JP2002537102A5 - - Google Patents
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- JP2002537102A5 JP2002537102A5 JP2000600618A JP2000600618A JP2002537102A5 JP 2002537102 A5 JP2002537102 A5 JP 2002537102A5 JP 2000600618 A JP2000600618 A JP 2000600618A JP 2000600618 A JP2000600618 A JP 2000600618A JP 2002537102 A5 JP2002537102 A5 JP 2002537102A5
- Authority
- JP
- Japan
- Prior art keywords
- microemulsion
- composition
- group
- composition according
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000004530 micro-emulsion Substances 0.000 description 35
- 239000000203 mixture Substances 0.000 description 30
- 238000000034 method Methods 0.000 description 17
- 239000000427 antigen Substances 0.000 description 10
- 102000036639 antigens Human genes 0.000 description 10
- 108091007433 antigens Proteins 0.000 description 10
- 239000002671 adjuvant Substances 0.000 description 9
- 239000003995 emulsifying agent Substances 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000010419 fine particle Substances 0.000 description 4
- 239000011859 microparticle Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 229920001214 Polysorbate 60 Polymers 0.000 description 3
- 241000700584 Simplexvirus Species 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 239000002955 immunomodulating agent Substances 0.000 description 3
- 229940121354 immunomodulator Drugs 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 230000037353 metabolic pathway Effects 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 244000045947 parasite Species 0.000 description 3
- 108091033319 polynucleotide Proteins 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 239000002157 polynucleotide Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000002584 immunomodulator Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- -1 polynucleoside Proteins 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical group [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- QWZLBLDNRUUYQI-UHFFFAOYSA-M Methylbenzethonium chloride Chemical compound [Cl-].CC1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 QWZLBLDNRUUYQI-UHFFFAOYSA-M 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920001244 Poly(D,L-lactide) Polymers 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 230000029662 T-helper 1 type immune response Effects 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical group O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- SXPWTBGAZSPLHA-UHFFFAOYSA-M cetalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SXPWTBGAZSPLHA-UHFFFAOYSA-M 0.000 description 1
- 229960000228 cetalkonium chloride Drugs 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- YLATXFLJXBPIPT-UHFFFAOYSA-N dodecyl hydrogen sulfate;4-methylpyridine Chemical compound CC1=CC=NC=C1.CCCCCCCCCCCCOS(O)(=O)=O YLATXFLJXBPIPT-UHFFFAOYSA-N 0.000 description 1
- XJWSAJYUBXQQDR-UHFFFAOYSA-M dodecyltrimethylammonium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)C XJWSAJYUBXQQDR-UHFFFAOYSA-M 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 229960002285 methylbenzethonium chloride Drugs 0.000 description 1
- 125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001432 poly(L-lactide) Polymers 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920002721 polycyanoacrylate Polymers 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- YYGNTYWPHWGJRM-AAJYLUCBSA-N squalene group Chemical group CC(C)=CCC\C(\C)=C\CC\C(\C)=C\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C YYGNTYWPHWGJRM-AAJYLUCBSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12185899P | 1999-02-26 | 1999-02-26 | |
| US60/121,858 | 1999-02-26 | ||
| US14639199P | 1999-07-29 | 1999-07-29 | |
| US60/146,391 | 1999-07-29 | ||
| US16199799P | 1999-10-28 | 1999-10-28 | |
| US60/161,997 | 1999-10-28 | ||
| PCT/US2000/003331 WO2000050006A2 (en) | 1999-02-26 | 2000-02-09 | Microemulsions with adsorbed macromoelecules and microparticles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011232182A Division JP6073053B2 (ja) | 1999-02-26 | 2011-10-21 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002537102A JP2002537102A (ja) | 2002-11-05 |
| JP2002537102A5 true JP2002537102A5 (enExample) | 2007-04-05 |
Family
ID=27382688
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000600618A Withdrawn JP2002537102A (ja) | 1999-02-26 | 2000-02-09 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2011232182A Expired - Lifetime JP6073053B2 (ja) | 1999-02-26 | 2011-10-21 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2014110216A Withdrawn JP2014169323A (ja) | 1999-02-26 | 2014-05-28 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2016125184A Pending JP2016172767A (ja) | 1999-02-26 | 2016-06-24 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011232182A Expired - Lifetime JP6073053B2 (ja) | 1999-02-26 | 2011-10-21 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2014110216A Withdrawn JP2014169323A (ja) | 1999-02-26 | 2014-05-28 | 吸着された高分子および微粒子を有するミクロエマルジョン |
| JP2016125184A Pending JP2016172767A (ja) | 1999-02-26 | 2016-06-24 | 吸着された高分子および微粒子を有するミクロエマルジョン |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8206749B1 (enExample) |
| EP (3) | EP1574210B1 (enExample) |
| JP (4) | JP2002537102A (enExample) |
| AT (1) | ATE297190T1 (enExample) |
| AU (1) | AU2875700A (enExample) |
| CA (2) | CA2689696C (enExample) |
| DE (1) | DE60020677T2 (enExample) |
| ES (2) | ES2242604T3 (enExample) |
| WO (1) | WO2000050006A2 (enExample) |
Families Citing this family (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| EP1574210B1 (en) | 1999-02-26 | 2016-04-06 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with adsorbed macromolecules |
| CA2421683C (en) * | 2000-09-28 | 2009-09-15 | Chiron Corporation | Microparticles for delivery of the heterologous nucleic acids |
| EP1322292B1 (en) * | 2000-09-28 | 2007-01-03 | Novartis Vaccines and Diagnostics, Inc. | Microparticle compositions and methods for the manufacture thereof |
| FR2814958B1 (fr) * | 2000-10-06 | 2003-03-07 | Aventis Pasteur | Composition vaccinale |
| US6552004B1 (en) * | 2000-10-30 | 2003-04-22 | Universite De Montreal | Delivery system for entrapping charged macromolecules and a method for preparing same |
| JP4188687B2 (ja) * | 2000-12-27 | 2008-11-26 | ダイナバックス テクノロジーズ コーポレイション | 免疫変調ポリヌクレオチド及びその使用法 |
| WO2003014316A2 (en) | 2001-08-07 | 2003-02-20 | Dynavax Technologies Corporation | Immunomodulatory compositions, formulations, and methods for use thereof |
| CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| AU2002334844B2 (en) * | 2001-10-03 | 2007-08-02 | Novartis Vaccines And Diagnostics, Inc. | Adjuvanted meningococcus compositions |
| US20050238660A1 (en) * | 2001-10-06 | 2005-10-27 | Babiuk Lorne A | Cpg formulations and related methods |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US7501134B2 (en) | 2002-02-20 | 2009-03-10 | Novartis Vaccines And Diagnostics, Inc. | Microparticles with adsorbed polypeptide-containing molecules |
| JP4726485B2 (ja) * | 2002-08-02 | 2011-07-20 | 大日本住友製薬株式会社 | 細菌細胞壁骨格成分製剤 |
| NZ538628A (en) | 2002-08-12 | 2008-06-30 | Dynavax Tech Corp | Immunomodulatory compositions, methods of making, and methods of use thereof |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| JP2006520746A (ja) | 2002-12-27 | 2006-09-14 | カイロン コーポレイション | リン脂質を含む免疫原性組成物 |
| EP1622566A4 (en) * | 2003-04-25 | 2008-06-25 | Novartis Vaccines & Diagnostic | COMPOSITIONS WITH CATIONIC MICROTEILS AND HCV E1E2 DNA AND METHOD OF APPLICATION THEREOF |
| CN1798548B (zh) | 2003-06-02 | 2010-05-05 | 诺华疫苗和诊断公司 | 基于含吸附类毒素和含多糖抗原微粒体的免疫原性组合物 |
| US20100075914A1 (en) * | 2008-04-18 | 2010-03-25 | Nanobio Corporation | Methods for treating herpes virus infections |
| US20050208083A1 (en) | 2003-06-04 | 2005-09-22 | Nanobio Corporation | Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof |
| EP1711058B1 (en) | 2004-01-23 | 2021-09-15 | Eden Research Plc | Methods of killing nematodes comprising the application of a terpene component |
| PT1753529E (pt) | 2004-05-20 | 2013-11-18 | Eden Research Plc | Composições contendo uma partícula oca de glucano ou uma partícula de parede celular encapsulando um componente de terpeno, e métodos para a sua produção e utilização |
| PE20061428A1 (es) | 2005-03-23 | 2007-01-16 | Glaxosmithkline Biolog Sa | Formulacion de vacuna que comprende un adyuvante de emulsion aceite en agua y 3d-mpl |
| EP1871349A1 (en) * | 2005-04-11 | 2008-01-02 | Nanobio Corporation | Quaternary ammonium halides for treatment of infectious conditions |
| EP2201961B1 (en) | 2005-06-27 | 2018-01-24 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| US20070036831A1 (en) * | 2005-08-09 | 2007-02-15 | Nanobio Corporation | Nanoemulsion compositions having anti-inflammatory activity |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| PT1951300E (pt) * | 2005-11-04 | 2011-09-05 | Novartis Vaccines & Diagnostic | Modificação do equilíbrio de th1/th2 em vacinas da influenza fragmentadas com adjuvantes |
| NZ568210A (en) * | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
| CA2628152C (en) * | 2005-11-04 | 2016-02-02 | Novartis Vaccines And Diagnostics S.R.L. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| ES2804472T3 (es) | 2005-12-13 | 2021-02-08 | Harvard College | Estructuras para trasplante celular |
| NZ569741A (en) | 2005-12-14 | 2012-02-24 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| US10138279B2 (en) | 2006-04-13 | 2018-11-27 | Regents Of The University Of Michigan | Compositions and methods for Bacillus anthracis vaccination |
| US9839685B2 (en) | 2006-04-13 | 2017-12-12 | The Regents Of The University Of Michigan | Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen |
| JP5437797B2 (ja) | 2006-06-12 | 2014-03-12 | サイトス バイオテクノロジー アーゲー | Ｒｎａバクテリオファージのウイルス様粒子にオリゴヌクレオチドをパッケージ化するための方法 |
| MX2009000660A (es) | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
| CA2671873C (en) | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
| US8877206B2 (en) * | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| CA2683974A1 (en) * | 2007-04-18 | 2008-10-30 | The Regents Of The University Of California | Protein-modified nano-droplets, compositions and methods of production |
| US9452209B2 (en) | 2007-04-20 | 2016-09-27 | Glaxosmithkline Biologicals Sa | Influenza vaccine |
| AU2008335457B2 (en) | 2007-12-07 | 2015-04-16 | Glaxosmithkline Biologicals S.A. | Compositions for inducing immune responses |
| US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
| EP2254602B1 (en) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Continuous cell programming devices |
| CN103990120B (zh) * | 2008-04-01 | 2018-06-05 | 伊耐特免疫治疗有限公司 | 抗感染剂及其用途 |
| BRPI0910464B1 (pt) | 2008-04-17 | 2021-08-10 | Pds Biotechnology Corporation | Uso de uso de um lipídio catiônico quiral consistindo de r-dotap a preparação de composição farmacêutica |
| US9144606B2 (en) | 2008-04-21 | 2015-09-29 | Nanobio Corporation | Nanoemulsion influenza vaccine |
| JP2011518844A (ja) | 2008-04-25 | 2011-06-30 | ナノバイオ コーポレーション | 真菌、酵母および糸状菌感染症を治療するためのナノエマルション |
| WO2009132343A1 (en) * | 2008-04-25 | 2009-10-29 | Nanobio Corporation | Nanoemulsions for treating onchomycosis |
| CA2725329C (en) | 2008-05-23 | 2013-10-01 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| NZ621834A (en) | 2008-06-27 | 2015-10-30 | Zoetis Services Llc | Novel adjuvant compositions |
| JP5722782B2 (ja) | 2008-09-26 | 2015-05-27 | ナノバイオ コーポレーション | ナノエマルジョン治療用組成物及びその使用方法 |
| US9278126B2 (en) | 2009-02-10 | 2016-03-08 | Seqirus UK Limited | Influenza vaccines with reduced amounts of squalene |
| EP3020412B1 (en) * | 2009-06-16 | 2017-10-11 | The Regents of the University of Michigan | An immunogenic composition comprising nanoemulsion inactivated rsv |
| GB0913442D0 (en) * | 2009-07-31 | 2009-09-16 | Univ Ramot | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
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| KR100701569B1 (ko) | 2006-07-10 | 2007-03-29 | 주식회사 경동나비엔 | 응축방지를 위한 저장식 보일러의 열교환기 구조 |
| EP2019117A1 (en) | 2007-07-27 | 2009-01-28 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Optimized purification process of recombinant growth factor protein |
| US8804125B2 (en) | 2010-03-12 | 2014-08-12 | Konica Minolta, Inc. | Detection method for intermolecular interaction and detection device thereof |
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| AT514720B1 (de) | 2013-08-30 | 2016-03-15 | Blum Gmbh Julius | Stellvorrichtung |
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| JP6287387B2 (ja) | 2014-03-12 | 2018-03-07 | 株式会社リコー | 液滴吐出装置の液体粘度検出方法、液滴吐出装置の制御方法、液滴吐出装置、及び液滴吐出装置の液体粘度を検出する回路 |
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-
2000
- 2000-02-09 EP EP05075823.4A patent/EP1574210B1/en not_active Expired - Lifetime
- 2000-02-09 EP EP00907228A patent/EP1156781B1/en not_active Revoked
- 2000-02-09 CA CA2689696A patent/CA2689696C/en not_active Expired - Lifetime
- 2000-02-09 AT AT00907228T patent/ATE297190T1/de active
- 2000-02-09 AU AU28757/00A patent/AU2875700A/en not_active Abandoned
- 2000-02-09 EP EP10179804A patent/EP2286792A1/en not_active Withdrawn
- 2000-02-09 CA CA2363141A patent/CA2363141C/en not_active Expired - Lifetime
- 2000-02-09 US US09/914,279 patent/US8206749B1/en not_active Expired - Fee Related
- 2000-02-09 DE DE60020677T patent/DE60020677T2/de not_active Expired - Lifetime
- 2000-02-09 ES ES00907228T patent/ES2242604T3/es not_active Expired - Lifetime
- 2000-02-09 JP JP2000600618A patent/JP2002537102A/ja not_active Withdrawn
- 2000-02-09 WO PCT/US2000/003331 patent/WO2000050006A2/en not_active Ceased
- 2000-02-09 ES ES05075823.4T patent/ES2579783T3/es not_active Expired - Lifetime
-
2006
- 2006-04-18 US US11/406,144 patent/US8309139B2/en not_active Expired - Fee Related
-
2011
- 2011-10-21 JP JP2011232182A patent/JP6073053B2/ja not_active Expired - Lifetime
-
2012
- 2012-09-14 US US13/618,020 patent/US8771747B2/en not_active Expired - Fee Related
- 2012-09-15 US US13/621,174 patent/US8734832B2/en not_active Expired - Fee Related
-
2014
- 2014-05-28 JP JP2014110216A patent/JP2014169323A/ja not_active Withdrawn
-
2016
- 2016-06-24 JP JP2016125184A patent/JP2016172767A/ja active Pending
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