JP2012017344A5 - - Google Patents
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- Publication number
- JP2012017344A5 JP2012017344A5 JP2011232182A JP2011232182A JP2012017344A5 JP 2012017344 A5 JP2012017344 A5 JP 2012017344A5 JP 2011232182 A JP2011232182 A JP 2011232182A JP 2011232182 A JP2011232182 A JP 2011232182A JP 2012017344 A5 JP2012017344 A5 JP 2012017344A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- microemulsion
- biologically active
- oil
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 72
- 239000004530 micro-emulsion Substances 0.000 claims 32
- 239000003921 oil Substances 0.000 claims 19
- 235000019198 oils Nutrition 0.000 claims 19
- 229920000642 polymer Polymers 0.000 claims 17
- 239000002671 adjuvant Substances 0.000 claims 14
- 239000011859 microparticle Substances 0.000 claims 14
- 239000003995 emulsifying agent Substances 0.000 claims 13
- 241001465754 Metazoa Species 0.000 claims 11
- 229920002521 macromolecule Polymers 0.000 claims 10
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 239000004094 surface-active agent Substances 0.000 claims 8
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims 6
- 230000000274 adsorptive effect Effects 0.000 claims 6
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 6
- 239000003093 cationic surfactant Substances 0.000 claims 6
- 230000028993 immune response Effects 0.000 claims 6
- 230000001939 inductive effect Effects 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 4
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 4
- 239000005556 hormone Substances 0.000 claims 4
- 239000002955 immunomodulating agent Substances 0.000 claims 4
- 229940121354 immunomodulator Drugs 0.000 claims 4
- 239000000543 intermediate Substances 0.000 claims 4
- 230000037353 metabolic pathway Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002736 nonionic surfactant Substances 0.000 claims 4
- 150000003505 terpenes Chemical class 0.000 claims 4
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 3
- 239000003945 anionic surfactant Substances 0.000 claims 3
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 3
- 229940088598 enzyme Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229940031439 squalene Drugs 0.000 claims 3
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 3
- DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 101710154606 Hemagglutinin Proteins 0.000 claims 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 2
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 101710176177 Protein A56 Proteins 0.000 claims 2
- 230000029662 T-helper 1 type immune response Effects 0.000 claims 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 2
- 239000010775 animal oil Substances 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 150000005690 diesters Chemical class 0.000 claims 2
- 239000010419 fine particle Substances 0.000 claims 2
- 239000000185 hemagglutinin Substances 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 208000037797 influenza A Diseases 0.000 claims 2
- 239000007764 o/w emulsion Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920001432 poly(L-lactide) Polymers 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920002721 polycyanoacrylate Polymers 0.000 claims 2
- -1 polyoxy Polymers 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 230000002103 transcriptional effect Effects 0.000 claims 2
- 150000005691 triesters Chemical class 0.000 claims 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical group [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
- QWZLBLDNRUUYQI-UHFFFAOYSA-M Methylbenzethonium chloride Chemical compound [Cl-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 QWZLBLDNRUUYQI-UHFFFAOYSA-M 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 claims 1
- 229960000228 cetalkonium chloride Drugs 0.000 claims 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 1
- YLATXFLJXBPIPT-UHFFFAOYSA-N dodecyl hydrogen sulfate;4-methylpyridine Chemical compound CC1=CC=NC=C1.CCCCCCCCCCCCOS(O)(=O)=O YLATXFLJXBPIPT-UHFFFAOYSA-N 0.000 claims 1
- XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229960002285 methylbenzethonium chloride Drugs 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- 150000003212 purines Chemical class 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- YYGNTYWPHWGJRM-AAJYLUCBSA-N squalene group Chemical group CC(C)=CCC\C(\C)=C\CC\C(\C)=C\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C YYGNTYWPHWGJRM-AAJYLUCBSA-N 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12185899P | 1999-02-26 | 1999-02-26 | |
| US14639199P | 1999-07-29 | 1999-07-29 | |
| US16199799P | 1999-10-28 | 1999-10-28 | |
| US60/161,997 | 1999-10-28 | ||
| US60/146,391 | 1999-10-28 | ||
| US60/121,858 | 1999-10-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600618A Division JP2002537102A (ja) | 1999-02-26 | 2000-02-09 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014110216A Division JP2014169323A (ja) | 1999-02-26 | 2014-05-28 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012017344A JP2012017344A (ja) | 2012-01-26 |
| JP2012017344A5 true JP2012017344A5 (enExample) | 2012-09-20 |
| JP6073053B2 JP6073053B2 (ja) | 2017-02-01 |
Family
ID=27382688
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600618A Withdrawn JP2002537102A (ja) | 1999-02-26 | 2000-02-09 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2011232182A Expired - Lifetime JP6073053B2 (ja) | 1999-02-26 | 2011-10-21 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2014110216A Withdrawn JP2014169323A (ja) | 1999-02-26 | 2014-05-28 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2016125184A Pending JP2016172767A (ja) | 1999-02-26 | 2016-06-24 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600618A Withdrawn JP2002537102A (ja) | 1999-02-26 | 2000-02-09 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014110216A Withdrawn JP2014169323A (ja) | 1999-02-26 | 2014-05-28 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2016125184A Pending JP2016172767A (ja) | 1999-02-26 | 2016-06-24 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8206749B1 (enExample) |
| EP (3) | EP1574210B1 (enExample) |
| JP (4) | JP2002537102A (enExample) |
| AT (1) | ATE297190T1 (enExample) |
| AU (1) | AU2875700A (enExample) |
| CA (2) | CA2363141C (enExample) |
| DE (1) | DE60020677T2 (enExample) |
| ES (2) | ES2242604T3 (enExample) |
| WO (1) | WO2000050006A2 (enExample) |
Families Citing this family (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| EP1574210B1 (en) | 1999-02-26 | 2016-04-06 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with adsorbed macromolecules |
| DE60125795T2 (de) | 2000-09-28 | 2007-10-18 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Mikropartikelzusammensetzungen und verfahren zu ihrer herstellung |
| ES2260291T3 (es) * | 2000-09-28 | 2006-11-01 | Chiron Corporation | Microparticulas para la administracion de acidos nucleicos heterologos. |
| FR2814958B1 (fr) * | 2000-10-06 | 2003-03-07 | Aventis Pasteur | Composition vaccinale |
| US6552004B1 (en) * | 2000-10-30 | 2003-04-22 | Universite De Montreal | Delivery system for entrapping charged macromolecules and a method for preparing same |
| US20030049266A1 (en) | 2000-12-27 | 2003-03-13 | Fearon Karen L. | Immunomodulatory polynucleotides and methods of using the same |
| AU2002326561B2 (en) | 2001-08-07 | 2008-04-03 | Dynavax Technologies Corporation | Immunomodulatory compositions, formulations, and methods for use thereof |
| ES2335979T3 (es) * | 2001-09-14 | 2010-04-07 | Cytos Biotechnology Ag | Empaquetamiento de cpg inmunoestimuladores en particulas similares a virus: metodo de preparacion y su uso. |
| AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| NZ532274A (en) * | 2001-10-03 | 2006-02-24 | Chiron Corp | Adjuvanted meningococcus compositions |
| CA2471968C (en) * | 2001-10-06 | 2013-07-23 | Merial Limited | Immunostimulatory nucleic acids and use thereof |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US7501134B2 (en) | 2002-02-20 | 2009-03-10 | Novartis Vaccines And Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
| JP4726485B2 (ja) * | 2002-08-02 | 2011-07-20 | 大日本住友製薬株式会社 | 細菌細胞壁骨格成分製剤 |
| CN100471486C (zh) * | 2002-08-12 | 2009-03-25 | 戴纳伐克斯技术股份有限公司 | 免疫调节组合物,其制备方法和使用方法 |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP2006520746A (ja) | 2002-12-27 | 2006-09-14 | カイロン コーポレイション | リン脂質を含む免疫原性組成物 |
| CA2523266A1 (en) * | 2003-04-25 | 2004-11-11 | Chiron Corporation | Compositions comprising cationic microparticles and hcv e1e2 dna and methods of use thereof |
| ATE437633T2 (de) | 2003-06-02 | 2009-08-15 | Novartis Vaccines & Diagnostic | Immunogene zusammensetzungen auf basis von biologisch abbaubaren mikroteilchen enthaltend ein diphtherie- und ein tetanustoxoid |
| US20050208083A1 (en) | 2003-06-04 | 2005-09-22 | Nanobio Corporation | Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof |
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-
2000
- 2000-02-09 EP EP05075823.4A patent/EP1574210B1/en not_active Expired - Lifetime
- 2000-02-09 DE DE60020677T patent/DE60020677T2/de not_active Expired - Lifetime
- 2000-02-09 EP EP00907228A patent/EP1156781B1/en not_active Revoked
- 2000-02-09 CA CA2363141A patent/CA2363141C/en not_active Expired - Lifetime
- 2000-02-09 ES ES00907228T patent/ES2242604T3/es not_active Expired - Lifetime
- 2000-02-09 JP JP2000600618A patent/JP2002537102A/ja not_active Withdrawn
- 2000-02-09 AT AT00907228T patent/ATE297190T1/de active
- 2000-02-09 EP EP10179804A patent/EP2286792A1/en not_active Withdrawn
- 2000-02-09 US US09/914,279 patent/US8206749B1/en not_active Expired - Fee Related
- 2000-02-09 CA CA2689696A patent/CA2689696C/en not_active Expired - Lifetime
- 2000-02-09 ES ES05075823.4T patent/ES2579783T3/es not_active Expired - Lifetime
- 2000-02-09 AU AU28757/00A patent/AU2875700A/en not_active Abandoned
- 2000-02-09 WO PCT/US2000/003331 patent/WO2000050006A2/en not_active Ceased
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2006
- 2006-04-18 US US11/406,144 patent/US8309139B2/en not_active Expired - Fee Related
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2011
- 2011-10-21 JP JP2011232182A patent/JP6073053B2/ja not_active Expired - Lifetime
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2012
- 2012-09-14 US US13/618,020 patent/US8771747B2/en not_active Expired - Fee Related
- 2012-09-15 US US13/621,174 patent/US8734832B2/en not_active Expired - Fee Related
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2014
- 2014-05-28 JP JP2014110216A patent/JP2014169323A/ja not_active Withdrawn
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2016
- 2016-06-24 JP JP2016125184A patent/JP2016172767A/ja active Pending
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