JP2013515074A5 - - Google Patents
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- JP2013515074A5 JP2013515074A5 JP2012546137A JP2012546137A JP2013515074A5 JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5 JP 2012546137 A JP2012546137 A JP 2012546137A JP 2012546137 A JP2012546137 A JP 2012546137A JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- alkyl
- hydrogen
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- VXTGRTCJPGCZEY-UHFFFAOYSA-N CC(C)c1ncc(C)cc1 Chemical compound CC(C)c1ncc(C)cc1 VXTGRTCJPGCZEY-UHFFFAOYSA-N 0.000 description 2
- YHNOESDAEBXEKL-UHFFFAOYSA-N CC(Oc(cc(C)cn1)c1OC)F Chemical compound CC(Oc(cc(C)cn1)c1OC)F YHNOESDAEBXEKL-UHFFFAOYSA-N 0.000 description 2
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- NNMDGCDHKUBXLD-UHFFFAOYSA-N CCC[n]1ncc(CC)c1 Chemical compound CCC[n]1ncc(CC)c1 NNMDGCDHKUBXLD-UHFFFAOYSA-N 0.000 description 2
- RUCVHSGXXFWNNI-UHFFFAOYSA-N CCOc1c[n]cc(C)c1 Chemical compound CCOc1c[n]cc(C)c1 RUCVHSGXXFWNNI-UHFFFAOYSA-N 0.000 description 2
- VSDSIAVCISLUES-UHFFFAOYSA-N CC[n]1c(C[n]2ncc(C)c2)cnc1 Chemical compound CC[n]1c(C[n]2ncc(C)c2)cnc1 VSDSIAVCISLUES-UHFFFAOYSA-N 0.000 description 2
- KPAKLDRKRZPLIC-UHFFFAOYSA-N CC[n]1ncc(C(C)C)c1 Chemical compound CC[n]1ncc(C(C)C)c1 KPAKLDRKRZPLIC-UHFFFAOYSA-N 0.000 description 2
- YKVHLOUDALCTFI-UHFFFAOYSA-N CCc1c[n](CC(F)F)nc1 Chemical compound CCc1c[n](CC(F)F)nc1 YKVHLOUDALCTFI-UHFFFAOYSA-N 0.000 description 2
- UEIBFJFIUFUTLY-UHFFFAOYSA-N CCc1c[n](CC2(C)COC2)nc1 Chemical compound CCc1c[n](CC2(C)COC2)nc1 UEIBFJFIUFUTLY-UHFFFAOYSA-N 0.000 description 2
- COBUOPSNTXXEDG-UHFFFAOYSA-N CCc1cncc(OCCO)c1 Chemical compound CCc1cncc(OCCO)c1 COBUOPSNTXXEDG-UHFFFAOYSA-N 0.000 description 2
- JQAAALSTPNFKJG-UHFFFAOYSA-N Cc(cc1OC)cnc1F Chemical compound Cc(cc1OC)cnc1F JQAAALSTPNFKJG-UHFFFAOYSA-N 0.000 description 2
- GLDVNBBRERZRAA-UHFFFAOYSA-N Cc1c[n](CC(F)=C)nc1 Chemical compound Cc1c[n](CC(F)=C)nc1 GLDVNBBRERZRAA-UHFFFAOYSA-N 0.000 description 2
- XQFNXRUFGNPQMH-UHFFFAOYSA-N Cc1c[n](CC(N)=O)nc1 Chemical compound Cc1c[n](CC(N)=O)nc1 XQFNXRUFGNPQMH-UHFFFAOYSA-N 0.000 description 2
- GWBOLHLPYRMTGI-UHFFFAOYSA-N Cc1c[n](Cc2cnc[n]2C)nc1 Chemical compound Cc1c[n](Cc2cnc[n]2C)nc1 GWBOLHLPYRMTGI-UHFFFAOYSA-N 0.000 description 2
- BWAUZXIXEVGYLT-UHFFFAOYSA-N Cc1cc(OCCF)cnc1 Chemical compound Cc1cc(OCCF)cnc1 BWAUZXIXEVGYLT-UHFFFAOYSA-N 0.000 description 2
- AEGDUGKVESUBLG-UHFFFAOYSA-N Cc1ccnc(CC#N)c1 Chemical compound Cc1ccnc(CC#N)c1 AEGDUGKVESUBLG-UHFFFAOYSA-N 0.000 description 2
- GVIFFJPQSOFWIT-UHFFFAOYSA-N Cc1ccnc(OCC(F)(F)F)c1 Chemical compound Cc1ccnc(OCC(F)(F)F)c1 GVIFFJPQSOFWIT-UHFFFAOYSA-N 0.000 description 2
- OUNUFEXYQGGHTO-UHFFFAOYSA-N Cc1ccnc(OCC(F)F)c1 Chemical compound Cc1ccnc(OCC(F)F)c1 OUNUFEXYQGGHTO-UHFFFAOYSA-N 0.000 description 2
- HYOBIUULDPLKIE-UHFFFAOYSA-N Cc1cnc(CO)cc1 Chemical compound Cc1cnc(CO)cc1 HYOBIUULDPLKIE-UHFFFAOYSA-N 0.000 description 2
- MRQAYFYTWNIVFN-UHFFFAOYSA-N Cc1cncc(CO)c1 Chemical compound Cc1cncc(CO)c1 MRQAYFYTWNIVFN-UHFFFAOYSA-N 0.000 description 2
- CKQXPRSCSFUGRC-UHFFFAOYSA-N Cc1cncc(F)c1 Chemical compound Cc1cncc(F)c1 CKQXPRSCSFUGRC-UHFFFAOYSA-N 0.000 description 2
- QVSPBYSZHUGCRL-UHFFFAOYSA-N Cc1cncc(OC(F)F)c1 Chemical compound Cc1cncc(OC(F)F)c1 QVSPBYSZHUGCRL-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28900309P | 2009-12-22 | 2009-12-22 | |
| US61/289,003 | 2009-12-22 | ||
| US35063110P | 2010-06-02 | 2010-06-02 | |
| US61/350,631 | 2010-06-02 | ||
| US36920110P | 2010-07-30 | 2010-07-30 | |
| US61/369,201 | 2010-07-30 | ||
| US38758210P | 2010-09-29 | 2010-09-29 | |
| US61/387,582 | 2010-09-29 | ||
| PCT/US2010/061484 WO2011087776A1 (en) | 2009-12-22 | 2010-12-21 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015034849A Division JP6132410B2 (ja) | 2009-12-22 | 2015-02-25 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515074A JP2013515074A (ja) | 2013-05-02 |
| JP2013515074A5 true JP2013515074A5 (enExample) | 2014-02-13 |
| JP5721187B2 JP5721187B2 (ja) | 2015-05-20 |
Family
ID=43859800
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546137A Expired - Fee Related JP5721187B2 (ja) | 2009-12-22 | 2010-12-21 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2015034849A Expired - Fee Related JP6132410B2 (ja) | 2009-12-22 | 2015-02-25 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2017067536A Expired - Fee Related JP6510580B2 (ja) | 2009-12-22 | 2017-03-30 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2018079069A Withdrawn JP2018131449A (ja) | 2009-12-22 | 2018-04-17 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015034849A Expired - Fee Related JP6132410B2 (ja) | 2009-12-22 | 2015-02-25 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2017067536A Expired - Fee Related JP6510580B2 (ja) | 2009-12-22 | 2017-03-30 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2018079069A Withdrawn JP2018131449A (ja) | 2009-12-22 | 2018-04-17 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20120040950A1 (enExample) |
| EP (3) | EP2516417B1 (enExample) |
| JP (4) | JP5721187B2 (enExample) |
| KR (1) | KR101758046B1 (enExample) |
| CN (1) | CN102762548B (enExample) |
| AU (1) | AU2010341573B2 (enExample) |
| BR (1) | BR112012018386A8 (enExample) |
| CA (1) | CA2785499C (enExample) |
| CL (1) | CL2012001714A1 (enExample) |
| ES (2) | ES2655391T3 (enExample) |
| IL (1) | IL220625A (enExample) |
| MX (2) | MX2012007403A (enExample) |
| NZ (1) | NZ600954A (enExample) |
| RU (1) | RU2573569C2 (enExample) |
| SG (2) | SG181917A1 (enExample) |
| WO (1) | WO2011087776A1 (enExample) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101660050B1 (ko) | 2008-01-04 | 2016-09-26 | 인텔리카인, 엘엘씨 | 특정 화학 물질, 조성물 및 방법 |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| CA2738429C (en) | 2008-09-26 | 2016-10-25 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| CA2760791C (en) | 2009-05-07 | 2017-06-20 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
| BR112012018386A8 (pt) | 2009-12-22 | 2017-12-19 | Vertex Pharma | "inibidores isoindolinona de fosfatidilinositol 3-quinase" |
| EP2571357B1 (en) | 2010-05-21 | 2016-07-06 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| NZ612909A (en) | 2011-01-10 | 2015-09-25 | Infinity Pharmaceuticals Inc | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
| CN103930422A (zh) | 2011-07-19 | 2014-07-16 | 无限药品股份有限公司 | 杂环化合物及其用途 |
| AU2012302197B2 (en) | 2011-08-29 | 2016-01-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP2841435B1 (en) * | 2012-04-25 | 2017-09-06 | RaQualia Pharma Inc. | Pyrrolopyridinone derivatives as ttx-s blockers |
| RS61089B1 (sr) | 2012-06-13 | 2020-12-31 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| UA110688C2 (uk) * | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
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| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
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| DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| BR112016006388A2 (pt) * | 2013-09-25 | 2017-08-01 | Vertex Pharma | inibidor seletivo da fosfatidilinositol 3-quinase gama |
| US9359365B2 (en) | 2013-10-04 | 2016-06-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
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| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| CN106456628A (zh) | 2014-03-19 | 2017-02-22 | 无限药品股份有限公司 | 用于治疗PI3K‑γ介导的障碍的杂环化合物 |
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| EP3131875A4 (en) * | 2014-04-16 | 2018-04-04 | Nanyang Technological University | Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins |
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| KR20170012558A (ko) * | 2014-06-13 | 2017-02-02 | 길리애드 사이언시즈, 인코포레이티드 | 포스파티딜이노시톨 3-키나제 억제제 |
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| EA201692266A1 (ru) | 2014-06-13 | 2017-06-30 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
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| US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
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