JP2014507250A - スクリーニング、診断及び生検のための二重エネルギー及び/又は造影強化乳房撮像のためのシステム及び方法 - Google Patents
スクリーニング、診断及び生検のための二重エネルギー及び/又は造影強化乳房撮像のためのシステム及び方法 Download PDFInfo
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Abstract
【選択図】図1
Description
・2D又は3Dモードにおける、単一の高エネルギー又は低エネルギー画像取得手法を使用する造影撮像(背景除去)。
・2D又は3Dモードにおける、二重エネルギー造影撮像
・3Dモードにおける二重エネルギー造影撮像。この場合、トモシンセシススキャン中に高エネルギー露光及び低エネルギー露光が、異なる角度で生じる[高エネルギー及び低エネルギーは、別個に再構成され、組み合わされて二重エネルギー体積を形成することができる]
・コンボ撮像モード。この場合、単一エネルギー撮像を使用して2D画像データセットが取得され、並びに単一エネルギー画像を使用して3D画像データが取得される
・トモシンセシス撮像モード。この場合、断層撮影スキャンの全体を通して乳房が圧縮されたままで留まる造影断層撮影スキャンにおけるN表示の合計の中で、異なる用途での大きな順応性のために、異なる投影画像が、異なる線量、kVps、mAs及びフィルターに割り当てられる
・一連の取得された投影画像において低エネルギースキャン及び高エネルギースキャンが交互に切り換るトモシンセシスモード
・ユーザーが選択可能なパターンにおける不等な比率で、投影画像のために低エネルギー及び高エネルギースキャンが実行されるトモシンセシスモード
・造影剤を使用し、二重エネルギー又は背景除去撮像のいずれかでの定位生検
・造影剤を使用し、二重エネルギー又は背景除去撮像のいずれかで取得されたトモシンセシススキャン画像を使用する直立生検
画像取得パラメータ選択
注射前及び注射後の投影画像が減算され得、得られた信号は、患者の動作を補正するために画像を登録するようシフトされ得る。
好ましい実施例
参考文献
1. Weider N,Semple JP,Welch WR,Folkman J.著,Tumor angiogenesis and metastasis:correlation in invasive breast carcinoma.New England Journal of Medicine 1991;324:1−8
2. Weidner N著,The importance of tumor angiogenesis;the evidence continues to grow.Am J Clin Pathol.2004年11月:122(5):696−703.
3. Lehman CD,Gatsonis C,Kuhl CKら著,MRI evaluation of the contralateral breast in women with recently diagnosed breast cancer.N Engl J Med 2007;356:1295−1303
4. Lindfors KK,Boone JM,Nelson TR,YangK,Kan AL,Miller DF著,Dedicated breast CT;initial clinical experience.Radiology 2008;246(3):725−733.
5. Prionas ND,Lindfors KK,Ray S,Huang SY,Beckett LA,Monsky WL,Boone JM著,Contrast−enhanced dedicated breast CT:initial clinical experience.Radiology. 2010年9月;256(3)714−23.
6. Chen SC,Carton AK,Albert M,Conant EF,Schnall MD,Maidment AD著,Initial clinical experience with contrast−enhanced digital breast tomosynthesis.Acad Radiol.2007年2月;14(2):229−38.
7. Carton AK,Gavenonis SC,Currivan JA,Conant EF,Schnall MD,Maidment AD著,Dual−energy contrast−enhanced digital breast tomosynthesis−a feasibility study.Br J Radiol.2010年4月;83(988):344−50.
8. Lewin JM,Isaacs PK,Vance V,Larke FJ著;Dual−energy contrast−enhanced digital subtraction mammography:feasibility.Radiology 2003;229:261−268.
9. Jong RA,Yaffe MJ,Skarpathiotakis M,ら著:Contrast−enhanced digital mommography:initaial clinical experience.Radiology 2003;228:842−850.
10. Diekmann F,Diekmann S,Jeunehomme F,ら著:Digital mammography using iodine−based contrast media:initaial clinical experience with dynamic contrast medium enhancement.Invest Radiol 2005;40:397−404.
11. Dromain C,Balleyguier C,Adler G,Garbay JR,Delaloge S著,Contrast−enhanced digital mommography.Eur J Radiol.2009;69:34−42.
12. Dromain C,Diekmann F,Jong RA,ら著:Contrast Enhanced Spectral Mammography:A Multi−reader Study,RSNA 2010,第96回Scientific Assembly and Scientific Meeting.
13. Jochelson M,Sung J,Dershaw DD,Heerdt A著;Bilateral.RSNA 2010,第96回Scientific Assembly and Scientific Meeting.
14. Niklasonら著,Digital tomosynthesisi in breast imaging.Radiology.1997年11月;205(2);399−406.
15. Kopansら著,Will tomosynthesis replace conventional mammography? Plenary Session SFN08:RSNA 2005.
16. Smith A.著,Full−field breast tomosynthesis.Radiol Manage.2005年9月〜10月;27(5):25−31
17. Poplack SP,Tosteson TD,Kogel CA,Nagy HM著.Digital breast tomosynthesis:initial experience in 98 women with abnormal digital screening mammography.AJR Am J Roentgenology.2007年9月;189(3)616−23.
18. Freiherr G.著,Breast tomosynthesis trials show promise.Diagnostic Imaging−San Francisco.2005,V27;N4:42−48.
19. Rafferty E,Niklason LT,Halpern Eら著,Assessing Radiologist Performance Using Combined Full−Field Digital Mammography and Breast Tomosynthesis Versus Full−Field Digital Mammography Alone:Results of a Multi−Center,Multi−Reader Trial,2007年Radiological Society of North America meeting,Chicago,IL.で提示.
20. Berg WA,Blume JD,Cormack JBら著,Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.JAMA 299:2151−2163,2008.
21. ICRP Publication 60:1990 Recommendations of the International Commission on Radiological Protection.
Claims (15)
- 造影強化された患者の乳房のマルチモードX線検査の方法であって、
血管造影剤を患者の乳房に導入することと、
(i)前記患者の乳房の多数の単一エネルギーX線2Dトモシンセシス投影画像と、(ii)前記乳房の低エネルギーX線2Dマンモグラムと、(iii)前記乳房の高エネルギーX線2Dマンモグラムを取得することであって、前記2Dトモシンセシス投影画像及び前記2Dマンモグラムとが、単一の乳房圧縮で撮影される、取得することと、
前記2Dトモシンセシス投影画像を、前記乳房の対応のスライスを表す3Dスライス画像にコンピュータ処理することと、
前記2D低エネルギーマンモグラム及び前記2D高エネルギーマンモグラムをコンピュータ処理して、前記乳房内の血管分布状態を強調表示する加重された組み合わせ2D画像を形成することと、
前記組み合わせ2D画像及び前記3Dスライス画像の1つ以上を表示することと、を含み、
前記表示された組み合わせ2D画像が、疑わしい血管異常の二次元での位置の特定を容易にし、前記3D画像が、前記異常の三次元での位置の特定並びに対応のスライス画像における前記異常の外観の可視化を容易にする、方法。 - 前記表示することが、前記組み合わせ2D画像及び前記3Dスライス画像の少なくとも1つを同時に表示することを含む、請求項1に記載の方法。
- 前記表示することが、前記組み合わせ2D画像及び前記3Dスライス画像の少なくとも1つをミューチュアルレジストレーションで表示することを含む、請求項1に記載の方法。
- 前記表示することが、前記組み合わせ2D画像及び複数の前記3Dスライス画像を同時に表示することを含む、請求項1に記載の方法。
- 前記表示することが、前記組み合わせ2D画像及び前記3Dスライス画像のサブセットを同時に表示することを含み、前記サブセットが、前記異常が出現する3Dスライス画像を含み、前記サブセットが、前記組み合わせ2D画像における前記異常の特定に応答して自動的に選択される、請求項1に記載の方法。
- 造影強化された患者の乳房のマルチモードX線検査の方法であって、
血管造影剤を患者の乳房に導入することと、
(i)前記乳房の対応のスライスを表す前記患者の乳房の3Dスライス画像であり、コンピュータ処理によって、前記患者の乳房の多数の単一エネルギーX線2Dトモシンセシス投影画像に再構成されるものと、(ii)前記乳房の低エネルギーX線2Dマンモグラムと、(iii)前記乳房の高エネルギーX線2Dマンモグラムとを取得することであって、前記2Dトモシンセシス投影画像及び前記2Dマンモグラムが、単一の乳房圧縮で撮影される、取得することと、
前記2D低エネルギーマンモグラム及び前記2D高エネルギーマンモグラムをコンピュータ処理して、前記乳房内の血管分布状態を強調表示する加重された組み合わせ2D画像を形成することと、
前記組み合わせ2D画像及び前記3Dスライス画像の1つ以上を表示することと、を含み、
前記表示された組み合わせ2D画像が、疑わしい血管異常の二次元での位置の特定を容易にし、前記3Dスライス画像が、前記異常の三次元での前記位置の特定並びに対応のスライス画像における前記異常の外観の可視化を容易にする、方法。 - 前記表示することが、前記組み合わせ2D画像及び前記3Dスライス画像の少なくとも1つを同時に表示することを含む、請求項6に記載の方法。
- 前記表示することが、前記組み合わせ2D画像及び前記3Dスライス画像の少なくとも1つをミューチュアルレジストレーションで表示することを含む、請求項6に記載の方法。
- 前記表示することが、前記組み合わせ2D画像及び複数の前記3Dスライス画像を同時に表示することを含む、請求項6に記載の方法。
- 患者の乳房のマルチモードX線検査の方法であって、
前記乳房に対する撮像用X線ビームの対応の角度で撮影された、前記乳房の多数のX線2Dトモシンセシス投影画像を、再構成アルゴリズムによってコンピュータ処理することによって形成された患者の乳房の対応のスライスを表す3Dスライス画像を取得することと、
前記造影剤の存在下で、前記乳房の低エネルギー2DX線マンモグラムと高エネルギー2DX線マンモグラムとの2D組み合わせ画像を取得することと、
前記2D組み合わせ画像と前記3Dスライス画像の1つ以上とをコンピュータディスプレイ上に同時に表示することと、を含み、
前記表示された組み合わせ2D画像が、疑わしい血管異常の二次元での位置の特定を容易にし、前記3Dスライス画像が、前記異常の三次元での前記位置の特定並びに対応のスライス画像における前記異常の外観の可視化を容易にする、方法。 - 前記2Dトモシンセシス投影画像が、単一エネルギー画像である、請求項10に記載の方法。
- 前記組み合わせ2D画像が、高エネルギー及び低エネルギー画像の加重された組み合わせである、請求項10に記載の方法。
- 前記2D投影画像が、二重エネルギー画像である、請求項10に記載の方法。
- 患者の乳房を撮像するためのシステムであって、
患者の乳房をX線で撮像するよう構成され、かつ(i)前記乳房の対応のスライスを表し、前記患者の乳房の多数の単一エネルギーX線2Dトモシンセシス投影画像を、コンピュータ処理することを通して再構成される、前記患者の乳房の3Dスライス画像と、(ii)前記乳房の低エネルギーX線2Dマンモグラムと、(iii)前記乳房の高エネルギーX線2Dマンモグラムとを生成するよう構成されたデータ取得及びコンピュータ処理システムであって、
前記2D低エネルギーマンモグラム及び前記2D高エネルギーマンモグラムを組み合わせて、前記乳房内の血管分布状態を強調表示する組み合わせ2D画像を形成するよう更に構成される前記データ取得及びコンピュータ処理システムと、
前記組み合わせ2D画像と前記3Dスライス画像の1つ以上を選択的に表示するよう構成されたコンピュータディスプレイシステムとを備え、
前記表示された組み合わせ2D画像が、疑わしい血管異常の二次元での位置の特定を容易にし、前記3Dスライス画像が、前記異常の三次元での前記位置の特定並びに対応のスライス画像における前記異常の外観の可視化を容易にする、システム。 - 前記データ取得及びコンピュータ処理システムが、前記3Dスライス画像のサブセットを選択することによって、前記組み合わせ2D画像内の異常の特定に応答するよう更に構成され、このサブセットが、前記特定された異常が出現する前記3Dスライス画像を含み、前記ディスプレイシステムが、前記組み合わせ2D画像及び前記3Dスライス画像のサブセットを同時に表示するよう更に構成される、請求項14に記載のシステム。
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CN110353709A (zh) | 2019-10-22 |
CN103477346A (zh) | 2013-12-25 |
US20150327826A1 (en) | 2015-11-19 |
US9020579B2 (en) | 2015-04-28 |
US20190290221A1 (en) | 2019-09-26 |
JP6057922B2 (ja) | 2017-01-11 |
AU2017202882A1 (en) | 2017-05-18 |
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