DK3943485T3 - Aryl- eller heteroaryl-substituerede benzenforbindelser - Google Patents
Aryl- eller heteroaryl-substituerede benzenforbindelser Download PDFInfo
- Publication number
- DK3943485T3 DK3943485T3 DK21175920.4T DK21175920T DK3943485T3 DK 3943485 T3 DK3943485 T3 DK 3943485T3 DK 21175920 T DK21175920 T DK 21175920T DK 3943485 T3 DK3943485 T3 DK 3943485T3
- Authority
- DK
- Denmark
- Prior art keywords
- aryl
- substituted benzene
- heteroaryl substituted
- benzene compounds
- compounds
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161474821P | 2011-04-13 | 2011-04-13 | |
US201161499595P | 2011-06-21 | 2011-06-21 | |
EP18200713.8A EP3486234B1 (en) | 2011-04-13 | 2012-04-13 | Aryl- or heteroaryl-substituted benzene compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3943485T3 true DK3943485T3 (da) | 2024-01-22 |
Family
ID=46045109
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18200713.8T DK3486234T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroaryl-substituerede benzenforbindelser |
DK16172386.1T DK3150580T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroarylsubstituerede benzenforbindelser |
DK21175920.4T DK3943485T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroaryl-substituerede benzenforbindelser |
DK12719529.5T DK2697199T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroarylsubstituerede benzenforbindelser |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18200713.8T DK3486234T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroaryl-substituerede benzenforbindelser |
DK16172386.1T DK3150580T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroarylsubstituerede benzenforbindelser |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12719529.5T DK2697199T3 (da) | 2011-04-13 | 2012-04-13 | Aryl- eller heteroarylsubstituerede benzenforbindelser |
Country Status (36)
Country | Link |
---|---|
US (14) | US8410088B2 (da) |
EP (5) | EP3486234B1 (da) |
JP (6) | JP5933686B2 (da) |
KR (7) | KR102032303B1 (da) |
CN (2) | CN107311921B (da) |
AR (1) | AR086008A1 (da) |
AU (1) | AU2012242595B2 (da) |
BR (2) | BR112013026324B1 (da) |
CA (2) | CA2832843C (da) |
CL (1) | CL2013002898A1 (da) |
CY (3) | CY1117986T1 (da) |
DK (4) | DK3486234T3 (da) |
ES (4) | ES2706951T3 (da) |
FI (1) | FI3943485T3 (da) |
HK (1) | HK1193804A1 (da) |
HR (3) | HRP20211297T8 (da) |
HU (4) | HUE042788T2 (da) |
IL (3) | IL228745A (da) |
JO (2) | JO3438B1 (da) |
LT (4) | LT2697199T (da) |
ME (1) | ME02500B (da) |
MX (2) | MX343685B (da) |
MY (1) | MY166171A (da) |
NZ (3) | NZ616298A (da) |
PE (1) | PE20140863A1 (da) |
PH (1) | PH12016502132A1 (da) |
PL (4) | PL2697199T3 (da) |
PT (4) | PT3943485T (da) |
RS (3) | RS58226B1 (da) |
RU (1) | RU2632193C2 (da) |
SG (1) | SG194447A1 (da) |
SI (4) | SI3150580T1 (da) |
SM (1) | SMT201600308B (da) |
TW (1) | TWI529162B (da) |
WO (1) | WO2012142504A1 (da) |
ZA (1) | ZA201307539B (da) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
US9175331B2 (en) * | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
CA3176977A1 (en) | 2010-09-10 | 2012-03-15 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
JP2014534178A (ja) * | 2011-09-30 | 2014-12-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 癌の処置方法 |
WO2013075084A1 (en) | 2011-11-18 | 2013-05-23 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2014124418A1 (en) * | 2013-02-11 | 2014-08-14 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
AU2013216721B2 (en) | 2012-02-10 | 2017-09-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2013138361A1 (en) * | 2012-03-12 | 2013-09-19 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
US10301290B2 (en) * | 2012-04-13 | 2019-05-28 | Epizyme, Inc. | Combination therapy for treating cancer |
IL282732B2 (en) * | 2012-04-13 | 2023-04-01 | Eisai R&D Man Co Ltd | Salt form of human histone methyltransferase inhibitor 2ezh |
US9562041B2 (en) | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
CA2884848C (en) * | 2012-09-28 | 2017-08-22 | Pfizer Inc. | Benzamide and heterobenzamide compounds |
CN110041250A (zh) | 2012-10-15 | 2019-07-23 | Epizyme股份有限公司 | 经取代的苯化合物 |
SI2908823T1 (sl) * | 2012-10-15 | 2019-11-29 | Epizyme Inc | Postopki zdravljenja raka |
AU2013371541B2 (en) * | 2012-12-13 | 2016-10-13 | Glaxosmithkline Llc | Enhancer of Zeste Homolog 2 inhibitors |
US20150313906A1 (en) * | 2012-12-19 | 2015-11-05 | Glaxosmithkline Llc | Combination |
UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
WO2014100646A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone compounds |
CA2894222A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
WO2014153090A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Pyrazole derivatives asprmt1 inhibitors and uses thereof |
EP2970133B1 (en) | 2013-03-14 | 2018-10-24 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
EP2970137A1 (en) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
LT2970132T (lt) | 2013-03-14 | 2021-01-11 | Epizyme, Inc. | Argininmetiltransferazės inhibitoriai ir jų panaudojimas |
US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
WO2014153100A2 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
EP2970135B1 (en) | 2013-03-14 | 2018-07-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
WO2014153235A2 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
WO2014153214A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
JP2016516046A (ja) | 2013-03-14 | 2016-06-02 | ジェネンテック, インコーポレイテッド | がんの治療方法及びがん薬物耐性を阻止する方法 |
WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
US9243001B2 (en) | 2013-03-15 | 2016-01-26 | Epizyme, Inc. | Substituted benzene compounds |
AU2014254392B2 (en) | 2013-03-15 | 2018-05-24 | Epizyme, Inc. | Substituted benzene compounds |
EP2970305B1 (en) | 2013-03-15 | 2017-02-22 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP2991980B1 (en) | 2013-04-30 | 2019-01-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
CA2914414A1 (en) * | 2013-06-06 | 2014-12-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
RU2016104044A (ru) * | 2013-07-10 | 2017-08-15 | Глэксосмитклайн Интеллекчуал Проперти (Nо.2) Лимитед | Ингибиторы усилителя zeste гомолога 2 |
US9624205B2 (en) | 2013-07-19 | 2017-04-18 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
WO2015010049A1 (en) * | 2013-07-19 | 2015-01-22 | Epizyme, Inc. | Substituted benzene compounds |
US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
MA38949A1 (fr) * | 2013-10-16 | 2017-07-31 | Eisai R&D Man Co Ltd | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
WO2015077193A1 (en) | 2013-11-19 | 2015-05-28 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
WO2015077194A1 (en) * | 2013-11-22 | 2015-05-28 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
EA201691079A1 (ru) | 2013-12-06 | 2017-03-31 | Эпизим, Инк. | Комбинированная терапия для лечения онкологического заболевания |
CN105037360B (zh) * | 2014-04-28 | 2016-08-17 | 四川大学 | 吡啶酮衍生物及其制备方法和用途 |
AP2016009605A0 (en) | 2014-06-17 | 2016-12-31 | Pfizer | Substituted dihydroisoquinolinone compounds |
CN106999498B (zh) | 2014-06-17 | 2021-06-08 | Epizyme股份有限公司 | 用于治疗淋巴瘤的ezh2抑制剂 |
US20170217941A1 (en) | 2014-06-25 | 2017-08-03 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
CN106794177A (zh) | 2014-10-16 | 2017-05-31 | Epizyme股份有限公司 | 治疗癌症的方法 |
EP3212639A1 (en) * | 2014-10-28 | 2017-09-06 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
US11236082B2 (en) | 2014-11-06 | 2022-02-01 | Dana-Farber Cancer Institute, Inc. | EZH2 inhibitors and uses thereof |
KR20240035908A (ko) | 2014-11-17 | 2024-03-18 | 에피자임, 인코포레이티드 | 암을 치료하기 위한 방법 |
TW201636344A (zh) | 2014-12-05 | 2016-10-16 | 美國禮來大藥廠 | Ezh2抑制劑 |
CN108135908A (zh) | 2015-04-20 | 2018-06-08 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
MX2017015938A (es) | 2015-06-10 | 2018-11-09 | Epizyme Inc | Inhibidores de ezh2 para el tratar linfomas. |
TW201708210A (zh) * | 2015-06-30 | 2017-03-01 | 葛蘭素史克智慧財產(第二)有限公司 | Zeste同源物2增強子之抑制劑 |
SG10201909199PA (en) | 2015-08-24 | 2019-11-28 | Epizyme Inc | Method for treating cancer |
TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ezh2抑制劑 |
US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
US20190083504A1 (en) * | 2015-10-06 | 2019-03-21 | Epizyme, Inc. | Method of treating medulloblastoma with an ezh2 inhibitor |
WO2017079757A1 (en) * | 2015-11-06 | 2017-05-11 | Epizyme, Inc. | Pediatric dosing for treatment of cancer with an ezh2 inhibitor |
MX2018005019A (es) | 2015-11-19 | 2018-06-13 | Jiangsu Hengrui Medicine Co | Derivado benzofurano, su metodo de preparacion, y sus usos en medicinas. |
CN105440023A (zh) * | 2015-12-10 | 2016-03-30 | 江苏理工学院 | Epz-6438的合成方法 |
TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
WO2017132518A1 (en) | 2016-01-29 | 2017-08-03 | Epizyme, Inc. | Combination therapy for treating cancer |
MX2018011102A (es) | 2016-03-15 | 2019-01-10 | Oryzon Genomics Sa | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. |
WO2017174023A1 (zh) * | 2016-04-08 | 2017-10-12 | 南京明德新药研发股份有限公司 | 作为ezh2抑制剂的联苯化合物 |
US10633371B2 (en) * | 2016-04-22 | 2020-04-28 | Dana-Farber Cancer Institute, Inc. | EZH2 inhibitors and uses thereof |
US10987353B2 (en) | 2016-05-04 | 2021-04-27 | The Wistar Institute Of Anatomy And Biology | Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs |
US10604531B2 (en) | 2016-05-05 | 2020-03-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Enhancer of zeste homolog 2 inhibitors |
EP3464643A4 (en) * | 2016-06-01 | 2020-04-01 | Epizyme Inc | USE OF EZH2 INHIBITORS FOR THE TREATMENT OF CANCER |
US11147819B2 (en) | 2016-06-17 | 2021-10-19 | Epizyme, Inc. | EZH2 inhibitors for treating cancer |
EP3529242A1 (en) | 2016-10-19 | 2019-08-28 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
WO2018102687A2 (en) | 2016-12-02 | 2018-06-07 | Epizyme, Inc. | Combination therapy for treating cancer |
US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
CN108314677B (zh) * | 2017-01-17 | 2020-06-30 | 安徽中科拓苒药物科学研究有限公司 | 一种ezh2抑制剂及其用途 |
AU2018210099A1 (en) * | 2017-01-19 | 2019-08-15 | Daiichi Sankyo Company, Limited | Pharmaceutical composition used for treatment of HTLV-1-associated myelopathy |
CN110191879A (zh) * | 2017-01-25 | 2019-08-30 | 恩瑞生物医药科技(上海)有限公司 | 一种组蛋白甲基转移酶ezh2抑制剂、其制备方法及其医药用途 |
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
WO2018195450A1 (en) * | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
MX2019012967A (es) | 2017-05-18 | 2020-01-20 | Jiangsu Hengrui Medicine Co | Cristal de base libre de derivados benzofurano y metodo de preparacion. |
US11602529B2 (en) | 2017-06-02 | 2023-03-14 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
US20230201212A1 (en) | 2017-06-13 | 2023-06-29 | Epizyme, Inc. | Inhibitors of ezh2 and methods of use thereof |
US11452727B2 (en) | 2017-09-05 | 2022-09-27 | Epizyme, Inc. | Combination therapy for treating cancer |
MX2020004731A (es) | 2017-11-14 | 2020-10-28 | Pfizer | Terapias de combinacion de inhibidor ezh2. |
DK4043466T3 (da) | 2018-01-31 | 2024-09-30 | Mirati Therapeutics Inc | PRC2-inhibitorer |
CN108640842B (zh) * | 2018-04-04 | 2021-06-04 | 大连九信精细化工有限公司 | 一种2-溴-5-氟硝基苯的合成方法 |
MX2020013117A (es) | 2018-06-07 | 2021-02-18 | Merck Sharp & Dohme Llc | Procesos para la preparacion de sugammadex. |
JP2021531340A (ja) | 2018-07-09 | 2021-11-18 | フォンダシヨン、アジール、デ、アブグルスFondation Asile Des Aveugles | 眼障害を治療するためのprc2サブユニットの阻害 |
CA3106589A1 (en) * | 2018-07-27 | 2020-01-30 | Suzhou Sinovent Pharma Co., Ltd. | Polysubstituted benzene compound and preparation method and use thereof |
KR102689665B1 (ko) | 2019-02-19 | 2024-07-31 | 한미약품 주식회사 | 신규한 헤테로트리시클릭 유도체 화합물 및 이의 용도 |
JP7395807B2 (ja) * | 2019-03-25 | 2023-12-12 | 上海華匯拓医薬科技有限公司 | アミド類化合物の調製方法及びその医薬分野の使用 |
CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
CN115551842B (zh) * | 2020-06-08 | 2024-04-23 | 南京明德新药研发有限公司 | 联苯类化合物 |
KR20230088422A (ko) * | 2020-10-13 | 2023-06-19 | 에보포인트 바이오사이언시스 컴퍼니 리미티드 | 다중치환된 벤젠 고리 화합물 말레이트의 결정형, 이의 제조 방법 및 이의 용도 |
CN114907299B (zh) * | 2021-02-08 | 2024-06-25 | 上海医药工业研究院 | 他泽司他关键中间体的盐型、其制备方法及其中间体 |
CN114907300B (zh) * | 2021-02-08 | 2024-05-28 | 上海医药工业研究院 | 他泽司他关键中间体的制备方法及其中间体 |
CN113292489B (zh) * | 2021-06-16 | 2022-08-30 | 泓博智源(开原)药业有限公司 | 二氯代二烷基烟腈的制备方法 |
CN113527275A (zh) * | 2021-07-20 | 2021-10-22 | 成都师范学院 | 一种sklb1039化合物及其制备方法和应用 |
CN113582863B (zh) * | 2021-08-19 | 2023-05-26 | 沈阳农业大学 | 一种氨乙基联苯类化合物及其制备方法和用途 |
KR20230081459A (ko) | 2021-11-30 | 2023-06-07 | 엘젠테라퓨틱스 주식회사 | 헤테로사이클릭이 치환된 신규한 3-페닐피리딘과 4-페닐피리딘 유도체 및 이의 용도 |
WO2023111810A1 (en) | 2021-12-14 | 2023-06-22 | Pfizer Inc. | Combination therapies and uses for treating cancer |
AU2023262308A1 (en) | 2022-04-27 | 2024-10-03 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
WO2023244917A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | 1,8-naphthyridin-2-one heterobifunctional bcl6 degraders |
WO2023244918A1 (en) | 2022-06-13 | 2023-12-21 | Treeline Biosciences, Inc. | Quinolone bcl6 bifunctional degraders |
CN115197202B (zh) * | 2022-07-15 | 2024-01-26 | 四川大学 | 一种ezh2共价抑制剂及其制备方法和应用 |
Family Cites Families (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
JPH0733729A (ja) | 1993-07-26 | 1995-02-03 | Kirin Brewery Co Ltd | N−シアノ−n′−置換−アリールカルボキシイミダミド化合物の製造法 |
AU694465B2 (en) * | 1993-12-27 | 1998-07-23 | Eisai Co. Ltd. | Anthranilic acid derivative |
DE19516776A1 (de) | 1995-05-10 | 1996-11-14 | Boehringer Ingelheim Int | Chromatin-Regulatorgene |
US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
JP3906935B2 (ja) | 1995-12-18 | 2007-04-18 | 杏林製薬株式会社 | N−置換ジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
AU6060099A (en) | 1998-09-30 | 2000-04-17 | Procter & Gamble Company, The | 2-substituted ketoamides |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
PT1357111E (pt) * | 2000-12-28 | 2009-10-20 | Shionogi & Co | Derivados de 2-piridona com afinidade para receptores de canabinóides do tipo 2 |
JP2004528295A (ja) * | 2001-01-30 | 2004-09-16 | サイトピア ピーティワイ リミテッド | キナーゼ阻害方法 |
US7700293B2 (en) | 2001-08-02 | 2010-04-20 | The Regents Of The University Of Michigan | Expression profile of prostate cancer |
US7998986B2 (en) * | 2001-12-21 | 2011-08-16 | Exelixis Patent Company Llc | Modulators of LXR |
JPWO2003070277A1 (ja) | 2002-02-19 | 2005-06-09 | 塩野義製薬株式会社 | 抗掻痒剤 |
TW200306155A (en) | 2002-03-19 | 2003-11-16 | Du Pont | Benzamides and advantageous compositions thereof for use as fungicides |
NZ541110A (en) | 2002-12-27 | 2008-11-28 | Sucampo Ag | Derivatives of prostaglandins for treating abdominal discomfort |
EP2476667B1 (en) | 2003-02-26 | 2014-07-16 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
WO2005014599A1 (en) * | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
US7442685B2 (en) | 2003-06-13 | 2008-10-28 | The University Of North Carolina At Chapel Hill | DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia |
EP1633740B1 (en) | 2003-06-19 | 2011-11-09 | GlaxoSmithKline LLC | 5-(acylamino)indazole derivatives as kinase inhibitors |
WO2005009961A2 (en) * | 2003-07-23 | 2005-02-03 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
DK1663194T3 (da) | 2003-08-26 | 2010-07-19 | Merck Hdac Res Llc | Anvendelse af SAHA til behandling af mesotheliom |
US20050059682A1 (en) | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
DE602005021770D1 (de) | 2004-03-11 | 2010-07-22 | Actelion Pharmaceuticals Ltd | Indol-1-yl-essigsäurederivate |
CN1286973C (zh) | 2004-04-12 | 2006-11-29 | 上海第二医科大学附属瑞金医院 | 一种组蛋白甲基转移酶及其制备方法 |
JP5160885B2 (ja) | 2004-06-01 | 2013-03-13 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 再構成ヒストンメチルトランスフェラーゼ複合体及びそのモジュレーターの識別方法 |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
EP1891434B1 (en) | 2005-06-02 | 2011-01-05 | The University of North Carolina at Chapel Hill | Purification, characterization and reconstitution of a ubiquitin e3 ligase |
FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
PT1940821E (pt) | 2005-10-19 | 2013-05-29 | Gruenenthal Gmbh | Novos ligandos do receptor de vanilóide e seu uso para a produção de medicamentos |
BRPI0617655A2 (pt) | 2005-10-21 | 2016-08-23 | Merck & Co Inc | composto ou um sal farmaceuticamente aceitável do mesmo, ou um isômero óptico do mesmo, uso de um composto, e, formulação farmacêutica |
WO2007053480A2 (en) | 2005-10-28 | 2007-05-10 | The University Of North Carolina At Chapel Hill | Protein demethylases comprising a jmjc domain |
CA2631236C (en) | 2005-12-01 | 2019-10-29 | Medical Prognosis Institute | Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
AU2006325746A1 (en) | 2005-12-14 | 2007-06-21 | Bristol-Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
WO2007087015A1 (en) | 2006-01-20 | 2007-08-02 | The University Of North Carolina At Chapel Hill | Diagnostic and therapeutic targets for leukemia |
JP2009537521A (ja) | 2006-05-15 | 2009-10-29 | アイアールエム・リミテッド・ライアビリティ・カンパニー | テレフタラメート化合物および組成物、ならびにhivインテグラーゼ阻害剤としてのそれらの使用 |
US20070287706A1 (en) | 2006-05-18 | 2007-12-13 | Dickson John K Jr | Certain substituted quinolones, compositions, and uses thereof |
US8022246B2 (en) | 2006-10-10 | 2011-09-20 | The Burnham Institute For Medical Research | Neuroprotective compositions and methods |
US8314087B2 (en) * | 2007-02-16 | 2012-11-20 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and methods of use |
WO2008104077A1 (en) | 2007-02-28 | 2008-09-04 | Methylgene Inc. | Small molecule inhibitors of protein arginine methyltransferases (prmts) |
WO2008109534A1 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting ezh2 gene expression and uses thereof |
WO2008113006A1 (en) | 2007-03-14 | 2008-09-18 | Xenon Pharmaceuticals Inc. | Methods of using quinolinone compounds in treating sodium channel-mediated diseases or conditions |
DE102007017884A1 (de) | 2007-04-13 | 2008-10-16 | Grünethal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
WO2009006577A2 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
ES2457418T3 (es) | 2007-07-16 | 2014-04-25 | Abbvie Inc. | Indazoles, bencisoxazoles y bencisotiazoles como inhibidores de proteína cinasas |
EP2215049B1 (en) * | 2007-10-31 | 2019-06-12 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
EA019974B1 (ru) | 2007-12-19 | 2014-07-30 | Кансер Рисерч Текнолоджи Лимитед | 8-ЗАМЕЩЕННЫЕ ПИРИДО[2,3-b]ПИРАЗИНЫ И ИХ ПРИМЕНЕНИЕ |
EP2235001B1 (en) | 2008-01-23 | 2014-12-24 | Bristol-Myers Squibb Company | Process for preparing pyridinone compounds |
WO2009124137A2 (en) | 2008-04-01 | 2009-10-08 | Mount Sinai School Of Medicine Of New York University | Method of suppressing gene transcription through histone lysine methylation |
US20100113415A1 (en) | 2008-05-29 | 2010-05-06 | Rajapakse Hemaka A | Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer |
UY31982A (es) * | 2008-07-16 | 2010-02-26 | Boehringer Ingelheim Int | Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas |
AU2009279616A1 (en) | 2008-08-08 | 2010-02-11 | New York Blood Center | Small molecule inhibitors of retroviral assembly and maturation |
FR2934995B1 (fr) | 2008-08-14 | 2010-08-27 | Sanofi Aventis | Composes d'azetidines polysubstitues, leur preparation et leur application en therapeutique |
KR20110130504A (ko) * | 2009-03-24 | 2011-12-05 | 사노피 | 9h-피롤로〔2,3-b:5,4-c'〕디피리딘 아자카르볼린 유도체, 그의 제조법, 및 그의 치료 용도 |
EP2411007A4 (en) | 2009-03-27 | 2012-12-05 | Uab Research Foundation | MODULATION OF IRES-MEDIATED TRANSLATION |
WO2011011366A2 (en) | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
EP2521558A4 (en) | 2009-12-30 | 2013-07-03 | Avon Prod Inc | TOPICAL LIGHTING COMPOSITION AND USES THEREOF |
SI2566327T1 (sl) * | 2010-05-07 | 2017-07-31 | Glaxosmithkline Llc | Indoli |
JP5864546B2 (ja) * | 2010-05-07 | 2016-02-17 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | インダゾール |
ES2528269T3 (es) * | 2010-05-07 | 2015-02-06 | Glaxosmithkline Llc | Azaindazoles |
WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
CA3176977A1 (en) | 2010-09-10 | 2012-03-15 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
WO2012068589A2 (en) | 2010-11-19 | 2012-05-24 | Constellation Pharmaceuticals | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2012075080A1 (en) | 2010-12-01 | 2012-06-07 | Glaxosmithkline Llc | Indoles |
WO2012075500A2 (en) | 2010-12-03 | 2012-06-07 | Epizyme, Inc. | 7-deazapurine modulators of histone methyltransferase, and methods of use thereof |
AU2012223448B2 (en) | 2011-02-28 | 2017-03-16 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
JO3438B1 (ar) * | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
JP2014534178A (ja) | 2011-09-30 | 2014-12-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 癌の処置方法 |
WO2013138361A1 (en) | 2012-03-12 | 2013-09-19 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
IL282732B2 (en) | 2012-04-13 | 2023-04-01 | Eisai R&D Man Co Ltd | Salt form of human histone methyltransferase inhibitor 2ezh |
US10301290B2 (en) | 2012-04-13 | 2019-05-28 | Epizyme, Inc. | Combination therapy for treating cancer |
US9562041B2 (en) | 2012-05-16 | 2017-02-07 | Glaxosmithkline Llc | Enhancer of zeste homolog 2 inhibitors |
SI2908823T1 (sl) | 2012-10-15 | 2019-11-29 | Epizyme Inc | Postopki zdravljenja raka |
CN110041250A (zh) | 2012-10-15 | 2019-07-23 | Epizyme股份有限公司 | 经取代的苯化合物 |
-
2011
- 2011-04-13 JO JOP/2018/0104A patent/JO3438B1/ar active
-
2012
- 2012-04-10 JO JOP/2012/0087A patent/JO3363B1/ar active
- 2012-04-12 TW TW101112994A patent/TWI529162B/zh active
- 2012-04-13 NZ NZ616298A patent/NZ616298A/en unknown
- 2012-04-13 BR BR112013026324-5A patent/BR112013026324B1/pt active IP Right Grant
- 2012-04-13 US US13/447,007 patent/US8410088B2/en active Active
- 2012-04-13 AR ARP120101288A patent/AR086008A1/es active IP Right Grant
- 2012-04-13 ES ES16172386T patent/ES2706951T3/es active Active
- 2012-04-13 RU RU2013150345A patent/RU2632193C2/ru active
- 2012-04-13 PT PT211759204T patent/PT3943485T/pt unknown
- 2012-04-13 PL PL12719529.5T patent/PL2697199T3/pl unknown
- 2012-04-13 DK DK18200713.8T patent/DK3486234T3/da active
- 2012-04-13 DK DK16172386.1T patent/DK3150580T3/da active
- 2012-04-13 LT LTEP12719529.5T patent/LT2697199T/lt unknown
- 2012-04-13 PT PT182007138T patent/PT3486234T/pt unknown
- 2012-04-13 LT LTEP18200713.8T patent/LT3486234T/lt unknown
- 2012-04-13 SI SI201231505T patent/SI3150580T1/sl unknown
- 2012-04-13 DK DK21175920.4T patent/DK3943485T3/da active
- 2012-04-13 MY MYPI2013003694A patent/MY166171A/en unknown
- 2012-04-13 CN CN201710425075.8A patent/CN107311921B/zh active Active
- 2012-04-13 ME MEP-2016-175A patent/ME02500B/me unknown
- 2012-04-13 PT PT16172386T patent/PT3150580T/pt unknown
- 2012-04-13 PT PT127195295T patent/PT2697199T/pt unknown
- 2012-04-13 EP EP18200713.8A patent/EP3486234B1/en active Active
- 2012-04-13 KR KR1020197005890A patent/KR102032303B1/ko active IP Right Grant
- 2012-04-13 KR KR1020197029487A patent/KR102154946B1/ko active IP Right Grant
- 2012-04-13 ES ES12719529.5T patent/ES2589555T3/es active Active
- 2012-04-13 JP JP2014505372A patent/JP5933686B2/ja active Active
- 2012-04-13 MX MX2013011921A patent/MX343685B/es active IP Right Grant
- 2012-04-13 PL PL18200713T patent/PL3486234T3/pl unknown
- 2012-04-13 CN CN201280029207.0A patent/CN104080769B/zh active Active
- 2012-04-13 NZ NZ717119A patent/NZ717119A/en unknown
- 2012-04-13 LT LTEP21175920.4T patent/LT3943485T/lt unknown
- 2012-04-13 CA CA2832843A patent/CA2832843C/en active Active
- 2012-04-13 HU HUE16172386A patent/HUE042788T2/hu unknown
- 2012-04-13 NZ NZ734744A patent/NZ734744A/en unknown
- 2012-04-13 ES ES18200713T patent/ES2886099T3/es active Active
- 2012-04-13 RS RS20190065A patent/RS58226B1/sr unknown
- 2012-04-13 ES ES21175920T patent/ES2973868T3/es active Active
- 2012-04-13 PL PL16172386T patent/PL3150580T3/pl unknown
- 2012-04-13 SI SI201230695A patent/SI2697199T1/sl unknown
- 2012-04-13 KR KR1020237027131A patent/KR20230134128A/ko not_active Application Discontinuation
- 2012-04-13 KR KR1020207024969A patent/KR102308488B1/ko active IP Right Grant
- 2012-04-13 PE PE2013002280A patent/PE20140863A1/es active IP Right Grant
- 2012-04-13 KR KR1020187030566A patent/KR101955871B1/ko active IP Right Grant
- 2012-04-13 KR KR1020217030083A patent/KR102566864B1/ko active IP Right Grant
- 2012-04-13 HU HUE21175920A patent/HUE066461T2/hu unknown
- 2012-04-13 AU AU2012242595A patent/AU2012242595B2/en active Active
- 2012-04-13 HR HRP20211297TT patent/HRP20211297T8/hr unknown
- 2012-04-13 EP EP23217912.7A patent/EP4360712A3/en active Pending
- 2012-04-13 HU HUE12719529A patent/HUE028837T2/en unknown
- 2012-04-13 EP EP16172386.1A patent/EP3150580B1/en active Active
- 2012-04-13 WO PCT/US2012/033648 patent/WO2012142504A1/en active Application Filing
- 2012-04-13 DK DK12719529.5T patent/DK2697199T3/da active
- 2012-04-13 PL PL21175920.4T patent/PL3943485T3/pl unknown
- 2012-04-13 BR BR122020006541-9A patent/BR122020006541B1/pt active IP Right Grant
- 2012-04-13 SI SI201231941T patent/SI3486234T1/sl unknown
- 2012-04-13 EP EP12719529.5A patent/EP2697199B1/en active Active
- 2012-04-13 FI FIEP21175920.4T patent/FI3943485T3/fi active
- 2012-04-13 RS RS20160706A patent/RS55113B1/sr unknown
- 2012-04-13 SI SI201232058T patent/SI3943485T1/sl unknown
- 2012-04-13 RS RS20211082A patent/RS62279B1/sr unknown
- 2012-04-13 KR KR1020137029930A patent/KR101914321B1/ko active Application Filing
- 2012-04-13 EP EP21175920.4A patent/EP3943485B1/en active Active
- 2012-04-13 CA CA3086473A patent/CA3086473A1/en active Pending
- 2012-04-13 HU HUE18200713A patent/HUE056552T2/hu unknown
- 2012-04-13 SG SG2013075478A patent/SG194447A1/en unknown
- 2012-04-13 LT LTEP16172386.1T patent/LT3150580T/lt unknown
- 2012-12-20 US US13/722,807 patent/US8765732B2/en active Active
-
2013
- 2013-10-06 IL IL228745A patent/IL228745A/en active IP Right Grant
- 2013-10-09 ZA ZA2013/07539A patent/ZA201307539B/en unknown
- 2013-10-10 CL CL2013002898A patent/CL2013002898A1/es unknown
- 2013-10-11 MX MX2020012695A patent/MX2020012695A/es unknown
-
2014
- 2014-05-12 US US14/275,667 patent/US9090562B2/en active Active
- 2014-07-11 HK HK14107089.1A patent/HK1193804A1/zh unknown
-
2015
- 2015-06-17 US US14/742,481 patent/US9549931B2/en active Active
- 2015-10-06 US US14/876,658 patent/US9522152B2/en active Active
-
2016
- 2016-03-14 JP JP2016050059A patent/JP2016147886A/ja not_active Withdrawn
- 2016-09-01 HR HRP20161115TT patent/HRP20161115T1/hr unknown
- 2016-09-07 CY CY20161100879T patent/CY1117986T1/el unknown
- 2016-09-08 SM SM201600308T patent/SMT201600308B/it unknown
- 2016-10-25 PH PH12016502132A patent/PH12016502132A1/en unknown
- 2016-11-08 US US15/346,677 patent/US10155002B2/en active Active
- 2016-11-29 IL IL249273A patent/IL249273B/en active IP Right Grant
-
2017
- 2017-05-17 US US15/598,078 patent/US9855275B2/en active Active
- 2017-11-17 US US15/816,907 patent/US10420775B2/en active Active
-
2018
- 2018-02-14 JP JP2018024505A patent/JP6778226B2/ja active Active
- 2018-09-27 JP JP2018181993A patent/JP2019014732A/ja active Pending
-
2019
- 2019-01-11 HR HRP20190074TT patent/HRP20190074T1/hr unknown
- 2019-01-14 CY CY191100038T patent/CY1121120T1/el unknown
- 2019-03-04 US US16/291,800 patent/US20190192526A1/en not_active Abandoned
- 2019-05-02 IL IL266418A patent/IL266418A/en active IP Right Grant
- 2019-10-22 US US16/660,339 patent/US11052093B2/en active Active
-
2020
- 2020-11-27 JP JP2020197115A patent/JP2021042243A/ja not_active Withdrawn
-
2021
- 2021-05-05 US US17/308,610 patent/US20210379076A1/en not_active Abandoned
- 2021-08-31 CY CY20211100771T patent/CY1124617T1/el unknown
-
2022
- 2022-11-11 JP JP2022181039A patent/JP2023011933A/ja active Pending
-
2024
- 2024-03-15 US US18/606,903 patent/US20240277723A1/en active Pending
- 2024-03-15 US US18/606,946 patent/US20240245698A1/en active Pending
- 2024-03-15 US US18/606,925 patent/US20240245697A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3943485T3 (da) | Aryl- eller heteroaryl-substituerede benzenforbindelser | |
SMT201600293B (it) | Composti chimici | |
CO7010838A2 (es) | Compuestos de imidazopirrolidinona | |
CO6900145A2 (es) | Compuesto de ciclopropanoamina | |
CO7071137A2 (es) | Compuetos inhibidores de beta-lactamasas | |
BR112013009935C8 (pt) | compostos | |
BR112013003753A2 (pt) | compostos | |
DK2699563T6 (da) | Hidtil ukendte pesticide parazolforbindelser | |
DK2834236T3 (da) | Heterocyclylforbindelser | |
BR112014012016A2 (pt) | compostos | |
DK2648516T3 (da) | Substituerede pyridinon-pyridinylforbindelser | |
CO6910197A2 (es) | Compuestos novedosos | |
CO6990736A2 (es) | Pirrolidina-2-carboxamidas sustituídas | |
DOP2012000224A (es) | Compuesto heterociclico | |
CO6801726A2 (es) | Compuestos | |
DK2649070T3 (da) | Triazolpyridinforbindelser | |
CO6950491A2 (es) | Compuestos plaguicidas | |
DK2804611T3 (da) | Chitosanafledte forbindelser | |
BR112014008067A2 (pt) | compostos antibacterianos | |
BR112013028029A2 (pt) | composto | |
BR112013010643A2 (pt) | compostos heterocíclicos | |
CL2014002034A1 (es) | Compuestos derivados de isoxazol-fenil-azetidina fenil sustituidos; y compuestos intermediarios. | |
BR112014009319A2 (pt) | compostos farmacêuticos | |
BR112012026803A2 (pt) | composto | |
BR112015002923A2 (pt) | compostos antibacterianos. |