JP2013512280A5 - - Google Patents
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- JP2013512280A5 JP2013512280A5 JP2012542161A JP2012542161A JP2013512280A5 JP 2013512280 A5 JP2013512280 A5 JP 2013512280A5 JP 2012542161 A JP2012542161 A JP 2012542161A JP 2012542161 A JP2012542161 A JP 2012542161A JP 2013512280 A5 JP2013512280 A5 JP 2013512280A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26556309P | 2009-12-01 | 2009-12-01 | |
| US61/265,563 | 2009-12-01 | ||
| US36411610P | 2010-07-14 | 2010-07-14 | |
| US61/364,116 | 2010-07-14 | ||
| PCT/US2010/058572 WO2011068881A1 (en) | 2009-12-01 | 2010-12-01 | Novel tricyclic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014171336A Division JP5985557B2 (ja) | 2009-12-01 | 2014-08-26 | 新規な三環式化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512280A JP2013512280A (ja) | 2013-04-11 |
| JP2013512280A5 true JP2013512280A5 (enExample) | 2014-01-23 |
| JP5607174B2 JP5607174B2 (ja) | 2014-10-15 |
Family
ID=44070404
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012542161A Active JP5607174B2 (ja) | 2009-12-01 | 2010-12-01 | 新規な三環式化合物 |
| JP2014171336A Expired - Fee Related JP5985557B2 (ja) | 2009-12-01 | 2014-08-26 | 新規な三環式化合物 |
| JP2016151711A Expired - Fee Related JP6298114B2 (ja) | 2009-12-01 | 2016-08-02 | 新規な三環式化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014171336A Expired - Fee Related JP5985557B2 (ja) | 2009-12-01 | 2014-08-26 | 新規な三環式化合物 |
| JP2016151711A Expired - Fee Related JP6298114B2 (ja) | 2009-12-01 | 2016-08-02 | 新規な三環式化合物 |
Country Status (41)
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2015105591A (ru) | 2008-06-10 | 2015-08-10 | Эббви Инк. | Новые трициклические соединения |
| CA2758359A1 (en) * | 2009-04-14 | 2010-10-21 | Astellas Pharma Inc. | Fused pyrrolopyridine derivative |
| JP5607174B2 (ja) | 2009-12-01 | 2014-10-15 | アッヴィ・インコーポレイテッド | 新規な三環式化合物 |
| AU2010326030A1 (en) * | 2009-12-01 | 2012-06-07 | Abbvie Inc. | Novel tricyclic compounds |
| WO2011086053A1 (en) | 2010-01-12 | 2011-07-21 | F. Hoffmann-La Roche Ag | Tricyclic heterocyclic compounds, compositions and methods of use thereof |
| CN103547580B (zh) * | 2011-03-22 | 2016-12-07 | 阿迪维纳斯疗法有限公司 | 取代的稠合三环化合物、其组合物及医药用途 |
| BR112013026744B1 (pt) | 2011-04-21 | 2022-05-17 | Origenis Gmbh | Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica |
| WO2013007765A1 (en) * | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
| BR112014002472A2 (pt) | 2011-08-12 | 2017-04-11 | Nissan Chemical Ind Ltd | "compostos heterocíclicos tricíclicos, seu uso, agente terapêutico para reumatismo articular e medicamento" |
| US20130072470A1 (en) * | 2011-09-21 | 2013-03-21 | Abbvie Inc. | Novel tricyclic compounds |
| CN102516146B (zh) * | 2011-11-24 | 2013-10-02 | 爱斯特（成都）生物制药有限公司 | 5位为氮的四元氮杂螺环衍生物及其制备方法和用途 |
| LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
| IN2015DN02008A (enExample) * | 2012-09-21 | 2015-08-14 | Advinus Therapeutics Ltd | |
| WO2014060113A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Novel kinase inhibitors |
| EP2955181B1 (en) | 2013-02-08 | 2019-10-30 | Nissan Chemical Corporation | Tricyclic pyrrolopyridine compound, and jak inhibitor |
| EP3290421B1 (en) | 2013-02-22 | 2019-01-02 | Pfizer Inc | Combination of pyrrolo [2, 3 -d]pyrimidine derivatives with one or more additional agents as inhibitors of janus- related kinases (jak) |
| JP6581509B2 (ja) | 2013-02-28 | 2019-09-25 | ティーウィノット テクノロジーズ リミテッド | 化合物を合成する化学工学プロセス及び装置 |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| WO2015061665A1 (en) | 2013-10-24 | 2015-04-30 | Abbvie Inc. | Jak1 selective inhibitor and uses thereof |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015157504A1 (en) * | 2014-04-11 | 2015-10-15 | Taipei Medical University | Histone deacetylase inhibitors |
| WO2015174376A1 (ja) | 2014-05-14 | 2015-11-19 | 日産化学工業株式会社 | ３環性化合物及びｊａｋ阻害剤 |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| EP3180344B1 (en) | 2014-08-12 | 2019-09-18 | Pfizer Inc | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| AU2015308136B2 (en) | 2014-08-25 | 2020-07-09 | Teewinot Technologies Limited | Apparatus and methods for the simultaneous production of cannabinoid compounds |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| US12570664B2 (en) * | 2015-10-16 | 2026-03-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913999PA (en) * | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
| US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| EP3402798B1 (en) | 2016-01-14 | 2021-04-28 | Handok Inc. | Compounds antagonizing a3 adenosine receptor, method for preparing them, and medical-use thereof |
| EP3433615A1 (en) | 2016-03-21 | 2019-01-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for diagnosis and treatment of solar lentigo |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| JP7291077B2 (ja) | 2016-12-16 | 2023-06-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｊａｋファミリーのキナーゼの低分子阻害物質 |
| TWI851536B (zh) | 2017-03-09 | 2024-08-11 | 美商艾伯維有限公司 | 治療克羅恩氏病和潰瘍性結腸炎之方法 |
| US11564922B2 (en) | 2017-03-09 | 2023-01-31 | Abbvie Inc. | Methods of treating crohn's disease and ulcerative colitis |
| WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| US10364245B2 (en) | 2017-06-07 | 2019-07-30 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
| WO2019057103A1 (zh) * | 2017-09-21 | 2019-03-28 | 上海华汇拓医药科技有限公司 | Jak激酶抑制剂及其制备方法和在医药领域的应用 |
| US10508113B2 (en) | 2018-03-12 | 2019-12-17 | Abbvie Inc. | Inhibitors of tyrosine kinase 2 mediated signaling |
| ES3061844T3 (en) | 2018-05-04 | 2026-04-07 | Incyte Corp | Salts of an fgfr inhibitor |
| MX2020011718A (es) | 2018-05-04 | 2021-02-15 | Incyte Corp | Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas. |
| TW202016110A (zh) * | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| HUE069611T2 (hu) * | 2018-08-31 | 2025-03-28 | Suzhou Pengxu Pharmatech Co Ltd | Eljárások upadacitinib és intermedierjei szintézisére |
| CN110872250B (zh) * | 2018-08-31 | 2023-01-10 | 苏州鹏旭医药科技有限公司 | 两种化合物及其制备方法和在合成乌西替尼中的用途 |
| EP3856742B1 (en) | 2018-11-01 | 2024-10-02 | Lynk Pharmaceuticals Co. Ltd. | Tricyclic janus kinase 1 inhibitors, and compositions and methods thereof |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| CN111217819B (zh) * | 2018-11-27 | 2021-05-14 | 杭州科巢生物科技有限公司 | 乌帕替尼的合成方法 |
| WO2020115212A1 (en) | 2018-12-05 | 2020-06-11 | Lek Pharmaceuticals D.D. | Crystalline phosphate salt of selective jak1 inhibitor upadacitinib |
| WO2020115213A1 (en) | 2018-12-07 | 2020-06-11 | Lek Pharmaceuticals D.D. | Solvate of a selective jak1 inhibitor |
| CN109761885B (zh) * | 2019-02-21 | 2020-06-26 | 北京悦康科创医药科技股份有限公司 | 一种阿加曲班异构体杂质的拆分方法 |
| US20210380596A1 (en) * | 2019-03-01 | 2021-12-09 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Upadacitinib crystal form and preparation method therefor and use thereof |
| PH12021552130A1 (en) | 2019-03-05 | 2022-08-31 | Incyte Corp | Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction |
| KR102737181B1 (ko) | 2019-03-14 | 2024-12-02 | 상하이 시너지 파마슈티컬 사이언시스 코., 엘티디. | Jak 억제제 및 그 제조방법과 의약분야에서의 응용 |
| WO2020202183A1 (en) | 2019-03-29 | 2020-10-08 | Mylan Laboratories Limited | The process for the preparation of upadacitinib and its intermediates |
| CN111909160B (zh) * | 2019-05-09 | 2024-05-28 | 苏州鹏旭医药科技有限公司 | 一种乌帕替尼盐类化合物及其制备方法 |
| EP4006028B1 (en) * | 2019-07-26 | 2025-07-02 | Zhuhai Yufan Biotechnologies Co., Ltd | Irak4 kinase inhibitor and preparation method therefor |
| CN110938048B (zh) * | 2019-12-02 | 2023-03-28 | 四川大学 | 路易酸催化的插入反应高效合成二氢呋喃衍生物 |
| WO2021113462A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
| JP7648027B2 (ja) * | 2019-12-19 | 2025-03-18 | クリア、スペイン、エセ、ア、ウ | ウパダシチニブの調製のための方法及び中間体 |
| CN111007184B (zh) * | 2019-12-30 | 2023-05-16 | 天津天士力圣特制药有限公司 | 一种4-甲基哌嗪-1-甲酰氯盐酸盐含量的检测方法 |
| WO2021176473A1 (en) | 2020-03-05 | 2021-09-10 | Mylan Laboratories Limited | A process for the preparation of upadacitinib and its intermediates |
| US11718622B2 (en) | 2020-03-16 | 2023-08-08 | Exelixis Inc. | Heterocyclic adenosine receptor antagonists |
| US20210371389A1 (en) * | 2020-04-24 | 2021-12-02 | Kansas Soybean Commission | One-step synthesis of soybean polyols |
| WO2021244323A1 (zh) * | 2020-06-05 | 2021-12-09 | 苏州科睿思制药有限公司 | 一种乌帕替尼的晶型及其制备方法和用途 |
| KR20230038229A (ko) | 2020-07-08 | 2023-03-17 | 크리스탈 파마슈티컬 (쑤저우) 씨오., 엘티디. | 우파다시티닙의 결정형, 이의 제조 방법 및 이의 용도 |
| WO2022044037A1 (en) | 2020-08-24 | 2022-03-03 | Mylan Laboratories Limited | An improved process for the preparation of upadacitinib intermediate |
| CA3192563A1 (en) * | 2020-09-14 | 2022-03-17 | Gilles Ouvry | Novel jak inhibitor compounds, method for synthesizing same and use thereof |
| CA3190745A1 (en) * | 2020-10-08 | 2022-04-14 | Dhananjay G. Sathe | Substituted tricyclic compounds |
| CN112578034B (zh) * | 2020-11-04 | 2022-02-11 | 广东众生睿创生物科技有限公司 | 一种手性胺小分子及其盐的质量控制方法 |
| CN114790208B (zh) * | 2021-01-26 | 2024-06-07 | 珠海宇繁生物科技有限责任公司 | 一种irak4激酶抑制剂及其制备方法 |
| AU2022233254A1 (en) | 2021-03-11 | 2023-10-26 | Janssen Pharmaceutica Nv | Lorpucitinib for use in the treatment of jak mediated disorders |
| MX2023011863A (es) * | 2021-04-07 | 2023-12-15 | Abbvie Inc | Cocristales de upadacitinib. |
| CN113200967B (zh) * | 2021-05-07 | 2022-05-24 | 中国人民解放军陆军军医大学 | 吲哚苯醌类化合物、其制备方法及其应用 |
| US20250206717A1 (en) * | 2021-05-13 | 2025-06-26 | Innovstone Therapeutics Limited | Compound having anti-tumor activity and use thereof |
| CN113603693B (zh) * | 2021-07-13 | 2022-08-26 | 陕西丽彩药业有限公司 | 一种2-溴-5-对甲苯磺酰基-5H-吡咯并[2,3-b]吡嗪的制备方法 |
| CN114380837B (zh) * | 2021-12-27 | 2023-06-30 | 上海邈金医药科技有限公司 | 一种具有Janus激酶抑制活性的化合物、包括该化合物的组合物及其应用 |
| EP4215196A1 (en) | 2022-01-24 | 2023-07-26 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a jak inhibitor |
| US12487299B2 (en) | 2022-06-20 | 2025-12-02 | Shanghai United Imaging Healthcare Co., Ltd. | Magnetic resonance imaging devices and radiation therapy systems including the magnetic resonance imaging devices |
| CN116836171B (zh) * | 2023-06-30 | 2024-06-04 | 凌科药业(杭州)有限公司 | 一种磺酰胺类化合物及其应用 |
| WO2025102268A1 (en) * | 2023-11-15 | 2025-05-22 | Lynk Pharmaceuticals Co. Ltd. | Solid state forms, pharmaceutical compositions, preparation methods and use thereof |
| CN117285537B (zh) * | 2023-11-27 | 2024-02-06 | 中节能万润股份有限公司 | 一种乌帕替尼的制备方法 |
Family Cites Families (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB716327A (en) | 1951-09-05 | 1954-10-06 | Ici Ltd | New heterocyclic compounds |
| US3663559A (en) | 1969-12-03 | 1972-05-16 | Union Carbide Corp | Preparation of oxo-furo-pyridines from furylvinyl isocyanates |
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US4053474A (en) | 1976-04-21 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine |
| US5605690A (en) | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| JP2988711B2 (ja) | 1989-10-20 | 1999-12-13 | 協和醗酵工業株式会社 | 縮合プリン誘導体 |
| HUT63170A (en) | 1990-01-11 | 1993-07-28 | Isis Pharmaceuticals Inc | Process and composition for detecting and modifying rna activity and gene expression |
| US6262241B1 (en) | 1990-08-13 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Compound for detecting and modulating RNA activity and gene expression |
| WO1992009304A1 (en) | 1990-11-26 | 1992-06-11 | Recker Robert R | Treatment for osteoporosis using growth hormone release factor (grf) in combination with parathyroid hormone (pth) |
| CA2736076A1 (en) | 1991-03-18 | 1992-09-19 | New York University | Monoclonal and chimeric antibodies specific for human tumor necrosis factor |
| KR100207360B1 (ko) | 1991-06-14 | 1999-07-15 | 돈 더블유. 슈미츠 | 이미다조[1,5,-a]퀸옥살린 |
| US5212310A (en) | 1991-12-19 | 1993-05-18 | Neurogen Corporation | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands |
| US5266698A (en) | 1992-04-30 | 1993-11-30 | Neurogen Corporation | Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands |
| US5306819A (en) | 1992-08-27 | 1994-04-26 | Neurogen Corporation | Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands |
| DE69303494T2 (de) | 1992-11-13 | 1997-01-16 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| NZ262797A (en) | 1993-02-26 | 1997-08-22 | Schering Corp | Polycyclic guanine derivatives, purine and pyrimidine precursors; medicaments |
| US5733905A (en) | 1993-07-29 | 1998-03-31 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5736540A (en) | 1993-07-29 | 1998-04-07 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| IL112248A0 (en) * | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5547975A (en) | 1994-09-20 | 1996-08-20 | Talley; John J. | Benzopyranopyrazolyl derivatives for the treatment of inflammation |
| RU2158127C2 (ru) | 1994-12-23 | 2000-10-27 | Варнер-Ламберт Компани | Способы ингибирования тирозинкиназы рецептора эпидермального фактора роста, азотсодержащие трициклические соединения, фармацевтическая композиция, предназначенная для введения ингибитора тирозинкиназы рецептора эпидермального фактора роста, например, erb-b2, erb-b3 или erb-b4, и противозачаточная композиция |
| US5521173A (en) | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| US5753648A (en) | 1995-01-17 | 1998-05-19 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5763137A (en) | 1995-08-04 | 1998-06-09 | Agfa-Gevaert, N.V. | Method for making a lithographic printing plate |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| ES2324846T3 (es) * | 1998-03-04 | 2009-08-17 | Bristol-Myers Squibb Company | Inhibidores de la proteina tirosina quinasa de imidazopirazina heterociclo-sustituida. |
| US6448253B1 (en) | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| CO5271670A1 (es) | 1999-10-29 | 2003-04-30 | Pfizer Prod Inc | Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas |
| TWI271406B (en) | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
| JP4100865B2 (ja) * | 1999-12-13 | 2008-06-11 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 三環式縮合異項環化合物、その製造法およびその医薬 |
| CA2420967A1 (en) | 2000-08-07 | 2002-02-14 | Neurogen Corporation | Heterocyclic compounds as ligands of the gabaa receptor |
| GB0115393D0 (en) | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| GB0124299D0 (en) | 2001-10-10 | 2001-11-28 | Astrazeneca Ab | Crystal structure of enzyme and uses thereof |
| US20050176796A1 (en) | 2002-02-19 | 2005-08-11 | D'alessio Roberto | Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents |
| TW200400034A (en) | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| JP2006501243A (ja) * | 2002-08-23 | 2006-01-12 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ３のピロールベースのインヒビター |
| MXPA05007503A (es) * | 2003-01-17 | 2005-09-21 | Warner Lambert Co | Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular. |
| US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
| US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| TW200524864A (en) * | 2003-11-10 | 2005-08-01 | Wyeth Corp | Sulfonyltetrahydro-3H-benzo(E)indole-8-amine compounds as 5-hydroxytryptamine-6 ligands |
| JP2007537296A (ja) | 2004-05-14 | 2007-12-20 | アボット・ラボラトリーズ | 治療薬としてのキナーゼ阻害薬 |
| AR049300A1 (es) * | 2004-06-15 | 2006-07-12 | Schering Corp | Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos |
| WO2006010567A1 (de) | 2004-07-23 | 2006-02-02 | Curacyte Discovery Gmbh | INHIBITOREN DER PHOSPHODIESTERASE 4 UND TNFα-FREISETZUNG |
| ZA200704888B (en) | 2004-11-22 | 2009-02-25 | Vertex Pharma | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases |
| EP1846408B1 (en) * | 2005-01-14 | 2013-03-20 | Janssen Pharmaceutica NV | 5-membered annelated heterocyclic pyrimidines as kinase inhibitors |
| CA2594422A1 (en) * | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as cell cycle kinase inhibitors |
| US20060183758A1 (en) | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
| US8138173B2 (en) * | 2005-04-01 | 2012-03-20 | 3M Innovative Properties Company | Pyrazolo[3,4-C]quinolines, pyrazolo[3,4-C]naphthyridines, analogs thereof, and methods |
| US7737279B2 (en) * | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| US7593820B2 (en) | 2005-05-12 | 2009-09-22 | Cytopia Research Pty Ltd | Crystal structure of human Janus Kinase 2 (JAK2) and uses thereof |
| CN101223168A (zh) * | 2005-07-14 | 2008-07-16 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
| CN102127078A (zh) * | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
| KR20080026654A (ko) * | 2005-07-14 | 2008-03-25 | 아스텔라스세이야쿠 가부시키가이샤 | 헤테로시클릭 야누스 키나제 3 억제제 |
| WO2007014011A2 (en) | 2005-07-21 | 2007-02-01 | Ardea Biosciences, Inc. | N-(arylamino)-sulfonamide inhibitors of mek |
| MX2008002165A (es) * | 2005-08-16 | 2008-04-29 | Irm Llc | Compuestos y composiciones como inhibidores de la proteina cinasa. |
| WO2007035935A1 (en) | 2005-09-23 | 2007-03-29 | Coley Pharmaceutical Group, Inc. | METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF |
| CA2624882C (en) * | 2005-10-06 | 2014-05-20 | Schering Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
| ES2390135T3 (es) | 2005-11-22 | 2012-11-06 | Merck Sharp & Dohme Corp. | Compuestos tricíclicos útiles como inhibidores de quinasas |
| TW200801008A (en) * | 2005-12-29 | 2008-01-01 | Abbott Lab | Protein kinase inhibitors |
| RU2008136784A (ru) * | 2006-02-15 | 2010-03-20 | Абботт Лаборэтриз (Us) | Пиразолохинолоновые соединения, фармацевтическая композиция на их основе, способ ингибирования поли(адф-рибоза)полимеразы (parp) и способы лечения воспаления, сепсиса, септического шока и рака |
| JP5386350B2 (ja) | 2006-05-31 | 2014-01-15 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体 |
| US7629346B2 (en) | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
| US20080090834A1 (en) | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
| US8063225B2 (en) | 2006-08-14 | 2011-11-22 | Chembridge Corporation | Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
| MX2009003650A (es) * | 2006-10-06 | 2009-04-22 | Abbott Lab | Nuevos imidazotiazoles e imidazoxazoles. |
| TW200900061A (en) * | 2007-01-12 | 2009-01-01 | Astellas Pharma Inc | Condensed pyridine compound |
| JP2010516812A (ja) * | 2007-01-30 | 2010-05-20 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 有糸分裂キナーゼの調節剤 |
| WO2008112695A2 (en) | 2007-03-12 | 2008-09-18 | Irm Llc | Pyrazolo [3,4-d] pyrimidines and 1, 2, 5, 6-tetraaza- as- indacenes as protein kinase inhibitors for cancer treatment |
| US7691869B2 (en) * | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| CN101641447A (zh) | 2007-04-04 | 2010-02-03 | 霍夫曼-拉罗奇有限公司 | 乙酰氧基酮的微生物还原 |
| WO2009005675A1 (en) * | 2007-06-28 | 2009-01-08 | Abbott Laboratories | Novel triazolopyridazines |
| CA2924418A1 (en) | 2007-07-30 | 2009-02-05 | Jean-Michel Vernier | Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same |
| BRPI0908433A2 (pt) * | 2008-02-06 | 2019-09-24 | Novartis Ag | pirrolo[2,3-d]piridinas e empregos destas como inibidores tirosina cinase |
| ATE522536T1 (de) | 2008-02-25 | 2011-09-15 | Hoffmann La Roche | Pyrrolopyrazin-kinasehemmer |
| CA2716223A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| KR101261514B1 (ko) | 2008-02-25 | 2013-05-07 | 에프. 호프만-라 로슈 아게 | 피롤로피라진 키나아제 저해제 |
| WO2009108827A1 (en) | 2008-02-29 | 2009-09-03 | Wyeth | Fused tricyclic pyrazolo[1, 5-a]pyrimidines, methods for preparation and uses thereof |
| RU2015105591A (ru) | 2008-06-10 | 2015-08-10 | Эббви Инк. | Новые трициклические соединения |
| CA2728559A1 (en) * | 2008-07-03 | 2010-01-07 | Exelixis Inc. | Cdk modulators |
| CA2758359A1 (en) * | 2009-04-14 | 2010-10-21 | Astellas Pharma Inc. | Fused pyrrolopyridine derivative |
| US8361962B2 (en) * | 2009-07-27 | 2013-01-29 | Roche Palo Alto Llc | Tricyclic inhibitors of JAK |
| AU2010326030A1 (en) * | 2009-12-01 | 2012-06-07 | Abbvie Inc. | Novel tricyclic compounds |
| JP5607174B2 (ja) | 2009-12-01 | 2014-10-15 | アッヴィ・インコーポレイテッド | 新規な三環式化合物 |
| WO2011156698A2 (en) | 2010-06-11 | 2011-12-15 | Abbott Laboratories | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS |
| WO2012149280A2 (en) | 2011-04-29 | 2012-11-01 | Abbott Laboratories | Novel tricyclic compounds |
| US20130072470A1 (en) | 2011-09-21 | 2013-03-21 | Abbvie Inc. | Novel tricyclic compounds |
| WO2015061665A1 (en) | 2013-10-24 | 2015-04-30 | Abbvie Inc. | Jak1 selective inhibitor and uses thereof |
| SG10201913999PA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
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