|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
KR101653842B1
(ko)
|
2008-01-04 |
2016-09-02 |
인텔리카인, 엘엘씨 |
특정 화학 물질, 조성물 및 방법
|
|
CA2738429C
(en)
|
2008-09-26 |
2016-10-25 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
|
CA2760791C
(en)
|
2009-05-07 |
2017-06-20 |
Intellikine, Inc. |
Heterocyclic compounds and uses thereof
|
|
RU2573569C2
(ru)
|
2009-12-22 |
2016-01-20 |
Вертекс Фармасьютикалз Инкорпорейтед |
Ингибиторы фосфатидилинозитол-3-киназы на основе изоиндолинона
|
|
JP5951600B2
(ja)
|
2010-05-21 |
2016-07-13 |
インフィニティー ファーマシューティカルズ， インコーポレイテッド |
キナーゼ調節のための、化合物、組成物および方法
|
|
CN103298474B
(zh)
|
2010-11-10 |
2016-06-29 |
无限药品股份有限公司 |
杂环化合物及其用途
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
AR084824A1
(es)
|
2011-01-10 |
2013-06-26 |
Intellikine Inc |
Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
|
|
AU2012284088B2
(en)
|
2011-07-19 |
2015-10-08 |
Infinity Pharmaceuticals Inc. |
Heterocyclic compounds and uses thereof
|
|
MX2014000648A
(es)
|
2011-07-19 |
2014-09-25 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y sus usos.
|
|
US8785470B2
(en)
|
2011-08-29 |
2014-07-22 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
RU2646754C2
(ru)
*
|
2012-04-25 |
2018-03-07 |
Раквалиа Фарма Инк. |
Производные пирролопиридинона в качестве ttx-s блокаторов
|
|
HUE042374T2
(hu)
|
2012-06-13 |
2019-06-28 |
Incyte Holdings Corp |
Szubsztituált triciklusos vegyületek mint FGFR inhibitorok
|
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
|
UA110688C2
(uk)
*
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
|
WO2014071109A1
(en)
|
2012-11-01 |
2014-05-08 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using pi3 kinase isoform modulators
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
UY35464A
(es)
|
2013-03-15 |
2014-10-31 |
Araxes Pharma Llc |
Inhibidores covalentes de kras g12c.
|
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
|
KR102469849B1
(ko)
|
2013-04-19 |
2022-11-23 |
인사이트 홀딩스 코포레이션 |
Fgfr 저해제로서 이환식 헤테로사이클
|
|
JP6340416B2
(ja)
*
|
2013-09-25 |
2018-06-06 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
ホスファチジルイノシトール３−キナーゼ−ガンマの選択的インヒビター
|
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
PE20160685A1
(es)
|
2013-10-04 |
2016-07-23 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y usos de los mismos
|
|
TWI659021B
(zh)
|
2013-10-10 |
2019-05-11 |
亞瑞克西斯製藥公司 |
Ｋｒａｓ ｇ１２ｃ之抑制劑
|
|
CN113620958A
(zh)
|
2014-03-19 |
2021-11-09 |
无限药品股份有限公司 |
用于治疗PI3K-γ介导的障碍的杂环化合物
|
|
WO2015160975A2
(en)
|
2014-04-16 |
2015-10-22 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
EP3131875A4
(en)
|
2014-04-16 |
2018-04-04 |
Nanyang Technological University |
Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
|
|
EA030373B1
(ru)
*
|
2014-04-23 |
2018-07-31 |
Такеда Фармасьютикал Компани Лимитед |
Изоиндолин-1-оновые производные в качестве положительных аллостерических модуляторов холинергического мускаринового m1 рецептора для лечения болезни альцгеймера
|
|
EA201692267A1
(ru)
|
2014-06-13 |
2017-06-30 |
Джилид Сайэнс, Инк. |
Ингибиторы фосфатидилинозитол-3-киназы
|
|
JP6346964B2
(ja)
*
|
2014-06-13 |
2018-06-20 |
ギリアード サイエンシーズ， インコーポレイテッド |
ホスファチジルイノシトール３−キナーゼ阻害剤
|
|
MX2016016530A
(es)
|
2014-06-13 |
2017-03-27 |
Gilead Sciences Inc |
Inhibidores de fosfatidilinositol 3-quinasa.
|
|
SG11201609527PA
(en)
|
2014-06-13 |
2016-12-29 |
Gilead Sciences Inc |
Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
AU2015274635B2
(en)
|
2014-06-13 |
2018-04-19 |
Gilead Sciences, Inc. |
Phosphatidylinositol 3-kinase inhibitors
|
|
US9708348B2
(en)
|
2014-10-03 |
2017-07-18 |
Infinity Pharmaceuticals, Inc. |
Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
AU2016219822B2
(en)
|
2015-02-20 |
2020-07-09 |
Incyte Holdings Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
WO2016134294A1
(en)
|
2015-02-20 |
2016-08-25 |
Incyte Corporation |
Bicyclic heterocycles as fgfr4 inhibitors
|
|
EP3280708B1
(en)
|
2015-04-10 |
2021-09-01 |
Araxes Pharma LLC |
Substituted quinazoline compounds and methods of use thereof
|
|
JP6789239B2
(ja)
|
2015-04-15 |
2020-11-25 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
PH12018500554B1
(en)
|
2015-09-14 |
2024-01-24 |
Infinity Pharmaceuticals Inc |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
|
WO2017045955A1
(en)
*
|
2015-09-14 |
2017-03-23 |
Basf Se |
Heterobicyclic compounds
|
|
WO2017058768A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356347A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356354A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058792A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356339A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058915A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
US10489249B2
(en)
|
2015-09-30 |
2019-11-26 |
Commvault Systems, Inc. |
Dynamic triggering of block-level backups based on block change thresholds and corresponding file identities using communication pathways between co-resident data agents
|
|
US10457669B2
(en)
|
2015-10-21 |
2019-10-29 |
Otsuka Pharmaceutical Co., Ltd. |
Benzolactam compounds as protein kinase inhibitors
|
|
KR20180073629A
(ko)
*
|
2015-10-22 |
2018-07-02 |
셀비타 에스에이 |
피리돈 유도체 및 키나제 억제제로서의 그의 용도
|
|
EA038635B9
(ru)
|
2015-11-16 |
2021-10-26 |
Араксис Фарма Ллк |
2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения
|
|
WO2017107087A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
ES2789756T3
(es)
|
2015-12-23 |
2020-10-26 |
Merck Sharp & Dohme |
Moduladores alostéricos de 6,7-dihidro-5H-pirrolo[3,4-b]piridin-5-ona del receptor de acetilcolina muscarínico M4
|
|
WO2017107089A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
WO2017153527A1
(en)
*
|
2016-03-10 |
2017-09-14 |
Astrazeneca Ab |
Novel inhibitors of phosphatidylinositol 3-kinase gamma
|
|
WO2017161116A1
(en)
|
2016-03-17 |
2017-09-21 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
|
|
JP6814814B2
(ja)
|
2016-03-17 |
2021-01-20 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体
|
|
GB201604970D0
(en)
|
2016-03-23 |
2016-05-04 |
Syngenta Participations Ag |
Improvements in or relating to organic compounds
|
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
RU2754507C2
(ru)
|
2016-06-24 |
2021-09-02 |
Инфинити Фармасьютикалз, Инк. |
Комбинированная терапия
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
EP3519402A1
(en)
|
2016-09-29 |
2019-08-07 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
US10377743B2
(en)
*
|
2016-10-07 |
2019-08-13 |
Araxes Pharma Llc |
Inhibitors of RAS and methods of use thereof
|
|
WO2018112842A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
|
|
WO2018112843A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
|
|
US11279689B2
(en)
|
2017-01-26 |
2022-03-22 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer
|
|
WO2018140514A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
|
US11358959B2
(en)
|
2017-01-26 |
2022-06-14 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
WO2018140512A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
EP3573967A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused hetero-hetero bicyclic compounds and methods of use thereof
|
|
GB201706327D0
(en)
|
2017-04-20 |
2017-06-07 |
Otsuka Pharma Co Ltd |
A pharmaceutical compound
|
|
CA3063440A1
(en)
|
2017-05-25 |
2018-11-29 |
Araxes Pharma Llc |
Covalent inhibitors of kras
|
|
CN110831933A
(zh)
|
2017-05-25 |
2020-02-21 |
亚瑞克西斯制药公司 |
喹唑啉衍生物作为突变kras、hras或nras的调节剂
|
|
JP2020521741A
(ja)
|
2017-05-25 |
2020-07-27 |
アラクセス ファーマ エルエルシー |
がんの処置のための化合物およびその使用の方法
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
US10945771B2
(en)
|
2017-06-09 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
Azabicyclo[4.1.0]heptane allosteric modulators of the M4 muscarinic acetylcholine receptor
|
|
JP6647738B2
(ja)
|
2017-06-12 |
2020-02-14 |
矢崎総業株式会社 |
電池パック
|
|
WO2019000237A1
(en)
*
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
WO2019000238A1
(en)
*
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
WO2019000236A1
(en)
|
2017-06-27 |
2019-01-03 |
Merck Sharp & Dohme Corp. |
ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
|
|
JP7476167B2
(ja)
*
|
2018-04-06 |
2024-04-30 |
アルトス ラブス，インコーポレーテッド |
Ａｔｆ６阻害剤およびその使用
|
|
EP3788046B1
(en)
|
2018-05-04 |
2025-12-10 |
Incyte Corporation |
Salts of an fgfr inhibitor
|
|
EP4309737A3
(en)
|
2018-05-04 |
2024-03-27 |
Incyte Corporation |
Solid forms of an fgfr inhibitor and processes for preparing the same
|
|
EP3829580A1
(en)
|
2018-08-01 |
2021-06-09 |
Araxes Pharma LLC |
Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
|
|
US11396502B2
(en)
|
2018-11-13 |
2022-07-26 |
Incyte Corporation |
Substituted heterocyclic derivatives as PI3K inhibitors
|
|
US11161838B2
(en)
|
2018-11-13 |
2021-11-02 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
US11078204B2
(en)
|
2018-11-13 |
2021-08-03 |
Incyte Corporation |
Heterocyclic derivatives as PI3K inhibitors
|
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
|
JP7644023B2
(ja)
*
|
2019-04-10 |
2025-03-11 |
ナンジン ゼンシャイン ファーマシューティカルズ カンパニー リミテッド |
ホスファチジルイノシトール３－キナーゼ阻害剤
|
|
EP3980010A4
(en)
|
2019-06-04 |
2023-06-07 |
Arcus Biosciences, Inc. |
2,3,5-TRISUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
WO2021076602A1
(en)
|
2019-10-14 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
WO2021076728A1
(en)
|
2019-10-16 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
JP7720840B2
(ja)
|
2019-12-04 |
2025-08-08 |
インサイト・コーポレイション |
Ｆｇｆｒ阻害剤としての三環式複素環
|
|
KR20220131900A
(ko)
|
2019-12-04 |
2022-09-29 |
인사이트 코포레이션 |
Fgfr 억제제의 유도체
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
PH12022500017A1
(en)
*
|
2020-04-29 |
2023-08-14 |
De Shaw Res Llc |
PI3K-a INHIBITORS AND METHODS OF USE THEREOF
|
|
AU2021382769B2
(en)
*
|
2020-11-20 |
2024-03-07 |
Tarapeutics Science Inc. |
Dihydroisoquinolinone and isoindolinone derivatives and uses thereof
|
|
US20240174679A1
(en)
*
|
2021-03-17 |
2024-05-30 |
Merck Sharp & Dohme Llc |
Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
|
|
CA3215903A1
(en)
|
2021-04-12 |
2022-10-20 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
|
|
EP4352059A1
(en)
|
2021-06-09 |
2024-04-17 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
WO2022261159A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
CN118302427A
(zh)
*
|
2021-12-02 |
2024-07-05 |
上海翰森生物医药科技有限公司 |
稠环类衍生物调节剂、其制备方法和应用
|
|
KR102670554B1
(ko)
*
|
2022-01-04 |
2024-05-30 |
주식회사 이노보테라퓨틱스 |
캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
|
|
US20250171444A1
(en)
*
|
2022-03-04 |
2025-05-29 |
Synnovation Therapeutics, Inc. |
PI3Ka INHIBITORS
|
|
EP4585596A4
(en)
*
|
2022-09-09 |
2025-12-10 |
Shanghai Yingli Pharm Co Ltd |
Nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and uses thereof
|
|
WO2024153238A1
(zh)
*
|
2023-01-20 |
2024-07-25 |
南京再明医药有限公司 |
四环化合物及其应用
|
|
WO2024251212A1
(en)
*
|
2023-06-06 |
2024-12-12 |
Revir Therapeutics, Inc. |
Isoindolinone and dihydropyrrolopridinone compounds and uses thereof
|
|
WO2025179441A1
(zh)
*
|
2024-02-27 |
2025-09-04 |
上海璎黎药业有限公司 |
一种三并环结构化合物、其药物组合物及应用
|