JP2013515074A5 - - Google Patents
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- Publication number
- JP2013515074A5 JP2013515074A5 JP2012546137A JP2012546137A JP2013515074A5 JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5 JP 2012546137 A JP2012546137 A JP 2012546137A JP 2012546137 A JP2012546137 A JP 2012546137A JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- alkyl
- hydrogen
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- NIKSILQAEVZVHC-UHFFFAOYSA-N CC(C)(c1ncc(C)cc1)O Chemical compound CC(C)(c1ncc(C)cc1)O NIKSILQAEVZVHC-UHFFFAOYSA-N 0.000 description 2
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- VXTGRTCJPGCZEY-UHFFFAOYSA-N CC(C)c1ncc(C)cc1 Chemical compound CC(C)c1ncc(C)cc1 VXTGRTCJPGCZEY-UHFFFAOYSA-N 0.000 description 2
- YHNOESDAEBXEKL-UHFFFAOYSA-N CC(Oc(cc(C)cn1)c1OC)F Chemical compound CC(Oc(cc(C)cn1)c1OC)F YHNOESDAEBXEKL-UHFFFAOYSA-N 0.000 description 2
- ZHMOEPVWAHFVOU-UHFFFAOYSA-N CC(c1cc(C)ccn1)C#N Chemical compound CC(c1cc(C)ccn1)C#N ZHMOEPVWAHFVOU-UHFFFAOYSA-N 0.000 description 2
- NNMDGCDHKUBXLD-UHFFFAOYSA-N CCC[n]1ncc(CC)c1 Chemical compound CCC[n]1ncc(CC)c1 NNMDGCDHKUBXLD-UHFFFAOYSA-N 0.000 description 2
- RUCVHSGXXFWNNI-UHFFFAOYSA-N CCOc1c[n]cc(C)c1 Chemical compound CCOc1c[n]cc(C)c1 RUCVHSGXXFWNNI-UHFFFAOYSA-N 0.000 description 2
- VSDSIAVCISLUES-UHFFFAOYSA-N CC[n]1c(C[n]2ncc(C)c2)cnc1 Chemical compound CC[n]1c(C[n]2ncc(C)c2)cnc1 VSDSIAVCISLUES-UHFFFAOYSA-N 0.000 description 2
- KPAKLDRKRZPLIC-UHFFFAOYSA-N CC[n]1ncc(C(C)C)c1 Chemical compound CC[n]1ncc(C(C)C)c1 KPAKLDRKRZPLIC-UHFFFAOYSA-N 0.000 description 2
- YKVHLOUDALCTFI-UHFFFAOYSA-N CCc1c[n](CC(F)F)nc1 Chemical compound CCc1c[n](CC(F)F)nc1 YKVHLOUDALCTFI-UHFFFAOYSA-N 0.000 description 2
- UEIBFJFIUFUTLY-UHFFFAOYSA-N CCc1c[n](CC2(C)COC2)nc1 Chemical compound CCc1c[n](CC2(C)COC2)nc1 UEIBFJFIUFUTLY-UHFFFAOYSA-N 0.000 description 2
- COBUOPSNTXXEDG-UHFFFAOYSA-N CCc1cncc(OCCO)c1 Chemical compound CCc1cncc(OCCO)c1 COBUOPSNTXXEDG-UHFFFAOYSA-N 0.000 description 2
- JQAAALSTPNFKJG-UHFFFAOYSA-N Cc(cc1OC)cnc1F Chemical compound Cc(cc1OC)cnc1F JQAAALSTPNFKJG-UHFFFAOYSA-N 0.000 description 2
- GLDVNBBRERZRAA-UHFFFAOYSA-N Cc1c[n](CC(F)=C)nc1 Chemical compound Cc1c[n](CC(F)=C)nc1 GLDVNBBRERZRAA-UHFFFAOYSA-N 0.000 description 2
- XQFNXRUFGNPQMH-UHFFFAOYSA-N Cc1c[n](CC(N)=O)nc1 Chemical compound Cc1c[n](CC(N)=O)nc1 XQFNXRUFGNPQMH-UHFFFAOYSA-N 0.000 description 2
- GWBOLHLPYRMTGI-UHFFFAOYSA-N Cc1c[n](Cc2cnc[n]2C)nc1 Chemical compound Cc1c[n](Cc2cnc[n]2C)nc1 GWBOLHLPYRMTGI-UHFFFAOYSA-N 0.000 description 2
- BWAUZXIXEVGYLT-UHFFFAOYSA-N Cc1cc(OCCF)cnc1 Chemical compound Cc1cc(OCCF)cnc1 BWAUZXIXEVGYLT-UHFFFAOYSA-N 0.000 description 2
- AEGDUGKVESUBLG-UHFFFAOYSA-N Cc1ccnc(CC#N)c1 Chemical compound Cc1ccnc(CC#N)c1 AEGDUGKVESUBLG-UHFFFAOYSA-N 0.000 description 2
- GVIFFJPQSOFWIT-UHFFFAOYSA-N Cc1ccnc(OCC(F)(F)F)c1 Chemical compound Cc1ccnc(OCC(F)(F)F)c1 GVIFFJPQSOFWIT-UHFFFAOYSA-N 0.000 description 2
- OUNUFEXYQGGHTO-UHFFFAOYSA-N Cc1ccnc(OCC(F)F)c1 Chemical compound Cc1ccnc(OCC(F)F)c1 OUNUFEXYQGGHTO-UHFFFAOYSA-N 0.000 description 2
- HYOBIUULDPLKIE-UHFFFAOYSA-N Cc1cnc(CO)cc1 Chemical compound Cc1cnc(CO)cc1 HYOBIUULDPLKIE-UHFFFAOYSA-N 0.000 description 2
- MRQAYFYTWNIVFN-UHFFFAOYSA-N Cc1cncc(CO)c1 Chemical compound Cc1cncc(CO)c1 MRQAYFYTWNIVFN-UHFFFAOYSA-N 0.000 description 2
- CKQXPRSCSFUGRC-UHFFFAOYSA-N Cc1cncc(F)c1 Chemical compound Cc1cncc(F)c1 CKQXPRSCSFUGRC-UHFFFAOYSA-N 0.000 description 2
- QVSPBYSZHUGCRL-UHFFFAOYSA-N Cc1cncc(OC(F)F)c1 Chemical compound Cc1cncc(OC(F)F)c1 QVSPBYSZHUGCRL-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28900309P | 2009-12-22 | 2009-12-22 | |
| US61/289,003 | 2009-12-22 | ||
| US35063110P | 2010-06-02 | 2010-06-02 | |
| US61/350,631 | 2010-06-02 | ||
| US36920110P | 2010-07-30 | 2010-07-30 | |
| US61/369,201 | 2010-07-30 | ||
| US38758210P | 2010-09-29 | 2010-09-29 | |
| US61/387,582 | 2010-09-29 | ||
| PCT/US2010/061484 WO2011087776A1 (en) | 2009-12-22 | 2010-12-21 | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015034849A Division JP6132410B2 (ja) | 2009-12-22 | 2015-02-25 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515074A JP2013515074A (ja) | 2013-05-02 |
| JP2013515074A5 true JP2013515074A5 (enExample) | 2014-02-13 |
| JP5721187B2 JP5721187B2 (ja) | 2015-05-20 |
Family
ID=43859800
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546137A Expired - Fee Related JP5721187B2 (ja) | 2009-12-22 | 2010-12-21 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2015034849A Expired - Fee Related JP6132410B2 (ja) | 2009-12-22 | 2015-02-25 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2017067536A Expired - Fee Related JP6510580B2 (ja) | 2009-12-22 | 2017-03-30 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2018079069A Withdrawn JP2018131449A (ja) | 2009-12-22 | 2018-04-17 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015034849A Expired - Fee Related JP6132410B2 (ja) | 2009-12-22 | 2015-02-25 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2017067536A Expired - Fee Related JP6510580B2 (ja) | 2009-12-22 | 2017-03-30 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
| JP2018079069A Withdrawn JP2018131449A (ja) | 2009-12-22 | 2018-04-17 | ホスファチジルイノシトール３−キナーゼのイソインドリノンインヒビター |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US20120040950A1 (enExample) |
| EP (3) | EP3309152B1 (enExample) |
| JP (4) | JP5721187B2 (enExample) |
| KR (1) | KR101758046B1 (enExample) |
| CN (1) | CN102762548B (enExample) |
| AU (1) | AU2010341573B2 (enExample) |
| BR (1) | BR112012018386A8 (enExample) |
| CA (1) | CA2785499C (enExample) |
| CL (1) | CL2012001714A1 (enExample) |
| ES (2) | ES2842399T3 (enExample) |
| IL (1) | IL220625A (enExample) |
| MX (2) | MX350761B (enExample) |
| NZ (1) | NZ600954A (enExample) |
| RU (1) | RU2573569C2 (enExample) |
| SG (2) | SG10201502073PA (enExample) |
| WO (1) | WO2011087776A1 (enExample) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| CA2711558C (en) | 2008-01-04 | 2016-12-13 | Intellikine, Inc. | Phosphatidyl inositol-3 kinase inhibiting compounds |
| JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン， エルエルシー | 複素環キナーゼ阻害剤 |
| EP2427195B1 (en) | 2009-05-07 | 2019-05-01 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| EP3309152B1 (en) | 2009-12-22 | 2020-09-09 | Vertex Pharmaceuticals Incorporated | Isoindolinone inhibitors of phosphatidylinositol 3-kinase |
| AU2011255218B2 (en) | 2010-05-21 | 2015-03-12 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| JP2013545749A (ja) | 2010-11-10 | 2013-12-26 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環化合物及びその使用 |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| AU2012205669B2 (en) | 2011-01-10 | 2015-08-20 | Infinity Pharmaceuticals Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| JP6027610B2 (ja) | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 複素環式化合物及びその使用 |
| EP2751093A1 (en) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX360323B (es) * | 2012-04-25 | 2018-10-29 | Raqualia Pharma Inc | Derivados de pirrolopiridinona como bloqueadores de ttx-s. |
| LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| UA110688C2 (uk) * | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| KR102229478B1 (ko) | 2012-11-01 | 2021-03-18 | 인피니티 파마슈티칼스, 인코포레이티드 | Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| AU2014324873B2 (en) | 2013-09-25 | 2018-11-08 | Vertex Pharmaceuticals Incorporated | A selective inhibitor of phosphatidylinositol 3-kinase-gamma |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PE20160685A1 (es) | 2013-10-04 | 2016-07-23 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
| JO3805B1 (ar) | 2013-10-10 | 2021-01-31 | Araxes Pharma Llc | مثبطات كراس جي12سي |
| SG10201808053XA (en) | 2014-03-19 | 2018-10-30 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
| US10294205B2 (en) | 2014-04-16 | 2019-05-21 | Nanyang Technological University | Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins |
| US20150320755A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| TWI664165B (zh) | 2014-04-23 | 2019-07-01 | 日商武田藥品工業股份有限公司 | 含氮雜環化合物 |
| US10308639B2 (en) | 2014-06-13 | 2019-06-04 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| CA2952044C (en) * | 2014-06-13 | 2019-01-29 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| JP6455995B2 (ja) | 2014-06-13 | 2019-01-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
| NZ726052A (en) | 2014-06-13 | 2018-04-27 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| AU2015274635B2 (en) | 2014-06-13 | 2018-04-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| SG11201706287PA (en) | 2015-02-20 | 2017-09-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
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| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
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| WO2017058792A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
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| WO2017058728A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10689356B2 (en) | 2015-09-28 | 2020-06-23 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356351A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| EP3356349A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
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