|
US2187108A
(en)
|
1938-05-27 |
1940-01-16 |
Du Pont |
Process of purifying lead nitrate solutions
|
|
JPS5727375B2
(enrdf_load_stackoverflow)
|
1973-06-01 |
1982-06-10 |
|
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
DE2712230C2
(de)
|
1977-03-19 |
1985-05-23 |
Bayer Ag, 5090 Leverkusen |
Verzweigte Segmentpolymere
|
|
US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
|
US4458066A
(en)
*
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
JPS58129411A
(ja)
|
1982-01-27 |
1983-08-02 |
Nippon Kogaku Kk <Nikon> |
リアフオ−カスコンバ−ジヨンレンズ
|
|
US4522811A
(en)
*
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
GB8311018D0
(en)
*
|
1983-04-22 |
1983-05-25 |
Amersham Int Plc |
Detecting mutations in dna
|
|
US4683195A
(en)
*
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683202A
(en)
*
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US5656493A
(en)
|
1985-03-28 |
1997-08-12 |
The Perkin-Elmer Corporation |
System for automated performance of the polymerase chain reaction
|
|
US4676980A
(en)
*
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4868103A
(en)
|
1986-02-19 |
1989-09-19 |
Enzo Biochem, Inc. |
Analyte detection by means of energy transfer
|
|
EP0264166B1
(en)
|
1986-04-09 |
1996-08-21 |
Genzyme Corporation |
Transgenic animals secreting desired proteins into milk
|
|
US4851331A
(en)
*
|
1986-05-16 |
1989-07-25 |
Allied Corporation |
Method and kit for polynucleotide assay including primer-dependant DNA polymerase
|
|
US5525464A
(en)
*
|
1987-04-01 |
1996-06-11 |
Hyseq, Inc. |
Method of sequencing by hybridization of oligonucleotide probes
|
|
US5202231A
(en)
*
|
1987-04-01 |
1993-04-13 |
Drmanac Radoje T |
Method of sequencing of genomes by hybridization of oligonucleotide probes
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
US5080891A
(en)
*
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5048530A
(en)
|
1988-08-17 |
1991-09-17 |
Robert Hurwitz |
Method of using an amniocentesis needle with improved sonographic visibility
|
|
US5720928A
(en)
*
|
1988-09-15 |
1998-02-24 |
New York University |
Image processing and analysis of individual nucleic acid molecules
|
|
WO1990006952A1
(en)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
|
US5075212A
(en)
|
1989-03-27 |
1991-12-24 |
University Of Patents, Inc. |
Methods of detecting picornaviruses in biological fluids and tissues
|
|
US5800992A
(en)
*
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
|
US5143854A
(en)
*
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
US5766849A
(en)
*
|
1989-07-11 |
1998-06-16 |
Gen-Probe Incorporated |
Methods of amplifying nucleic acids using promoter-containing primer sequence
|
|
GB2236186B
(en)
*
|
1989-08-22 |
1994-01-05 |
Finnigan Mat Gmbh |
Process and device for laser desorption of analyte molecular ions, especially of biomolecules
|
|
CA2045175C
(en)
|
1989-11-06 |
2003-03-18 |
Arthur I. Skoultchi |
Production of proteins using homologous recombination
|
|
US5641628A
(en)
*
|
1989-11-13 |
1997-06-24 |
Children's Medical Center Corporation |
Non-invasive method for isolation and detection of fetal DNA
|
|
US5272071A
(en)
|
1989-12-22 |
1993-12-21 |
Applied Research Systems Ars Holding N.V. |
Method for the modification of the expression characteristics of an endogenous gene of a given cell line
|
|
WO1991010674A1
(en)
*
|
1990-01-12 |
1991-07-25 |
Scripps Clinic And Research Foundation |
Nucleic acid enzymes for cleaving dna
|
|
US6013431A
(en)
*
|
1990-02-16 |
2000-01-11 |
Molecular Tool, Inc. |
Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
|
|
US5321131A
(en)
*
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
|
US5210015A
(en)
*
|
1990-08-06 |
1993-05-11 |
Hoffman-La Roche Inc. |
Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
|
|
US6004744A
(en)
|
1991-03-05 |
1999-12-21 |
Molecular Tool, Inc. |
Method for determining nucleotide identity through extension of immobilized primer
|
|
US5719262A
(en)
*
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
DK51092D0
(da)
|
1991-05-24 |
1992-04-15 |
Ole Buchardt |
Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
|
|
DE4214112A1
(de)
*
|
1991-08-02 |
1993-02-04 |
Europ Lab Molekularbiolog |
Neues verfahren zur sequenzierung von nukleinsaeuren
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
EP0552108B1
(en)
*
|
1992-01-17 |
1999-11-10 |
Lakowicz, Joseph R. |
Energy transfer phase-modulation fluoro-immunoassay
|
|
GB9208733D0
(en)
|
1992-04-22 |
1992-06-10 |
Medical Res Council |
Dna sequencing method
|
|
GB9211979D0
(en)
*
|
1992-06-05 |
1992-07-15 |
Buchard Ole |
Uses of nucleic acid analogues
|
|
DE69316369D1
(en)
*
|
1992-07-27 |
1998-02-19 |
Hybridon Inc |
Oligonukleotid alkylphosphonothiate
|
|
ATE316573T1
(de)
|
1992-10-30 |
2006-02-15 |
Gen Hospital Corp |
Wechselwirkendes fallensystem zur isolierung von proteinen
|
|
US5547835A
(en)
|
1993-01-07 |
1996-08-20 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
|
US6194144B1
(en)
*
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
|
US5605798A
(en)
*
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
|
CA2154358A1
(en)
*
|
1993-01-21 |
1994-08-04 |
Hybridon, Inc. |
Integrated oligonucleotides
|
|
US6045996A
(en)
*
|
1993-10-26 |
2000-04-04 |
Affymetrix, Inc. |
Hybridization assays on oligonucleotide arrays
|
|
US6156501A
(en)
|
1993-10-26 |
2000-12-05 |
Affymetrix, Inc. |
Arrays of modified nucleic acid probes and methods of use
|
|
US5849542A
(en)
|
1993-11-17 |
1998-12-15 |
Amersham Pharmacia Biotech Uk Limited |
Primer extension mass spectroscopy nucleic acid sequencing method
|
|
JP3175110B2
(ja)
|
1994-02-07 |
2001-06-11 |
オーキッド・バイオサイエンシーズ・インコーポレイテッド |
リガーゼ／ポリメラーゼ媒体された単一ヌクレオチド多型のジェネティックビットアナリシスおよび遺伝子解析におけるその使用
|
|
US5637684A
(en)
*
|
1994-02-23 |
1997-06-10 |
Isis Pharmaceuticals, Inc. |
Phosphoramidate and phosphorothioamidate oligomeric compounds
|
|
US5851770A
(en)
|
1994-04-25 |
1998-12-22 |
Variagenics, Inc. |
Detection of mismatches by resolvase cleavage using a magnetic bead support
|
|
ATE248224T1
(de)
|
1994-04-25 |
2003-09-15 |
Avitech Diagnostics Inc |
Die bestimmung von mutationen durch spaltung mit resolvase
|
|
US5834189A
(en)
|
1994-07-08 |
1998-11-10 |
Visible Genetics Inc. |
Method for evaluation of polymorphic genetic sequences, and the use thereof in identification of HLA types
|
|
EP0773991B1
(en)
*
|
1994-07-15 |
2004-06-09 |
Cephalon, Inc. |
Active calpain expressed by baculovirus
|
|
US5849483A
(en)
|
1994-07-28 |
1998-12-15 |
Ig Laboratories, Inc. |
High throughput screening method for sequences or genetic alterations in nucleic acids
|
|
US5589330A
(en)
|
1994-07-28 |
1996-12-31 |
Genzyme Corporation |
High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides
|
|
US5662813A
(en)
*
|
1994-10-21 |
1997-09-02 |
Bioseparations, Inc. |
Method for separation of nucleated fetal erythrocytes from maternal blood samples
|
|
US5807718A
(en)
|
1994-12-02 |
1998-09-15 |
The Scripps Research Institute |
Enzymatic DNA molecules
|
|
US6297028B1
(en)
|
1995-01-09 |
2001-10-02 |
Boehringer Ingelheim International Gmbh |
IL-2R-associated polypeptide and DNA molecules coding therefor
|
|
US6239273B1
(en)
*
|
1995-02-27 |
2001-05-29 |
Affymetrix, Inc. |
Printing molecular library arrays
|
|
DE19515552A1
(de)
|
1995-04-27 |
1996-10-31 |
Europ Lab Molekularbiolog |
Simultane Sequenzierung von Nukleinsäuren
|
|
US5955599A
(en)
|
1995-06-01 |
1999-09-21 |
Hybridon, Inc. |
Process for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkages
|
|
US6140482A
(en)
|
1995-06-01 |
2000-10-31 |
Hybridon, Inc. |
Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same
|
|
US5614622A
(en)
*
|
1995-06-01 |
1997-03-25 |
Hybridon, Inc. |
5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
|
|
US5962674A
(en)
|
1995-06-01 |
1999-10-05 |
Hybridon, Inc. |
Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
|
|
US5981186A
(en)
|
1995-06-30 |
1999-11-09 |
Visible Genetics, Inc. |
Method and apparatus for DNA-sequencing using reduced number of sequencing mixtures
|
|
US5637683A
(en)
*
|
1995-07-13 |
1997-06-10 |
Cornell Research Foundation, Inc. |
Nucleic acid analog with amide linkage and method of making that analog
|
|
US5652356A
(en)
*
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
|
JP3193301B2
(ja)
*
|
1995-09-14 |
2001-07-30 |
麒麟麦酒株式会社 |
生理活性タンパク質ｐ１６０
|
|
US5869242A
(en)
*
|
1995-09-18 |
1999-02-09 |
Myriad Genetics, Inc. |
Mass spectrometry to assess DNA sequence polymorphisms
|
|
GB9519638D0
(en)
*
|
1995-09-26 |
1995-11-29 |
Dynal As |
Method
|
|
AU2069597A
(en)
|
1996-03-04 |
1997-09-22 |
Genetrace Systems, Inc. |
Methods of screening nucleic acids using mass spectrometry
|
|
AU2217597A
(en)
|
1996-03-18 |
1997-10-22 |
Sequenom, Inc. |
Dna sequencing by mass spectrometry
|
|
US6759217B2
(en)
|
1996-03-26 |
2004-07-06 |
Oncomedx, Inc. |
Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
|
|
DK0938320T3
(da)
|
1996-03-26 |
2010-10-18 |
Michael S Kopreski |
Metode til at ud af plasma eller serum tilvejebringe ekstraheret ekstracellulært RNA for at detektere, overvåge eller vurdere cancer
|
|
BR9710836A
(pt)
*
|
1996-04-25 |
2000-10-24 |
Spectrametrix Inc |
Ensaio de analitos usando marcas em partìculas
|
|
US5928906A
(en)
*
|
1996-05-09 |
1999-07-27 |
Sequenom, Inc. |
Process for direct sequencing during template amplification
|
|
US5786146A
(en)
*
|
1996-06-03 |
1998-07-28 |
The Johns Hopkins University School Of Medicine |
Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
|
|
AU740238B2
(en)
|
1996-06-14 |
2001-11-01 |
Sarnoff Corporation |
Method for polynucleotide sequencing
|
|
AU4089397A
(en)
|
1996-08-26 |
1998-03-19 |
Hybridon, Inc. |
Improved reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages
|
|
US5849546A
(en)
|
1996-09-13 |
1998-12-15 |
Epicentre Technologies Corporation |
Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
|
|
US5886165A
(en)
*
|
1996-09-24 |
1999-03-23 |
Hybridon, Inc. |
Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
|
|
GB9620209D0
(en)
*
|
1996-09-27 |
1996-11-13 |
Cemu Bioteknik Ab |
Method of sequencing DNA
|
|
US6057134A
(en)
|
1996-10-07 |
2000-05-02 |
Ambion, Inc. |
Modulating the efficiency of nucleic acid amplification reactions with 3' modified oligonucleotides
|
|
US6024925A
(en)
*
|
1997-01-23 |
2000-02-15 |
Sequenom, Inc. |
Systems and methods for preparing low volume analyte array elements
|
|
US6140053A
(en)
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
|
US7285422B1
(en)
|
1997-01-23 |
2007-10-23 |
Sequenom, Inc. |
Systems and methods for preparing and analyzing low volume analyte array elements
|
|
DE69735112T2
(de)
|
1996-11-06 |
2006-09-07 |
Sequenom, Inc., San Diego |
Verfahren zur Analyse und Vorrichtung
|
|
ATE232880T1
(de)
|
1996-11-18 |
2003-03-15 |
Takeshi Imanishi |
Neue nucleotidanaloga
|
|
US6017702A
(en)
*
|
1996-12-05 |
2000-01-25 |
The Perkin-Elmer Corporation |
Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
|
|
US5876934A
(en)
*
|
1996-12-18 |
1999-03-02 |
Pharmacia Biotech Inc. |
DNA sequencing method
|
|
US6046005A
(en)
*
|
1997-01-15 |
2000-04-04 |
Incyte Pharmaceuticals, Inc. |
Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
|
|
US20010051341A1
(en)
|
1997-03-04 |
2001-12-13 |
Isis Innovation Limited |
Non-invasive prenatal diagnosis
|
|
GB9704444D0
(en)
|
1997-03-04 |
1997-04-23 |
Isis Innovation |
Non-invasive prenatal diagnosis
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US5849497A
(en)
|
1997-04-03 |
1998-12-15 |
The Research Foundation Of State University Of New York |
Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker
|
|
US6143496A
(en)
|
1997-04-17 |
2000-11-07 |
Cytonix Corporation |
Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
|
|
US5739314A
(en)
*
|
1997-04-25 |
1998-04-14 |
Hybridon, Inc. |
Method for synthesizing 2'-O-substituted pyrimidine nucleosides
|
|
ES2260837T3
(es)
|
1997-05-30 |
2006-11-01 |
Xenomics |
Procedimiento para detectar secuencias de acidos nucleicos en la orina.
|
|
EP0998697A4
(en)
*
|
1997-07-25 |
2002-07-24 |
Affymetrix Inc |
METHOD AND SYSTEM FOR OBTAINING A CHIP DESIGN DATABASE WITH PROBE SETS
|
|
AU9198298A
(en)
*
|
1997-08-15 |
1999-03-08 |
Affymetrix, Inc. |
Polymorphism detection utilizing clustering analysis
|
|
DE19754482A1
(de)
*
|
1997-11-27 |
1999-07-01 |
Epigenomics Gmbh |
Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
|
|
US5998143A
(en)
|
1997-12-05 |
1999-12-07 |
The Perkin-Elmer Corporation |
Cycle sequencing thermal profiles
|
|
EP1053352B1
(en)
|
1998-02-04 |
2002-09-18 |
Variagenics, Inc. |
Mismatch detection techniques
|
|
SG71920A1
(en)
*
|
1998-04-27 |
2000-04-18 |
Texas Instruments Inc |
Method and apparatus for driving a polyphase brushless dc motor
|
|
US6183958B1
(en)
*
|
1998-05-06 |
2001-02-06 |
Variagenics, Inc. |
Probes for variance detection
|
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
|
US20030022207A1
(en)
*
|
1998-10-16 |
2003-01-30 |
Solexa, Ltd. |
Arrayed polynucleotides and their use in genome analysis
|
|
US6140054A
(en)
|
1998-09-30 |
2000-10-31 |
University Of Utah Research Foundation |
Multiplex genotyping using fluorescent hybridization probes
|
|
US6610492B1
(en)
|
1998-10-01 |
2003-08-26 |
Variagenics, Inc. |
Base-modified nucleotides and cleavage of polynucleotides incorporating them
|
|
NO986133D0
(no)
*
|
1998-12-23 |
1998-12-23 |
Preben Lexow |
FremgangsmÕte for DNA-sekvensering
|
|
US6136541A
(en)
|
1999-02-22 |
2000-10-24 |
Vialogy Corporation |
Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
|
|
US6142681A
(en)
|
1999-02-22 |
2000-11-07 |
Vialogy Corporation |
Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
|
|
AU3418800A
(en)
|
1999-03-24 |
2000-10-09 |
Exiqon A/S |
Improved synthesis of (2.2.1)bicyclo nucleosides
|
|
US6368834B1
(en)
*
|
1999-04-06 |
2002-04-09 |
Genome Technologies, Llc |
PCR genome walking with synthetic primer
|
|
IL145607A0
(en)
|
1999-04-30 |
2002-06-30 |
Methexis N V |
Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
|
|
KR20010001577A
(ko)
|
1999-06-07 |
2001-01-05 |
윤종용 |
고분자 광산발생제를 이용한 올리고펩티드 핵산 탐침의 제조방법
|
|
JP2003524738A
(ja)
*
|
1999-06-28 |
2003-08-19 |
カリフォルニア インスティチュート オブ テクノロジー |
微細製作エラストマーバルブおよびポンプシステム
|
|
US6440706B1
(en)
|
1999-08-02 |
2002-08-27 |
Johns Hopkins University |
Digital amplification
|
|
AU6629200A
(en)
|
1999-08-25 |
2001-03-19 |
Philip P Garner |
Alpha-helical peptide nucleic acid alpha-pna
|
|
US20050287592A1
(en)
|
2000-08-29 |
2005-12-29 |
Yeda Research And Development Co. Ltd. |
Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks
|
|
US6274320B1
(en)
|
1999-09-16 |
2001-08-14 |
Curagen Corporation |
Method of sequencing a nucleic acid
|
|
AU7751600A
(en)
|
1999-10-06 |
2001-05-10 |
Amersham Biosciences Corp. |
Method for detecting mutations using arrayed primer extension
|
|
CA2386791A1
(en)
|
1999-10-08 |
2001-04-19 |
Protogene Laboratories, Inc. |
Method and apparatus for performing large numbers of reactions using array assembly
|
|
US6221600B1
(en)
|
1999-10-08 |
2001-04-24 |
Board Of Regents, The University Of Texas System |
Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
|
|
US6297016B1
(en)
|
1999-10-08 |
2001-10-02 |
Applera Corporation |
Template-dependent ligation with PNA-DNA chimeric probes
|
|
US20030190644A1
(en)
|
1999-10-13 |
2003-10-09 |
Andreas Braun |
Methods for generating databases and databases for identifying polymorphic genetic markers
|
|
US6709816B1
(en)
|
1999-10-18 |
2004-03-23 |
Affymetrix, Inc. |
Identification of alleles
|
|
EP1373561B1
(en)
|
2000-06-13 |
2009-02-18 |
The Trustees of Boston University |
Use of mass-matched nucleotides in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
|
|
WO2002018616A1
(en)
|
2000-09-01 |
2002-03-07 |
Hitachi Chemical Co., Ltd. |
Adjusting the efficiency of nucleic acid template amplification by attenuated pcr with template-mimic oligonucleotides
|
|
US6664056B2
(en)
|
2000-10-17 |
2003-12-16 |
The Chinese University Of Hong Kong |
Non-invasive prenatal monitoring
|
|
US6929911B2
(en)
|
2000-11-01 |
2005-08-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for determining genetic affiliation, substructure and gene flow within human populations
|
|
US20060136142A1
(en)
*
|
2000-11-02 |
2006-06-22 |
Kurt Berlin |
Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the DNA
|
|
DE10061348C2
(de)
*
|
2000-12-06 |
2002-10-24 |
Epigenomics Ag |
Verfahren zur Quantifizierung von Cytosin-Methylierungen in komplex amplifizierter genomischer DNA
|
|
EP1229128A1
(en)
*
|
2001-01-31 |
2002-08-07 |
Boehringer Mannheim Gmbh |
New method for genotype determination
|
|
DE10112515B4
(de)
*
|
2001-03-09 |
2004-02-12 |
Epigenomics Ag |
Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
|
|
US20050064406A1
(en)
*
|
2001-04-20 |
2005-03-24 |
Eugene Zabarovsky |
Methods for high throughput genome analysis using restriction site tagged microarrays
|
|
JP2004531271A
(ja)
|
2001-06-22 |
2004-10-14 |
ユニバーシティ オブ ジュネーブ |
染色体不均衡により引き起こされる疾患を検出する方法
|
|
DE10130800B4
(de)
*
|
2001-06-22 |
2005-06-23 |
Epigenomics Ag |
Verfahren zum Nachweis von Cytosin-Methylierung mit hoher Sensitivität
|
|
US20050037388A1
(en)
*
|
2001-06-22 |
2005-02-17 |
University Of Geneva |
Method for detecting diseases caused by chromosomal imbalances
|
|
BR0211155A
(pt)
*
|
2001-07-15 |
2005-02-01 |
Keck Graduate Inst |
Amplificação de fragmentos de ácido nucléico com uso de agentes de corte
|
|
ATE502119T1
(de)
*
|
2001-07-25 |
2011-04-15 |
Oncomedx Inc |
Verfahren zur bewertung pathologischer krankheitszustände unter verwendung extrazellulärer rna
|
|
KR20040028991A
(ko)
*
|
2001-08-20 |
2004-04-03 |
다카라 바이오 가부시키가이샤 |
핵산 증폭 방법
|
|
US6927028B2
(en)
|
2001-08-31 |
2005-08-09 |
Chinese University Of Hong Kong |
Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
|
|
DE10201138B4
(de)
|
2002-01-08 |
2005-03-10 |
Epigenomics Ag |
Verfahren zum Nachweis von Cytosin-Methylierungsmustern durch exponentielle Ligation hybridisierter Sondenoligonukleotide (MLA)
|
|
US20030211522A1
(en)
|
2002-01-18 |
2003-11-13 |
Landes Gregory M. |
Methods for fetal DNA detection and allele quantitation
|
|
WO2003074723A2
(en)
|
2002-03-01 |
2003-09-12 |
Ravgen, Inc. |
Methods for detection of genetic disorders
|
|
US6977162B2
(en)
|
2002-03-01 |
2005-12-20 |
Ravgen, Inc. |
Rapid analysis of variations in a genome
|
|
EP1487999B1
(en)
|
2002-03-15 |
2006-12-27 |
Epigenomics AG |
Discovery and diagnostic methods using 5-methylcytosine dna glycosylase
|
|
US6908755B2
(en)
*
|
2002-03-21 |
2005-06-21 |
Ken-Shwo Dai |
Human megakaryocyte-associated tyrosine kinase (MATK)-related gene variant associated with lung cancers
|
|
AU2003227544A1
(en)
|
2002-03-25 |
2003-10-08 |
Epigenomics Ag |
Method for the analysis of methylation patterns within nucleic acids by means of mass spectrometry
|
|
US7081339B2
(en)
|
2002-04-12 |
2006-07-25 |
Primera Biosystems, Inc. |
Methods for variation detection
|
|
US7442506B2
(en)
|
2002-05-08 |
2008-10-28 |
Ravgen, Inc. |
Methods for detection of genetic disorders
|
|
US20030211483A1
(en)
|
2002-05-09 |
2003-11-13 |
Schroeder Benjamin G. |
Methods for the enrichment of low-abundance polynucleotides
|
|
WO2004013284A2
(en)
|
2002-08-02 |
2004-02-12 |
Tufts University |
A method to assess genomic dna methylation using high-performance liquid chromatography-electospray ionization mass spectrometry
|
|
CN102344960B
(zh)
*
|
2002-09-06 |
2014-06-18 |
波士顿大学信托人 |
基因表达的定量
|
|
EP1613723B1
(en)
*
|
2002-11-27 |
2013-05-15 |
Sequenom, Inc. |
Fragmentation-based methods for sequence variation detection and discovery
|
|
US7235359B2
(en)
|
2003-01-17 |
2007-06-26 |
The Chinese University Of Hong Kong |
Method for diagnosing preeclampsia by detecting hCRH mRNA
|
|
EP1590477B1
(en)
|
2003-01-29 |
2009-07-29 |
454 Corporation |
Methods of amplifying and sequencing nucleic acids
|
|
CA2517017A1
(en)
|
2003-02-28 |
2004-09-16 |
Ravgen, Inc. |
Methods for detection of genetic disorders
|
|
AU2003900944A0
(en)
|
2003-02-28 |
2003-03-13 |
The University Of Queensland |
Cell isolation & enrichment
|
|
AU2004217872B2
(en)
|
2003-03-05 |
2010-03-25 |
Genetic Technologies Limited |
Identification of fetal DNA and fetal cell markers in maternal plasma or serum
|
|
US20050009059A1
(en)
|
2003-05-07 |
2005-01-13 |
Affymetrix, Inc. |
Analysis of methylation status using oligonucleotide arrays
|
|
WO2005010145A2
(en)
*
|
2003-07-05 |
2005-02-03 |
The Johns Hopkins University |
Method and compositions for detection and enumeration of genetic variations
|
|
WO2005012578A1
(en)
|
2003-07-31 |
2005-02-10 |
Sequenom, Inc. |
Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms
|
|
WO2005021793A1
(en)
|
2003-08-29 |
2005-03-10 |
Pantarhei Bioscience B.V. |
Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
|
|
WO2005023091A2
(en)
|
2003-09-05 |
2005-03-17 |
The Trustees Of Boston University |
Method for non-invasive prenatal diagnosis
|
|
EP1668154B1
(en)
*
|
2003-09-22 |
2008-11-26 |
Trisogen Biotechnology Limited Partnership |
Methods useful for detecting an alteration in a locus copy number
|
|
CN101985619B
(zh)
|
2003-10-08 |
2014-08-20 |
波士顿大学信托人 |
染色体异常的产前诊断方法
|
|
ATE435301T1
(de)
|
2003-10-16 |
2009-07-15 |
Sequenom Inc |
Nicht invasiver nachweis fötaler genetischer merkmale
|
|
JP4917891B2
(ja)
|
2003-10-21 |
2012-04-18 |
オリオン ゲノミクス エルエルシー |
差次的酵素的断片化の方法
|
|
EP1678329A4
(en)
|
2003-10-30 |
2008-07-02 |
Tufts New England Medical Ct |
PRENATAL DIAGNOSIS USING CELL-FREE FEDERAL DNA IN FRUIT WATER
|
|
US20070111233A1
(en)
*
|
2003-10-30 |
2007-05-17 |
Bianchi Diana W |
Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
|
|
US7709262B2
(en)
*
|
2004-02-18 |
2010-05-04 |
Trustees Of Boston University |
Method for detecting and quantifying rare mutations/polymorphisms
|
|
US20100216153A1
(en)
|
2004-02-27 |
2010-08-26 |
Helicos Biosciences Corporation |
Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
|
|
JP4492156B2
(ja)
|
2004-03-03 |
2010-06-30 |
ニプロ株式会社 |
血清アルブミンドメインを含む蛋白質
|
|
AU2005230936B2
(en)
|
2004-03-26 |
2010-08-05 |
Agena Bioscience, Inc. |
Base specific cleavage of methylation-specific amplification products in combination with mass analysis
|
|
US7608394B2
(en)
|
2004-03-26 |
2009-10-27 |
Sequenom, Inc. |
Methods and compositions for phenotype identification based on nucleic acid methylation
|
|
US7468249B2
(en)
|
2004-05-05 |
2008-12-23 |
Biocept, Inc. |
Detection of chromosomal disorders
|
|
ATE449168T1
(de)
|
2004-06-01 |
2009-12-15 |
Univ North Carolina |
Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür
|
|
US7709194B2
(en)
|
2004-06-04 |
2010-05-04 |
The Chinese University Of Hong Kong |
Marker for prenatal diagnosis and monitoring
|
|
EP1794321A2
(en)
|
2004-07-30 |
2007-06-13 |
Whitehead Institute For Biomedical Research |
Markers of alterations in the y chromosome and uses therefor
|
|
US20060094039A1
(en)
*
|
2004-09-20 |
2006-05-04 |
Ron Rosenfeld |
Diagnosis of fetal aneuploidy
|
|
US7415644B2
(en)
|
2004-10-22 |
2008-08-19 |
International Business Machines Corporation |
Self-repairing of microprocessor array structures
|
|
ATE443161T1
(de)
|
2004-11-29 |
2009-10-15 |
Univ Regensburg Klinikum |
Mittel und verfahren für den nachweis von methylierter dna
|
|
AU2005308916B2
(en)
|
2004-11-29 |
2011-07-21 |
Sequenom, Inc. |
Kits and methods for detecting methylated DNA
|
|
AU2006224971B2
(en)
|
2005-03-18 |
2009-07-02 |
Boston University |
A method for the detection of chromosomal aneuploidies
|
|
JP5629051B2
(ja)
|
2005-03-18 |
2014-11-19 |
ザ チャイニーズ ユニバーシティー オブ ホンコンＴｈｅ Ｃｈｉｎｅｓｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｈｏｎｇｋｏｎｇ |
出生前診断およびモニタリングのためのマーカー
|
|
US20070048755A1
(en)
*
|
2005-03-22 |
2007-03-01 |
New York University |
Assay for determining the sex of primates
|
|
EP1910574A2
(en)
|
2005-08-02 |
2008-04-16 |
Sequenom, Inc. |
Methods and compositions for disease prognosis based on nucleic acid methylation
|
|
US20070122823A1
(en)
|
2005-09-01 |
2007-05-31 |
Bianchi Diana W |
Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
|
|
LT2385143T
(lt)
|
2006-02-02 |
2016-11-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Neinvazinė vaisiaus genetinė atranka pasitelkiant skaitmeninę analizę
|
|
SI2351858T1
(sl)
|
2006-02-28 |
2015-06-30 |
University Of Louisville Research Foundation Med Center Three, |
Zaznavanje fetalnih kromosomskih nenormalnosti z uporabo tandema polimorfizmov posameznih nukleotidov
|
|
BRPI0709545A2
(pt)
*
|
2006-03-06 |
2011-07-19 |
Univ Columbia |
amplificação especìfica de seqüência de dna fetal de uma mistura de origem fetal-maternal
|
|
WO2007121276A2
(en)
|
2006-04-12 |
2007-10-25 |
Biocept, Inc. |
Enrichment of circulating fetal dna
|
|
US7901884B2
(en)
*
|
2006-05-03 |
2011-03-08 |
The Chinese University Of Hong Kong |
Markers for prenatal diagnosis and monitoring
|
|
US7754428B2
(en)
|
2006-05-03 |
2010-07-13 |
The Chinese University Of Hong Kong |
Fetal methylation markers
|
|
EP2602321B1
(en)
|
2006-05-31 |
2017-08-23 |
Sequenom, Inc. |
Methods and compositions for the extraction and amplification of nucleic acid from a sample
|
|
WO2007147074A2
(en)
*
|
2006-06-14 |
2007-12-21 |
Living Microsystems, Inc. |
Use of highly parallel snp genotyping for fetal diagnosis
|
|
JP2009540802A
(ja)
|
2006-06-16 |
2009-11-26 |
セクエノム， インコーポレイテッド |
サンプルからの核酸を増幅、検出および定量するための方法および組成物
|
|
US7902345B2
(en)
*
|
2006-12-05 |
2011-03-08 |
Sequenom, Inc. |
Detection and quantification of biomolecules using mass spectrometry
|
|
US8133701B2
(en)
|
2006-12-05 |
2012-03-13 |
Sequenom, Inc. |
Detection and quantification of biomolecules using mass spectrometry
|
|
US8262900B2
(en)
*
|
2006-12-14 |
2012-09-11 |
Life Technologies Corporation |
Methods and apparatus for measuring analytes using large scale FET arrays
|
|
WO2008098142A2
(en)
|
2007-02-08 |
2008-08-14 |
Sequenom, Inc. |
Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
|
|
WO2008103761A2
(en)
|
2007-02-20 |
2008-08-28 |
Sequenom, Inc. |
Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
|
|
GB0703996D0
(en)
|
2007-03-01 |
2007-04-11 |
Oxitec Ltd |
Nucleic acid detection
|
|
CN101641452B
(zh)
|
2007-03-26 |
2013-10-23 |
塞昆纳姆股份有限公司 |
限制性核酸内切酶增强的多态序列检测
|
|
WO2008157264A2
(en)
|
2007-06-15 |
2008-12-24 |
Sequenom, Inc. |
Combined methods for the detection of chromosomal aneuploidy
|
|
SI2557520T1
(sl)
*
|
2007-07-23 |
2021-08-31 |
The Chinese University Of Hong Kong, |
Določanje neravnovesja zaporedja nukleinske kisline
|
|
WO2009032779A2
(en)
|
2007-08-29 |
2009-03-12 |
Sequenom, Inc. |
Methods and compositions for the size-specific seperation of nucleic acid from a sample
|
|
ATE549419T1
(de)
|
2007-08-29 |
2012-03-15 |
Sequenom Inc |
Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
|
|
US8748100B2
(en)
|
2007-08-30 |
2014-06-10 |
The Chinese University Of Hong Kong |
Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
|
|
WO2009039507A2
(en)
*
|
2007-09-21 |
2009-03-26 |
Biocept, Inc. |
Identification and isolation of fetal cells and nucleic acid
|
|
KR20100089060A
(ko)
|
2007-10-04 |
2010-08-11 |
할싸이언 몰레큘러 |
전자 현미경으로 핵산 중합체를 시퀀싱하는 방법
|
|
US8455197B2
(en)
*
|
2007-10-04 |
2013-06-04 |
Commonwealth Scientific And Industrial Research Organisation |
Nucleic acid amplification
|
|
US8093063B2
(en)
*
|
2007-11-29 |
2012-01-10 |
Quest Diagnostics Investments Incorporated |
Assay for detecting genetic abnormalities in genomic nucleic acids
|
|
EP3699291B1
(en)
|
2008-01-17 |
2024-08-07 |
Sequenom, Inc. |
Single molecule nucleic acid sequence analysis processes and compositions
|
|
WO2009114543A2
(en)
|
2008-03-11 |
2009-09-17 |
Sequenom, Inc. |
Nucleic acid-based tests for prenatal gender determination
|
|
AU2009228312B2
(en)
|
2008-03-26 |
2015-05-21 |
Sequenom, Inc. |
Restriction endonuclease enhanced polymorphic sequence detection
|
|
US20110229877A1
(en)
|
2008-07-07 |
2011-09-22 |
Oxford Nanopore Technologies Limited |
Enzyme-pore constructs
|
|
CN102171565B
(zh)
|
2008-08-04 |
2015-04-29 |
纳特拉公司 |
等位基因调用和倍性调用的方法
|
|
ES2599967T3
(es)
|
2008-09-16 |
2017-02-06 |
Sequenom, Inc. |
Procedimientos y composiciones para el enriquecimiento basado en metilación de ácido nucleico fetal de una muestra materna útiles para diagnósticos prenatales no invasivos
|
|
US8962247B2
(en)
|
2008-09-16 |
2015-02-24 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
|
US8476013B2
(en)
|
2008-09-16 |
2013-07-02 |
Sequenom, Inc. |
Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
ES2620294T3
(es)
|
2008-09-20 |
2017-06-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
|
|
US20100240054A1
(en)
|
2008-09-22 |
2010-09-23 |
Biocept, Inc. |
Identification and isolation of fetal cells and nucleic acid
|
|
CN102301002A
(zh)
*
|
2008-11-12 |
2011-12-28 |
卡里斯生命科学卢森堡控股有限责任公司 |
使用外来体来确定表现型的方法和系统
|
|
WO2010065470A2
(en)
|
2008-12-01 |
2010-06-10 |
Consumer Genetics, Inc. |
Compositions and methods for detecting background male dna during fetal sex determination
|
|
WO2010107946A2
(en)
|
2009-03-18 |
2010-09-23 |
Sequenom, Inc. |
Use of thermostable endonucleases for generating reporter molecules
|
|
EP3964586A1
(en)
|
2009-04-03 |
2022-03-09 |
Sequenom, Inc. |
Nucleic acid preparation compositions and methods
|
|
US8211735B2
(en)
*
|
2009-06-08 |
2012-07-03 |
International Business Machines Corporation |
Nano/microwire solar cell fabricated by nano/microsphere lithography
|
|
US8563242B2
(en)
|
2009-08-11 |
2013-10-22 |
The Chinese University Of Hong Kong |
Method for detecting chromosomal aneuploidy
|
|
AU2015252141A1
(en)
|
2009-09-16 |
2015-12-03 |
Sequenom Center For Molecular Medicine |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
|
CN102770558B
(zh)
|
2009-11-05 |
2016-04-06 |
香港中文大学 |
由母本生物样品进行胎儿基因组的分析
|
|
EA034241B1
(ru)
|
2009-11-06 |
2020-01-21 |
Те Чайниз Юниверсити Ов Гонконг |
Способ пренатальной диагностики дисбаланса последовательности
|
|
EP3660165B1
(en)
|
2009-12-22 |
2023-01-04 |
Sequenom, Inc. |
Processes and kits for identifying aneuploidy
|
|
US8700341B2
(en)
|
2010-01-19 |
2014-04-15 |
Verinata Health, Inc. |
Partition defined detection methods
|
|
CA2786351C
(en)
|
2010-01-19 |
2022-01-25 |
Verinata Health, Inc. |
Method for identifying a fetal aneuploidy of a chromosome of interest
|
|
EP2529032B1
(en)
|
2010-01-26 |
2017-01-25 |
Nipd Genetics Ltd |
Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
|
|
US8940487B2
(en)
|
2010-02-09 |
2015-01-27 |
UmiTaq Bio |
Methods and compositions for universal detection of nucleic acids
|
|
EP2569453B1
(en)
|
2010-05-14 |
2015-12-16 |
Fluidigm Corporation |
Nucleic acid isolation methods
|
|
EP2569447A4
(en)
|
2010-05-14 |
2013-11-27 |
Fluidigm Corp |
ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY
|
|
CA3037126C
(en)
|
2010-05-18 |
2023-09-12 |
Natera, Inc. |
Methods for non-invasive prenatal ploidy calling
|
|
US8603742B2
(en)
|
2010-07-06 |
2013-12-10 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Methods for the diagnosis of fetal disease
|
|
US20120021919A1
(en)
|
2010-07-23 |
2012-01-26 |
Thomas Scholl |
Identification of Differentially Represented Fetal or Maternal Genomic Regions and Uses Thereof
|
|
AU2011348267A1
(en)
|
2010-12-23 |
2013-08-01 |
Sequenom, Inc. |
Fetal genetic variation detection
|
|
WO2012118745A1
(en)
|
2011-02-28 |
2012-09-07 |
Arnold Oliphant |
Assay systems for detection of aneuploidy and sex determination
|
|
EP2702168B1
(en)
|
2011-04-29 |
2018-01-17 |
Sequenom, Inc. |
Quantification of a minority nucleic acid species
|
|
US9139874B2
(en)
|
2011-07-07 |
2015-09-22 |
Life Technologies Corporation |
Bi-directional sequencing compositions and methods
|
|
DK2764459T3
(da)
|
2011-10-06 |
2021-08-23 |
Sequenom Inc |
Fremgangsmåder og processer til ikke-invasiv bedømmelse af genetiske variationer
|
|
US9367663B2
(en)
|
2011-10-06 |
2016-06-14 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
EP3243908B1
(en)
|
2011-10-11 |
2019-01-02 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
EP3757210B1
(en)
|
2012-03-02 |
2022-08-24 |
Sequenom, Inc. |
Methods for enriching cancer nucleic acid from a biological sample
|
|
US9920361B2
(en)
|
2012-05-21 |
2018-03-20 |
Sequenom, Inc. |
Methods and compositions for analyzing nucleic acid
|
|
WO2013176958A1
(en)
|
2012-05-21 |
2013-11-28 |
Sequenom, Inc. |
Methods and compositions for analyzing nucleic acid
|
|
CA2874195C
(en)
|
2012-05-21 |
2020-08-25 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
WO2014011928A1
(en)
|
2012-07-13 |
2014-01-16 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
US11060145B2
(en)
|
2013-03-13 |
2021-07-13 |
Sequenom, Inc. |
Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus
|
|
US11365447B2
(en)
|
2014-03-13 |
2022-06-21 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
CN106544407B
(zh)
|
2015-09-18 |
2019-11-08 |
广州华大基因医学检验所有限公司 |
确定受体cfDNA样本中供体来源cfDNA比例的方法
|
|
JP6447765B1
(ja)
|
2017-11-21 |
2019-01-09 |
株式会社リコー |
検査デバイス及びデバイス
|