JP2013515038A5 - - Google Patents
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- Publication number
- JP2013515038A5 JP2013515038A5 JP2012545293A JP2012545293A JP2013515038A5 JP 2013515038 A5 JP2013515038 A5 JP 2013515038A5 JP 2012545293 A JP2012545293 A JP 2012545293A JP 2012545293 A JP2012545293 A JP 2012545293A JP 2013515038 A5 JP2013515038 A5 JP 2013515038A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- chloro
- methoxy
- dihydro
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 40
- 125000001424 substituent group Chemical group 0.000 claims description 38
- 125000000623 heterocyclic group Chemical group 0.000 claims description 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000005842 heteroatoms Chemical group 0.000 claims description 14
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 229910052717 sulfur Inorganic materials 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 9
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 5
- 125000001475 halogen functional group Chemical group 0.000 claims description 4
- ZHCAAFJSYLFLPX-UHFFFAOYSA-N nitrocyclohexatriene Chemical group [O-][N+](=O)C1=CC=C=C[CH]1 ZHCAAFJSYLFLPX-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 20
- 239000011780 sodium chloride Substances 0.000 claims 20
- -1 hydroxy-carbonyl Chemical group 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 16
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 13
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 12
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- QMNUDYFKZYBWQX-UHFFFAOYSA-N Quinazolinone Chemical compound C1=CC=C2C(=O)N=CNC2=C1 QMNUDYFKZYBWQX-UHFFFAOYSA-N 0.000 claims 5
- VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 230000002062 proliferating Effects 0.000 claims 4
- VRHFNFAYNMYVRL-DFUCFPRFSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(O)=O)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)C(O)=O)=CC=C(Cl)C=C1 VRHFNFAYNMYVRL-DFUCFPRFSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- CLRSLRWKONPSRQ-IIPSPAQQSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 CLRSLRWKONPSRQ-IIPSPAQQSA-N 0.000 claims 2
- BZZYIHQWCXHSMZ-FMSKOOSDSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)NCC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)NCC2)=CC=C(Cl)C=C1 BZZYIHQWCXHSMZ-FMSKOOSDSA-N 0.000 claims 2
- QHQFWUOURSTSOD-BXKNEMSHSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)C2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)C2)=CC=C(Cl)C=C1 QHQFWUOURSTSOD-BXKNEMSHSA-N 0.000 claims 2
- VZDNISKFMYZWGF-YFMCWZQFSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 VZDNISKFMYZWGF-YFMCWZQFSA-N 0.000 claims 2
- MTVMVQKGJODTNB-TWCVDLNQSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2N=CC(=NC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)C2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2N=CC(=NC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)C2)=CC=C(Cl)C=C1 MTVMVQKGJODTNB-TWCVDLNQSA-N 0.000 claims 2
- VTLCXFTWJRIHPW-JUPNEIPRSA-N C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=NC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 VTLCXFTWJRIHPW-JUPNEIPRSA-N 0.000 claims 2
- CLRSLRWKONPSRQ-VKGCBGSESA-N C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)C1C1=CC=C(Cl)C=C1 Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C[C@@H]2CC[C@H](CC2)N2CC(=O)N(C)CC2)C1C1=CC=C(Cl)C=C1 CLRSLRWKONPSRQ-VKGCBGSESA-N 0.000 claims 2
- VJKZBIAHWHAYLE-BYIWRISSSA-N C1=CC(C(C)[N-]CC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 Chemical compound C1=CC(C(C)[N-]CC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 VJKZBIAHWHAYLE-BYIWRISSSA-N 0.000 claims 2
- 101700032565 MDM2 Proteins 0.000 claims 2
- 102100019155 MDM2 Human genes 0.000 claims 2
- 108050005300 MDM4 Proteins 0.000 claims 2
- 102000017274 MDM4 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- IXFIHZIZFSCBSU-GYNNIAEXSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 IXFIHZIZFSCBSU-GYNNIAEXSA-N 0.000 claims 2
- NKIPMVCPPOTZLF-TWZRQJNISA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N)CC1 NKIPMVCPPOTZLF-TWZRQJNISA-N 0.000 claims 2
- CUTQVOMRGYKGPV-XPTYZIKRSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(C)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(C)=O)CC1 CUTQVOMRGYKGPV-XPTYZIKRSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001404 mediated Effects 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- FSLIGGSDKPKMAE-HHHXNRCGSA-N (1R)-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 FSLIGGSDKPKMAE-HHHXNRCGSA-N 0.000 claims 1
- ULWYHYVMAQFGPV-MUUNZHRXSA-N (1R)-1-(4-chlorophenyl)-7-cyclobutyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@H]2N(C(=O)CC=3C=C(C(=CC=32)OC2CCC2)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 ULWYHYVMAQFGPV-MUUNZHRXSA-N 0.000 claims 1
- WFSJVHLKSNYJNJ-KWMCUTETSA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(N(C)C)C=C1 WFSJVHLKSNYJNJ-KWMCUTETSA-N 0.000 claims 1
- GYPIVOQVWAXHTL-QKUPIINXSA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(1R)-1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@H](C)C2=CC=C(C=C2)N2[C@@H](C=3C=C(C(=CC=3CC2=O)OC)O[C@H](C)CC)C=2C=CC(Cl)=CC=2)CCC(N(C)C)CC1 GYPIVOQVWAXHTL-QKUPIINXSA-N 0.000 claims 1
- GYPIVOQVWAXHTL-SERWZODPSA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(1S)-1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C)C2=CC=C(C=C2)N2[C@@H](C=3C=C(C(=CC=3CC2=O)OC)O[C@H](C)CC)C=2C=CC(Cl)=CC=2)CCC(N(C)C)CC1 GYPIVOQVWAXHTL-SERWZODPSA-N 0.000 claims 1
- NQEKLQPGKRJSLR-PLTNMMHCSA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)CC1CC1 NQEKLQPGKRJSLR-PLTNMMHCSA-N 0.000 claims 1
- GQUCZUQLQVPONT-XGCWNURASA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-XGCWNURASA-N 0.000 claims 1
- SSACIXCQKGESKK-LDLUVENISA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxoazetidin-1-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N1CCC1=O SSACIXCQKGESKK-LDLUVENISA-N 0.000 claims 1
- RNOXGLRIZIHGIA-DHYKOVJISA-N (1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)CC1=CC=NC=C1 RNOXGLRIZIHGIA-DHYKOVJISA-N 0.000 claims 1
- GQUCZUQLQVPONT-CBZJRKILSA-N (1R)-7-[(2S)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-CBZJRKILSA-N 0.000 claims 1
- BCXOYMISBMICAY-ZNTKNIQHSA-N (1R,3R)-3-amino-N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethylcyclopentane-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)[C@@H]1CC[C@@H](N)C1 BCXOYMISBMICAY-ZNTKNIQHSA-N 0.000 claims 1
- PHQMADNKFUIKQR-NSNZTIKBSA-N (1R,3R)-N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-3-(dimethylamino)-N-ethylcyclopentane-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)[C@@H]1CC[C@@H](N(C)C)C1 PHQMADNKFUIKQR-NSNZTIKBSA-N 0.000 claims 1
- FSLIGGSDKPKMAE-MHZLTWQESA-N (1S)-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)C)=CC=C(Cl)C=C1 FSLIGGSDKPKMAE-MHZLTWQESA-N 0.000 claims 1
- AZTLSCFOQHSCPJ-LJAQVGFWSA-N (1S)-1-(4-chlorophenyl)-2-[4-(imidazol-1-ylmethyl)phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(CN3C=NC=C3)=CC=2)=CC=C(Cl)C=C1 AZTLSCFOQHSCPJ-LJAQVGFWSA-N 0.000 claims 1
- QBSUFBUZLULMMR-NBLPZQPVSA-N (1S)-1-(4-chlorophenyl)-2-[4-[(1R)-1-[4-(2-hydroxyethyl)-2-oxopiperazin-1-yl]ethyl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@@H](C)N2C(CN(CCO)CC2)=O)=CC=C(Cl)C=C1 QBSUFBUZLULMMR-NBLPZQPVSA-N 0.000 claims 1
- QBSUFBUZLULMMR-KATKFWMUSA-N (1S)-1-(4-chlorophenyl)-2-[4-[(1S)-1-[4-(2-hydroxyethyl)-2-oxopiperazin-1-yl]ethyl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(CCO)CC2)=O)=CC=C(Cl)C=C1 QBSUFBUZLULMMR-KATKFWMUSA-N 0.000 claims 1
- YJNAVDANBICIEK-IYXVLPAFSA-N (1S)-1-(4-chlorophenyl)-2-[4-[1-[4-(dimethylamino)piperidin-1-yl]-1-oxopropan-2-yl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C(C)C(=O)N2CCC(CC2)N(C)C)=CC=C(Cl)C=C1 YJNAVDANBICIEK-IYXVLPAFSA-N 0.000 claims 1
- FOWSNFVTTAEKAG-KMXYMDJGSA-N (1S)-1-(4-chlorophenyl)-2-[4-[1-[4-(dimethylamino)piperidin-1-yl]propan-2-yl]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)C(C)CN2CCC(CC2)N(C)C)=CC=C(Cl)C=C1 FOWSNFVTTAEKAG-KMXYMDJGSA-N 0.000 claims 1
- USHZDANZDYMQEF-IAOIYQAASA-N (1S)-1-(4-chlorophenyl)-2-[4-[[3-hydroxy-3-(hydroxymethyl)cyclobutyl]methyl-methylamino]phenyl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2CC(O)(CO)C2)=CC=C(Cl)C=C1 USHZDANZDYMQEF-IAOIYQAASA-N 0.000 claims 1
- RZUHCUIVYJGOIV-RXQDXVOQSA-N (1S)-1-(4-chlorophenyl)-2-[6-[(3-hydroxycyclobutyl)methyl-methylamino]pyridin-3-yl]-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=NC(=CC=2)N(C)CC2CC(O)C2)=CC=C(Cl)C=C1 RZUHCUIVYJGOIV-RXQDXVOQSA-N 0.000 claims 1
- AJYCGDGWEQCZPL-QJWGWKRISA-N (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1R)-1-(2-oxopiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@@H](C)N2C(CNCC2)=O)=CC=C(Cl)C=C1 AJYCGDGWEQCZPL-QJWGWKRISA-N 0.000 claims 1
- LSYZCGXOQBYVHS-WRGVRERRSA-N (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1S)-1-(2-oxo-1,3-diazinan-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(NCCC2)=O)=CC=C(Cl)C=C1 LSYZCGXOQBYVHS-WRGVRERRSA-N 0.000 claims 1
- DQYUFTJKOQNYEW-HUBRWUETSA-N (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[(1S)-1-(2-oxo-4-propan-2-ylpiperazin-1-yl)ethyl]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(CN(CC2)C(C)C)=O)=CC=C(Cl)C=C1 DQYUFTJKOQNYEW-HUBRWUETSA-N 0.000 claims 1
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- FFVFJJBZJBHZIM-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopentylmethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC4CCCC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 FFVFJJBZJBHZIM-UHFFFAOYSA-N 0.000 claims 1
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- LNCPCAOWLSIUHY-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopropylmethoxy)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCC3CC3)C=C2C1C1=CC=C(Cl)C=C1 LNCPCAOWLSIUHY-UHFFFAOYSA-N 0.000 claims 1
- DKUWCMYBWAHUTQ-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(cyclopropylmethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC4CC4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 DKUWCMYBWAHUTQ-UHFFFAOYSA-N 0.000 claims 1
- GISIOMMIMKOXTN-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-(ethylamino)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NCC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 GISIOMMIMKOXTN-UHFFFAOYSA-N 0.000 claims 1
- VVDDORQGXUJPER-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[2-(dimethylamino)ethyl-propan-2-ylamino]-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(CCN(C)C)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 VVDDORQGXUJPER-UHFFFAOYSA-N 0.000 claims 1
- FCBRTBOGTKJWAZ-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCCCN(C)C)C=C2C1C1=CC=C(Cl)C=C1 FCBRTBOGTKJWAZ-UHFFFAOYSA-N 0.000 claims 1
- PNKLLKMWZQIKPN-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[ethyl(propan-2-yl)amino]-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(C(C)C)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 PNKLLKMWZQIKPN-UHFFFAOYSA-N 0.000 claims 1
- JACOXKJSMHWXBW-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-[methyl(propan-2-yl)amino]-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(N(C)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 JACOXKJSMHWXBW-UHFFFAOYSA-N 0.000 claims 1
- ULWYHYVMAQFGPV-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclobutyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC3CCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 ULWYHYVMAQFGPV-UHFFFAOYSA-N 0.000 claims 1
- MHGXKPUYAMKXAI-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclobutyloxy-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC3CCC3)C=C2C1C1=CC=C(Cl)C=C1 MHGXKPUYAMKXAI-UHFFFAOYSA-N 0.000 claims 1
- CYNOADCVDNGVMP-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclohexyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC3CCCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 CYNOADCVDNGVMP-UHFFFAOYSA-N 0.000 claims 1
- DHGQMFQADXESFR-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclopentyloxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OC3CCCC3)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 DHGQMFQADXESFR-UHFFFAOYSA-N 0.000 claims 1
- ZSLWBMUIYALXCF-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-cyclopentyloxy-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC3CCCC3)C=C2C1C1=CC=C(Cl)C=C1 ZSLWBMUIYALXCF-UHFFFAOYSA-N 0.000 claims 1
- AKPFFHYQTZCFGK-UHFFFAOYSA-N 1-(4-chlorophenyl)-7-methoxy-2-(4-methoxyphenyl)-6-(2-morpholin-4-ylethoxy)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OCCN3CCOCC3)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 AKPFFHYQTZCFGK-UHFFFAOYSA-N 0.000 claims 1
- WZUWEYHQEOXAPA-KGUSEGQSSA-N 1-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]piperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(C(N)=O)CC1 WZUWEYHQEOXAPA-KGUSEGQSSA-N 0.000 claims 1
- ZDRUXXFMVAAUQM-QHSQBYJISA-N 1-[2-(aminomethyl)-4-chlorophenyl]-7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)CN)N1C1=CC=C(N(C)C)C=C1 ZDRUXXFMVAAUQM-QHSQBYJISA-N 0.000 claims 1
- ARAFNDUTCGIPIF-HZRSZRRBSA-N 1-[2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)NC1=CC(Cl)=CC=C1C1C2=CC(O[C@H](C)CC)=C(OC)C=C2CC(=O)N1C1=CC=C(N(C)C)C=C1 ARAFNDUTCGIPIF-HZRSZRRBSA-N 0.000 claims 1
- MEMPXHHRCPTSPQ-QHSQBYJISA-N 1-[2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]-3-methylurea Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(=O)NC)N1C1=CC=C(N(C)C)C=C1 MEMPXHHRCPTSPQ-QHSQBYJISA-N 0.000 claims 1
- WGYKJEFTTXDLPM-YFTDMWITSA-N 1-acetyl-N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethylpiperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCN(C(C)=O)CC1 WGYKJEFTTXDLPM-YFTDMWITSA-N 0.000 claims 1
- VSFQSMFEUCRBPB-UHFFFAOYSA-N 2-(1-benzofuran-5-yl)-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=C3C=COC3=CC=2)C1C1=CC=C(Cl)C=C1 VSFQSMFEUCRBPB-UHFFFAOYSA-N 0.000 claims 1
- RWFZJJVATFIDJU-UHFFFAOYSA-N 2-[2-[1-(4-chlorophenyl)-6,7-diethoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-5-methylphenoxy]acetic acid Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC(C)=CC=2)OCC(O)=O)C1C1=CC=C(Cl)C=C1 RWFZJJVATFIDJU-UHFFFAOYSA-N 0.000 claims 1
- FDSGDNWDFWOSKG-UHFFFAOYSA-N 2-[4-(3-amino-5-ethyl-1H-pyrazol-4-yl)phenyl]-1-(4-chlorophenyl)-6-methoxy-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound N1N=C(N)C(C=2C=CC(=CC=2)N2C(CC3=CC(OC)=C(OC(C)C)C=C3C2C=2C=CC(Cl)=CC=2)=O)=C1CC FDSGDNWDFWOSKG-UHFFFAOYSA-N 0.000 claims 1
- KCHWGOINQZGMEL-MMHRDOBHSA-N 2-[4-[(1-acetylpiperidin-4-yl)methyl-methylamino]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C(C)=O)CC1 KCHWGOINQZGMEL-MMHRDOBHSA-N 0.000 claims 1
- NPKXDNQKQFTRBW-JWPKJQAESA-N 2-[4-[(1-butanoylpiperidin-4-yl)methyl-methylamino]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1CN(C(=O)CCC)CCC1CN(C)C1=CC=C(N2C(CC3=CC(OC)=C(O[C@H](C)CC)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=C1 NPKXDNQKQFTRBW-JWPKJQAESA-N 0.000 claims 1
- OXJJQMUURYIRHE-MHJPDIQUSA-N 2-[4-[1-(4-acetylpiperazin-1-yl)ethyl]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCN(C(C)=O)CC1 OXJJQMUURYIRHE-MHJPDIQUSA-N 0.000 claims 1
- GCXCGDIQFCHUMB-XFBJNOSPSA-N 2-[4-[1-[(1-acetylpiperidin-4-yl)amino]ethyl]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)NC1CCN(C(C)=O)CC1 GCXCGDIQFCHUMB-XFBJNOSPSA-N 0.000 claims 1
- FEKNZLNAQTVOJQ-PZYDJRQWSA-N 2-[4-[1-[(3R)-3-aminopyrrolidin-1-yl]ethyl]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](N)C1 FEKNZLNAQTVOJQ-PZYDJRQWSA-N 0.000 claims 1
- HJQCTIJQFOSKJM-KFJXUYOJSA-N 2-[4-[1-[(3S)-3-aminopiperidin-1-yl]ethyl]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](N)C1 HJQCTIJQFOSKJM-KFJXUYOJSA-N 0.000 claims 1
- FEKNZLNAQTVOJQ-PUICROFKSA-N 2-[4-[1-[(3S)-3-aminopyrrolidin-1-yl]ethyl]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](N)C1 FEKNZLNAQTVOJQ-PUICROFKSA-N 0.000 claims 1
- CCBQKDPYECHDEH-KJLUBMIJSA-N 2-[4-[benzyl(methyl)amino]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC=C1 CCBQKDPYECHDEH-KJLUBMIJSA-N 0.000 claims 1
- VXPGOMCNIIPIBX-YCUTZVODSA-N 2-[4-[butan-2-yl(methyl)amino]phenyl]-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C(C)CC)C=C1 VXPGOMCNIIPIBX-YCUTZVODSA-N 0.000 claims 1
- PLYVUCMDEPTIKS-UHFFFAOYSA-N 2-[4-chloro-2-[1-(4-chlorophenyl)-6,7-diethoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenoxy]acetic acid Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCC(O)=O)C1C1=CC=C(Cl)C=C1 PLYVUCMDEPTIKS-UHFFFAOYSA-N 0.000 claims 1
- JEPSLBRGAHBWPO-UHFFFAOYSA-N 2-[5-chloro-2-(2-hydroxyethoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCO)C1C1=CC=C(Cl)C=C1 JEPSLBRGAHBWPO-UHFFFAOYSA-N 0.000 claims 1
- DDSMNBCNXBLKGK-UHFFFAOYSA-N 2-[5-chloro-2-(2-morpholin-4-ylethoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCN2CCOCC2)C1C1=CC=C(Cl)C=C1 DDSMNBCNXBLKGK-UHFFFAOYSA-N 0.000 claims 1
- MLCHJUUBMWHAIQ-UHFFFAOYSA-N 2-[5-chloro-2-(3-hydroxypropoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCCO)C1C1=CC=C(Cl)C=C1 MLCHJUUBMWHAIQ-UHFFFAOYSA-N 0.000 claims 1
- NFHXBIXVQYVNLG-UHFFFAOYSA-N 2-[5-chloro-2-(3-morpholin-4-ylpropoxy)phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCCN2CCOCC2)C1C1=CC=C(Cl)C=C1 NFHXBIXVQYVNLG-UHFFFAOYSA-N 0.000 claims 1
- VJUYFAVJFGAQJI-UHFFFAOYSA-N 2-[5-chloro-2-[2-(dimethylamino)ethoxy]phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCN(C)C)C1C1=CC=C(Cl)C=C1 VJUYFAVJFGAQJI-UHFFFAOYSA-N 0.000 claims 1
- XJIUQTDGTRZXPG-UHFFFAOYSA-N 2-[5-chloro-2-[3-(dimethylamino)propoxy]phenyl]-1-(4-chlorophenyl)-6,7-diethoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C(=CC=C(Cl)C=2)OCCCN(C)C)C1C1=CC=C(Cl)C=C1 XJIUQTDGTRZXPG-UHFFFAOYSA-N 0.000 claims 1
- JRHHGSISIYTFKK-QHSQBYJISA-N 2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chloro-N-methylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)C(=O)NC)N1C1=CC=C(N(C)C)C=C1 JRHHGSISIYTFKK-QHSQBYJISA-N 0.000 claims 1
- YXFUXFRGJVZDGR-WPUOIDIFSA-N 2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorobenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)C(N)=O)N1C1=CC=C(N(C)C)C=C1 YXFUXFRGJVZDGR-WPUOIDIFSA-N 0.000 claims 1
- YCWHCXOQTNXEOQ-HZRSZRRBSA-N 2-[[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-6-yl]oxy]-N,N-dimethylacetamide Chemical compound O=C1CC=2C=C(OCC(=O)N(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 YCWHCXOQTNXEOQ-HZRSZRRBSA-N 0.000 claims 1
- VXURYYOGRCRVAD-QHSQBYJISA-N 2-[[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-6-yl]oxy]-N-methylacetamide Chemical compound O=C1CC=2C=C(OCC(=O)NC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 VXURYYOGRCRVAD-QHSQBYJISA-N 0.000 claims 1
- SKWMRUGTMVZVCU-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-1-ethyl-6,7-dimethoxy-4H-quinazolin-2-one Chemical compound C12=CC(OC)=C(OC)C=C2N(CC)C(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 SKWMRUGTMVZVCU-UHFFFAOYSA-N 0.000 claims 1
- WCBRMAYCVKGXQA-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1,4-dihydroquinazolin-2-one Chemical compound C1=2C=C(OC)C(OC)=CC=2NC(=O)N(C=2C=CC(=CC=2)N(C)C)C1C1=CC=C(Cl)C=C1 WCBRMAYCVKGXQA-UHFFFAOYSA-N 0.000 claims 1
- FJENVYOWUKWINX-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1-methyl-4H-quinazolin-2-one Chemical compound O=C1N(C)C=2C=C(OC)C(OC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 FJENVYOWUKWINX-UHFFFAOYSA-N 0.000 claims 1
- UWRTWDHHFWNXHR-UHFFFAOYSA-N 4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-6,7-dimethoxy-1-propan-2-yl-4H-quinazolin-2-one Chemical compound O=C1N(C(C)C)C=2C=C(OC)C(OC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 UWRTWDHHFWNXHR-UHFFFAOYSA-N 0.000 claims 1
- UXMFFRFGEASXKL-UHFFFAOYSA-N 4-(4-chlorophenyl)-6,7-dimethoxy-3-(4-methoxyphenyl)-1,4-dihydroquinazolin-2-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)NC2=CC(OC)=C(OC)C=C2C1C1=CC=C(Cl)C=C1 UXMFFRFGEASXKL-UHFFFAOYSA-N 0.000 claims 1
- KMDWMNNOGQIKKJ-SONOPUAISA-N 4-[(1R)-7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-ethyl-N-methylbenzamide Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C1=CC=C(C(=O)N(C)CC)C=C1 KMDWMNNOGQIKKJ-SONOPUAISA-N 0.000 claims 1
- XSLLHXSBGFXGQO-GEFUHLBYSA-N 4-[(1S)-1-[4-[(1S)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]morpholin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)[C@H](C)N2C(COCC2)=O)=CC=C(Cl)C=C1 XSLLHXSBGFXGQO-GEFUHLBYSA-N 0.000 claims 1
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- JGOSSRBMKCJJIY-DHFMJDSQSA-N 4-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]morpholin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCOCC1=O JGOSSRBMKCJJIY-DHFMJDSQSA-N 0.000 claims 1
- QOLTZMPOMACYPK-UEWHNOOISA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N,N-diethylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)N(CC)CC)C=C1 QOLTZMPOMACYPK-UEWHNOOISA-N 0.000 claims 1
- TVNIKLNLRXIQTJ-KUFXBUICSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N,N-dimethylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)N(C)C)C=C1 TVNIKLNLRXIQTJ-KUFXBUICSA-N 0.000 claims 1
- KMDWMNNOGQIKKJ-COBFLCELSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-ethyl-N-methylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)N(C)CC)C=C1 KMDWMNNOGQIKKJ-COBFLCELSA-N 0.000 claims 1
- RBLIIYLWBPXMKY-LFDVRYLKSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-methyl-N-pyridin-4-ylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)N(C)C1=CC=NC=C1 RBLIIYLWBPXMKY-LFDVRYLKSA-N 0.000 claims 1
- IUQAKEHMVHKSQK-MOJDWNGGSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-methylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(=O)NC)C=C1 IUQAKEHMVHKSQK-MOJDWNGGSA-N 0.000 claims 1
- SRTLVNYOFHBWLX-DXHYANOHSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-pyridin-3-ylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)NC1=CC=CN=C1 SRTLVNYOFHBWLX-DXHYANOHSA-N 0.000 claims 1
- RNWVPOVKXVXIJL-DXHYANOHSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-pyridin-4-ylbenzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(=O)NC1=CC=NC=C1 RNWVPOVKXVXIJL-DXHYANOHSA-N 0.000 claims 1
- QHMCRBZHTBCHBB-DIERRCTGSA-N 4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]benzamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(N)=O)C=C1 QHMCRBZHTBCHBB-DIERRCTGSA-N 0.000 claims 1
- UGPJKFXFWRTNJI-YAYCPNDQSA-N 4-[[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]-N-methylanilino]methyl]-N,N-dimethylpiperidine-1-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCN(C(=O)N(C)C)CC1 UGPJKFXFWRTNJI-YAYCPNDQSA-N 0.000 claims 1
- DRNGLYHKYPNTEA-UHFFFAOYSA-N 4-azaniumylcyclohexane-1-carboxylate Chemical compound NC1CCC(C(O)=O)CC1 DRNGLYHKYPNTEA-UHFFFAOYSA-N 0.000 claims 1
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- PLFZIENRXZPGRC-SIHBAMTISA-N 6-[(2R)-butan-2-yl]oxy-4-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-7-methoxy-1,4-dihydroquinazolin-2-one Chemical compound O=C1NC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 PLFZIENRXZPGRC-SIHBAMTISA-N 0.000 claims 1
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- VKBFVDLFDUMDJH-ZRTDVJLTSA-N 6-[(2R)-butan-2-yl]oxy-4-(4-chlorophenyl)-7-methoxy-3-(4-methoxyphenyl)-1,4-dihydroquinazolin-2-one Chemical compound O=C1NC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 VKBFVDLFDUMDJH-ZRTDVJLTSA-N 0.000 claims 1
- SPERJNVVAORMFD-UHFFFAOYSA-N 7-(3-aminopropoxy)-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OCCCN)C=C2C1C1=CC=C(Cl)C=C1 SPERJNVVAORMFD-UHFFFAOYSA-N 0.000 claims 1
- VJILSXLNURLYKQ-UHFFFAOYSA-N 7-(4-aminobutan-2-yloxy)-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)CCN)C=C2C1C1=CC=C(Cl)C=C1 VJILSXLNURLYKQ-UHFFFAOYSA-N 0.000 claims 1
- HDRUEURGRSLHGV-UHFFFAOYSA-N 7-(benzylamino)-1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C(N2C(CC3=CC=C(NCC=4C=CC=CC=4)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 HDRUEURGRSLHGV-UHFFFAOYSA-N 0.000 claims 1
- RWPVJYLYROQPGA-UHFFFAOYSA-N 7-(butan-2-ylamino)-1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound C12=CC(NC(C)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 RWPVJYLYROQPGA-UHFFFAOYSA-N 0.000 claims 1
- XANMKHLJUIDKIA-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chloro-2-methylphenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)C)N1C1=CC=C(N(C)C)C=C1 XANMKHLJUIDKIA-COBFLCELSA-N 0.000 claims 1
- WIPMDHIKQIIBRZ-WPUOIDIFSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chloro-3-fluorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(F)C(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 WIPMDHIKQIIBRZ-WPUOIDIFSA-N 0.000 claims 1
- ZDFNGXONWSEQIW-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chloro-3-methylphenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(C)C(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 ZDFNGXONWSEQIW-COBFLCELSA-N 0.000 claims 1
- MZZAHEIEFZBLAM-WPUOIDIFSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chloro-3-nitrophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=C(C(Cl)=CC=2)[N+]([O-])=O)N1C1=CC=C(N(C)C)C=C1 MZZAHEIEFZBLAM-WPUOIDIFSA-N 0.000 claims 1
- UJXGRVKFFJNJHW-WPUOIDIFSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(2,4-dimethoxyphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1OC UJXGRVKFFJNJHW-WPUOIDIFSA-N 0.000 claims 1
- YNACVAVWLRGYTJ-OJQMSQGESA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(2,4-dimethylphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C=C1C YNACVAVWLRGYTJ-OJQMSQGESA-N 0.000 claims 1
- HIYNOZILCATDQE-GJNAARLKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(3,4-dichlorophenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(Cl)C(Cl)=C1 HIYNOZILCATDQE-GJNAARLKSA-N 0.000 claims 1
- LZLWYZVRKPFOMW-WPUOIDIFSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(3,4-dimethoxyphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C(OC)=C1 LZLWYZVRKPFOMW-WPUOIDIFSA-N 0.000 claims 1
- SXOZWLOGBOOJGT-OJQMSQGESA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(3,4-dimethylphenyl)-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C(C)=C1 SXOZWLOGBOOJGT-OJQMSQGESA-N 0.000 claims 1
- LASKDMXYDZITII-UEWHNOOISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-(2-methylpropoxy)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OCC(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 LASKDMXYDZITII-UEWHNOOISA-N 0.000 claims 1
- NQDGYXBFKYQRNB-LWMFVPLKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]-1,4-dihydroisoquinolin-3-one Chemical compound CC[C@@H](C)OC1=CC=2C(C=3C=CC(Cl)=CC=3)N(C=3C=CC(OC)=CC=3)C(=O)CC=2C=C1OCC(=O)N1CCN(C)CC1 NQDGYXBFKYQRNB-LWMFVPLKSA-N 0.000 claims 1
- IZNBOAXCTAKMTE-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 IZNBOAXCTAKMTE-COBFLCELSA-N 0.000 claims 1
- VPRKVRZMYBXTBU-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-(4-methoxyphenyl)-6-propoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(O[C@H](C)CC)C(OCCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(Cl)C=C1 VPRKVRZMYBXTBU-COBFLCELSA-N 0.000 claims 1
- ALFZUDGOPZPEEV-JKTWZELDSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(1-hydroxyethyl)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)O)C=C1 ALFZUDGOPZPEEV-JKTWZELDSA-N 0.000 claims 1
- BZXDBHNFAVZURR-BPNQMYTISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C=1C(C)=NNC=1C BZXDBHNFAVZURR-BPNQMYTISA-N 0.000 claims 1
- MDVVWBPMXFTBHY-UEWHNOOISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(diethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(CC)CC)C=C1 MDVVWBPMXFTBHY-UEWHNOOISA-N 0.000 claims 1
- NQHVYBHGANOBDK-QHSQBYJISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)-2-methoxyphenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1OC NQHVYBHGANOBDK-QHSQBYJISA-N 0.000 claims 1
- YRAPUEIRQLUTOO-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)-2-methylphenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1C YRAPUEIRQLUTOO-COBFLCELSA-N 0.000 claims 1
- WFSJVHLKSNYJNJ-KUFXBUICSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dimethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C)C=C1 WFSJVHLKSNYJNJ-KUFXBUICSA-N 0.000 claims 1
- IBEZDRDXZURKDS-GFTAOQHMSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(dipropylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(N(CCC)CCC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 IBEZDRDXZURKDS-GFTAOQHMSA-N 0.000 claims 1
- YONHVRPOCPIMLH-KUFXBUICSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(ethylamino)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound C1=CC(NCC)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 YONHVRPOCPIMLH-KUFXBUICSA-N 0.000 claims 1
- JJLIBSXLCMDFQN-MOJDWNGGSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-(hydroxymethyl)phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(CO)C=C1 JJLIBSXLCMDFQN-MOJDWNGGSA-N 0.000 claims 1
- UZJSRPMFHLXPHV-VZESWDRUSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(2,3-difluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC(F)=C1F UZJSRPMFHLXPHV-VZESWDRUSA-N 0.000 claims 1
- VMCBHKDWUHBLLH-PVFJFFHYSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(2-fluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC=C1F VMCBHKDWUHBLLH-PVFJFFHYSA-N 0.000 claims 1
- CMPUGZMYMCNDNR-VZESWDRUSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(3,4-difluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=C(F)C(F)=C1 CMPUGZMYMCNDNR-VZESWDRUSA-N 0.000 claims 1
- IIUUWNOYXDCTMQ-PVFJFFHYSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(3-fluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=CC(F)=C1 IIUUWNOYXDCTMQ-PVFJFFHYSA-N 0.000 claims 1
- ZPDDLUSCRIMLHQ-GGPMTTHASA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(3-fluoropyridin-4-yl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=NC=C1F ZPDDLUSCRIMLHQ-GGPMTTHASA-N 0.000 claims 1
- UPIGHRRSNOLMSP-PVFJFFHYSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[(4-fluorophenyl)methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1=CC=C(F)C=C1 UPIGHRRSNOLMSP-PVFJFFHYSA-N 0.000 claims 1
- VJKLOQORULSKFF-KGUSEGQSSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-(4-hydroxypiperidin-1-yl)ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(O)CC1 VJKLOQORULSKFF-KGUSEGQSSA-N 0.000 claims 1
- NZESLGIMRIFPHV-BYIWRISSSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-(dimethylamino)ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(C)C)C=C1 NZESLGIMRIFPHV-BYIWRISSSA-N 0.000 claims 1
- PRNZCVIDSHKDNA-AZMKAGDRSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](N(C)C)C1 PRNZCVIDSHKDNA-AZMKAGDRSA-N 0.000 claims 1
- GYGWNGPTHLLSMO-JRTRQYOMSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3R)-3-hydroxypiperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@@H](O)C1 GYGWNGPTHLLSMO-JRTRQYOMSA-N 0.000 claims 1
- LCOSUZXFINJPCD-FVQHBTCESA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@@H](O)C1 LCOSUZXFINJPCD-FVQHBTCESA-N 0.000 claims 1
- DIXHRXPCUUVAHD-HHCNDGNYSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3S)-3-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](N(C)C)C1 DIXHRXPCUUVAHD-HHCNDGNYSA-N 0.000 claims 1
- PRNZCVIDSHKDNA-JAHCQJHZSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](N(C)C)C1 PRNZCVIDSHKDNA-JAHCQJHZSA-N 0.000 claims 1
- GYGWNGPTHLLSMO-YGAMUSMISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3S)-3-hydroxypiperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC[C@H](O)C1 GYGWNGPTHLLSMO-YGAMUSMISA-N 0.000 claims 1
- LCOSUZXFINJPCD-RQVNELMKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](O)C1 LCOSUZXFINJPCD-RQVNELMKSA-N 0.000 claims 1
- HRXDZOTWDGLFEY-XOBGVXBPSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[2-(dimethylamino)ethylamino]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)NCCN(C)C)C=C1 HRXDZOTWDGLFEY-XOBGVXBPSA-N 0.000 claims 1
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- GYPIVOQVWAXHTL-BKCPDIIESA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[4-(dimethylamino)piperidin-1-yl]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(N(C)C)CC1 GYPIVOQVWAXHTL-BKCPDIIESA-N 0.000 claims 1
- MWSVWRXYPZBKKI-BKCPDIIESA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[1-[ethyl(piperidin-4-yl)amino]ethyl]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C1CCNCC1 MWSVWRXYPZBKKI-BKCPDIIESA-N 0.000 claims 1
- SUPMGGSRFVOUPP-JWPKJQAESA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[1-(cyclobutanecarbonyl)piperidin-4-yl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC(CC1)CCN1C(=O)C1CCC1 SUPMGGSRFVOUPP-JWPKJQAESA-N 0.000 claims 1
- PDKRAXLLYFKWKW-LHTANEHXSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[[1-(cyclopropanecarbonyl)piperidin-4-yl]methyl-methylamino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC(CC1)CCN1C(=O)C1CC1 PDKRAXLLYFKWKW-LHTANEHXSA-N 0.000 claims 1
- HNTSTHIXELQIPD-DXHYANOHSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclobutyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C1CCC1 HNTSTHIXELQIPD-DXHYANOHSA-N 0.000 claims 1
- NEJMSBJUNRLLHK-LWMFVPLKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclohexyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C1CCCCC1 NEJMSBJUNRLLHK-LWMFVPLKSA-N 0.000 claims 1
- RZRBVIFRDBTMPA-KJLUBMIJSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclohexylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCCCC1 RZRBVIFRDBTMPA-KJLUBMIJSA-N 0.000 claims 1
- LIHRLMVZGOPNGV-LFDVRYLKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopentyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C1CCCC1 LIHRLMVZGOPNGV-LFDVRYLKSA-N 0.000 claims 1
- VFFNEZDWIBZNQT-LWMFVPLKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopentylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CCCC1 VFFNEZDWIBZNQT-LWMFVPLKSA-N 0.000 claims 1
- NQEKLQPGKRJSLR-DXHYANOHSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC1CC1 NQEKLQPGKRJSLR-DXHYANOHSA-N 0.000 claims 1
- KSAOEVWTPSXOAI-LHTANEHXSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[cyclopropylmethyl(pyridin-4-ylmethyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(CC=1C=CN=CC=1)CC1CC1 KSAOEVWTPSXOAI-LHTANEHXSA-N 0.000 claims 1
- OKUUYLUYHPMBTE-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[ethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)CC)C=C1 OKUUYLUYHPMBTE-COBFLCELSA-N 0.000 claims 1
- XUAWKMIBBCCTFC-KJLUBMIJSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[ethyl(pyridin-4-ylmethyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(CC)CC1=CC=NC=C1 XUAWKMIBBCCTFC-KJLUBMIJSA-N 0.000 claims 1
- XYROPMRDJQRZQO-LFDVRYLKSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-2-[4-[furan-3-ylmethyl(methyl)amino]phenyl]-6-methoxy-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)CC=1C=COC=1 XYROPMRDJQRZQO-LFDVRYLKSA-N 0.000 claims 1
- YOTZCWQSUJCUQM-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-(3-hydroxypropoxy)-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OCCCO)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 YOTZCWQSUJCUQM-COBFLCELSA-N 0.000 claims 1
- WIRWVJIKHXPPPF-UBIBJYAGSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-[3-(dimethylamino)propoxy]-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OCCCN(C)C)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 WIRWVJIKHXPPPF-UBIBJYAGSA-N 0.000 claims 1
- LFLACZRNZALIIF-KUFXBUICSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-ethoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound C1=2C=C(O[C@H](C)CC)C(OCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(Cl)C=C1 LFLACZRNZALIIF-KUFXBUICSA-N 0.000 claims 1
- AGDZKJPJHMEPJW-WPUOIDIFSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(1-methylindazol-5-yl)-1,4-dihydroisoquinolin-3-one Chemical compound C=1C=C2N(C)N=CC2=CC=1N1C(=O)CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C1C1=CC=C(Cl)C=C1 AGDZKJPJHMEPJW-WPUOIDIFSA-N 0.000 claims 1
- SNYJOABYQQMNMR-DXHYANOHSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(2-methoxy-4-morpholin-4-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C(=C1)OC)=CC=C1N1CCOCC1 SNYJOABYQQMNMR-DXHYANOHSA-N 0.000 claims 1
- ALKKFALWFQJEEH-KUFXBUICSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(2-methoxy-5-methylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC(C)=CC=C1OC ALKKFALWFQJEEH-KUFXBUICSA-N 0.000 claims 1
- NFLOANPRJQMBJE-KUFXBUICSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxy-2-methylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1C NFLOANPRJQMBJE-KUFXBUICSA-N 0.000 claims 1
- GQUCZUQLQVPONT-MOJDWNGGSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methoxyphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(OC)C=C1 GQUCZUQLQVPONT-MOJDWNGGSA-N 0.000 claims 1
- PZAJLQJGZRXWJJ-XZATXCMXSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-methylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C)C=C1 PZAJLQJGZRXWJJ-XZATXCMXSA-N 0.000 claims 1
- SMESOWQZCFBECR-COBFLCELSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-pyrazol-1-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1C=CC=N1 SMESOWQZCFBECR-COBFLCELSA-N 0.000 claims 1
- LUWAWFOOPZTPHR-UEWHNOOISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-(4-pyrrolidin-1-ylphenyl)-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1CCCC1 LUWAWFOOPZTPHR-UEWHNOOISA-N 0.000 claims 1
- RSKLVMJITCOSKY-XOBGVXBPSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-morpholin-4-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCOCC1 RSKLVMJITCOSKY-XOBGVXBPSA-N 0.000 claims 1
- LBHRNHIJVFKNRX-XOBGVXBPSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-pyrrolidin-1-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCCC1 LBHRNHIJVFKNRX-XOBGVXBPSA-N 0.000 claims 1
- SRGSBORUYIIAQG-XOBGVXBPSA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1-thiomorpholin-4-ylethyl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCSCC1 SRGSBORUYIIAQG-XOBGVXBPSA-N 0.000 claims 1
- SXFXYYOGQWUAAF-QHSQBYJISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(1H-pyrazol-4-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C=1C=NNC=1 SXFXYYOGQWUAAF-QHSQBYJISA-N 0.000 claims 1
- SSACIXCQKGESKK-QHSQBYJISA-N 7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-(2-oxoazetidin-1-yl)phenyl]-1,4-dihydroisoquinolin-3-one Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N1CCC1=O SSACIXCQKGESKK-QHSQBYJISA-N 0.000 claims 1
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- NEFIWXAITYMWFC-UXUDZYTPSA-N N-[(3S)-1-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]pyrrolidin-3-yl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CC[C@H](NC(C)=O)C1 NEFIWXAITYMWFC-UXUDZYTPSA-N 0.000 claims 1
- KJXXFLDYJMPUJB-UHFFFAOYSA-N N-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-2-methylpropanamide Chemical compound C12=CC(NC(=O)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 KJXXFLDYJMPUJB-UHFFFAOYSA-N 0.000 claims 1
- PEYVYAMBSDFHAF-UHFFFAOYSA-N N-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-N-propan-2-ylacetamide Chemical compound C12=CC(N(C(C)=O)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 PEYVYAMBSDFHAF-UHFFFAOYSA-N 0.000 claims 1
- ZRXAJWXGUDVHGN-UHFFFAOYSA-N N-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-N-propan-2-ylpropanamide Chemical compound C12=CC(N(C(C)C)C(=O)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 ZRXAJWXGUDVHGN-UHFFFAOYSA-N 0.000 claims 1
- QIDKXFMFVFWYKZ-UHFFFAOYSA-N N-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]acetamide Chemical compound C=1C=C(N2C(CC3=CC=C(NC(C)=O)C=C3C2C=2C=CC(Cl)=CC=2)=O)C=CC=1N(C)CC1=CC=NC=C1 QIDKXFMFVFWYKZ-UHFFFAOYSA-N 0.000 claims 1
- LXXWMRDUHMJDSX-UHFFFAOYSA-N N-[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]propanamide Chemical compound C12=CC(NC(=O)CC)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 LXXWMRDUHMJDSX-UHFFFAOYSA-N 0.000 claims 1
- WKPFGADMDMLPOJ-XFBJNOSPSA-N N-[1-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]piperidin-4-yl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N1CCC(NC(C)=O)CC1 WKPFGADMDMLPOJ-XFBJNOSPSA-N 0.000 claims 1
- MDPBDRRLFSBADH-MHJPDIQUSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-(2-methylpropyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CC(C)C)C(C)=O)C=C1 MDPBDRRLFSBADH-MHJPDIQUSA-N 0.000 claims 1
- XRUNANKQUQZZNC-YFTDMWITSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-(cyclohexylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1CCCCC1 XRUNANKQUQZZNC-YFTDMWITSA-N 0.000 claims 1
- LHNPXHSLMAUGIN-GJBZRHMXSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-(cyclopentylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1CCCC1 LHNPXHSLMAUGIN-GJBZRHMXSA-N 0.000 claims 1
- ATKHBPCXKQWXSO-SELMQKCGSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-(cyclopropylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1CC1 ATKHBPCXKQWXSO-SELMQKCGSA-N 0.000 claims 1
- ISZJXPGTOBQNAT-MHJPDIQUSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-[2-(dimethylamino)ethyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CCN(C)C)C(C)=O)C=C1 ISZJXPGTOBQNAT-MHJPDIQUSA-N 0.000 claims 1
- UHIZAMVQBHNXKL-BKCPDIIESA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-[3-(dimethylamino)propyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CCCN(C)C)C(C)=O)C=C1 UHIZAMVQBHNXKL-BKCPDIIESA-N 0.000 claims 1
- BBVSSIWLUURIDP-SELMQKCGSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-cyclobutylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCC1 BBVSSIWLUURIDP-SELMQKCGSA-N 0.000 claims 1
- OOULIXIKZOCRBO-GJBZRHMXSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-cyclohexylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCCCC1 OOULIXIKZOCRBO-GJBZRHMXSA-N 0.000 claims 1
- CDFSEMCZAQDSNO-XFBJNOSPSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-cyclopentylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCCC1 CDFSEMCZAQDSNO-XFBJNOSPSA-N 0.000 claims 1
- MIWPYNAIUIOYKL-LZSMQVGWSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-cyclopropylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CC1 MIWPYNAIUIOYKL-LZSMQVGWSA-N 0.000 claims 1
- YVAVCAKGUBEWEN-GGUFMPKBSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethyl-1-methylpiperidine-3-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCCN(C)C1 YVAVCAKGUBEWEN-GGUFMPKBSA-N 0.000 claims 1
- ULAMUJSRTJOWES-XHTYTWNBSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethyl-1-methylpiperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCN(C)CC1 ULAMUJSRTJOWES-XHTYTWNBSA-N 0.000 claims 1
- KWECQJWBXPVDCV-IQEJMKLESA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethyl-1-methylpyrrolidine-3-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCN(C)C1 KWECQJWBXPVDCV-IQEJMKLESA-N 0.000 claims 1
- YMCKBFUGFIAEDK-DHFMJDSQSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(CC)C(C)=O)C=C1 YMCKBFUGFIAEDK-DHFMJDSQSA-N 0.000 claims 1
- CQVINMJHLMFOCD-BKCPDIIESA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethylpiperidine-4-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCNCC1 CQVINMJHLMFOCD-BKCPDIIESA-N 0.000 claims 1
- MJEHQZBSRNQRJR-UXQVXNSPSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-ethylpyrrolidine-3-carboxamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(CC)C(=O)C1CCNC1 MJEHQZBSRNQRJR-UXQVXNSPSA-N 0.000 claims 1
- VGLGNSRSXLUAAG-XFBJNOSPSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-piperidin-4-ylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)C1CCNCC1 VGLGNSRSXLUAAG-XFBJNOSPSA-N 0.000 claims 1
- NPNGTASCYCHYIZ-KGUSEGQSSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-propan-2-ylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(C(C)N(C(C)C)C(C)=O)C=C1 NPNGTASCYCHYIZ-KGUSEGQSSA-N 0.000 claims 1
- XWCSRRFSBLBOIM-KGUSEGQSSA-N N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]-N-propylacetamide Chemical compound C1=CC(C(C)N(CCC)C(C)=O)=CC=C1N1C(=O)CC2=CC(OC)=C(O[C@H](C)CC)C=C2C1C1=CC=C(Cl)C=C1 XWCSRRFSBLBOIM-KGUSEGQSSA-N 0.000 claims 1
- CGHWWFPSIJEUJL-VITKDRCNSA-N N-[2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(C)=O)N1C1=CC=C(N(C)C)C=C1 CGHWWFPSIJEUJL-VITKDRCNSA-N 0.000 claims 1
- JUYRXVSXIUFQOJ-MFUYNUFSSA-N N-[2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]propanamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(=O)CC)N1C1=CC=C(N(C)C)C=C1 JUYRXVSXIUFQOJ-MFUYNUFSSA-N 0.000 claims 1
- LWFLQMUHUMIQJZ-UHFFFAOYSA-N N-[2-[[1-(4-chlorophenyl)-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-3-oxo-1,4-dihydroisoquinolin-7-yl]-propan-2-ylamino]ethyl]acetamide Chemical compound C12=CC(N(CCNC(C)=O)C(C)C)=CC=C2CC(=O)N(C=2C=CC(=CC=2)N(C)CC=2C=CN=CC=2)C1C1=CC=C(Cl)C=C1 LWFLQMUHUMIQJZ-UHFFFAOYSA-N 0.000 claims 1
- VJSBKCNOCNHASS-UHFFFAOYSA-N N-[4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]-2,2,2-trifluoro-N-methylacetamide Chemical compound C1=2C=C(OC(C)C)C(OC)=CC=2CC(=O)N(C=2C=CC(=CC=2)N(C)C(=O)C(F)(F)F)C1C1=CC=C(Cl)C=C1 VJSBKCNOCNHASS-UHFFFAOYSA-N 0.000 claims 1
- HCKIIIXWNXBFTC-PVFJFFHYSA-N N-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]-N-(cyclopentylmethyl)acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C(C)=O)CC1CCCC1 HCKIIIXWNXBFTC-PVFJFFHYSA-N 0.000 claims 1
- VHKNQTVTMKLMIT-QHSQBYJISA-N N-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]-N-methylacetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(N(C)C(C)=O)C=C1 VHKNQTVTMKLMIT-QHSQBYJISA-N 0.000 claims 1
- KPVWHIFTYCQQON-WPUOIDIFSA-N N-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C1=CC=C(NC(C)=O)C=C1 KPVWHIFTYCQQON-WPUOIDIFSA-N 0.000 claims 1
- KEWVRNRHTOLMLI-UHFFFAOYSA-N N-[5-chloro-2-[6,7-diethoxy-2-(4-methoxyphenyl)-3-oxo-1,4-dihydroisoquinolin-1-yl]phenyl]acetamide Chemical compound C1=2C=C(OCC)C(OCC)=CC=2CC(=O)N(C=2C=CC(OC)=CC=2)C1C1=CC=C(Cl)C=C1NC(C)=O KEWVRNRHTOLMLI-UHFFFAOYSA-N 0.000 claims 1
- APSINCLWOMYKMT-MFUYNUFSSA-N N-[[2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]methyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)CNC(C)=O)N1C1=CC=C(N(C)C)C=C1 APSINCLWOMYKMT-MFUYNUFSSA-N 0.000 claims 1
- FZSXPBWAGIQNPL-YFTDMWITSA-N N-benzyl-N-[1-[4-[7-[(2R)-butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-3-oxo-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]acetamide Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1C(C)N(C(C)=O)CC1=CC=CC=C1 FZSXPBWAGIQNPL-YFTDMWITSA-N 0.000 claims 1
- IXFIHZIZFSCBSU-HMWLHKMWSA-N N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 IXFIHZIZFSCBSU-HMWLHKMWSA-N 0.000 claims 1
- CKRMTHWXSWZXBS-ZNRJSADQSA-N N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 Chemical compound N1([C@@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 CKRMTHWXSWZXBS-ZNRJSADQSA-N 0.000 claims 1
- IXFIHZIZFSCBSU-UVAXCULCSA-N N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(C)C)CC1 IXFIHZIZFSCBSU-UVAXCULCSA-N 0.000 claims 1
- CKRMTHWXSWZXBS-NEBSNYDKSA-N N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 Chemical compound N1([C@H](C=2C=C(C(=CC=2CC1=O)OC)O[C@H](C)CC)C=1C=CC(Cl)=CC=1)C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 CKRMTHWXSWZXBS-NEBSNYDKSA-N 0.000 claims 1
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- DGBIUOGUEVXYOO-IHCZHZLTSA-N N1([C@H]2CC[C@@H](CC2)CN(C)C2=CC=C(C=N2)N2C(C=3C=C(C(=CC=3CC2=O)O)OC(C)C)C=2C=CC(Cl)=CC=2)CN(C)C(=O)C1 Chemical compound N1([C@H]2CC[C@@H](CC2)CN(C)C2=CC=C(C=N2)N2C(C=3C=C(C(=CC=3CC2=O)O)OC(C)C)C=2C=CC(Cl)=CC=2)CN(C)C(=O)C1 DGBIUOGUEVXYOO-IHCZHZLTSA-N 0.000 claims 1
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- WJLGIZVNZCLDIH-AKVZGJDWSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(=O)N(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(=O)N(C)C)CC1 WJLGIZVNZCLDIH-AKVZGJDWSA-N 0.000 claims 1
- DAVPCRYBGNFETN-AIFRQZDJSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(C)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)C(C)=O)CC1 DAVPCRYBGNFETN-AIFRQZDJSA-N 0.000 claims 1
- MELOZMHGPBUJQN-TWDYDMQUSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)S(C)(=O)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](N(CC)S(C)(=O)=O)CC1 MELOZMHGPBUJQN-TWDYDMQUSA-N 0.000 claims 1
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- SOQIVQVXODQKOH-BOANWVEESA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC(C)C)CC1 SOQIVQVXODQKOH-BOANWVEESA-N 0.000 claims 1
- CKRMTHWXSWZXBS-NZFRUTCLSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)CC)CC1 CKRMTHWXSWZXBS-NZFRUTCLSA-N 0.000 claims 1
- FRKOBZOXSFARTP-GYNNIAEXSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)N(C)C)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NC(=O)N(C)C)CC1 FRKOBZOXSFARTP-GYNNIAEXSA-N 0.000 claims 1
- INYDRJRTQPGLJK-BYCNXYFQSA-N O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NS(C)(=O)=O)CC1 Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C=CC(Cl)=CC=2)N1C(C=C1)=CC=C1N(C)C[C@H]1CC[C@H](NS(C)(=O)=O)CC1 INYDRJRTQPGLJK-BYCNXYFQSA-N 0.000 claims 1
- CNJDIPUBVSAEKF-WPUOIDIFSA-N [2-[7-[(2R)-butan-2-yl]oxy-2-[4-(dimethylamino)phenyl]-6-methoxy-3-oxo-1,4-dihydroisoquinolin-1-yl]-5-chlorophenyl]urea Chemical compound O=C1CC=2C=C(OC)C(O[C@H](C)CC)=CC=2C(C=2C(=CC(Cl)=CC=2)NC(N)=O)N1C1=CC=C(N(C)C)C=C1 CNJDIPUBVSAEKF-WPUOIDIFSA-N 0.000 claims 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 claims 1
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- 125000004429 atoms Chemical group 0.000 claims 1
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- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
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- 238000004519 manufacturing process Methods 0.000 claims 1
- TZTVTMGZQVEMTM-PGRZUCIQSA-N methyl (2S)-1-[(1S)-1-[4-[(1S)-1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]phenyl]ethyl]pyrrolidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCCN1[C@@H](C)C1=CC=C(N2C(CC3=CC(OC)=C(OC(C)C)C=C3[C@@H]2C=2C=CC(Cl)=CC=2)=O)C=C1 TZTVTMGZQVEMTM-PGRZUCIQSA-N 0.000 claims 1
- VRMVNHJSHIHIKW-UHFFFAOYSA-N methyl 4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]-3-(1,3-thiazol-5-ylmethoxy)benzoate Chemical compound C=1N=CSC=1COC1=CC(C(=O)OC)=CC=C1N(C(CC1=CC(OC)=C(OC(C)C)C=C11)=O)C1C1=CC=C(Cl)C=C1 VRMVNHJSHIHIKW-UHFFFAOYSA-N 0.000 claims 1
- DDRYRORLOXFFJR-UHFFFAOYSA-N methyl 4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]-3-(2H-tetrazol-5-ylmethoxy)benzoate Chemical compound N1=NNN=C1COC1=CC(C(=O)OC)=CC=C1N(C(CC1=CC(OC)=C(OC(C)C)C=C11)=O)C1C1=CC=C(Cl)C=C1 DDRYRORLOXFFJR-UHFFFAOYSA-N 0.000 claims 1
- JYOYRUXXCYCZMF-UHFFFAOYSA-N methyl 4-[1-(4-chlorophenyl)-6-methoxy-3-oxo-7-propan-2-yloxy-1,4-dihydroisoquinolin-2-yl]-3-methoxybenzoate Chemical compound COC1=CC(C(=O)OC)=CC=C1N1C(=O)CC2=CC(OC)=C(OC(C)C)C=C2C1C1=CC=C(Cl)C=C1 JYOYRUXXCYCZMF-UHFFFAOYSA-N 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
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- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 1
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- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
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US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
CU24130B1 (es) * | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
JP5856980B2 (ja) | 2010-01-27 | 2016-02-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
CA2812061A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
US9278944B2 (en) * | 2011-03-16 | 2016-03-08 | Mitsubishi Tanabe Pharma Corporation | Nitrogen-containing saturated heterocyclic compound |
US20140066369A1 (en) * | 2011-04-19 | 2014-03-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
WO2012175487A1 (en) * | 2011-06-20 | 2012-12-27 | Novartis Ag | Cyclohexyl isoquinolinone compounds |
EP2721008B1 (en) | 2011-06-20 | 2015-04-29 | Novartis AG | Hydroxy substituted isoquinolinone derivatives as p53 (mdm2 or mdm4) inhibitors |
US9376425B2 (en) | 2011-09-27 | 2016-06-28 | Amgen, Inc. | Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer |
RU2639523C2 (ru) | 2011-10-18 | 2017-12-21 | Эйлерон Терапьютикс, Инк. | Пептидомиметические макроциклы и их применение |
CN104080787B (zh) * | 2011-11-29 | 2016-09-14 | 诺华股份有限公司 | 吡唑并吡咯烷化合物 |
US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
UY34591A (es) * | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
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JP6450192B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス,インコーポレイテッド | トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物 |
CN104321325B (zh) | 2012-05-24 | 2016-11-16 | 诺华股份有限公司 | 吡咯并吡咯烷酮化合物 |
CN104520714A (zh) | 2012-07-31 | 2015-04-15 | 诺华股份有限公司 | 与对人双微体2(mdm2)抑制剂的敏感性相关的标志物 |
JP5764628B2 (ja) * | 2012-09-14 | 2015-08-19 | 田辺三菱製薬株式会社 | 医薬組成物 |
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