JP2014516931A5 - - Google Patents
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- Publication number
- JP2014516931A5 JP2014516931A5 JP2014505372A JP2014505372A JP2014516931A5 JP 2014516931 A5 JP2014516931 A5 JP 2014516931A5 JP 2014505372 A JP2014505372 A JP 2014505372A JP 2014505372 A JP2014505372 A JP 2014505372A JP 2014516931 A5 JP2014516931 A5 JP 2014516931A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- halo
- alkylamino
- membered heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000005843 halogen group Chemical group 0.000 claims 30
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 27
- -1 C 1 -C 6 alkoxyl Chemical group 0.000 claims 22
- 125000003118 aryl group Chemical group 0.000 claims 21
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 18
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 16
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 14
- 125000005842 heteroatom Chemical group 0.000 claims 10
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000003386 piperidinyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- BAQLUVXNKOTTHU-UHFFFAOYSA-N metofenazate Chemical compound COC1=C(OC)C(OC)=CC(C(=O)OCCN2CCN(CCCN3C4=CC(Cl)=CC=C4SC4=CC=CC=C43)CC2)=C1 BAQLUVXNKOTTHU-UHFFFAOYSA-N 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000003965 isoxazolidinyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000005310 triazolidinyl group Chemical group N1(NNCC1)* 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474821P | 2011-04-13 | 2011-04-13 | |
| US61/474,821 | 2011-04-13 | ||
| US201161499595P | 2011-06-21 | 2011-06-21 | |
| US61/499,595 | 2011-06-21 | ||
| PCT/US2012/033648 WO2012142504A1 (en) | 2011-04-13 | 2012-04-13 | Aryl-or heteroaryl-substituted benzene compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016050059A Division JP2016147886A (ja) | 2011-04-13 | 2016-03-14 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516931A JP2014516931A (ja) | 2014-07-17 |
| JP2014516931A5 true JP2014516931A5 (enExample) | 2015-06-11 |
| JP5933686B2 JP5933686B2 (ja) | 2016-06-15 |
Family
ID=46045109
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505372A Active JP5933686B2 (ja) | 2011-04-13 | 2012-04-13 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2016050059A Withdrawn JP2016147886A (ja) | 2011-04-13 | 2016-03-14 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2018024505A Active JP6778226B2 (ja) | 2011-04-13 | 2018-02-14 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2018181993A Pending JP2019014732A (ja) | 2011-04-13 | 2018-09-27 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2020197115A Withdrawn JP2021042243A (ja) | 2011-04-13 | 2020-11-27 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2022181039A Pending JP2023011933A (ja) | 2011-04-13 | 2022-11-11 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016050059A Withdrawn JP2016147886A (ja) | 2011-04-13 | 2016-03-14 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2018024505A Active JP6778226B2 (ja) | 2011-04-13 | 2018-02-14 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2018181993A Pending JP2019014732A (ja) | 2011-04-13 | 2018-09-27 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2020197115A Withdrawn JP2021042243A (ja) | 2011-04-13 | 2020-11-27 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
| JP2022181039A Pending JP2023011933A (ja) | 2011-04-13 | 2022-11-11 | アリール置換またはヘテロアリール置換ベンゼン化合物 |
Country Status (35)
Families Citing this family (115)
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