JP2013537518A5 - - Google Patents
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- Publication number
- JP2013537518A5 JP2013537518A5 JP2013518814A JP2013518814A JP2013537518A5 JP 2013537518 A5 JP2013537518 A5 JP 2013537518A5 JP 2013518814 A JP2013518814 A JP 2013518814A JP 2013518814 A JP2013518814 A JP 2013518814A JP 2013537518 A5 JP2013537518 A5 JP 2013537518A5
- Authority
- JP
- Japan
- Prior art keywords
- rna
- liposome
- lipid
- motomeko
- liposome according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002502 liposome Substances 0.000 claims description 34
- 150000002632 lipids Chemical class 0.000 claims description 14
- 230000002163 immunogen Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- 230000028993 immune response Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000000232 Lipid Bilayer Substances 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 3
- 241000710929 Alphavirus Species 0.000 claims description 2
- 241000233866 Fungi Species 0.000 claims description 2
- 101000926057 Human herpesvirus 2 (strain G) Envelope glycoprotein C Proteins 0.000 claims description 2
- 108060004795 Methyltransferase Proteins 0.000 claims description 2
- 108700026244 Open Reading Frames Proteins 0.000 claims description 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 244000045947 parasite Species 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 11
- 102100034170 Interferon-induced, double-stranded RNA-activated protein kinase Human genes 0.000 description 3
- 101000926535 Homo sapiens Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 2
- 101710089751 Interferon-induced, double-stranded RNA-activated protein kinase Proteins 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101710196290 Eukaryotic translation initiation factor 2-alpha kinase 2 Proteins 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36183010P | 2010-07-06 | 2010-07-06 | |
| US61/361,830 | 2010-07-06 | ||
| US37883710P | 2010-08-31 | 2010-08-31 | |
| US61/378,837 | 2010-08-31 | ||
| PCT/US2011/043105 WO2012006378A1 (en) | 2010-07-06 | 2011-07-06 | Liposomes with lipids having an advantageous pka- value for rna delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016194747A Division JP2017043626A (ja) | 2010-07-06 | 2016-09-30 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537518A JP2013537518A (ja) | 2013-10-03 |
| JP2013537518A5 true JP2013537518A5 (enExample) | 2014-08-07 |
Family
ID=44534956
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518814A Pending JP2013537518A (ja) | 2010-07-06 | 2011-07-06 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2016194747A Pending JP2017043626A (ja) | 2010-07-06 | 2016-09-30 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2018133133A Pending JP2019006777A (ja) | 2010-07-06 | 2018-07-13 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2020139108A Pending JP2020189881A (ja) | 2010-07-06 | 2020-08-20 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2022168831A Active JP7531561B2 (ja) | 2010-07-06 | 2022-10-21 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2024123187A Pending JP2024153806A (ja) | 2010-07-06 | 2024-07-30 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016194747A Pending JP2017043626A (ja) | 2010-07-06 | 2016-09-30 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2018133133A Pending JP2019006777A (ja) | 2010-07-06 | 2018-07-13 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2020139108A Pending JP2020189881A (ja) | 2010-07-06 | 2020-08-20 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2022168831A Active JP7531561B2 (ja) | 2010-07-06 | 2022-10-21 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| JP2024123187A Pending JP2024153806A (ja) | 2010-07-06 | 2024-07-30 | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
Country Status (19)
| Country | Link |
|---|---|
| US (15) | US20130171241A1 (enExample) |
| EP (1) | EP2590626B1 (enExample) |
| JP (6) | JP2013537518A (enExample) |
| CN (1) | CN103153284B (enExample) |
| AU (1) | AU2011276234B2 (enExample) |
| BR (1) | BR112013000244A2 (enExample) |
| CA (1) | CA2804396C (enExample) |
| DK (1) | DK2590626T3 (enExample) |
| ES (1) | ES2557382T3 (enExample) |
| HR (1) | HRP20151349T1 (enExample) |
| HU (1) | HUE026646T2 (enExample) |
| MX (1) | MX2013000164A (enExample) |
| PL (1) | PL2590626T3 (enExample) |
| PT (1) | PT2590626E (enExample) |
| RS (1) | RS54489B1 (enExample) |
| RU (1) | RU2589503C2 (enExample) |
| SI (1) | SI2590626T1 (enExample) |
| SM (1) | SMT201600007B (enExample) |
| WO (1) | WO2012006378A1 (enExample) |
Families Citing this family (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8530708B2 (en) | 2003-07-25 | 2013-09-10 | Honeywell International Inc. | Processes for selective dehydrohalogenation of halogenated alkanes |
| PL2591114T3 (pl) | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| SI3243526T1 (sl) | 2010-07-06 | 2020-02-28 | Glaxosmithkline Biologicals S.A. | Dostava RNA za sprožitev večih imunskih poti |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| EP2590676B1 (en) | 2010-07-06 | 2016-08-17 | GlaxoSmithKline Biologicals SA | Virion-like delivery particles for self-replicating rna molecules |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| RS63329B1 (sr) | 2010-08-31 | 2022-07-29 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
| DK4008357T3 (da) * | 2010-08-31 | 2023-02-20 | Glaxosmithkline Biologicals Sa | Små liposomer til afgivelse af immunogen-kodende RNA |
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