877B1 (enExample)
CN (1) CN101052643B (enExample)
AU (2) AU2005282889B2 (enExample)
CA (1) CA2578775C (enExample)
DK (1) DK1794174T3 (enExample)
ES (2) ES2543207T3 (enExample)
NZ (1) NZ553581A (enExample)
PL (1) PL1794174T3 (enExample)
PT (1) PT1794174E (enExample)
SI (1) SI1794174T1 (enExample)
WO (1) WO2006028742A2 (enExample)

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