JP2012533565A5 - - Google Patents
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- Publication number
- JP2012533565A5 JP2012533565A5 JP2012520810A JP2012520810A JP2012533565A5 JP 2012533565 A5 JP2012533565 A5 JP 2012533565A5 JP 2012520810 A JP2012520810 A JP 2012520810A JP 2012520810 A JP2012520810 A JP 2012520810A JP 2012533565 A5 JP2012533565 A5 JP 2012533565A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- oral pharmaceutical
- composition according
- oral
- mgbg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 20
- MXWHMTNPTTVWDM-NXOFHUPFSA-N mitoguazone Chemical compound NC(N)=N\N=C(/C)\C=N\N=C(N)N MXWHMTNPTTVWDM-NXOFHUPFSA-N 0.000 claims 12
- 229960003539 mitoguazone Drugs 0.000 claims 12
- 230000036470 plasma concentration Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 231100000957 no side effect Toxicity 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 208000007117 Oral Ulcer Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 201000007100 Pharyngitis Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000002399 aphthous stomatitis Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 239000008008 oral excipient Substances 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22606009P | 2009-07-16 | 2009-07-16 | |
| US61/226,060 | 2009-07-16 | ||
| US29009509P | 2009-12-24 | 2009-12-24 | |
| US61/290,095 | 2009-12-24 | ||
| PCT/US2010/042253 WO2011009039A2 (en) | 2009-07-16 | 2010-07-16 | Pharmaceutical for oral delivery comprising mgbg and methods of treating disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015180110A Division JP2016065045A (ja) | 2009-07-16 | 2015-09-11 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533565A JP2012533565A (ja) | 2012-12-27 |
| JP2012533565A5 true JP2012533565A5 (enExample) | 2013-09-12 |
| JP6112449B2 JP6112449B2 (ja) | 2017-04-12 |
Family
ID=43450234
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520810A Active JP6112449B2 (ja) | 2009-07-16 | 2010-07-16 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
| JP2015180110A Pending JP2016065045A (ja) | 2009-07-16 | 2015-09-11 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
| JP2018040226A Expired - Fee Related JP6883930B2 (ja) | 2009-07-16 | 2018-03-06 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
| JP2019213582A Pending JP2020063258A (ja) | 2009-07-16 | 2019-11-26 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015180110A Pending JP2016065045A (ja) | 2009-07-16 | 2015-09-11 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
| JP2018040226A Expired - Fee Related JP6883930B2 (ja) | 2009-07-16 | 2018-03-06 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
| JP2019213582A Pending JP2020063258A (ja) | 2009-07-16 | 2019-11-26 | Ｍｇｂｇを含む経口送達用の医薬品および疾患を処置する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8258186B2 (enExample) |
| EP (2) | EP3473247A1 (enExample) |
| JP (4) | JP6112449B2 (enExample) |
| CN (2) | CN102686222B (enExample) |
| AU (2) | AU2010273277B2 (enExample) |
| BR (1) | BR112012000862A8 (enExample) |
| CA (1) | CA2768018C (enExample) |
| DK (1) | DK2453886T3 (enExample) |
| ES (1) | ES2715173T3 (enExample) |
| NZ (3) | NZ715686A (enExample) |
| WO (1) | WO2011009039A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2627676T3 (es) | 2007-03-09 | 2017-07-31 | Pathologica Llc | MGBG para la regulación de osteopontina y el tratamiento de la esclerosis múltiple |
| US9675566B2 (en) * | 2009-07-16 | 2017-06-13 | Pathologica Llc | Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing |
| NZ715686A (en) | 2009-07-16 | 2017-08-25 | Pathologica Llc | Pharmaceutical for oral delivery comprising mgbg and methods of treating disease |
| PL2665471T3 (pl) | 2011-01-19 | 2018-06-29 | Pathologica, Llc. | Doustne farmaceutyczne postacie dawkowane o kontrolowanym uwalnianiu zawierające mgbg |
| WO2013083813A2 (en) * | 2011-12-07 | 2013-06-13 | Universität Zürich | Modulators of spermine/spermidine n'-acetyltransferase (ssat) and ssat associated proteins for use in prevention or treatment of rheumatoid arthritis |
| WO2014062552A1 (en) * | 2012-10-15 | 2014-04-24 | Nestec Sa | Methods for maintaining eye health and ameliorating opthalmic maladies in animals |
| ES2859553T3 (es) | 2013-01-08 | 2021-10-04 | Pathologica Llc | Mitoguazona para el tratamiento de esclerosis múltiple progresiva |
| LT3432914T (lt) | 2016-03-25 | 2020-12-10 | Aminex Therapeutics, Inc. | Biologiškai įsisavinami poliaminai |
| WO2018027149A1 (en) * | 2016-08-04 | 2018-02-08 | University Of Miami | Methods of treating alport syndrome |
| JP6840386B2 (ja) * | 2017-04-26 | 2021-03-10 | 学校法人 関西大学 | 細胞足場材料製造用組成物ならびに細胞足場材料およびその製造方法 |
| AU2021247185A1 (en) * | 2020-04-03 | 2022-11-03 | Baylor College Of Medicine | TNFα signaling triggers tumor-promoting inflammation that can be targeted to therapy |
| AU2021354039A1 (en) | 2020-09-30 | 2023-05-25 | Aminex Therapeutics, Inc. | Combination drug substance of polyamine transport inhibitor and dfmo |
| WO2024155775A2 (en) * | 2023-01-19 | 2024-07-25 | Dare Bioscience, Inc. | Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis |
| WO2024155777A2 (en) * | 2023-01-19 | 2024-07-25 | Dare Bioscience, Inc. | Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis |
| AU2024211707A1 (en) * | 2023-01-25 | 2025-08-07 | Dare Bioscience, Inc. | Compositions and methods for treating dysmenorrhea |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4201788A (en) * | 1976-10-20 | 1980-05-06 | University Patents, Inc. | Process for alleviating proliferative skin diseases |
| US5614557A (en) * | 1977-07-11 | 1997-03-25 | Marion Merrell Et Compagnie C/O Merrell Pharmaceuticals Inc. | Method of controlling tumor growth rate |
| US5580715A (en) | 1994-08-05 | 1996-12-03 | The Regents Of The University Of California | Diagnosis of cancer having clonal macrophage involvement |
| US5639600A (en) | 1994-08-05 | 1997-06-17 | The Regents Of The University Of California | Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement |
| US5698563A (en) | 1995-01-13 | 1997-12-16 | Alteon Inc. | Bis- hydrazones! |
| US6274630B1 (en) | 1996-09-13 | 2001-08-14 | University Of Florida Research Foundation, Inc. | Method of inhibiting biosynthesis of EIf5A |
| AR009380A1 (es) | 1996-10-21 | 2000-04-12 | Sumitomo Chemical Co | Proceso de preparacion de un derivado de piridazin-3-ona, util como herbicida, acido carboxilico de utilizacion en el mismo, sal de este ultimo y proceso para preparar dicho acido carboxilico |
| US6083496A (en) | 1996-10-22 | 2000-07-04 | Universite Laval | Polyamine transport inhibitors |
| EP1001927A2 (en) | 1997-07-15 | 2000-05-24 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
| US5889061A (en) | 1997-10-15 | 1999-03-30 | Wisconsin Alumni Research Foundation | Conformationally restricted polyamines |
| US7087648B1 (en) * | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| US8198334B2 (en) | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
| US6169115B1 (en) * | 1998-05-22 | 2001-01-02 | Rima Kaddurah-Daouk | Use of aminoguanidine analogs for the treatment of diseases of the nervous system |
| IL146127A0 (en) | 1999-04-30 | 2002-07-25 | Slil Biomedical Corp | Conformationally restricted polymine analogs as disease therapies |
| US7312244B2 (en) | 1999-04-30 | 2007-12-25 | Cellgate, Inc. | Polyamine analog-amino acid conjugates useful as anticancer agents |
| US6544541B1 (en) | 1999-06-02 | 2003-04-08 | Cardiovascular Solutions, Inc. | Devices and compounds for treating arterial restenosis |
| US7754765B2 (en) | 2000-12-01 | 2010-07-13 | Radical Vision Therapeutics Inc | Copper chelators for treating ocular inflammation |
| JP4253503B2 (ja) | 2001-01-08 | 2009-04-15 | メディクエスト セラピューティックス インク | 疎水性ポリアミン類似体及びそれらの使用方法 |
| WO2003013245A1 (en) | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| WO2003016491A2 (en) | 2001-08-15 | 2003-02-27 | The Regents Of The University Of California | Retrovirus isolated from mantle histiocytes in mantle cell lymphoma |
| AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| US7622117B2 (en) | 2002-04-17 | 2009-11-24 | Dynamis Therapeutics, Inc. | 3-deoxyglucosone and skin |
| US20060160087A1 (en) | 2003-01-31 | 2006-07-20 | Mcgrath Michael | Monitoring and treatment of amyotrophic lateral sclerosis |
| US20050025825A1 (en) | 2003-07-31 | 2005-02-03 | Xanodyne Pharmacal, Inc. | Tranexamic acid formulations with reduced adverse effects |
| WO2005041988A1 (en) | 2003-10-22 | 2005-05-12 | University Of Florida | Method and composition for pain amelioration |
| EP1730100A1 (en) | 2004-03-29 | 2006-12-13 | MediQuest Therapeutics, Inc. | Polyamine analogs that activate antizyme frameshifting |
| US7445794B1 (en) | 2004-04-29 | 2008-11-04 | The Regents Of The University Of Colorado | Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors |
| AU2006275679B2 (en) | 2005-07-29 | 2012-04-12 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of Chk2 kinase inhibitors for cancer treatment |
| US7879914B2 (en) * | 2005-09-23 | 2011-02-01 | Pathlogica LLC | Methods for treating viral infections using polyamine analogs |
| WO2007040535A1 (en) | 2005-10-03 | 2007-04-12 | Cellgate, Inc. | Use of polyamine analogs for treatment and prevention of intestinal polyps |
| US20080026209A1 (en) * | 2006-07-28 | 2008-01-31 | Sunitha Grandhee | Automotive panel having polyurethane primer |
| US20110091418A1 (en) | 2006-09-25 | 2011-04-21 | Pathlogica, LLC | Methods for treating viral infections using polyamine analogs |
| ES2627676T3 (es) | 2007-03-09 | 2017-07-31 | Pathologica Llc | MGBG para la regulación de osteopontina y el tratamiento de la esclerosis múltiple |
| WO2008112251A1 (en) | 2007-03-14 | 2008-09-18 | Progen Pharmaceuticals, Inc. | Cyclopropyl-containing polyamine analogs as disease therapies |
| WO2009018368A1 (en) * | 2007-07-30 | 2009-02-05 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Combination treatment of nmda (n-methyl-d-aspartate)-enhancer, glycine transporter inhibitor, d-amino acid oxidase inhibitor (daaoi) for neuropsychiatric disorders |
| US9675566B2 (en) | 2009-07-16 | 2017-06-13 | Pathologica Llc | Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing |
| NZ715686A (en) | 2009-07-16 | 2017-08-25 | Pathologica Llc | Pharmaceutical for oral delivery comprising mgbg and methods of treating disease |
| EP2283830A1 (en) | 2009-07-23 | 2011-02-16 | Actogenix N.V. | Aqueous enteric capsule coating |
| PL2665471T3 (pl) | 2011-01-19 | 2018-06-29 | Pathologica, Llc. | Doustne farmaceutyczne postacie dawkowane o kontrolowanym uwalnianiu zawierające mgbg |
| ES2859553T3 (es) | 2013-01-08 | 2021-10-04 | Pathologica Llc | Mitoguazona para el tratamiento de esclerosis múltiple progresiva |
-
2010
- 2010-07-16 NZ NZ715686A patent/NZ715686A/en not_active IP Right Cessation
- 2010-07-16 CN CN201080041853.XA patent/CN102686222B/zh not_active Expired - Fee Related
- 2010-07-16 CN CN201510274080.4A patent/CN104997762B/zh not_active Expired - Fee Related
- 2010-07-16 AU AU2010273277A patent/AU2010273277B2/en not_active Ceased
- 2010-07-16 EP EP18210165.9A patent/EP3473247A1/en not_active Ceased
- 2010-07-16 US US12/837,753 patent/US8258186B2/en not_active Expired - Fee Related
- 2010-07-16 NZ NZ628513A patent/NZ628513A/en not_active IP Right Cessation
- 2010-07-16 BR BR112012000862A patent/BR112012000862A8/pt not_active Application Discontinuation
- 2010-07-16 CA CA2768018A patent/CA2768018C/en active Active
- 2010-07-16 EP EP10800602.4A patent/EP2453886B1/en active Active
- 2010-07-16 WO PCT/US2010/042253 patent/WO2011009039A2/en not_active Ceased
- 2010-07-16 NZ NZ597488A patent/NZ597488A/en not_active IP Right Cessation
- 2010-07-16 JP JP2012520810A patent/JP6112449B2/ja active Active
- 2010-07-16 ES ES10800602T patent/ES2715173T3/es active Active
- 2010-07-16 DK DK10800602.4T patent/DK2453886T3/en active
-
2012
- 2012-07-24 US US13/556,948 patent/US8609734B2/en not_active Expired - Fee Related
-
2013
- 2013-10-25 US US14/063,541 patent/US9616035B2/en not_active Expired - Fee Related
-
2015
- 2015-09-11 JP JP2015180110A patent/JP2016065045A/ja active Pending
-
2016
- 2016-12-01 AU AU2016266049A patent/AU2016266049B2/en not_active Ceased
-
2017
- 2017-02-23 US US15/441,122 patent/US20170290788A1/en not_active Abandoned
-
2018
- 2018-03-06 JP JP2018040226A patent/JP6883930B2/ja not_active Expired - Fee Related
-
2019
- 2019-11-26 JP JP2019213582A patent/JP2020063258A/ja active Pending
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