JP2016525121A5 - - Google Patents
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- JP2016525121A5 JP2016525121A5 JP2016527137A JP2016527137A JP2016525121A5 JP 2016525121 A5 JP2016525121 A5 JP 2016525121A5 JP 2016527137 A JP2016527137 A JP 2016527137A JP 2016527137 A JP2016527137 A JP 2016527137A JP 2016525121 A5 JP2016525121 A5 JP 2016525121A5
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- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- compound
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 144
- 239000001257 hydrogen Substances 0.000 claims description 144
- 125000000217 alkyl group Chemical group 0.000 claims description 118
- 150000001875 compounds Chemical class 0.000 claims description 99
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 90
- 229910052757 nitrogen Inorganic materials 0.000 claims description 68
- 125000003545 alkoxy group Chemical group 0.000 claims description 65
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 64
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 50
- 150000002431 hydrogen Chemical class 0.000 claims description 44
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 32
- 229910052799 carbon Inorganic materials 0.000 claims description 32
- 125000005843 halogen group Chemical group 0.000 claims description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 27
- -1 methoxy, substituted ethoxy Chemical group 0.000 claims description 23
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 22
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 18
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 18
- 125000001153 fluoro group Chemical group F* 0.000 claims description 18
- 125000005842 heteroatom Chemical group 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 239000011593 sulfur Substances 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 150000003839 salts Chemical class 0.000 claims description 10
- 206010002091 Anaesthesia Diseases 0.000 claims description 8
- 230000037005 anaesthesia Effects 0.000 claims description 8
- 206010039897 Sedation Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000036280 sedation Effects 0.000 claims description 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 229940124597 therapeutic agent Drugs 0.000 claims description 3
- 206010010904 Convulsion Diseases 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 230000000155 isotopic effect Effects 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- 208000005809 status epilepticus Diseases 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 11
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 9
- 208000035475 disorder Diseases 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- 0 C[C@](CCC1)(CC2(*)*)[C@@]1[C@](CC1)[C@]2[C@@](C)(CC2(C)C)C1(*)C[C@@]2O Chemical compound C[C@](CCC1)(CC2(*)*)[C@@]1[C@](CC1)[C@]2[C@@](C)(CC2(C)C)C1(*)C[C@@]2O 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019106471A JP6974388B2 (ja) | 2013-07-19 | 2019-06-06 | 向神経活性ステロイド、組成物、およびそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361856592P | 2013-07-19 | 2013-07-19 | |
| US61/856,592 | 2013-07-19 | ||
| PCT/US2014/047246 WO2015010054A2 (en) | 2013-07-19 | 2014-07-18 | Neuroactive steroids, compositions, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019106471A Division JP6974388B2 (ja) | 2013-07-19 | 2019-06-06 | 向神経活性ステロイド、組成物、およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016525121A JP2016525121A (ja) | 2016-08-22 |
| JP2016525121A5 true JP2016525121A5 (enExample) | 2017-08-31 |
| JP6578277B2 JP6578277B2 (ja) | 2019-09-18 |
Family
ID=52346850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016527137A Active JP6578277B2 (ja) | 2013-07-19 | 2014-07-18 | 向神経活性ステロイド、組成物、およびそれらの使用 |
| JP2019106471A Active JP6974388B2 (ja) | 2013-07-19 | 2019-06-06 | 向神経活性ステロイド、組成物、およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019106471A Active JP6974388B2 (ja) | 2013-07-19 | 2019-06-06 | 向神経活性ステロイド、組成物、およびそれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20160152658A1 (enExample) |
| EP (2) | EP3021852B1 (enExample) |
| JP (2) | JP6578277B2 (enExample) |
| CN (1) | CN105555277B (enExample) |
| AU (1) | AU2014290400B2 (enExample) |
| BR (1) | BR112016000975B1 (enExample) |
| CA (2) | CA2918735C (enExample) |
| CY (1) | CY1124330T1 (enExample) |
| DK (1) | DK3021852T3 (enExample) |
| ES (1) | ES2864719T3 (enExample) |
| HR (1) | HRP20210610T1 (enExample) |
| HU (1) | HUE053900T2 (enExample) |
| LT (1) | LT3021852T (enExample) |
| PL (1) | PL3021852T3 (enExample) |
| PT (1) | PT3021852T (enExample) |
| RS (1) | RS61733B1 (enExample) |
| RU (1) | RU2754534C2 (enExample) |
| SI (1) | SI3021852T1 (enExample) |
| SM (1) | SMT202100229T1 (enExample) |
| WO (1) | WO2015010054A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101583620B (zh) | 2005-11-28 | 2016-08-17 | 马里纳斯医药公司 | 加奈索酮组合物及其制备和使用方法 |
| ES2738526T3 (es) | 2011-10-14 | 2020-01-23 | Sage Therapeutics Inc | Compuestos 19-norpregnano 3,3-disustituidos, composiciones y usos de los mismos |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| WO2014169831A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof |
| HRP20190232T1 (hr) | 2013-04-17 | 2019-03-22 | Sage Therapeutics, Inc. | 19-nor c3,3-disupstituirani c21-n-pirazolil steroidi i postupci za njihovu upotrebu |
| HRP20200995T1 (hr) | 2013-04-17 | 2020-11-27 | Sage Therapeutics, Inc. | 19-nor neuroaktivni steroidi za metode liječenja |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| SMT202100229T1 (it) | 2013-07-19 | 2021-05-07 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e loro usi |
| SMT202100048T1 (it) | 2013-08-23 | 2021-03-15 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e loro usi |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| JP6742308B2 (ja) | 2014-10-16 | 2020-08-19 | セージ セラピューティクス， インコーポレイテッド | Ｃｎｓ障害を処置するための組成物および方法 |
| AU2015331749A1 (en) | 2014-10-16 | 2017-05-04 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| ES2793237T3 (es) | 2014-11-27 | 2020-11-13 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| SI3250210T1 (sl) | 2015-01-26 | 2021-07-30 | Sage Therapeutics, Inc. | Sestavki in metode za zdravljenje CNS motenj |
| US10329320B2 (en) | 2015-02-20 | 2019-06-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| WO2016164763A1 (en) * | 2015-04-10 | 2016-10-13 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| AR105044A1 (es) | 2015-06-18 | 2017-08-30 | Sage Therapeutics Inc | Soluciones de esteroides neuroactivos y sus métodos de uso, recipiente |
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| US20200306262A1 (en) * | 2015-11-20 | 2020-10-01 | Sage Therapeutics, Inc. | Compounds and methods of their use |
| SG11201807785VA (en) | 2016-03-08 | 2018-10-30 | Sage Therapeutics Inc | Neuroactive steroids, compositions, and uses thereof |
| CN109689673B (zh) | 2016-07-11 | 2023-03-14 | 萨奇治疗股份有限公司 | C17、c20和c21取代的神经活性类固醇及其使用方法 |
| AU2017296295B2 (en) | 2016-07-11 | 2022-02-24 | Sage Therapeutics, Inc. | C7, C12, and C16 substituted neuroactive steroids and their methods of use |
| WO2018031748A1 (en) | 2016-08-11 | 2018-02-15 | Ovid Therapeutics Inc. | Methods and compositions for treatment of epileptic disorders |
| CN115974954A (zh) | 2016-08-23 | 2023-04-18 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体 |
| US10391105B2 (en) | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
| CN107236015A (zh) * | 2017-06-15 | 2017-10-10 | 甘肃兰药药业有限公司 | 一种醋酸阿比特龙还原杂质及其制备方法 |
| EP3720867A1 (en) | 2017-12-08 | 2020-10-14 | Sage Therapeutics, Inc. | Deuterated 21 -[4-cyano-pyrazol-1 -yl]-19-nor-pregan-3. alpha-ol-20-one derivatives for treating cns disorders |
| WO2020118142A1 (en) | 2018-12-07 | 2020-06-11 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of pospartum depression |
| CN114206900A (zh) | 2019-05-31 | 2022-03-18 | 萨奇治疗股份有限公司 | 神经活性类固醇及其组合物 |
| CA3145923A1 (en) | 2019-08-05 | 2021-02-11 | David Czekai | Ganaxolone for use in treatment of status epilepticus |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| CN110903339A (zh) * | 2019-12-06 | 2020-03-24 | 南京正济医药研究有限公司 | 一种罗库溴胺中间体5α-甾烷-2-烯-17-酮的制备方法 |
| WO2021113834A1 (en) | 2019-12-06 | 2021-06-10 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in treating tuberous sclerosis complex |
| US20230346801A1 (en) | 2020-03-25 | 2023-11-02 | Sage Therapeutics, Inc. | Use of agents for treatment of respiratory conditions |
| US12410209B2 (en) | 2021-06-29 | 2025-09-09 | Board Of Regents, The University Of Texas System | Modified glucocorticoids |
| CN114409718A (zh) * | 2021-12-31 | 2022-04-29 | 湖北武当安泰药业有限公司 | 去氢表雄酮催化加氢制备表雄酮的方法 |
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2014
- 2014-07-18 SM SM20210229T patent/SMT202100229T1/it unknown
- 2014-07-18 CN CN201480051239.XA patent/CN105555277B/zh active Active
- 2014-07-18 PT PT148262124T patent/PT3021852T/pt unknown
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- 2014-07-18 CA CA2918735A patent/CA2918735C/en active Active
- 2014-07-18 EP EP14826212.4A patent/EP3021852B1/en active Active
- 2014-07-18 RU RU2016105436A patent/RU2754534C2/ru active
- 2014-07-18 US US14/906,043 patent/US20160152658A1/en not_active Abandoned
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- 2014-07-18 EP EP21152393.1A patent/EP3868382A1/en active Pending
- 2014-07-18 BR BR112016000975-4A patent/BR112016000975B1/pt active IP Right Grant
- 2014-07-18 WO PCT/US2014/047246 patent/WO2015010054A2/en not_active Ceased
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- 2014-07-18 CA CA3199003A patent/CA3199003A1/en active Pending
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