CL2015001735A1 - Conectores hidrofilicos auto inmolativos y sus conjugados - Google Patents

Conectores hidrofilicos auto inmolativos y sus conjugados

Info

Publication number
CL2015001735A1
CL2015001735A1 CL2015001735A CL2015001735A CL2015001735A1 CL 2015001735 A1 CL2015001735 A1 CL 2015001735A1 CL 2015001735 A CL2015001735 A CL 2015001735A CL 2015001735 A CL2015001735 A CL 2015001735A CL 2015001735 A1 CL2015001735 A1 CL 2015001735A1
Authority
CL
Chile
Prior art keywords
immolating
conjugates
connectors
hydrophilic
self
Prior art date
Application number
CL2015001735A
Other languages
English (en)
Spanish (es)
Inventor
Rong-Hwa Lin
Shih-Yao Lin
Yu-Chi Hsieh
Chiu-Chen Huang
Original Assignee
Bioalliance Cv
Abgenomics Internat Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalliance Cv, Abgenomics Internat Inc filed Critical Bioalliance Cv
Publication of CL2015001735A1 publication Critical patent/CL2015001735A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CL2015001735A 2012-12-21 2015-06-18 Conectores hidrofilicos auto inmolativos y sus conjugados CL2015001735A1 (es)

Applications Claiming Priority (2)

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US201261745448P 2012-12-21 2012-12-21
US201361785027P 2013-03-14 2013-03-14

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CL2015001735A1 true CL2015001735A1 (es) 2016-08-19

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EP (1) EP2935259B1 (OSRAM)
JP (1) JP6482471B2 (OSRAM)
KR (2) KR20150119848A (OSRAM)
CN (2) CN108546283A (OSRAM)
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AU (1) AU2013364065B2 (OSRAM)
BR (1) BR112015014712A2 (OSRAM)
CA (1) CA2896690A1 (OSRAM)
CL (1) CL2015001735A1 (OSRAM)
DK (1) DK2935259T3 (OSRAM)
ES (1) ES2714951T3 (OSRAM)
IL (1) IL239506B (OSRAM)
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RU (2) RU2015129800A (OSRAM)
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