JP2011525911A5 - - Google Patents
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- JP2011525911A5 JP2011525911A5 JP2011515706A JP2011515706A JP2011525911A5 JP 2011525911 A5 JP2011525911 A5 JP 2011525911A5 JP 2011515706 A JP2011515706 A JP 2011515706A JP 2011515706 A JP2011515706 A JP 2011515706A JP 2011525911 A5 JP2011525911 A5 JP 2011525911A5
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- Prior art keywords
- vaccine composition
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- 239000000203 mixture Substances 0.000 claims 26
- 229960005486 vaccine Drugs 0.000 claims 17
- 238000000034 method Methods 0.000 claims 9
- 241000714165 Feline leukemia virus Species 0.000 claims 5
- 229930182558 Sterol Natural products 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims 5
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 5
- 229930182490 saponin Natural products 0.000 claims 5
- 150000007949 saponins Chemical class 0.000 claims 5
- 150000003432 sterols Chemical class 0.000 claims 5
- 235000003702 sterols Nutrition 0.000 claims 5
- 230000004936 stimulating effect Effects 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 3
- 229930186217 Glycolipid Natural products 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000004584 polyacrylic acid Substances 0.000 claims 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7623208P | 2008-06-27 | 2008-06-27 | |
| US61/076,232 | 2008-06-27 | ||
| US21455709P | 2009-04-24 | 2009-04-24 | |
| US61/214,557 | 2009-04-24 | ||
| PCT/IB2009/052724 WO2009156960A2 (en) | 2008-06-27 | 2009-06-24 | Novel adjuvant compositions |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014011040A Division JP5882370B2 (ja) | 2008-06-27 | 2014-01-24 | 新規なアジュバント組成物 |
| JP2014011047A Division JP5824538B2 (ja) | 2008-06-27 | 2014-01-24 | 新規なアジュバント組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011525911A JP2011525911A (ja) | 2011-09-29 |
| JP2011525911A5 true JP2011525911A5 (enExample) | 2012-08-09 |
| JP5659332B2 JP5659332B2 (ja) | 2015-01-28 |
Family
ID=41445049
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515706A Active JP5659332B2 (ja) | 2008-06-27 | 2009-06-24 | 新規なアジュバント組成物 |
| JP2014011040A Active JP5882370B2 (ja) | 2008-06-27 | 2014-01-24 | 新規なアジュバント組成物 |
| JP2014011047A Active JP5824538B2 (ja) | 2008-06-27 | 2014-01-24 | 新規なアジュバント組成物 |
| JP2015053170A Active JP6038211B2 (ja) | 2008-06-27 | 2015-03-17 | 新規なアジュバント組成物 |
| JP2016209399A Active JP6294938B2 (ja) | 2008-06-27 | 2016-10-26 | 新規なアジュバント組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014011040A Active JP5882370B2 (ja) | 2008-06-27 | 2014-01-24 | 新規なアジュバント組成物 |
| JP2014011047A Active JP5824538B2 (ja) | 2008-06-27 | 2014-01-24 | 新規なアジュバント組成物 |
| JP2015053170A Active JP6038211B2 (ja) | 2008-06-27 | 2015-03-17 | 新規なアジュバント組成物 |
| JP2016209399A Active JP6294938B2 (ja) | 2008-06-27 | 2016-10-26 | 新規なアジュバント組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US8580280B2 (enExample) |
| EP (4) | EP3056214B1 (enExample) |
| JP (5) | JP5659332B2 (enExample) |
| KR (1) | KR101333852B1 (enExample) |
| CN (4) | CN102076358B (enExample) |
| AR (1) | AR072378A1 (enExample) |
| AU (1) | AU2009263759B2 (enExample) |
| BR (2) | BR122021025097B1 (enExample) |
| CA (3) | CA2960734C (enExample) |
| CL (1) | CL2010001360A1 (enExample) |
| CO (1) | CO6331297A2 (enExample) |
| CY (2) | CY1117650T1 (enExample) |
| DK (2) | DK3056214T3 (enExample) |
| ES (2) | ES2728949T3 (enExample) |
| HR (1) | HRP20190876T1 (enExample) |
| HU (2) | HUE043493T2 (enExample) |
| LT (1) | LT3056214T (enExample) |
| ME (1) | ME01199B (enExample) |
| MX (6) | MX2010014026A (enExample) |
| NZ (5) | NZ589079A (enExample) |
| PH (2) | PH12014501836A1 (enExample) |
| PL (2) | PL3056214T3 (enExample) |
| PT (1) | PT3056214T (enExample) |
| RU (1) | RU2510280C2 (enExample) |
| SI (2) | SI2310046T1 (enExample) |
| TW (4) | TWI622400B (enExample) |
| UY (1) | UY31942A (enExample) |
| WO (1) | WO2009156960A2 (enExample) |
| ZA (1) | ZA201007835B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8444989B1 (en) * | 2008-04-18 | 2013-05-21 | Boehringer Ingelheim Vetmedica Gmbh | One dose vaccination against mycoplasma infections of pigs |
| LT3056214T (lt) * | 2008-06-27 | 2019-06-10 | Zoetis Services Llc | Naujos adjuvantų kompozicijos |
| TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
| EP2376107B1 (en) | 2008-12-09 | 2014-05-21 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| BR112012002963A2 (pt) * | 2009-08-12 | 2017-10-24 | Sigmoid Pharma Ltd | composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa |
| FR2957803B1 (fr) * | 2010-03-24 | 2012-06-01 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Diluants adjuvants de vaccins vivants pour maladies porcines |
| AU2011259718B2 (en) * | 2010-05-28 | 2016-03-03 | Zoetis Belgium S.A. | Vaccines comprising cholesterol and CpG as sole adjuvant - carrier molecules |
| MX345704B (es) * | 2011-06-10 | 2017-02-10 | Novartis Tiergesundheit Ag | Vacuna bovinas y métodos. |
| ES2673957T5 (es) | 2011-10-03 | 2021-12-15 | Croda Int Plc | Nanopartículas, procedimiento para la preparación y utilización de las mismas como portadoras de moléculas anfipáticas o hidrofóbicas en el campo de la medicina, incluyendo el tratamiento del cáncer, y compuestos de tipo alimentario |
| EP4218808A3 (en) * | 2012-03-12 | 2023-08-09 | Advanced BioAdjuvants, LLC | Adjuvant and vaccine compositions |
| JP6195630B2 (ja) | 2012-12-28 | 2017-09-13 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ | マイコプラズマ抗原を含む免疫原性組成物 |
| UA121193C2 (uk) | 2012-12-28 | 2020-04-27 | Бьорінгер Інгельхайм Ветмедіка Гмбх | Спосіб одержання імуногенної композиції проти мікоплазми |
| CN103127495B (zh) * | 2013-01-28 | 2015-04-08 | 重庆市畜牧科学院 | 二联灭活苗的制剂及其制备方法 |
| AU2014315353A1 (en) * | 2013-09-05 | 2016-03-10 | Zoetis Services Llc | Hendra and Nipah virus G glycoprotein immunogenic compositions |
| WO2015042369A2 (en) * | 2013-09-19 | 2015-03-26 | Zoetis Llc | Oil-based adjuvants |
| WO2015057777A1 (en) | 2013-10-17 | 2015-04-23 | Zoetis Llc | Methods and compositions for treatment of s. equi infection |
| EP3074003B1 (en) * | 2013-11-26 | 2023-01-11 | Zoetis Services LLC | Compositions for induction of immune response |
| US10195261B2 (en) | 2014-11-26 | 2019-02-05 | VaxLiant, LLC | Adjuvant compositions and related methods |
| EP3223846B1 (en) * | 2014-11-26 | 2023-09-06 | Huvepharma, Inc. | Adjuvant compositions and related methods |
| DK3244920T5 (da) * | 2015-01-16 | 2024-10-07 | Zoetis Services Llc | Mund- og klovsyge-vaccine |
| JP6925277B2 (ja) * | 2015-03-24 | 2021-08-25 | ヒューベファーマ・インコーポレイテッドＨｕｖｅｐｈａｒｍａ， Ｉｎｃ． | アジュバント組成物及び関連する方法 |
| CN104771754B (zh) * | 2015-04-02 | 2018-02-13 | 武汉科前生物股份有限公司 | 一种猪圆环病毒2型灭活疫苗水性佐剂及应用 |
| CN106267183B (zh) * | 2015-06-09 | 2023-02-28 | 普莱柯生物工程股份有限公司 | 含有佐剂的活疫苗组合物及其制备方法和应用 |
| CN106344920B (zh) * | 2015-07-16 | 2020-11-27 | 普莱柯生物工程股份有限公司 | 一种疫苗用佐剂及其应用 |
| US10456459B2 (en) | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
| SI3325015T1 (sl) * | 2015-07-20 | 2021-08-31 | Zoetis Services Llc | Liposomske pomožne sestavine |
| JP2018530620A (ja) * | 2015-10-19 | 2018-10-18 | カディラ・ヘルスケア・リミテッド | 同一の分野の発明を含有する新規アジュバント及びワクチン組成物 |
| EP3402878A1 (en) | 2016-01-11 | 2018-11-21 | Zoetis Services LLC | Novel cross protective vaccine compositions for porcine epidemic diarrhea virus |
| WO2017165366A1 (en) | 2016-03-21 | 2017-09-28 | South Dakota Board Of Regents | Orf virus-based platform for vaccine delivery |
| CA3025524C (en) | 2016-06-02 | 2023-03-07 | Zoetis Services Llc | Composition comprising turkey rhinotracheitis and infectious bronchitis strain qx antigens, with cpg oligonucleotide in an oil emulsion |
| EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201703529D0 (en) | 2017-03-06 | 2017-04-19 | Cambridge Entpr Ltd | Vaccine composition |
| US10092604B1 (en) * | 2017-12-21 | 2018-10-09 | Bioceuticals Pte. Ltd. | Methods for treatment of skin infectious diseases using microorganisms |
| MX2020009639A (es) | 2018-03-16 | 2021-01-08 | Zoetis Services Llc | Vacunas de peptídos contra interleucina-31. |
| CN108853493A (zh) * | 2018-07-26 | 2018-11-23 | 中国人民解放军陆军军医大学 | 麦冬皂苷d及其纳米乳在制备疫苗佐剂中的应用 |
| US11046734B2 (en) | 2018-07-27 | 2021-06-29 | Research Development Foundation | Chimeric immunogenic polypeptides |
| WO2020055503A1 (en) * | 2018-09-14 | 2020-03-19 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| CN109675028A (zh) * | 2019-03-01 | 2019-04-26 | 龙阔（苏州）生物工程有限公司 | 疫苗佐剂及其制备方法和应用及猪繁殖与呼吸综合征疫苗 |
| JP2022540197A (ja) * | 2019-07-12 | 2022-09-14 | リサーチ ディベロップメント ファウンデーション | エーリキアワクチンおよび免疫原性組成物 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| CN116209361A (zh) * | 2020-06-19 | 2023-06-02 | 金伯利-克拉克环球有限公司 | 用于减少氨产生的动物饲料组合物 |
| CA3182453A1 (en) * | 2020-06-19 | 2021-12-23 | Ning Wei | Saponin containing extracts prepared from hesperaloe useful in the treatment of non-human animals |
| TWI884296B (zh) * | 2020-08-11 | 2025-05-21 | 美商碩騰服務公司 | 抗冠狀病毒疫苗 |
| CN114848807A (zh) * | 2021-02-04 | 2022-08-05 | 洛阳赛威生物科技有限公司 | 一种蜂胶佐剂组合物、及其制备方法以及应用 |
| WO2023056117A1 (en) * | 2021-10-02 | 2023-04-06 | Massachusetts Institute Of Technology | Synergistic combination of alum and non-liposome, non-micelle particle vaccine adjuvants |
| WO2024170728A1 (fr) * | 2023-02-16 | 2024-08-22 | Vaxinano | Composition vaccinale comprenant un systeme de delivrance d'une bacterie entiere inactivee via des nanoparticules polysaccharidiques cationiques sans adjuvant |
| WO2025006564A1 (en) | 2023-06-26 | 2025-01-02 | Research Development Foundation | Immunoreactive peptides |
| CN116747312B (zh) * | 2023-07-21 | 2025-08-08 | 辽宁成大生物股份有限公司 | 一种疫苗冻干保护剂、制剂及制备方法 |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4264587A (en) * | 1979-08-01 | 1981-04-28 | Pedersen Niels C | Vaccine for preventing persistent feline leukemia viremia in cats |
| NZ221306A (en) * | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| US5084269A (en) | 1986-11-06 | 1992-01-28 | Kullenberg Fred W | Adjuvant for dose treatment with antigens |
| EP0273512B1 (en) | 1986-12-19 | 1991-02-27 | Duphar International Research B.V | Stabilised adjuvant suspension comprising dimethyl dioctadecyl ammonium bromide |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| NZ230747A (en) * | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| RU1615918C (ru) | 1989-05-22 | 1995-07-09 | Всероссийский научно-исследовательский институт защиты животных | Адъювант |
| CA2127466A1 (en) * | 1992-01-06 | 1993-07-22 | Keith Haffer | Feline leukemia virus vaccines |
| ZA936095B (en) | 1992-08-21 | 1994-03-14 | Univ Melbourne | Cytokine applications. |
| US6764682B1 (en) | 1994-06-16 | 2004-07-20 | Aventis Pasteur Limited | Adjuvant compositions containing more than one adjuvant |
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6846489B1 (en) * | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
| US6610661B1 (en) | 1996-10-11 | 2003-08-26 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| EP0855184A1 (en) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
| EP1039935A4 (en) | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| EP2172216A3 (en) | 1997-03-10 | 2010-11-24 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| CN1254292A (zh) * | 1997-04-30 | 2000-05-24 | 梅里厄奥拉瓦克斯公司 | 通过膈下内吸收途径使用的抗螺杆菌疫苗组合物,以及粘膜/非肠道联用免疫方法 |
| EP1027033B1 (en) | 1997-05-14 | 2009-07-22 | The University Of British Columbia | High efficiency encapsulation of nucleic acids in lipid vesicles |
| EP2085090A3 (en) | 1997-06-06 | 2012-05-02 | The Regents of the University of California | Inhibitors of DNA immunostimulatory sequence activity |
| ES2281936T3 (es) * | 1997-10-20 | 2007-10-01 | Bayer Corporation | Vacuna contra neospora. |
| EP0953641A3 (en) * | 1998-03-26 | 2002-03-13 | Pfizer Products Inc. | Polynucleotide molecules encoding neospora proteins |
| ATE305507T1 (de) | 1998-05-14 | 2005-10-15 | Coley Pharm Gmbh | Verfahren zur regulierung der hematopoiese mit hilfe von cpg oligonukleotide |
| IL139813A0 (en) | 1998-05-22 | 2002-02-10 | Loeb Health Res Inst At The Ot | Methods and products for inducing mucosal immunity |
| US20040247662A1 (en) | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
| AU773204C (en) | 1998-08-10 | 2005-05-19 | Antigenics Llc | Compositions of CPG and saponin adjuvants and methods thereof |
| AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
| US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| ATE529130T1 (de) | 1999-04-08 | 2011-11-15 | Intercell Usa Inc | Trockenformulierung für transkutane immunisierung |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| TR200103018T2 (tr) | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| AU4978100A (en) | 1999-04-29 | 2000-11-17 | Coley Pharmaceutical Gmbh | Screening for immunostimulatory dna functional modifyers |
| DE60131430T2 (de) | 2000-01-14 | 2008-10-16 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
| US20010044416A1 (en) | 2000-01-20 | 2001-11-22 | Mccluskie Michael J. | Immunostimulatory nucleic acids for inducing a Th2 immune response |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| ES2248283T3 (es) | 2000-02-21 | 2006-03-16 | Pharmexa A/S | Nuevo procedimiento para reducir los niveles de amiloide. |
| US7115579B2 (en) | 2000-05-01 | 2006-10-03 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| GB0025577D0 (en) | 2000-10-18 | 2000-12-06 | Smithkline Beecham Biolog | Vaccine |
| ES2307568T3 (es) | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
| US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
| US7713942B2 (en) | 2001-04-04 | 2010-05-11 | Nordic Vaccine Technology A/S | Cage-like microparticle complexes comprising sterols and saponins for delivery of polynucleotides |
| US20030072764A1 (en) | 2001-04-05 | 2003-04-17 | O'hagan Derek | Mucosal boosting following parenteral priming |
| US7105495B2 (en) | 2001-04-30 | 2006-09-12 | Idera Pharmaceuticals, Inc. | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides |
| WO2002094845A2 (en) | 2001-05-21 | 2002-11-28 | Intercell Ag | Method for stabilising of nucleic acids |
| JP2005509591A (ja) * | 2001-06-15 | 2005-04-14 | リバファーム・インコーポレイテッド | ヌクレオシドワクチンアジュバント |
| CN101524532B (zh) * | 2001-07-02 | 2014-03-19 | 硕腾P有限责任公司 | 单剂量猪肺炎支原体疫苗 |
| WO2003004051A2 (en) * | 2001-07-02 | 2003-01-16 | Pfizer Products Inc. | Mycoplasma hyopneumoniae vaccine and methods for reducing mycoplasma bovis pneumonia in cattle |
| US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
| JP2005518343A (ja) | 2001-08-03 | 2005-06-23 | メダレックス， インク． | 新規なｐｇｃ−１イソフォームおよびその使用媒介型免疫治療を向上させるためのその使用 |
| CA2456328C (en) | 2001-08-07 | 2015-05-26 | Dynavax Technologies Corporation | Complexes of a short cpg-containing oligonucleotide bound to the surface of a solid phase microcarrier and methods for use thereof |
| US20030138434A1 (en) | 2001-08-13 | 2003-07-24 | Campbell Robert L. | Agents for enhancing the immune response |
| AU2002331643B2 (en) | 2001-08-17 | 2007-10-11 | Coley Pharmaceutical Gmbh | Combination motif immune stimulatory oligonucleotides with improved activity |
| CN1571633A (zh) | 2001-08-28 | 2005-01-26 | 辉瑞产品公司 | 牛支原体刺激模型及施用牛支原体的方法以及诱导肺炎损伤的方法 |
| EP2196217A1 (en) | 2001-09-14 | 2010-06-16 | Cytos Biotechnology AG | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| US20030119774A1 (en) | 2001-09-25 | 2003-06-26 | Marianna Foldvari | Compositions and methods for stimulating an immune response |
| GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| US20050238660A1 (en) | 2001-10-06 | 2005-10-27 | Babiuk Lorne A | Cpg formulations and related methods |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| EP1441763A2 (en) | 2001-11-07 | 2004-08-04 | Inex Pharmaceuticals Corp. | Mucosal adjuvants comprising an oligonucleotide and a cationic lipid |
| AU2002358616A1 (en) | 2001-12-07 | 2003-06-17 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
| AU2003203079B8 (en) | 2002-02-04 | 2009-01-15 | Oncothyreon Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| US8088388B2 (en) | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| CA2476854A1 (en) | 2002-02-19 | 2003-08-28 | Syntherica Corporation | Surrogate antibodies and methods of preparation and use thereof |
| ES2734652T3 (es) | 2002-04-04 | 2019-12-11 | Zoetis Belgium S A | Oligorribonucleótidos inmunoestimulantes que contienen G y U |
| AU2003262379A1 (en) | 2002-04-16 | 2003-11-03 | Auburn University | TRANSIENT AND/OR PERMANENT MODIFICATION OF SEXUAL BEHAVIOR AND/OR FERTILITY USING RECOMBINANT CHIMERIC GnRH |
| JP2006515266A (ja) | 2002-04-22 | 2006-05-25 | バイオニケ ライフ サイエンシーズ インコーポレイテッド | オリゴヌクレオチド組成物および免疫応答の調節のためのそれらの使用 |
| KR100456681B1 (ko) | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 ｄｎａ 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
| EP1507850A1 (en) | 2002-05-28 | 2005-02-23 | MERCK PATENT GmbH | A method for generating antigen-presenting cells |
| CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
| SE0201701D0 (sv) | 2002-06-05 | 2002-06-05 | Gotovax Ab | Treatment of epithelial tumors and infections |
| AU2003243409A1 (en) | 2002-06-05 | 2003-12-22 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids |
| AU2003263963A1 (en) | 2002-08-01 | 2004-02-23 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Method of treating inflammatory arthropathies with suppressors of cpg oligonucleotides |
| KR20050073608A (ko) | 2002-11-05 | 2005-07-14 | 제임스 하디 인터내셔널 파이낸스 비.브이. | 규산칼슘 수화물의 제조방법 및 제조장치 |
| ES2303046T3 (es) * | 2003-01-29 | 2008-08-01 | Pfizer Products Inc. | Vacunas caninas contra bordetella bronchiseptica. |
| AU2003900767A0 (en) * | 2003-02-21 | 2003-03-13 | St Vincent's Hospital Sydney Limited | Idiotypic vaccine |
| CN100560719C (zh) | 2003-03-26 | 2009-11-18 | 赛托斯生物技术公司 | Melan-a肽类似物-病毒样颗粒偶联物 |
| RU2541809C2 (ru) | 2003-04-04 | 2015-02-20 | Зоетис Пи ЛЛК | Микрофлюидизированные эмульсии "масло в воде" и композиции вакцины |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| GB0323965D0 (en) * | 2003-10-13 | 2003-11-19 | Glaxosmithkline Biolog Sa | Immunogenic compositions |
| EP1722815A1 (en) * | 2004-03-09 | 2006-11-22 | Chiron Corporation | Influenza virus vaccines |
| EP1742659B1 (en) * | 2004-04-05 | 2013-03-13 | Pah Usa 15 Llc | Microfluidized oil-in-water emulsions and vaccine compositions |
| CA2583061C (en) * | 2004-10-06 | 2015-02-17 | Kwang Guan Tay | Antibody production method |
| GB0426481D0 (en) * | 2004-12-02 | 2005-01-05 | Vaccine Technology Ltd | Composition |
| CA2604488A1 (en) * | 2005-04-07 | 2006-10-12 | Pharmacia & Upjohn Company Llc | Formulations and process for production of bordetella bronchiseptica p68 antigen and vaccines |
| US20060241076A1 (en) * | 2005-04-26 | 2006-10-26 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
| WO2007042884A1 (en) * | 2005-10-07 | 2007-04-19 | Pfizer Products Inc. | Vaccines and methods to treat canine influenza |
| EP1954252B1 (en) * | 2005-12-02 | 2016-02-03 | GlaxoSmithKline Biologicals SA | Nanoparticles for use in immunogenic compositions |
| JP2009524434A (ja) * | 2006-01-26 | 2009-07-02 | エイチエックス・ダイアグノスティックス・インコーポレイテッド | トリインフルエンザウイルス亜型ｈ５ヘマグルチニンに結合するモノクローナル抗体およびそれらの使用 |
| KR101202553B1 (ko) * | 2006-01-26 | 2012-11-20 | 화이자 프로덕츠 인코포레이티드 | 신규 당지질 보조제 조성물 |
| SG177887A1 (en) * | 2006-12-15 | 2012-02-28 | Schering Plough Ltd | Method for replicating influenza virus in culture |
| US8193246B2 (en) * | 2006-12-19 | 2012-06-05 | Marina Biotech, Inc. | Lipids and lipid assemblies comprising transfection enhancer elements |
| US20080292663A1 (en) | 2007-05-22 | 2008-11-27 | Gerber Jay D | Adjuvant compositions and methods for delivering vaccines |
| CL2008001806A1 (es) | 2007-06-20 | 2008-09-05 | Wyeth Corp | Composicion de vacuna en emulsion agua en aceite que comprende un antigeno y un adyuvante en la fase acuosa; y metodo de elaboracion. |
| LT3056214T (lt) * | 2008-06-27 | 2019-06-10 | Zoetis Services Llc | Naujos adjuvantų kompozicijos |
| EP2402032B1 (en) | 2009-02-27 | 2019-08-14 | Toray Industries, Inc. | Immunogenic composition |
| US10456459B2 (en) * | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
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