JP2016508136A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016508136A5 JP2016508136A5 JP2015549842A JP2015549842A JP2016508136A5 JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5 JP 2015549842 A JP2015549842 A JP 2015549842A JP 2015549842 A JP2015549842 A JP 2015549842A JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5
- Authority
- JP
- Japan
- Prior art keywords
- linker
- self
- bond
- compound
- destructing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
- 125000006850 spacer group Chemical group 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 13
- 239000003814 drug Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000012453 solvate Substances 0.000 claims description 12
- 125000002252 acyl group Chemical group 0.000 claims description 11
- 230000008685 targeting Effects 0.000 claims description 4
- 125000005647 linker group Chemical group 0.000 claims 79
- 150000001875 compounds Chemical class 0.000 claims 36
- 150000001413 amino acids Chemical class 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 13
- 229940024606 amino acid Drugs 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 12
- 125000000539 amino acid group Chemical group 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 239000004472 Lysine Substances 0.000 claims 5
- 229960003646 lysine Drugs 0.000 claims 5
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 4
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- ONCCWDRMOZMNSM-FBCQKBJTSA-N compound Z Chemical compound N1=C2C(=O)NC(N)=NC2=NC=C1C(=O)[C@H]1OP(O)(=O)OC[C@H]1O ONCCWDRMOZMNSM-FBCQKBJTSA-N 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 229920001515 polyalkylene glycol Polymers 0.000 claims 4
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000004419 alkynylene group Chemical group 0.000 claims 3
- 229960002173 citrulline Drugs 0.000 claims 3
- 229920000768 polyamine Polymers 0.000 claims 3
- 229960004295 valine Drugs 0.000 claims 3
- 239000004474 valine Substances 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 235000013477 citrulline Nutrition 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 201000010175 gallbladder cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 229960004857 mitomycin Drugs 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 229960002429 proline Drugs 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
- DLGAUVSRZXNATA-DHYYHALDSA-N (2s,3s)-2-amino-3-methylpentanoic acid;(2s)-pyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1.CC[C@H](C)[C@H](N)C(O)=O DLGAUVSRZXNATA-DHYYHALDSA-N 0.000 claims 1
- NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 229960003121 arginine Drugs 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims 1
- 229930188854 dolastatin Natural products 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims 1
- 229960005501 duocarmycin Drugs 0.000 claims 1
- 229930184221 duocarmycin Natural products 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 229960002743 glutamine Drugs 0.000 claims 1
- 229960002885 histidine Drugs 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960003136 leucine Drugs 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960005190 phenylalanine Drugs 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960004799 tryptophan Drugs 0.000 claims 1
- -1 tubricin Chemical compound 0.000 claims 1
- 229960004441 tyrosine Drugs 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 0 CC(OC(C(N1CCN(*)CC1)=O)c(cc1)ccc1NC)=O Chemical compound CC(OC(C(N1CCN(*)CC1)=O)c(cc1)ccc1NC)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745448P | 2012-12-21 | 2012-12-21 | |
| US61/745,448 | 2012-12-21 | ||
| US201361785027P | 2013-03-14 | 2013-03-14 | |
| US61/785,027 | 2013-03-14 | ||
| PCT/US2013/077306 WO2014100762A1 (en) | 2012-12-21 | 2013-12-20 | Hydrophilic self-immolative linkers and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016508136A JP2016508136A (ja) | 2016-03-17 |
| JP2016508136A5 true JP2016508136A5 (OSRAM) | 2018-06-14 |
| JP6482471B2 JP6482471B2 (ja) | 2019-03-13 |
Family
ID=50979293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549842A Expired - Fee Related JP6482471B2 (ja) | 2012-12-21 | 2013-12-20 | 親水性の自壊性リンカー及びそのコンジュゲート |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US9943610B2 (OSRAM) |
| EP (1) | EP2935259B1 (OSRAM) |
| JP (1) | JP6482471B2 (OSRAM) |
| KR (2) | KR20150119848A (OSRAM) |
| CN (2) | CN108546283A (OSRAM) |
| AR (1) | AR094280A1 (OSRAM) |
| AU (1) | AU2013364065B2 (OSRAM) |
| BR (1) | BR112015014712A2 (OSRAM) |
| CA (1) | CA2896690A1 (OSRAM) |
| CL (1) | CL2015001735A1 (OSRAM) |
| DK (1) | DK2935259T3 (OSRAM) |
| ES (1) | ES2714951T3 (OSRAM) |
| IL (1) | IL239506B (OSRAM) |
| MX (1) | MX379355B (OSRAM) |
| MY (1) | MY169117A (OSRAM) |
| NZ (1) | NZ630601A (OSRAM) |
| PH (1) | PH12015501422A1 (OSRAM) |
| PT (1) | PT2935259T (OSRAM) |
| RU (2) | RU2015129800A (OSRAM) |
| SG (2) | SG11201504887TA (OSRAM) |
| TW (1) | TWI716339B (OSRAM) |
| WO (1) | WO2014100762A1 (OSRAM) |
| ZA (1) | ZA201504941B (OSRAM) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| JP5829793B2 (ja) | 2007-03-14 | 2015-12-09 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 結合性リガンドが結合したツブリシンの薬剤送達結合体 |
| WO2009002993A1 (en) | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| RU2617402C2 (ru) | 2011-06-10 | 2017-04-25 | Мерсана Терапьютикс, Инк. | Конъюгаты белок-полимер-лекарственное средство |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| EP2908818A4 (en) | 2012-10-16 | 2016-07-13 | Endocyte Inc | CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE |
| AU2013364065B2 (en) | 2012-12-21 | 2018-10-04 | Altrubio Inc. | Hydrophilic self-immolative linkers and conjugates thereof |
| MY174813A (en) | 2013-03-15 | 2020-05-16 | Zymeworks Inc | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| WO2015054669A1 (en) | 2013-10-11 | 2015-04-16 | Asana Biosciences, Llc | Protein-polymer-drug conjugates |
| CA2926586C (en) | 2013-10-11 | 2020-04-07 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
| AU2014373640B2 (en) | 2013-12-27 | 2018-08-30 | Var2 Pharmaceuticals Aps | VAR2CSA-drug conjugates |
| CA2935077C (en) | 2013-12-27 | 2022-03-15 | Geoffrey C. Winters | Sulfonamide-containing linkage systems for drug conjugates |
| JP2017523958A (ja) * | 2014-06-20 | 2017-08-24 | バイオアライアンス コマンディテール フェンノートシャップ | 抗ｃｄ２２抗体−薬物コンジュゲート及びその使用方法 |
| SG10201811124YA (en) * | 2014-06-20 | 2019-01-30 | Abgenomics Int Inc | Her2 antibody-drug conjugates |
| CA2952876A1 (en) | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-folate receptor alpha (fra) antibody-drug conjugates and methods of using thereof |
| EP3185908B1 (en) * | 2014-08-28 | 2020-04-15 | Pfizer Inc | Stability-modulating linkers for use with antibody drug conjugates |
| CA2960899C (en) | 2014-09-17 | 2021-08-17 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
| CN112494657B (zh) | 2014-10-03 | 2025-02-11 | 西纳福克斯股份有限公司 | 磺酰胺接头、其缀合物及制备方法 |
| WO2016090050A1 (en) * | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| EP3277305B1 (en) | 2015-03-31 | 2021-07-21 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a trimeric tnf family ligand |
| WO2016183359A1 (en) * | 2015-05-12 | 2016-11-17 | Blinkbio, Inc. | Silicon based drug conjugates and methods of using same |
| WO2017002776A1 (ja) * | 2015-06-29 | 2017-01-05 | 第一三共株式会社 | 抗体－薬物コンジュゲートの選択的製造方法 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| EP3165237B1 (en) | 2015-11-03 | 2018-12-19 | Industrial Technology Research Institute | Antibody-drug conjugate (adc) and method for forming the same |
| TWI753875B (zh) | 2016-01-08 | 2022-02-01 | 美商美國全心醫藥生技股份有限公司 | 四價抗psgl-1抗體及其用途 |
| EP3413922B1 (en) | 2016-02-08 | 2025-12-10 | SynAffix B.V. | Improved sulfamide linkers for use in bioconjugates |
| JP2019507741A (ja) | 2016-02-08 | 2019-03-22 | シンアフィックス ビー．ブイ． | 治療において使用するためのスルファミドリンカーを含むバイオコンジュゲート |
| US11590239B2 (en) | 2016-02-08 | 2023-02-28 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting CD30 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137458A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137457A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| BR112018070191A2 (pt) | 2016-03-30 | 2019-01-29 | Convatec Technologies Inc | curativos para ferida modificados |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| CN109963870B (zh) | 2016-06-08 | 2023-07-28 | 艾伯维公司 | 抗b7-h3抗体和抗体药物偶联物 |
| CN109475567A (zh) | 2016-06-09 | 2019-03-15 | 布兰克生物股份有限公司 | 基于硅烷醇的治疗有效载荷 |
| DK3525826T3 (da) | 2016-10-11 | 2020-08-24 | Byondis Bv | Ikke-lineære selvofrende linkere og konjugater deraf |
| CN110088086B (zh) * | 2016-11-25 | 2022-12-16 | 迈威(上海)生物科技股份有限公司 | 用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途 |
| CN109810039B (zh) * | 2017-11-22 | 2021-11-12 | 迈威(上海)生物科技股份有限公司 | 一种用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途 |
| CN108101825B (zh) * | 2016-11-25 | 2022-02-22 | 迈威(上海)生物科技股份有限公司 | 用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途 |
| KR20190104381A (ko) | 2017-01-06 | 2019-09-09 | 어비디티 바이오사이언시스 엘엘씨 | 핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법 |
| US11299509B2 (en) | 2017-02-10 | 2022-04-12 | The Board Of Trustees Of The University Of Illinois | Trigger-activatable sugar conjugates for cancer-selective labeling and targeting |
| CA3067829A1 (en) | 2017-06-23 | 2018-12-27 | VelosBio Inc. | Ror1 antibody immunoconjugates |
| IL271903B2 (en) | 2017-07-11 | 2025-04-01 | Synthorx Inc | Combination of unnatural nucleotides and methods therefor |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| SG11202000939PA (en) | 2017-08-03 | 2020-02-27 | Synthorx Inc | Cytokine conjugates for the treatment of proliferative and infectious diseases |
| MX2020003596A (es) | 2017-10-04 | 2020-07-22 | Avidity Biosciences Inc | Composiciones de acido nucleico-polipeptido y usos de las mismos. |
| JP7506601B2 (ja) | 2017-12-06 | 2024-06-26 | アビディティー バイオサイエンシーズ，インク． | 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法 |
| WO2019165453A1 (en) | 2018-02-26 | 2019-08-29 | Synthorx, Inc. | Il-15 conjugates and uses thereof |
| WO2019183270A1 (en) * | 2018-03-23 | 2019-09-26 | The Regents Of The University Of California | Puromycin-based probes and methods of use thereof |
| WO2019185586A1 (en) | 2018-03-26 | 2019-10-03 | Universidad Complutense De Madrid | Ligands for enhanced imaging and drug delivery to neuroblastoma cells |
| BR112020024022A2 (pt) | 2018-05-29 | 2021-02-23 | Bristol-Myers Squibb Company | porções autoimolantes modificadas para uso em profármacos e conjugados e métodos de uso e preparação |
| EP3876973B1 (en) | 2018-11-08 | 2025-10-22 | Synthorx, Inc. | Interleukin 10 conjugates and uses thereof |
| IL319265A (en) | 2018-12-21 | 2025-04-01 | Avidity Biosciences Inc | Anti-transferrin receptor antibodies and their uses |
| CN116063505B (zh) | 2019-01-30 | 2024-05-03 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| EP3923974A4 (en) | 2019-02-06 | 2023-02-08 | Synthorx, Inc. | IL-2 CONJUGATES AND METHODS OF USE THEREOF |
| AU2020263487A1 (en) | 2019-04-25 | 2021-12-16 | Avidity Biosciences, Inc. | Nucleic acid compositions and methods of multi-exon skipping |
| CA3140063A1 (en) * | 2019-05-20 | 2020-11-26 | Novartis Ag | Antibody drug conjugates having linkers comprising hydrophilic groups |
| CA3142283A1 (en) | 2019-06-06 | 2020-12-10 | Avidity Biosciences, Inc. | Nucleic acid-polypeptide compositions and uses thereof |
| WO2020247818A1 (en) | 2019-06-06 | 2020-12-10 | Avidity Biosciences, Inc. | Una amidites and uses thereof |
| TW202124385A (zh) | 2019-09-10 | 2021-07-01 | 美商欣爍克斯公司 | 治療自體免疫疾病之il-2接合物及使用方法 |
| CA3156405A1 (en) | 2019-11-04 | 2021-05-14 | Synthorx, Inc. | Interleukin 10 conjugates and uses thereof |
| CA3172111A1 (en) | 2020-03-19 | 2021-09-23 | Barbora MALECOVA | Compositions and methods of treating facioscapulohumeral muscular dystrophy |
| EP4656242A2 (en) | 2020-03-27 | 2025-12-03 | Avidity Biosciences, Inc. | Compositions and methods of treating muscle dystrophy |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| EP4162954A4 (en) * | 2020-06-08 | 2025-05-07 | SystImmune, Inc. | Camptothecin drug having high-stability hydrophilic connecting unit and conjugate thereof |
| IL299860A (en) | 2020-07-21 | 2023-03-01 | Genentech Inc | Antibody-conjugated chemical factors for the discharge of BRM and their methods |
| WO2022094262A1 (en) | 2020-10-30 | 2022-05-05 | Avacta Life Sciences Limited | Fap-activated serum extended half-life therapeutic conjugates |
| CN116981479A (zh) | 2020-12-17 | 2023-10-31 | 塔夫茨大学信托人 | Fap激活的放射治疗诊断法以及与之相关的用途 |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| TW202308701A (zh) * | 2021-04-29 | 2023-03-01 | 大陸商上海匯連生物醫藥有限公司 | 抗體偶聯藥物的製備方法及應用 |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| EP4370555A4 (en) | 2021-07-13 | 2025-11-12 | Truebinding Inc | METHODS FOR PREVENTING PROTEIN AGGREGATION |
| CN118265544A (zh) | 2021-09-16 | 2024-06-28 | 艾维迪提生物科学公司 | 治疗面肩肱型肌营养不良的组合物和方法 |
| CN118119640A (zh) * | 2021-09-30 | 2024-05-31 | 味之素株式会社 | 抗体和功能性物质的位点选择性的缀合物或其盐、以及其制造中使用的抗体衍生物和化合物或它们的盐 |
| EP4410830A1 (en) * | 2021-09-30 | 2024-08-07 | Ajinomoto Co., Inc. | Conjugate of antibody and functional substance or salt thereof, and antibody derivative and compound or salts thereof to be used in producing conjugate or salt thereof |
| KR102793244B1 (ko) | 2021-10-06 | 2025-04-07 | 주식회사 엘지에너지솔루션 | 안전성이 향상된 배터리 팩 |
| TW202332694A (zh) | 2021-10-07 | 2023-08-16 | 英商阿凡克塔生命科學公司 | 血清半衰期延長之ｐｄ－ｌ１結合多肽 |
| EP4413038A1 (en) | 2021-10-07 | 2024-08-14 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
| CN118524852A (zh) | 2021-11-09 | 2024-08-20 | 真和制药有限公司 | 治疗或抑制心血管疾病的方法 |
| US12290565B2 (en) | 2021-11-17 | 2025-05-06 | Altrubio Inc. | Methods of using anti-PSGL-1 antibodies in combination with JAK inhibitors to treat T-cell mediated inflammatory diseases or cancers |
| KR20240125036A (ko) | 2021-12-23 | 2024-08-19 | 마이레큘, 인크. | 폴리뉴클레오타이드의 전달을 위한 조성물 |
| AR128331A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpos y métodos de estos |
| AR128330A1 (es) | 2022-01-26 | 2024-04-17 | Genentech Inc | Inductores químicos de degradación conjugados con anticuerpo y métodos de estos |
| CN119213021A (zh) | 2022-02-10 | 2024-12-27 | 艾菲赛尔治疗株式会社 | 与CD40L特异性结合的Stefin A蛋白变体及其用途 |
| US12071621B2 (en) | 2022-04-05 | 2024-08-27 | Avidity Biosciences, Inc. | Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping |
| EP4512411A2 (en) | 2022-04-07 | 2025-02-26 | Twinpig Biolab, Inc. | Itgb2-mediated drug delivery system |
| WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
| WO2024026474A1 (en) | 2022-07-29 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle |
| EP4588489A1 (en) * | 2022-09-16 | 2025-07-23 | Shanghai Junshi Biosciences Co., Ltd. | Linker for antibody-drug conjugate and use thereof |
| WO2024077212A2 (en) * | 2022-10-06 | 2024-04-11 | The Regents Of The University Of California | Site-specific covalent ligation of human serum albumin |
| AU2023379457A1 (en) | 2022-11-14 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| AR132368A1 (es) | 2023-04-18 | 2025-06-18 | Astrazeneca Ab | Conjugados que comprenden enlazadores escindibles |
| US12491257B2 (en) | 2023-06-27 | 2025-12-09 | Avidity Biosciences, Inc. | Compositions and methods of using PRKAG2-targeting antibody-oligonucleotide conjugates |
| WO2025007063A1 (en) | 2023-06-30 | 2025-01-02 | Avidity Biosciences, Inc. | Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates |
| WO2025158385A1 (en) | 2024-01-25 | 2025-07-31 | Genzyme Corporation | Pegylated il-2 for suppressing adaptive immune response to gene therapy |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5198560A (en) | 1990-04-27 | 1993-03-30 | Bristol-Myers Squibb Company | Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof |
| CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| IL114909A (en) | 1994-08-12 | 1999-10-28 | Immunomedics Inc | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
| US6548530B1 (en) | 1995-10-03 | 2003-04-15 | The Scripps Research Institute | CBI analogs of CC-1065 and the duocarmycins |
| ATE301639T1 (de) | 1996-03-08 | 2005-08-15 | Scripps Research Inst | Mcbi analoge von cc-1065 und die duocarmycine |
| CA2255703A1 (en) | 1996-05-31 | 1997-12-04 | Dale L. Boger | Analogs of cc-1065 and the duocarmycins |
| ATE271041T1 (de) | 1997-05-22 | 2004-07-15 | Scripps Research Inst | Analoga von duocarmycin and cc-1065 |
| US6262271B1 (en) | 1997-10-14 | 2001-07-17 | The Scripps Research Institute | ISO-CBI and ISO-CI analogs of CC-1065 and the duocarmycins |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US20020106728A1 (en) | 2000-06-20 | 2002-08-08 | Genentech, Inc. | NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders |
| US6762020B1 (en) | 1999-03-15 | 2004-07-13 | Protein Design Labs, Inc. | Methods of diagnosing breast cancer |
| DE19926154A1 (de) | 1999-06-09 | 2000-12-14 | Ktb Tumorforschungs Gmbh | Verfahren zur Herstellung einer injizierbaren Arzneimittelzubereitung |
| US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| US20030083263A1 (en) | 2001-04-30 | 2003-05-01 | Svetlana Doronina | Pentapeptide compounds and uses related thereto |
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| EP2000148A1 (en) | 2001-06-20 | 2008-12-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of prostate cancer |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| KR20040101502A (ko) | 2002-04-16 | 2004-12-02 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
| HUE057124T2 (hu) | 2002-05-02 | 2022-04-28 | Wyeth Holdings Llc | Calicheamicin származék - hordozó konjugátumok |
| US20090068178A1 (en) | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| PT2357006E (pt) | 2002-07-31 | 2016-01-22 | Seattle Genetics Inc | Conjugados de fármacos e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infeciosa |
| WO2004043493A1 (en) | 2002-11-14 | 2004-05-27 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| US8420086B2 (en) | 2002-12-13 | 2013-04-16 | Immunomedics, Inc. | Camptothecin conjugates of anti-CD22 antibodies for treatment of B cell diseases |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| SG149815A1 (en) | 2003-11-06 | 2009-02-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| US20050232919A1 (en) | 2004-02-12 | 2005-10-20 | Morphotek, Inc. | Monoclonal antibodies that specifically block biological activity of a tumor antigen |
| JP5064037B2 (ja) | 2004-02-23 | 2012-10-31 | ジェネンテック， インコーポレイテッド | 複素環式自壊的リンカーおよび結合体 |
| HUE045882T2 (hu) | 2004-03-23 | 2020-01-28 | Ascendis Pharma Gmbh | Polimer prodrug önmagát lehasító linkerrel |
| JP4861308B2 (ja) | 2004-04-07 | 2012-01-25 | ジェネンテック， インコーポレイテッド | 抗体結合体の質量分析 |
| US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| WO2008020827A2 (en) | 2005-08-01 | 2008-02-21 | Biogen Idec Ma Inc. | Altered polypeptides, immunoconjugates thereof, and methods related thereto |
| WO2007103288A2 (en) | 2006-03-02 | 2007-09-13 | Seattle Genetics, Inc. | Engineered antibody drug conjugates |
| RS54163B1 (sr) * | 2006-05-30 | 2015-12-31 | Genentech Inc. | Anti-cd22 antitela, njihovi imunokonjugati i njihova upotreba |
| SG172684A1 (en) | 2006-06-07 | 2011-07-28 | Bioalliance Cv | Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same |
| CA2663375A1 (en) | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| GB0619291D0 (en) | 2006-09-29 | 2006-11-08 | Ucb Sa | Altered antibodies |
| CA2699837C (en) | 2006-12-01 | 2017-06-13 | Seattle Genetics, Inc. | Variant target binding agents and uses thereof |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| EP2129402A2 (en) | 2007-02-16 | 2009-12-09 | KTB Tumorforschungsgesellschaft mbH | Receptor and antigen targeted prodrug |
| ES2550757T3 (es) | 2007-12-18 | 2015-11-12 | Bioalliance C.V. | Anticuerpos que reconocen un epítopo que contiene carbohidratos en CD43 y ACE expresados en células cancerosas y métodos de uso de los mismos |
| MX2010007767A (es) | 2008-01-18 | 2010-08-09 | Medimmune Llc | Anticuerpos manipulados con cisteina para conjugacion especifica de sitio. |
| ES2547552T3 (es) | 2008-02-01 | 2015-10-07 | Genentech, Inc. | Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos |
| CA2754531A1 (en) | 2009-03-06 | 2010-09-30 | Seattle Genetics, Inc. | Antibody drug conjugates (adc) that bind to 24p4c12 proteins |
| KR101861295B1 (ko) | 2009-06-04 | 2018-05-25 | 노파르티스 아게 | ＩｇＧ 콘쥬게이션을 위한 자리의 확인 방법 |
| AU2010270979B2 (en) | 2009-06-22 | 2015-04-23 | Medimmune, Llc | Engineered Fc regions for site-specific conjugation |
| GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
| TWI796132B (zh) | 2010-02-24 | 2023-03-11 | 美商免疫遺傳股份有限公司 | 葉酸受體１抗體類和免疫共軛物類及彼等之用途 |
| TWI540136B (zh) | 2010-04-15 | 2016-07-01 | 梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
| MX374267B (es) | 2010-04-21 | 2025-03-06 | Syntarga Bv | Conjugados novedosos de analogos cc-1065 y ligaduras bifuncionales. |
| AU2011265054B2 (en) | 2010-06-08 | 2016-09-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| WO2012112708A1 (en) | 2011-02-15 | 2012-08-23 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and methods of preparation |
| HRP20180358T1 (hr) | 2011-04-01 | 2018-04-06 | Immunogen, Inc. | Postupci povećavanja djelotvornosti terapije raka usmjerene protiv folr1 |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| JP6209159B2 (ja) | 2011-06-21 | 2017-10-04 | イミュノジェン・インコーポレーテッド | ペプチドリンカーを有する新規メイタンシノイド誘導体およびその結合体 |
| EP2794653B1 (en) | 2011-12-23 | 2019-03-13 | Pfizer Inc | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| WO2013103800A1 (en) | 2012-01-06 | 2013-07-11 | Bioalliance C.V. | Anti-transferrin receptor antibodies and methods using same |
| US9981046B2 (en) | 2012-05-15 | 2018-05-29 | Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. | Drug-conjugates, conjugation methods, and uses thereof |
| US9056141B2 (en) * | 2012-05-31 | 2015-06-16 | Synchem, Inc. | Thiol-ene click chemistry for drug conjugates |
| TW201408696A (zh) | 2012-07-09 | 2014-03-01 | Genentech Inc | 抗ｃｄ２２抗體及免疫結合物 |
| JP6117921B2 (ja) | 2012-07-12 | 2017-04-19 | ハンヂョウ ディーエイシー バイオテック カンパニー リミテッド | 細胞毒性剤と細胞結合受容体との共役体 |
| CN112587658A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| WO2014057118A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
| BR112015013444B1 (pt) | 2012-12-13 | 2022-11-01 | Immunomedics, Inc | Uso de um imunoconjugado |
| ES2819573T3 (es) | 2012-12-13 | 2021-04-16 | Immunomedics Inc | Método para producir inmunoconjugados de anticuerpo-SN-38 con un enlazador CL2A |
| AU2013364065B2 (en) | 2012-12-21 | 2018-10-04 | Altrubio Inc. | Hydrophilic self-immolative linkers and conjugates thereof |
| WO2014107024A1 (ko) | 2013-01-03 | 2014-07-10 | 셀트리온 | 항체-링커-약물 결합체, 그의 제조방법 및 그를 포함하는 항암제 조성물 |
| WO2014124316A2 (en) | 2013-02-08 | 2014-08-14 | Irm Llc | Specific sites for modifying antibodies to make immunoconjugates |
| BR112015022585B1 (pt) | 2013-03-15 | 2023-04-04 | Regeneron Pharmaceuticals, Inc | Composto, composição farmacêutica, conjugado droga-anticorpo, e, uso dos mesmos |
| US20140363454A1 (en) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Antibody-Drug Conjugates, Compositions and Methods of Use |
| SG10201911860VA (en) | 2014-01-10 | 2020-02-27 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs showing improved in vivo antitumor activity |
| CA2952876A1 (en) | 2014-06-20 | 2015-12-23 | Bioalliance C.V. | Anti-folate receptor alpha (fra) antibody-drug conjugates and methods of using thereof |
| SG10201811124YA (en) | 2014-06-20 | 2019-01-30 | Abgenomics Int Inc | Her2 antibody-drug conjugates |
| JP2017523958A (ja) | 2014-06-20 | 2017-08-24 | バイオアライアンス コマンディテール フェンノートシャップ | 抗ｃｄ２２抗体−薬物コンジュゲート及びその使用方法 |
| TWI753875B (zh) | 2016-01-08 | 2022-02-01 | 美商美國全心醫藥生技股份有限公司 | 四價抗psgl-1抗體及其用途 |
-
2013
- 2013-12-20 AU AU2013364065A patent/AU2013364065B2/en not_active Ceased
- 2013-12-20 ES ES13865282T patent/ES2714951T3/es active Active
- 2013-12-20 MX MX2015007918A patent/MX379355B/es unknown
- 2013-12-20 PT PT13865282T patent/PT2935259T/pt unknown
- 2013-12-20 TW TW102147572A patent/TWI716339B/zh not_active IP Right Cessation
- 2013-12-20 AR ARP130105028A patent/AR094280A1/es unknown
- 2013-12-20 JP JP2015549842A patent/JP6482471B2/ja not_active Expired - Fee Related
- 2013-12-20 RU RU2015129800A patent/RU2015129800A/ru unknown
- 2013-12-20 BR BR112015014712A patent/BR112015014712A2/pt not_active Application Discontinuation
- 2013-12-20 NZ NZ630601A patent/NZ630601A/en not_active IP Right Cessation
- 2013-12-20 US US14/654,486 patent/US9943610B2/en active Active
- 2013-12-20 RU RU2019105549A patent/RU2019105549A/ru unknown
- 2013-12-20 CN CN201810460861.6A patent/CN108546283A/zh active Pending
- 2013-12-20 CA CA2896690A patent/CA2896690A1/en not_active Abandoned
- 2013-12-20 DK DK13865282.1T patent/DK2935259T3/en active
- 2013-12-20 SG SG11201504887TA patent/SG11201504887TA/en unknown
- 2013-12-20 KR KR1020157019681A patent/KR20150119848A/ko not_active Abandoned
- 2013-12-20 EP EP13865282.1A patent/EP2935259B1/en active Active
- 2013-12-20 US US14/137,799 patent/US9089614B2/en not_active Expired - Fee Related
- 2013-12-20 MY MYPI2015001576A patent/MY169117A/en unknown
- 2013-12-20 KR KR1020217034685A patent/KR20210132742A/ko not_active Abandoned
- 2013-12-20 WO PCT/US2013/077306 patent/WO2014100762A1/en not_active Ceased
- 2013-12-20 SG SG10201705150RA patent/SG10201705150RA/en unknown
- 2013-12-20 CN CN201380073519.6A patent/CN105102455B/zh not_active Expired - Fee Related
-
2015
- 2015-06-17 US US14/742,621 patent/US9408923B2/en not_active Expired - Fee Related
- 2015-06-18 CL CL2015001735A patent/CL2015001735A1/es unknown
- 2015-06-18 IL IL239506A patent/IL239506B/en active IP Right Grant
- 2015-06-19 PH PH12015501422A patent/PH12015501422A1/en unknown
- 2015-07-09 ZA ZA2015/04941A patent/ZA201504941B/en unknown
-
2018
- 2018-03-13 US US15/920,229 patent/US20180264131A1/en not_active Abandoned
-
2020
- 2020-12-10 US US17/118,228 patent/US20210113710A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016508136A5 (OSRAM) | ||
| RU2015129800A (ru) | Гидрофильные саморазрушающиеся линкеры и их конъюгаты | |
| JP2017525755A5 (OSRAM) | ||
| JP2017528418A5 (OSRAM) | ||
| WO2023078021A1 (en) | Bcma monoclonal antibody and the antibody-drug conjugate | |
| RU2017101331A (ru) | Конъюгаты антитело к her2 - лекарственное средство | |
| CN116196435B (zh) | 包含sting激动剂的抗体药物缀合物 | |
| KR102459469B1 (ko) | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 | |
| RU2017101681A (ru) | Конъюгаты анти-cd22 антитело - лекарственное средство и способы их применения | |
| RU2017101662A (ru) | Конъюгаты антитела против фолатного рецептора альфа (fra) c лекарственным средством и способы их применения | |
| ES2715776T3 (es) | Auristatinas que tienen una unidad de ácido aminobenzoico en el extremo N | |
| AU2017408164B2 (en) | Conjugation of a cytotoxic drug with bis-linkage | |
| CA2991975C (en) | Novel linkers and their uses in specific conjugation of drugs to a biological molecule | |
| KR20230034957A (ko) | 캄프토테신 유사체를 갖는 세포-결합 분자의 접합체 | |
| ES2647927T3 (es) | Conjugados enlazadores del fármaco auriestatina | |
| JP2019172710A5 (OSRAM) | ||
| JP2015524796A5 (ja) | 細胞毒性剤と細胞結合受容体との共役体 | |
| KR20220024914A (ko) | 분지형 링커를 사용한 세포독성제 대 세포 결합 분자의 접합체 | |
| EP3210627A1 (en) | Conjugates of cell binding molecules with cytotoxic agents | |
| JP2016521256A5 (OSRAM) | ||
| EA037203B1 (ru) | Конъюгаты антитело-лекарственное средство с самостабилизирующимися линкерами | |
| CN113195487A (zh) | 2，3-二氨基琥珀酰基偶联物连接子 | |
| JP2009500424A5 (OSRAM) | ||
| KR20250100803A (ko) | 분지형 링커를 갖는 아마니타 독소의 접합체 | |
| WO2005070457A1 (en) | Melphalan prodrugs |