AU2010273277B2 - Pharmaceutical for oral delivery comprising MGBG and methods of treating disease - Google Patents

Pharmaceutical for oral delivery comprising MGBG and methods of treating disease Download PDF

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Publication number
AU2010273277B2
AU2010273277B2 AU2010273277A AU2010273277A AU2010273277B2 AU 2010273277 B2 AU2010273277 B2 AU 2010273277B2 AU 2010273277 A AU2010273277 A AU 2010273277A AU 2010273277 A AU2010273277 A AU 2010273277A AU 2010273277 B2 AU2010273277 B2 AU 2010273277B2
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AU
Australia
Prior art keywords
mgbg
pain
recited
pharmaceutical composition
polyamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010273277A
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English (en)
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AU2010273277A1 (en
Inventor
Jeremy Blitzer
John Mckearn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pathologica LLC
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Pathologica LLC
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Filing date
Publication date
Application filed by Pathologica LLC filed Critical Pathologica LLC
Publication of AU2010273277A1 publication Critical patent/AU2010273277A1/en
Priority to AU2016266049A priority Critical patent/AU2016266049B2/en
Application granted granted Critical
Publication of AU2010273277B2 publication Critical patent/AU2010273277B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
AU2010273277A 2009-07-16 2010-07-16 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease Ceased AU2010273277B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016266049A AU2016266049B2 (en) 2009-07-16 2016-12-01 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22606009P 2009-07-16 2009-07-16
US61/226,060 2009-07-16
US29009509P 2009-12-24 2009-12-24
US61/290,095 2009-12-24
PCT/US2010/042253 WO2011009039A2 (en) 2009-07-16 2010-07-16 Pharmaceutical for oral delivery comprising mgbg and methods of treating disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016266049A Division AU2016266049B2 (en) 2009-07-16 2016-12-01 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease

Publications (2)

Publication Number Publication Date
AU2010273277A1 AU2010273277A1 (en) 2012-02-02
AU2010273277B2 true AU2010273277B2 (en) 2016-12-22

Family

ID=43450234

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2010273277A Ceased AU2010273277B2 (en) 2009-07-16 2010-07-16 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease
AU2016266049A Ceased AU2016266049B2 (en) 2009-07-16 2016-12-01 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016266049A Ceased AU2016266049B2 (en) 2009-07-16 2016-12-01 Pharmaceutical for oral delivery comprising MGBG and methods of treating disease

Country Status (11)

Country Link
US (4) US8258186B2 (enExample)
EP (2) EP2453886B1 (enExample)
JP (4) JP6112449B2 (enExample)
CN (2) CN104997762B (enExample)
AU (2) AU2010273277B2 (enExample)
BR (1) BR112012000862A8 (enExample)
CA (1) CA2768018C (enExample)
DK (1) DK2453886T3 (enExample)
ES (1) ES2715173T3 (enExample)
NZ (3) NZ628513A (enExample)
WO (1) WO2011009039A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2627676T3 (es) 2007-03-09 2017-07-31 Pathologica Llc MGBG para la regulación de osteopontina y el tratamiento de la esclerosis múltiple
US9675566B2 (en) * 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
NZ628513A (en) 2009-07-16 2016-01-29 Pathologica Llc Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
EP2665471B1 (en) * 2011-01-19 2017-12-27 Pathologica, LLC. Controlled release oral pharmaceutical dosage forms comprising mgbg
WO2013083813A2 (en) * 2011-12-07 2013-06-13 Universität Zürich Modulators of spermine/spermidine n'-acetyltransferase (ssat) and ssat associated proteins for use in prevention or treatment of rheumatoid arthritis
US20140107218A1 (en) * 2012-10-15 2014-04-17 Nestec Sa Methods for maintaining eye health and ameliorating opthalmic maladies in animals
WO2014110154A1 (en) * 2013-01-08 2014-07-17 Pathologica Llc Methods and comp0stions for treatment of demyelinating diseases
DK3785706T3 (da) 2016-03-25 2023-09-11 Aminex Therapeutics Inc Biotilgængelige polyaminer
WO2018027149A1 (en) * 2016-08-04 2018-02-08 University Of Miami Methods of treating alport syndrome
JP6840386B2 (ja) * 2017-04-26 2021-03-10 学校法人 関西大学 細胞足場材料製造用組成物ならびに細胞足場材料およびその製造方法
EP4126017A4 (en) * 2020-04-03 2024-05-22 Baylor College of Medicine Tnf-alpha signaling triggers tumor-promoting inflammation that can be targeted to therapy
JP2023545674A (ja) 2020-09-30 2023-10-31 アミネックス セラピューティクス， インコーポレイテッド ポリアミン輸送阻害剤およびｄｆｍｏの配合原薬
WO2024155777A2 (en) * 2023-01-19 2024-07-25 Dare Bioscience, Inc. Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis
WO2024155775A2 (en) * 2023-01-19 2024-07-25 Dare Bioscience, Inc. Compositions and techniques for treatment of polycystic ovarian syndrome (pcos) and endometriosis
WO2024158951A2 (en) * 2023-01-25 2024-08-02 Dare Bioscience, Inc. Compositions and methods for treating dysmenorrhea

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201788A (en) * 1976-10-20 1980-05-06 University Patents, Inc. Process for alleviating proliferative skin diseases
US5614557A (en) * 1977-07-11 1997-03-25 Marion Merrell Et Compagnie C/O Merrell Pharmaceuticals Inc. Method of controlling tumor growth rate
US5639600A (en) 1994-08-05 1997-06-17 The Regents Of The University Of California Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
US5580715A (en) 1994-08-05 1996-12-03 The Regents Of The University Of California Diagnosis of cancer having clonal macrophage involvement
US5698563A (en) 1995-01-13 1997-12-16 Alteon Inc. Bis- hydrazones!
EP0946177B1 (en) 1996-09-13 2005-05-04 University Of Florida Research Foundation, Inc. METHOD OF INHIBITING BIOSYNTHESIS OF EIf5A
AR009380A1 (es) 1996-10-21 2000-04-12 Sumitomo Chemical Co Proceso de preparacion de un derivado de piridazin-3-ona, util como herbicida, acido carboxilico de utilizacion en el mismo, sal de este ultimo y proceso para preparar dicho acido carboxilico
US6083496A (en) 1996-10-22 2000-07-04 Universite Laval Polyamine transport inhibitors
WO1999003823A2 (en) 1997-07-15 1999-01-28 Oridigm Corporation Novel polyamine analogues as therapeutic and diagnostic agents
US5889061A (en) 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US8198334B2 (en) 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US6169115B1 (en) * 1998-05-22 2001-01-02 Rima Kaddurah-Daouk Use of aminoguanidine analogs for the treatment of diseases of the nervous system
HK1040993B (en) 1999-04-30 2006-11-10 Cellgate, Inc. Polyamines and their use in therapy
US6544541B1 (en) 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
WO2002091989A2 (en) 2000-11-08 2002-11-21 Slil Biomedical Corporation Antiviral therapies using polyamine or polyamine analog-amino acid conjugates
US7754765B2 (en) 2000-12-01 2010-07-13 Radical Vision Therapeutics Inc Copper chelators for treating ocular inflammation
US6963010B2 (en) 2001-01-08 2005-11-08 Mediquest Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
US7045550B2 (en) 2001-08-07 2006-05-16 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
CA2454879A1 (en) 2001-08-15 2003-02-27 The Regents Of The University Of California Retrovirus isolated from mantle histiocytes in mantle cell lymphoma
US7030126B2 (en) 2001-11-16 2006-04-18 Als Therapy Development Foundation, Inc. Use of polyamine analogs for amyotrophic lateral sclerosis
US7622117B2 (en) 2002-04-17 2009-11-24 Dynamis Therapeutics, Inc. 3-deoxyglucosone and skin
EP1613263A4 (en) 2003-01-31 2007-11-28 Pathologica Llc MONITORING AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
US20050025825A1 (en) 2003-07-31 2005-02-03 Xanodyne Pharmacal, Inc. Tranexamic acid formulations with reduced adverse effects
US20050113455A1 (en) 2003-10-22 2005-05-26 Bergeron Raymond J.Jr. Method and composition for amelioration of pain
AU2004319105A1 (en) 2004-03-29 2005-11-10 Mediquest Therapeutics, Inc. Polyamine analogs that activate antizyme frameshifting
WO2005107801A2 (en) 2004-04-29 2005-11-17 The Regents Of The University Of Colorado Systems and methods for treating human inflammatory and proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors and/or ucp and/or fas antibodies
EP1912635B1 (en) 2005-07-29 2014-03-05 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Use of chk2 kinase inhibitors for cancer treatment
WO2007035957A2 (en) 2005-09-23 2007-03-29 Pathologica, Llc. Methods for treating viral infections using polyamine analogs
WO2007040535A1 (en) 2005-10-03 2007-04-12 Cellgate, Inc. Use of polyamine analogs for treatment and prevention of intestinal polyps
US20080026209A1 (en) * 2006-07-28 2008-01-31 Sunitha Grandhee Automotive panel having polyurethane primer
US20110091418A1 (en) 2006-09-25 2011-04-21 Pathlogica, LLC Methods for treating viral infections using polyamine analogs
ES2627676T3 (es) * 2007-03-09 2017-07-31 Pathologica Llc MGBG para la regulación de osteopontina y el tratamiento de la esclerosis múltiple
WO2008112251A1 (en) 2007-03-14 2008-09-18 Progen Pharmaceuticals, Inc. Cyclopropyl-containing polyamine analogs as disease therapies
WO2009018368A1 (en) * 2007-07-30 2009-02-05 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Combination treatment of nmda (n-methyl-d-aspartate)-enhancer, glycine transporter inhibitor, d-amino acid oxidase inhibitor (daaoi) for neuropsychiatric disorders
NZ628513A (en) 2009-07-16 2016-01-29 Pathologica Llc Pharmaceutical for oral delivery comprising mgbg and methods of treating disease
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
EP2283830A1 (en) 2009-07-23 2011-02-16 Actogenix N.V. Aqueous enteric capsule coating
EP2665471B1 (en) 2011-01-19 2017-12-27 Pathologica, LLC. Controlled release oral pharmaceutical dosage forms comprising mgbg
WO2014110154A1 (en) 2013-01-08 2014-07-17 Pathologica Llc Methods and comp0stions for treatment of demyelinating diseases

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