JP2020536098A5 - - Google Patents
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- JP2020536098A5 JP2020536098A5 JP2020519254A JP2020519254A JP2020536098A5 JP 2020536098 A5 JP2020536098 A5 JP 2020536098A5 JP 2020519254 A JP2020519254 A JP 2020519254A JP 2020519254 A JP2020519254 A JP 2020519254A JP 2020536098 A5 JP2020536098 A5 JP 2020536098A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- patient
- composition according
- administered
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 22
- HIZCTWCPHWUPFU-UHFFFAOYSA-N Glycerol tribenzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(OC(=O)C=1C=CC=CC=1)COC(=O)C1=CC=CC=C1 HIZCTWCPHWUPFU-UHFFFAOYSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 208000035544 Nonketotic hyperglycinaemia Diseases 0.000 claims description 6
- 201000011205 glycine encephalopathy Diseases 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- ITRIWXSLDIKBHK-UHFFFAOYSA-N (3-benzoyloxy-2-hydroxypropyl) benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC(O)COC(=O)C1=CC=CC=C1 ITRIWXSLDIKBHK-UHFFFAOYSA-N 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 230000003111 delayed effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 239000003937 drug carrier Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003405 delayed action preparation Substances 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762569251P | 2017-10-06 | 2017-10-06 | |
| US62/569,251 | 2017-10-06 | ||
| PCT/US2018/052879 WO2019070478A1 (en) | 2017-10-06 | 2018-09-26 | USE OF A BENZOATE-CONTAINING COMPOSITION FOR TREATING GLYCINIC ENCEPHALOPATHY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020536098A JP2020536098A (ja) | 2020-12-10 |
| JP2020536098A5 true JP2020536098A5 (enExample) | 2021-08-12 |
Family
ID=65994915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020519254A Pending JP2020536098A (ja) | 2017-10-06 | 2018-09-26 | グリシン脳症を治療するためのベンゾエート含有組成物の使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11304923B2 (enExample) |
| EP (1) | EP3691630A4 (enExample) |
| JP (1) | JP2020536098A (enExample) |
| KR (1) | KR20200065012A (enExample) |
| CN (1) | CN111212637A (enExample) |
| AU (2) | AU2018345244A1 (enExample) |
| BR (1) | BR112020005856A2 (enExample) |
| CA (1) | CA3078609A1 (enExample) |
| EA (1) | EA202090666A1 (enExample) |
| WO (1) | WO2019070478A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113473981A (zh) * | 2019-02-25 | 2021-10-01 | 拉什大学医学中心 | 含肉桂酸的组合物以及其使用方法 |
| AU2020315331A1 (en) | 2019-07-16 | 2022-02-03 | Rush University Medical Center | Use of a benzoate containing composition to treat neurodegenerative disorders |
| WO2022093922A1 (en) | 2020-10-28 | 2022-05-05 | Rush University Medical Center | Use of a cinnamein composition for the treatment of glycine encephalopathy and urea cycle disorders |
| WO2022132894A1 (en) * | 2020-12-16 | 2022-06-23 | Rush University Medical Center | Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015509489A (ja) * | 2012-02-10 | 2015-03-30 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | がんの処置のためのグリシン開裂系の阻害 |
| HUE053671T2 (hu) | 2014-01-17 | 2021-07-28 | Univ Rush Medical Center | Gliceril-tribenzoátot tartalmazó készítmény neurodegeneratív rendellenességben történõ alkalmazása |
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2018
- 2018-09-26 BR BR112020005856-4A patent/BR112020005856A2/pt not_active IP Right Cessation
- 2018-09-26 EP EP18865150.9A patent/EP3691630A4/en active Pending
- 2018-09-26 CA CA3078609A patent/CA3078609A1/en active Pending
- 2018-09-26 CN CN201880063022.9A patent/CN111212637A/zh active Pending
- 2018-09-26 KR KR1020207011606A patent/KR20200065012A/ko not_active Ceased
- 2018-09-26 EA EA202090666A patent/EA202090666A1/ru unknown
- 2018-09-26 US US16/648,422 patent/US11304923B2/en active Active
- 2018-09-26 WO PCT/US2018/052879 patent/WO2019070478A1/en not_active Ceased
- 2018-09-26 JP JP2020519254A patent/JP2020536098A/ja active Pending
- 2018-09-26 AU AU2018345244A patent/AU2018345244A1/en not_active Abandoned
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2022
- 2022-01-17 AU AU2022200277A patent/AU2022200277A1/en not_active Abandoned