JP2013515074A5 - - Google Patents

Download PDF

Info

Publication number
JP2013515074A5
JP2013515074A5 JP2012546137A JP2012546137A JP2013515074A5 JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5 JP 2012546137 A JP2012546137 A JP 2012546137A JP 2012546137 A JP2012546137 A JP 2012546137A JP 2013515074 A5 JP2013515074 A5 JP 2013515074A5
Authority
JP
Japan
Prior art keywords
aliphatic
alkyl
hydrogen
acceptable salt
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012546137A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013515074A (ja
JP5721187B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/061484 external-priority patent/WO2011087776A1/en
Publication of JP2013515074A publication Critical patent/JP2013515074A/ja
Publication of JP2013515074A5 publication Critical patent/JP2013515074A5/ja
Application granted granted Critical
Publication of JP5721187B2 publication Critical patent/JP5721187B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012546137A 2009-12-22 2010-12-21 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター Expired - Fee Related JP5721187B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US28900309P 2009-12-22 2009-12-22
US61/289,003 2009-12-22
US35063110P 2010-06-02 2010-06-02
US61/350,631 2010-06-02
US36920110P 2010-07-30 2010-07-30
US61/369,201 2010-07-30
US38758210P 2010-09-29 2010-09-29
US61/387,582 2010-09-29
PCT/US2010/061484 WO2011087776A1 (en) 2009-12-22 2010-12-21 Isoindolinone inhibitors of phosphatidylinositol 3-kinase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015034849A Division JP6132410B2 (ja) 2009-12-22 2015-02-25 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター

Publications (3)

Publication Number Publication Date
JP2013515074A JP2013515074A (ja) 2013-05-02
JP2013515074A5 true JP2013515074A5 (enExample) 2014-02-13
JP5721187B2 JP5721187B2 (ja) 2015-05-20

Family

ID=43859800

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012546137A Expired - Fee Related JP5721187B2 (ja) 2009-12-22 2010-12-21 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2015034849A Expired - Fee Related JP6132410B2 (ja) 2009-12-22 2015-02-25 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2017067536A Expired - Fee Related JP6510580B2 (ja) 2009-12-22 2017-03-30 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2018079069A Withdrawn JP2018131449A (ja) 2009-12-22 2018-04-17 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2015034849A Expired - Fee Related JP6132410B2 (ja) 2009-12-22 2015-02-25 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2017067536A Expired - Fee Related JP6510580B2 (ja) 2009-12-22 2017-03-30 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター
JP2018079069A Withdrawn JP2018131449A (ja) 2009-12-22 2018-04-17 ホスファチジルイノシトール3−キナーゼのイソインドリノンインヒビター

Country Status (16)

Country Link
US (4) US20120040950A1 (enExample)
EP (3) EP2516417B1 (enExample)
JP (4) JP5721187B2 (enExample)
KR (1) KR101758046B1 (enExample)
CN (1) CN102762548B (enExample)
AU (1) AU2010341573B2 (enExample)
BR (1) BR112012018386A8 (enExample)
CA (1) CA2785499C (enExample)
CL (1) CL2012001714A1 (enExample)
ES (2) ES2655391T3 (enExample)
IL (1) IL220625A (enExample)
MX (2) MX2012007403A (enExample)
NZ (1) NZ600954A (enExample)
RU (1) RU2573569C2 (enExample)
SG (2) SG10201502073PA (enExample)
WO (1) WO2011087776A1 (enExample)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
KR101660050B1 (ko) 2008-01-04 2016-09-26 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
MX2012007403A (es) 2009-12-22 2012-09-12 Vertex Pharma Inhibidores de isoindolinona de fosfatidinositol 3-cinasa.
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
US8901133B2 (en) 2010-11-10 2014-12-02 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
EP3238722B1 (en) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones
TWI565709B (zh) 2011-07-19 2017-01-11 英菲尼提製藥股份有限公司 雜環化合物及其用途
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
HK1199725A1 (en) 2011-08-29 2015-07-17 无限药品股份有限公司 Heterocyclic compounds and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TWI577677B (zh) * 2012-04-25 2017-04-11 拉夸里亞創藥股份有限公司 作爲ttx-s阻斷劑之吡咯並吡啶酮衍生物
EP3176170B1 (en) 2012-06-13 2018-11-14 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
UA110688C2 (uk) * 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
NZ708563A (en) 2012-11-01 2019-02-22 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
SG10201708520YA (en) 2013-04-19 2017-12-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US10301304B2 (en) * 2013-09-25 2019-05-28 Vertex Pharmaceuticals Incorporated Selective inhibitor of phosphatidylinositol 3-kinase-gamma
EA201690713A1 (ru) 2013-10-04 2016-08-31 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения и их применения
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Kras g12c之抑制劑
EP4066834A1 (en) 2014-03-19 2022-10-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015160307A1 (en) * 2014-04-16 2015-10-22 Nanyang Technological University Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins
ES2811088T3 (es) 2014-04-23 2021-03-10 Takeda Pharmaceuticals Co Derivados de isoindolin-1-ona como actividad del modulador alostérico positivo del receptor M1 muscarínico colinérgico para el tratamiento de la enfermedad de Alzheimer
KR20170015508A (ko) 2014-06-13 2017-02-08 길리애드 사이언시즈, 인코포레이티드 포스파티딜이노시톨 3-키나제 억제제로서의 퀴나졸리논 유도체
JP6455995B2 (ja) 2014-06-13 2019-01-23 ギリアード サイエンシーズ, インコーポレイテッド ホスファチジルイノシトール3−キナーゼ阻害剤
EP3154969B1 (en) 2014-06-13 2019-10-09 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
ES2833025T3 (es) 2014-06-13 2021-06-14 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-quinasa
US9499523B2 (en) * 2014-06-13 2016-11-22 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MX373169B (es) 2015-02-20 2020-04-24 Incyte Holdings Corp Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr).
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
EA201792214A1 (ru) 2015-04-10 2018-01-31 Араксис Фарма Ллк Соединения замещенного хиназолина
US10428064B2 (en) 2015-04-15 2019-10-01 Araxes Pharma Llc Fused-tricyclic inhibitors of KRAS and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
NZ740616A (en) 2015-09-14 2023-05-26 Infinity Pharmaceuticals Inc Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017045955A1 (en) * 2015-09-14 2017-03-23 Basf Se Heterobicyclic compounds
EP3356354A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356353A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356359B1 (en) 2015-09-28 2021-10-20 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356351A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
EP3356347A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
WO2017058902A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
EP3356349A1 (en) 2015-09-28 2018-08-08 Araxes Pharma LLC Inhibitors of kras g12c mutant proteins
US10489249B2 (en) 2015-09-30 2019-11-26 Commvault Systems, Inc. Dynamic triggering of block-level backups based on block change thresholds and corresponding file identities using communication pathways between co-resident data agents
HUE068392T2 (hu) 2015-10-21 2024-12-28 Otsuka Pharma Co Ltd Benzolaktám vegyületek mint fehérje kináz gátlók
KR20180073629A (ko) * 2015-10-22 2018-07-02 셀비타 에스에이 피리돈 유도체 및 키나제 억제제로서의 그의 용도
KR20240113606A (ko) 2015-11-16 2024-07-22 아락세스 파마 엘엘씨 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
WO2017107089A1 (en) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2017107087A1 (en) * 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 6, 7-dihydro-5h-pyrrolo [3, 4-b] pyridin-5-oneallosteric modulators of the m4 muscarinic acetylcholine receptor
WO2017112719A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 6,7-dihydro-5h-pyrrolo[3,4-b]pyridin-5-one allosteric modulators of the m4 muscarinic acetylcholine receptor
EA036388B1 (ru) * 2016-03-10 2020-11-03 Астразенека Аб Ингибиторы фосфатидилинозитол-3-киназы гамма
HRP20201405T1 (hr) 2016-03-17 2020-11-27 F. Hoffmann - La Roche Ag Derivat 5-etil-4-metil-pirazol-3-karboksamida, koji djeluje kao agonist taar-a
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
GB201604970D0 (en) 2016-03-23 2016-05-04 Syngenta Participations Ag Improvements in or relating to organic compounds
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2017281797A1 (en) 2016-06-24 2019-01-24 Infinity Pharmaceuticals, Inc. Combination therapies
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
CN110036010A (zh) 2016-09-29 2019-07-19 亚瑞克西斯制药公司 Kras g12c突变蛋白的抑制剂
EP3523289A1 (en) * 2016-10-07 2019-08-14 Araxes Pharma LLC Heterocyclic compounds as inhibitors of ras and methods of use thereof
WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
JP7327802B2 (ja) 2017-01-26 2023-08-16 アラクセス ファーマ エルエルシー 縮合ヘテロ-ヘテロ二環式化合物およびその使用方法
WO2018140599A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
EP3573954A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
US11136308B2 (en) 2017-01-26 2021-10-05 Araxes Pharma Llc Substituted quinazoline and quinazolinone compounds and methods of use thereof
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
EP3630745A2 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Covalent inhibitors of kras
EP3630746A1 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Compounds and methods of use thereof for treatment of cancer
EP3630747A1 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Quinazoline derivatives as modulators of mutant kras, hras or nras
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
WO2018226545A1 (en) * 2017-06-09 2018-12-13 Merck Sharp & Dohme Corp. Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor
JP6647738B2 (ja) 2017-06-12 2020-02-14 矢崎総業株式会社 電池パック
WO2019000238A1 (en) * 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
WO2019000236A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
WO2019000237A1 (en) 2017-06-27 2019-01-03 Merck Sharp & Dohme Corp. ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR
MX2020010469A (es) * 2018-04-06 2021-04-19 Praxis Biotech LLC Inhibidores del atf6 y sus usos.
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
CR20240498A (es) 2018-05-04 2025-01-08 Incyte Corp FORMAS SÓLIDAS DE UN INHIBIDOR DE FGFR Y PROCESOS PARA PREPARARLAS (Divisional EXP. 2020-0590)
JP2021532157A (ja) 2018-08-01 2021-11-25 アラクセス ファーマ エルエルシー がんを処置するための複素環式スピロ化合物およびその使用方法
WO2020102150A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors
WO2020102198A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors
US11396502B2 (en) 2018-11-13 2022-07-26 Incyte Corporation Substituted heterocyclic derivatives as PI3K inhibitors
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
EP3952870B1 (en) 2019-04-10 2025-09-24 Nanjing Zenshine Pharmaceuticals Co., Ltd. Phosphatidylinositol 3-kinase inhibitors
WO2020247496A1 (en) 2019-06-04 2020-12-10 Arcus Biosciences, Inc. 2,3,5-trisubstituted pyrazolo[1,5-a]pyrimidine compounds
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JOP20220083A1 (ar) 2019-10-14 2023-01-30 Incyte Corp حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
PE20221504A1 (es) 2019-12-04 2022-09-30 Incyte Corp Derivados de un inhibidor de fgfr
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
MX2022013417A (es) * 2020-04-29 2022-11-14 Relay Therapeutics Inc Inhibidores de fosfatidilinositol 3 cinasa (pi3k) alfa y metodos de uso de los mismos.
JP7728027B2 (ja) * 2020-11-20 2025-08-22 安徽中科拓苒▲薬▼物科学研究有限公司 ジヒドロイソキノリノン及びイソインドリノン誘導体並びにそれらの使用
US20240174679A1 (en) * 2021-03-17 2024-05-30 Merck Sharp & Dohme Llc Heteroaroyl amides as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
EP4323405A1 (en) 2021-04-12 2024-02-21 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
EP4352059A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
JP2024522188A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Fgfr阻害剤としての三環式ヘテロ環
EP4426286A4 (en) * 2021-11-03 2025-12-24 Relay Therapeutics Inc Bifunctional PI3K-Alpha Inhibitors and Their Uses
CN118302427A (zh) * 2021-12-02 2024-07-05 上海翰森生物医药科技有限公司 稠环类衍生物调节剂、其制备方法和应用
KR102670554B1 (ko) * 2022-01-04 2024-05-30 주식회사 이노보테라퓨틱스 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
US20250171444A1 (en) * 2022-03-04 2025-05-29 Synnovation Therapeutics, Inc. PI3Ka INHIBITORS
WO2024051784A1 (zh) * 2022-09-09 2024-03-14 上海璎黎药业有限公司 一种含氮杂环化合物、其药物组合物及应用
WO2024153238A1 (zh) * 2023-01-20 2024-07-25 南京再明医药有限公司 四环化合物及其应用
WO2024251212A1 (en) * 2023-06-06 2024-12-12 Revir Therapeutics, Inc. Isoindolinone and dihydropyrrolopridinone compounds and uses thereof
WO2025179441A1 (zh) * 2024-02-27 2025-09-04 上海璎黎药业有限公司 一种三并环结构化合物、其药物组合物及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57134467A (en) * 1981-02-13 1982-08-19 Dai Ichi Seiyaku Co Ltd Pyridine derivative and its preparation
CA2527814A1 (en) * 2003-06-02 2004-12-16 Abbott Laboratories Isoindolin-1-one compounds as kinase inhibitors
JPWO2005085214A1 (ja) 2004-03-05 2008-01-17 萬有製薬株式会社 ジアリール置換複素5員環誘導体
SE0400970D0 (sv) * 2004-04-14 2004-04-14 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
GB0504753D0 (en) 2005-03-08 2005-04-13 Astrazeneca Ab Chemical compounds
TW200728277A (en) * 2005-06-29 2007-08-01 Palau Pharma Sa Bicyclic derivatives as P38 inhibitors
TW200804281A (en) * 2006-02-16 2008-01-16 Astrazeneca Ab New metabotropic glutamate receptor-potentiating isoindolones
CN101421237A (zh) * 2006-02-16 2009-04-29 阿斯利康(瑞典)有限公司 增效亲代谢性谷氨酸受体的异吲哚酮
US8110681B2 (en) * 2006-03-17 2012-02-07 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compounds for the treatment of spinal muscular atrophy and other uses
BRPI0810175A2 (pt) * 2007-04-11 2014-12-30 Exelixis Inc Inibidores pirididopirinidinona de p13k alfa
MX2012007403A (es) 2009-12-22 2012-09-12 Vertex Pharma Inhibidores de isoindolinona de fosfatidinositol 3-cinasa.

Similar Documents

Publication Publication Date Title
JP2013515074A5 (enExample)
RU2012131416A (ru) Ингибиторы фосфатидилинозитол-3-киназы на основе изоиндолинона
JP6936823B2 (ja) 抗癌活性及び抗増殖活性を呈する2−アミノピリミジン−6−オン及び類似体
KR101585848B1 (ko) 관절염의 치료 방법
CA2903288C (en) N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
CN112424181B (zh) 作为sting调节剂的取代的缩合噻吩
TW202019900A (zh) Ptpn11抑制劑
JP2018505898A5 (enExample)
JP2016513661A5 (enExample)
WO2017040993A4 (en) Small molecule inhibitors of dyrk1a and uses thereof
JP7244504B2 (ja) PI3K-γ阻害剤としての三級ヒドロキシ基で置換された縮合イミダゾール誘導体
JP2010513532A (ja) スフィンゴシン−1−ホスフェート受容体作働薬および拮抗薬化合物
JP2014037426A5 (enExample)
JP2016539927A (ja) Jak1選択的阻害剤とその使用
JPWO2021013735A5 (enExample)
JP2009537461A5 (enExample)
JP2016527217A5 (enExample)
JP2014500295A5 (enExample)
JP2017533968A5 (enExample)
JP2024519487A (ja) Nav1.8阻害薬としてのアリール 3-オキソピペラジンカルボキサミド類及びヘテロアリール 3-オキソピペラジンカルボキサミド類
JP2014502641A5 (enExample)
JP2021509113A (ja) キナーゼ阻害剤としての複素環式アミド
JP2011518168A5 (enExample)
JP2017511339A5 (enExample)
JP2011509301A5 (enExample)