JP2011528902A5 - - Google Patents
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- JP2011528902A5 JP2011528902A5 JP2011519253A JP2011519253A JP2011528902A5 JP 2011528902 A5 JP2011528902 A5 JP 2011528902A5 JP 2011519253 A JP2011519253 A JP 2011519253A JP 2011519253 A JP2011519253 A JP 2011519253A JP 2011528902 A5 JP2011528902 A5 JP 2011528902A5
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- Prior art keywords
- seq
- antigen
- antibody
- binding fragment
- acid sequence
- Prior art date
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- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 17
- 241000712431 Influenza A virus Species 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 206010022000 influenza Diseases 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8383808P | 2008-07-25 | 2008-07-25 | |
| US61/083,838 | 2008-07-25 | ||
| US18158209P | 2009-05-27 | 2009-05-27 | |
| US61/181,582 | 2009-05-27 | ||
| PCT/IB2009/006623 WO2010010467A2 (en) | 2008-07-25 | 2009-07-27 | Neutralizing anti-influenza a virus antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528902A JP2011528902A (ja) | 2011-12-01 |
| JP2011528902A5 true JP2011528902A5 (show.php) | 2012-09-13 |
Family
ID=41570664
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2011519253A Pending JP2011528902A (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8685402B2 (show.php) |
| EP (2) | EP2313433A2 (show.php) |
| JP (3) | JP5607620B2 (show.php) |
| KR (2) | KR20110049802A (show.php) |
| CN (2) | CN102164613B (show.php) |
| AU (2) | AU2009275226B2 (show.php) |
| BR (1) | BRPI0911699B8 (show.php) |
| CA (2) | CA2733218A1 (show.php) |
| CO (1) | CO6341572A2 (show.php) |
| CR (2) | CR20110079A (show.php) |
| EC (1) | ECSP11010823A (show.php) |
| ES (1) | ES2662519T3 (show.php) |
| GT (1) | GT201100023A (show.php) |
| IL (2) | IL210771A0 (show.php) |
| MA (1) | MA32577B1 (show.php) |
| MX (2) | MX2011000767A (show.php) |
| NZ (2) | NZ590890A (show.php) |
| RU (1) | RU2553325C2 (show.php) |
| WO (2) | WO2010010467A2 (show.php) |
| ZA (2) | ZA201101113B (show.php) |
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| CN101970483A (zh) | 2007-12-06 | 2011-02-09 | 达纳-法伯癌症研究公司 | 抗流感病毒抗体及其使用方法 |
| EP2313433A2 (en) * | 2008-07-25 | 2011-04-27 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| CA2849668A1 (en) * | 2010-03-08 | 2011-09-15 | Celltrion, Inc. | Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses |
| US10676520B2 (en) | 2010-06-17 | 2020-06-09 | Trellis Bioscience, Llc | Antibodies useful in passive influenza immunization |
| US9534042B2 (en) * | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| WO2012045001A2 (en) * | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| WO2012145572A1 (en) | 2011-04-20 | 2012-10-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| CA2838999C (en) | 2011-07-14 | 2021-02-16 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses |
| CA2841551C (en) * | 2011-07-18 | 2020-07-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| CN107417789A (zh) * | 2011-07-18 | 2017-12-01 | 生物医学学会 | 中和抗甲型流感病毒抗体及其用途 |
| WO2013020074A2 (en) * | 2011-08-03 | 2013-02-07 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
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| EP2768858B1 (en) * | 2011-10-18 | 2018-08-01 | Emory University | Antibodies directed against influenza |
| KR20130059721A (ko) * | 2011-11-29 | 2013-06-07 | (주)셀트리온 | 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자 |
| CA2892992A1 (en) | 2011-12-02 | 2013-06-06 | Aimm Therapeutics B.V. | Influenza a virus specific antibodies |
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| RU2502745C2 (ru) * | 2011-12-30 | 2013-12-27 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело "anti-flu", рекомбинантные вирусные векторы и фармацевтические композиции для профилактики и терапии гриппа типа а |
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| US9969794B2 (en) * | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| JP6431477B2 (ja) | 2012-05-10 | 2018-12-05 | マサチューセッツ インスティテュート オブ テクノロジー | インフルエンザの中和のための薬剤 |
| CN103665157B (zh) * | 2012-09-14 | 2016-06-29 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1c4 |
| CN103665154B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子3c4 |
| CN103665155B (zh) * | 2012-09-14 | 2016-07-06 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1f2 |
| CN103665156B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的结合分子3e1 |
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| MX387277B (es) * | 2013-03-14 | 2025-03-12 | Contrafect Corp | Composiciones basadas en anticuerpos neutralizantes suministrados intranasalmente para eficacia terapéutica aumentada. |
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| CN104892753B (zh) * | 2014-03-07 | 2019-11-29 | 神州细胞工程有限公司 | 一种中和人感染h7n9甲型流感病毒的抗体及其用途 |
| HRP20201530T1 (hr) | 2014-05-13 | 2020-12-11 | The Trustees Of The University Of Pennsylvania | Kompozicije koje sadrže aav koji eksprimira konstrukte dvojnih antitijela i njihove primjene |
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2009
- 2009-07-27 EP EP09759983A patent/EP2313433A2/en not_active Withdrawn
- 2009-07-27 US US12/509,835 patent/US8685402B2/en active Active
- 2009-07-27 KR KR1020117003495A patent/KR20110049802A/ko not_active Withdrawn
- 2009-07-27 MX MX2011000767A patent/MX2011000767A/es active IP Right Grant
- 2009-07-27 MX MX2011000768A patent/MX2011000768A/es not_active Application Discontinuation
- 2009-07-27 CN CN200980132989.9A patent/CN102164613B/zh active Active
- 2009-07-27 WO PCT/IB2009/006623 patent/WO2010010467A2/en not_active Ceased
- 2009-07-27 CN CN2009801329884A patent/CN102216327A/zh active Pending
- 2009-07-27 WO PCT/IB2009/006616 patent/WO2010010466A2/en not_active Ceased
- 2009-07-27 AU AU2009275226A patent/AU2009275226B2/en active Active
- 2009-07-27 JP JP2011519252A patent/JP5607620B2/ja active Active
- 2009-07-27 JP JP2011519253A patent/JP2011528902A/ja active Pending
- 2009-07-27 ES ES09745097.7T patent/ES2662519T3/es active Active
- 2009-07-27 NZ NZ590890A patent/NZ590890A/xx not_active IP Right Cessation
- 2009-07-27 CA CA2733218A patent/CA2733218A1/en not_active Abandoned
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