JP2016185988A5 - - Google Patents
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- JP2016185988A5 JP2016185988A5 JP2016145286A JP2016145286A JP2016185988A5 JP 2016185988 A5 JP2016185988 A5 JP 2016185988A5 JP 2016145286 A JP2016145286 A JP 2016145286A JP 2016145286 A JP2016145286 A JP 2016145286A JP 2016185988 A5 JP2016185988 A5 JP 2016185988A5
- Authority
- JP
- Japan
- Prior art keywords
- cell culture
- vaccine
- dna
- residual
- bpl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000004113 cell culture Methods 0.000 claims 15
- 229960005486 vaccine Drugs 0.000 claims 13
- 238000000034 method Methods 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical group O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 4
- 229940100198 alkylating agent Drugs 0.000 claims 4
- 239000002168 alkylating agent Substances 0.000 claims 4
- 229960000380 propiolactone Drugs 0.000 claims 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 2
- 239000007764 o/w emulsion Substances 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 229940031439 squalene Drugs 0.000 claims 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 2
- 210000002845 virion Anatomy 0.000 claims 2
- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000001818 capillary gel electrophoresis Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73278605P | 2005-11-01 | 2005-11-01 | |
| US60/732,786 | 2005-11-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014149517A Division JP6639077B2 (ja) | 2005-11-01 | 2014-07-23 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016185988A JP2016185988A (ja) | 2016-10-27 |
| JP2016185988A5 true JP2016185988A5 (enExample) | 2017-01-05 |
| JP7049761B2 JP7049761B2 (ja) | 2022-04-07 |
Family
ID=37969762
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538454A Active JP5602366B2 (ja) | 2005-11-01 | 2006-11-01 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
| JP2011206634A Withdrawn JP2011256209A (ja) | 2005-11-01 | 2011-09-21 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
| JP2014149517A Active JP6639077B2 (ja) | 2005-11-01 | 2014-07-23 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
| JP2016145286A Active JP7049761B2 (ja) | 2005-11-01 | 2016-07-25 | β－プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
| JP2019192740A Pending JP2020023557A (ja) | 2005-11-01 | 2019-10-23 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538454A Active JP5602366B2 (ja) | 2005-11-01 | 2006-11-01 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
| JP2011206634A Withdrawn JP2011256209A (ja) | 2005-11-01 | 2011-09-21 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
| JP2014149517A Active JP6639077B2 (ja) | 2005-11-01 | 2014-07-23 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019192740A Pending JP2020023557A (ja) | 2005-11-01 | 2019-10-23 | β−プロピオラクトン処理による低レベルの残存細胞ＤＮＡを含む細胞由来のウイルスワクチン |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10655108B2 (enExample) |
| EP (3) | EP1951296B2 (enExample) |
| JP (5) | JP5602366B2 (enExample) |
| KR (1) | KR20080081254A (enExample) |
| CN (2) | CN101365480B (enExample) |
| AT (1) | ATE494906T1 (enExample) |
| AU (2) | AU2006310171B2 (enExample) |
| CA (1) | CA2627971A1 (enExample) |
| CY (1) | CY1111378T1 (enExample) |
| DE (1) | DE602006019629D1 (enExample) |
| DK (1) | DK1951296T4 (enExample) |
| EA (1) | EA014062B1 (enExample) |
| ES (2) | ES2359214T5 (enExample) |
| HK (1) | HK1207828A1 (enExample) |
| NZ (1) | NZ567817A (enExample) |
| PL (2) | PL1951296T5 (enExample) |
| PT (1) | PT2301572E (enExample) |
| SI (1) | SI1951296T2 (enExample) |
| WO (1) | WO2007052163A2 (enExample) |
Families Citing this family (47)
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| WO2007052163A2 (en) * | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| BR122019013216B8 (pt) | 2006-01-27 | 2021-07-27 | Seqirus Uk Ltd | ensaio imunológico para análise de uma vacina contra influenza |
| EP3456348B1 (en) | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| CN101784283A (zh) * | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| EP2268309B1 (en) | 2008-03-18 | 2015-01-21 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| CA2741961A1 (en) * | 2008-11-05 | 2010-05-14 | Glaxosmithkline Biologicals S.A. | Novel method |
| FR2949344A1 (fr) | 2009-04-27 | 2011-03-04 | Novartis Ag | Vaccins de protection contre la grippe |
| EP2401384B1 (en) | 2009-05-21 | 2012-10-03 | Novartis AG | Reverse genetics using non-endogenous pol i promoters |
| EP2459722B1 (en) | 2009-07-31 | 2017-09-06 | Seqirus UK Limited | Reverse genetics systems |
| IN2012DN03418A (enExample) | 2009-10-09 | 2015-10-23 | Childrens Medical Center | |
| WO2011048560A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Improved reverse genetics methods for virus rescue |
| CN102858961A (zh) | 2010-05-03 | 2013-01-02 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
| CA2796213A1 (en) * | 2010-05-06 | 2011-11-10 | Novartis Ag | Organic peroxide compounds for microorganism inactivation |
| US8945904B2 (en) | 2010-05-21 | 2015-02-03 | Novartis Ag | Influenza virus reassortment |
| KR102113512B1 (ko) | 2010-06-01 | 2020-05-22 | 노파르티스 아게 | 동결건조하지 않는 인플루엔자 백신 항원의 농축 |
| CN102939104A (zh) | 2010-06-01 | 2013-02-20 | 诺华有限公司 | 用冻干浓缩疫苗抗原 |
| CN103052399B (zh) | 2010-08-12 | 2016-06-29 | 依生生物制药控股有限公司 | 用于减少病毒组合物中dna杂质的方法 |
| ES2531577T3 (es) | 2010-08-20 | 2015-03-17 | Novartis Ag | Conjuntos de agujas para la administración de vacuna soluble contra la gripe |
| JP5999817B2 (ja) * | 2011-02-25 | 2016-10-05 | ノバルティス アーゲー | 外因性の内部陽性対照 |
| SG11201401998VA (en) | 2011-11-03 | 2014-05-29 | Sentinext Therapeutics Sdn Bhd | Vaccines directed against human enteroviruses |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| JP6054883B2 (ja) | 2012-03-02 | 2016-12-27 | ノバルティス アーゲー | インフルエンザウイルスの再集合 |
| JP5918870B2 (ja) | 2012-03-06 | 2016-05-18 | クルセル ホランド ベー ヴェー | インフルエンザに対する改善されたワクチン接種 |
| EP2855701A1 (en) | 2012-06-04 | 2015-04-08 | Novartis AG | Improved safety testing |
| CA2893429A1 (en) | 2012-12-03 | 2014-06-12 | Synthetic Genomics Vaccines, Inc. | Influenza virus reassortment |
| MX372963B (es) | 2013-03-13 | 2020-04-01 | Seqirus Uk Ltd | Reordenamiento del virus de influenza b. |
| SG11201509265SA (en) | 2013-05-10 | 2015-12-30 | Novartis Ag | Avoiding narcolepsy risk in influenza vaccines |
| DE202013005130U1 (de) | 2013-06-05 | 2013-09-10 | Novartis Ag | Influenza Virus Reassortierung |
| DE202013005100U1 (de) | 2013-06-05 | 2013-08-26 | Novartis Ag | Influenza Virus Reassortierung |
| CA2914604A1 (en) | 2013-06-06 | 2014-12-11 | Novartis Ag | Influenza virus reassortment |
| US10080792B2 (en) | 2013-09-23 | 2018-09-25 | Engen Bio, Inc. | Influenza vaccine and therapy |
| CN104436157A (zh) | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | 流感疫苗和治疗 |
| CN104513317B (zh) * | 2013-09-30 | 2018-12-14 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
| AU2014350370B2 (en) | 2013-11-15 | 2017-04-13 | Novartis Ag | Removal of residual cell culture impurities |
| JP6774149B2 (ja) * | 2014-05-28 | 2020-10-21 | ナショナル ヘルス リサーチ インスティテューツＮａｔｉｏｎａｌ Ｈｅａｌｔｈ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅｓ | エンテロウイルス感染に対する免疫原としてのウイルス粒子およびその生産 |
| KR20180035807A (ko) | 2015-06-26 | 2018-04-06 | 세퀴러스 유케이 리미티드 | 항원적으로 매치된 인플루엔자 백신 |
| WO2017005880A1 (en) | 2015-07-07 | 2017-01-12 | Seqirus UK Limited | Influenza potency assays |
| EP3184119A1 (en) * | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
| JP7432506B2 (ja) | 2017-10-30 | 2024-02-16 | 武田薬品工業株式会社 | 脂質エンベロープウイルスを不活化するための環境適合性の界面活性剤 |
| CN109652384B (zh) * | 2019-02-21 | 2021-10-26 | 昆明理工大学 | 一种体外培养戊型肝炎病毒的方法 |
| BR112022008711A2 (pt) * | 2019-11-07 | 2022-07-19 | Seqirus Uk Ltd | Métodos para produzir uma vacina viral e reduzir o tamanho da partícula viral |
| IL293031A (en) | 2019-11-18 | 2022-07-01 | Seqirus Pty Ltd | A method for producing reassortant influenza viruses |
| US20240156943A1 (en) * | 2021-03-30 | 2024-05-16 | Denka Company Limited | Influenza vaccine |
| CN115354071A (zh) * | 2022-08-10 | 2022-11-18 | 上海药明生基医药科技有限公司 | 一种检测重组腺相关病毒宿主细胞dna残留的方法 |
| CN116407624B (zh) * | 2023-04-14 | 2024-04-09 | 吉林省农业科学院(中国农业科技东北创新中心) | 一种鸡传染性支气管炎细菌样颗粒疫苗的制备方法和应用 |
| TW202516000A (zh) * | 2023-07-25 | 2025-04-16 | 日商Ｋｍ生物醫藥股份有限公司 | 利用雞蛋培養法進行的去活化流感疫苗的製備方法 |
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| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| WO2007052163A2 (en) * | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| KR101464783B1 (ko) * | 2006-09-15 | 2014-11-26 | 메디뮨 엘엘씨 | 높은 역가로 바이러스 증식을 지원하는 ｍｄｃｋ 세포주 및 이를 이용한 생물반응기 공정 |
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2006
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- 2006-11-01 KR KR1020087013164A patent/KR20080081254A/ko not_active Ceased
- 2006-11-01 CN CN200680046034.8A patent/CN101365480B/zh not_active Expired - Fee Related
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