JP2010504913A5 - - Google Patents
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- Publication number
- JP2010504913A5 JP2010504913A5 JP2009529277A JP2009529277A JP2010504913A5 JP 2010504913 A5 JP2010504913 A5 JP 2010504913A5 JP 2009529277 A JP2009529277 A JP 2009529277A JP 2009529277 A JP2009529277 A JP 2009529277A JP 2010504913 A5 JP2010504913 A5 JP 2010504913A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- optionally substituted
- aryl
- optionally
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000001424 substituent group Chemical group 0.000 claims 451
- 125000000623 heterocyclic group Chemical group 0.000 claims 75
- 125000003118 aryl group Chemical group 0.000 claims 68
- 125000001072 heteroaryl group Chemical group 0.000 claims 65
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 63
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 63
- 125000003710 aryl alkyl group Chemical group 0.000 claims 62
- 125000000753 cycloalkyl group Chemical group 0.000 claims 62
- 150000001875 compounds Chemical class 0.000 claims 55
- 125000000217 alkyl group Chemical group 0.000 claims 42
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 40
- 125000000547 substituted alkyl group Chemical group 0.000 claims 40
- 125000005843 halogen group Chemical group 0.000 claims 37
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 34
- 125000000304 alkynyl group Chemical group 0.000 claims 29
- 125000005842 heteroatom Chemical group 0.000 claims 26
- 125000003342 alkenyl group Chemical group 0.000 claims 23
- 125000004438 haloalkoxy group Chemical group 0.000 claims 21
- 229910052757 nitrogen Inorganic materials 0.000 claims 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 18
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims 17
- 125000001188 haloalkyl group Chemical group 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- -1 — OR 4 Chemical group 0.000 claims 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 229940002612 prodrug Drugs 0.000 claims 8
- 125000004076 pyridyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 125000002541 furyl group Chemical group 0.000 claims 7
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 7
- 125000002971 oxazolyl group Chemical group 0.000 claims 7
- 125000003226 pyrazolyl group Chemical group 0.000 claims 7
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 7
- 125000001544 thienyl group Chemical group 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 6
- 125000000168 pyrrolyl group Chemical group 0.000 claims 6
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 125000003831 tetrazolyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000003944 tolyl group Chemical group 0.000 claims 3
- 230000005931 immune cell recruitment Effects 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 102000004310 Ion Channels Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000016396 cytokine production Effects 0.000 claims 1
- 125000004212 difluorophenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84732506P | 2006-09-26 | 2006-09-26 | |
| US11/861,278 US8779154B2 (en) | 2006-09-26 | 2007-09-25 | Fused ring compounds for inflammation and immune-related uses |
| PCT/US2007/020864 WO2008039520A2 (en) | 2006-09-26 | 2007-09-26 | Fused ring compounds for inflammation and immune-related uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010504913A JP2010504913A (ja) | 2010-02-18 |
| JP2010504913A5 true JP2010504913A5 (enExample) | 2011-08-18 |
Family
ID=39230829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009529277A Ceased JP2010504913A (ja) | 2006-09-26 | 2007-09-26 | 炎症及び免疫関連使用のための縮合環化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8779154B2 (enExample) |
| EP (1) | EP2086983A4 (enExample) |
| JP (1) | JP2010504913A (enExample) |
| AU (1) | AU2007300450B2 (enExample) |
| CA (1) | CA2664301A1 (enExample) |
| WO (1) | WO2008039520A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4323957B2 (ja) * | 2002-01-22 | 2009-09-02 | バイオマテラ インコーポレイテッド | 生物分解性ポリマーの乾燥方法 |
| JP5221147B2 (ja) * | 2005-01-25 | 2013-06-26 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫に関連する用途に用いる化合物 |
| TW200806292A (en) | 2006-01-25 | 2008-02-01 | Synta Pharmaceuticals Corp | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| WO2007087442A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| EP1983971A4 (en) * | 2006-01-25 | 2010-11-24 | Synta Pharmaceuticals Corp | SUBSTITUTED AROMATIC COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS |
| EP2001476A4 (en) * | 2006-03-20 | 2010-12-22 | Synta Pharmaceuticals Corp | BENZOIMIDAZOLYL-PARAZINE-BASED COMPOUNDS FOR INFLAMMATION USES AND IMMUNE DISORDERS |
| KR101054325B1 (ko) | 2006-03-31 | 2011-08-04 | 얀센 파마슈티카 엔.브이. | 히스타민 ｈ４ 수용체 조절제로서의 벤조이미다졸―２―일 피리미딘 및 피라진 |
| EP2240029A4 (en) * | 2008-01-07 | 2012-08-22 | Synta Pharmaceuticals Corp | COMPOUNDS FOR USE AGAINST INFLAMMATORY AND IMMUNOMIC DISEASES |
| AR071112A1 (es) * | 2008-03-31 | 2010-05-26 | Genentech Inc | Derivados de benzopirano y benzoxepina inhibidores de quinasaspi3k, utiles como agentes anticancer,y composiciones farmaceuticas que los contienen. |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| US8288379B2 (en) * | 2009-04-22 | 2012-10-16 | Boehringer Ingelheim International Gmbh | Thia-triaza-cyclopentazulenes |
| AU2010299820A1 (en) * | 2009-09-28 | 2012-04-19 | F. Hoffmann-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
| PL2483278T3 (pl) | 2009-09-28 | 2014-05-30 | Hoffmann La Roche | Związki benzoksazepinowe stanowiące inhibitor pi3k i ich zastosowanie w leczeniu nowotworu |
| US8993612B2 (en) | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| MX336881B (es) * | 2009-10-29 | 2016-02-04 | Bristol Myers Squibb Co | Compuestos heterociclicos triciclicos. |
| US20120231006A1 (en) | 2009-11-20 | 2012-09-13 | Amgen Inc. | Anti-orai1 antigen binding proteins and uses thereof |
| CA2825966A1 (en) | 2011-03-21 | 2012-09-27 | F. Hoffmann-La Roche Ag | Benzoxazepin compounds selective for pi3k p110 delta and methods of use |
| WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| US9055750B2 (en) | 2012-02-03 | 2015-06-16 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113791A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
| IN2014DN07224A (enExample) | 2012-02-03 | 2015-04-24 | Basf Se | |
| EP2825533B1 (en) | 2012-03-13 | 2016-10-19 | Basf Se | Fungicidal pyrimidine compounds |
| WO2013135672A1 (en) | 2012-03-13 | 2013-09-19 | Basf Se | Fungicidal pyrimidine compounds |
| EP2738172A1 (en) | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
| WO2014118099A1 (en) | 2013-01-30 | 2014-08-07 | Basf Se | Fungicidal naphthoquinones and derivatives |
| HRP20200253T1 (hr) | 2013-03-06 | 2020-05-29 | Janssen Pharmaceutica Nv | Benzoimidazol-2-il pirimidinski modulatori histaminskog h4 receptora |
| EP2848615A1 (en) | 2013-07-03 | 2015-03-18 | Almirall, S.A. | New pyrazole derivatives as CRAC channel modulators |
| EP3507278B1 (en) | 2016-09-02 | 2021-01-27 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
| BR112019019740A2 (pt) | 2017-05-12 | 2020-04-14 | Mavalon Therapeutics Ltd | compostos heterocíclicos substituídos como moduladores alostéricos de receptores de glutamato metabotrópicos de grupo ii |
| WO2019032632A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | ALKYLPHENYL COMPOUNDS |
| US11059784B2 (en) | 2017-08-09 | 2021-07-13 | Bristol-Myers Squibb Company | Oxime ether compounds |
| EP3849552A1 (en) | 2018-09-14 | 2021-07-21 | Rhizen Pharmaceuticals AG | Compositions comprising a crac inhibitor and a corticosteroid and methods of use thereof |
| MX2022008627A (es) | 2020-01-13 | 2022-11-08 | Verge Analytics Inc | Pirazolo-pirimidinas sustituidas y usos de las mismas. |
| CN114621070B (zh) * | 2022-04-02 | 2024-03-19 | 上海陶术生物科技有限公司 | 3,4-二氢萘-1(2h)-酮衍生物的合成方法 |
| WO2025082467A1 (zh) * | 2023-10-19 | 2025-04-24 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
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| DE3131625A1 (de) | 1980-09-16 | 1982-06-09 | VEB Werk für Fernsehelektronik im VEB Kombinat Mikroelektronik, DDR 1160 Berlin | Kristallin-fluessige substanzen des dihydrophenanthrens |
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| JP5221147B2 (ja) | 2005-01-25 | 2013-06-26 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫に関連する用途に用いる化合物 |
| NZ590359A (en) | 2005-01-25 | 2012-08-31 | Synta Pharmaceuticals Corp | Pyrazine compounds for inflammation and immune-related uses |
| WO2007087442A2 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| TWI417096B (zh) | 2006-01-25 | 2013-12-01 | Synta Pharmaceuticals Corp | 用於發炎及免疫相關用途之苯基及吡啶基化合物 |
| CA2639910A1 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| TW200806292A (en) | 2006-01-25 | 2008-02-01 | Synta Pharmaceuticals Corp | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| EP1983971A4 (en) | 2006-01-25 | 2010-11-24 | Synta Pharmaceuticals Corp | SUBSTITUTED AROMATIC COMPOUNDS FOR USE AGAINST INFLAMMATION AND IMMUNE DISORDERS |
| US20070254926A1 (en) | 2006-01-31 | 2007-11-01 | Jun Jiang | Pyridylphenyl compounds for inflammation and immune-related uses |
| EP2001476A4 (en) | 2006-03-20 | 2010-12-22 | Synta Pharmaceuticals Corp | BENZOIMIDAZOLYL-PARAZINE-BASED COMPOUNDS FOR INFLAMMATION USES AND IMMUNE DISORDERS |
| JP2009530409A (ja) | 2006-03-23 | 2009-08-27 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫関連使用用のベンゾイミダゾリル−ピリジン化合物 |
| EP2086326B1 (en) | 2006-11-13 | 2014-01-08 | Synta Pharmaceuticals Corp. | Cyclohexenyl-aryl compounds for inflammation and immune-related uses |
| AU2008219115A1 (en) | 2007-02-16 | 2008-08-28 | Synta Pharmaceuticals Corp. | Substituted fused-ring compounds for inflammation and immune-related uses |
| AU2008282737A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Vinyl-aryl derivatives for inflammation and immune-related uses |
| WO2009017819A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Pyridine compounds for inflammation and immune-related uses |
| CA2695143A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Heterocycle-aryl compounds for inflammation and immune-related uses |
| US8324219B2 (en) | 2007-09-20 | 2012-12-04 | Synta Pharmaceuticals Corp. | Substituted benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
| EP2240029A4 (en) | 2008-01-07 | 2012-08-22 | Synta Pharmaceuticals Corp | COMPOUNDS FOR USE AGAINST INFLAMMATORY AND IMMUNOMIC DISEASES |
-
2007
- 2007-09-25 US US11/861,278 patent/US8779154B2/en not_active Expired - Fee Related
- 2007-09-26 EP EP07861381A patent/EP2086983A4/en not_active Withdrawn
- 2007-09-26 JP JP2009529277A patent/JP2010504913A/ja not_active Ceased
- 2007-09-26 CA CA002664301A patent/CA2664301A1/en not_active Abandoned
- 2007-09-26 WO PCT/US2007/020864 patent/WO2008039520A2/en not_active Ceased
- 2007-09-26 AU AU2007300450A patent/AU2007300450B2/en not_active Ceased
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