JP2006506378A5 - - Google Patents
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- Publication number
- JP2006506378A5 JP2006506378A5 JP2004546158A JP2004546158A JP2006506378A5 JP 2006506378 A5 JP2006506378 A5 JP 2006506378A5 JP 2004546158 A JP2004546158 A JP 2004546158A JP 2004546158 A JP2004546158 A JP 2004546158A JP 2006506378 A5 JP2006506378 A5 JP 2006506378A5
- Authority
- JP
- Japan
- Prior art keywords
- memantine
- donepezil
- medicament
- use according
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 14
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 9
- 229960004640 memantine Drugs 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 229960003530 donepezil Drugs 0.000 claims description 7
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 230000007370 cognitive improvement Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 230000002411 adverse Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 2
- XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229960004136 rivastigmine Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42091802P | 2002-10-24 | 2002-10-24 | |
| PCT/GB2003/004549 WO2004037234A2 (en) | 2002-10-24 | 2003-10-23 | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011195242A Division JP2011246491A (ja) | 2002-10-24 | 2011-09-07 | １−アミノシクロヘキサン誘導体及びアセチルコリンエステラーゼ阻害薬を用いる併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006506378A JP2006506378A (ja) | 2006-02-23 |
| JP2006506378A5 true JP2006506378A5 (enExample) | 2009-09-10 |
Family
ID=32176649
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004546158A Pending JP2006506378A (ja) | 2002-10-24 | 2003-10-23 | １−アミノシクロヘキサン誘導体及びアセチルコリンエステラーゼ阻害薬を用いる併用療法 |
| JP2011195242A Pending JP2011246491A (ja) | 2002-10-24 | 2011-09-07 | １−アミノシクロヘキサン誘導体及びアセチルコリンエステラーゼ阻害薬を用いる併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011195242A Pending JP2011246491A (ja) | 2002-10-24 | 2011-09-07 | １−アミノシクロヘキサン誘導体及びアセチルコリンエステラーゼ阻害薬を用いる併用療法 |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US20040087658A1 (enExample) |
| EP (2) | EP1556019A2 (enExample) |
| JP (2) | JP2006506378A (enExample) |
| KR (2) | KR100852834B1 (enExample) |
| CN (1) | CN100339070C (enExample) |
| AU (1) | AU2003274353B2 (enExample) |
| CA (1) | CA2502432A1 (enExample) |
| EA (1) | EA008863B1 (enExample) |
| GE (1) | GEP20094759B (enExample) |
| MX (1) | MXPA04006900A (enExample) |
| NO (1) | NO20052462L (enExample) |
| PL (1) | PL376476A1 (enExample) |
| TW (1) | TW200418446A (enExample) |
| UA (1) | UA83645C2 (enExample) |
| WO (1) | WO2004037234A2 (enExample) |
| ZA (1) | ZA200503204B (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
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| CN100339070C (zh) * | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1－氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| US20050113458A1 (en) * | 2003-10-22 | 2005-05-26 | Forest Laboratories, Inc. | Use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic a-beta peptides in amyloidopathies |
| US20060020042A1 (en) * | 2004-01-05 | 2006-01-26 | Forest Laboratories, Inc. | Memantine for the treatment of mild and mild to moderate Alzheimer's disease |
| TW200531680A (en) * | 2004-03-03 | 2005-10-01 | Merz Pharma Gmbh & Co Kgaa | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease |
| US8058291B2 (en) * | 2005-04-06 | 2011-11-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of CNS-related conditions |
| KR101301429B1 (ko) * | 2004-11-23 | 2013-08-30 | 아다마스 파마슈티칼스, 인코포레이티드 | 서방성 코팅 또는 매트릭스 및 ｎｍｄａ 수용체 길항제를포함하는 조성물, 대상에 대한 상기 ｎｍｄａ 길항제의투여 방법 |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
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| US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
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| FR2931677B1 (fr) * | 2008-06-02 | 2010-08-20 | Sanofi Aventis | Association d'un agoniste partiel des recepteurs nicotiniques et d'un inhibiteur d'acetylcholinesterase, composition la contenant et son utilisation dans le traitement des troubles cognitifs |
| TW201010691A (en) * | 2008-06-12 | 2010-03-16 | Merz Pharma Gmbh & Co Kgaa | 1-amino-alkylcyclohexane derivatives for the treatment of sleep disorders |
| CN102123703A (zh) * | 2008-09-10 | 2011-07-13 | 莫茨药物股份两合公司 | 用于治疗耳鸣中认知损害的1-氨基-烷基环己烷衍生物 |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
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| BR112012008346B1 (pt) | 2009-09-11 | 2021-12-21 | Vivoryon Therapeutics N.V. | Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica |
| TWI491395B (zh) * | 2009-09-30 | 2015-07-11 | Ct Lab Inc | 一種內含用以治療神經退化性疾病之立即釋出與長效釋出藥物的口服劑量配方 |
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| CN109789134A (zh) | 2016-07-27 | 2019-05-21 | 考里安国际公司 | 与口服递送药代动力学生物等效的透皮递送系统 |
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| WO2019018185A1 (en) | 2017-07-15 | 2019-01-24 | Arisan Therapeutics Inc. | ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS |
| WO2019023239A1 (en) * | 2017-07-25 | 2019-01-31 | William Beaumont Hospital | METHODS FOR DIAGNOSING AND TREATING ALZHEIMER'S DISEASE |
| MX2020002078A (es) | 2017-08-24 | 2020-09-21 | Adamas Pharma Llc | Composiciones de amantadina, preparaciones de estas y métodos de uso. |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| US10098861B1 (en) | 2017-10-24 | 2018-10-16 | Syneurx International (Taiwan) Corp. | Pharmaceutical composition comprising sodium benzoate compound and clozapine, and uses thereof |
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| US10213394B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
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| FI3843702T3 (fi) | 2019-05-31 | 2023-10-09 | Tecnimede Sociedade Tecnico Medicinal Sa | Memantiinin ja donepetsiilin välittömästi vapauttava vakioannoksinen yhdistelmä |
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-
2003
- 2003-10-23 CN CNB200380104613XA patent/CN100339070C/zh not_active Expired - Fee Related
- 2003-10-23 KR KR1020077016542A patent/KR100852834B1/ko not_active Expired - Fee Related
- 2003-10-23 KR KR1020057007052A patent/KR100777904B1/ko not_active Expired - Fee Related
- 2003-10-23 WO PCT/GB2003/004549 patent/WO2004037234A2/en not_active Ceased
- 2003-10-23 CA CA002502432A patent/CA2502432A1/en not_active Abandoned
- 2003-10-23 EA EA200500699A patent/EA008863B1/ru unknown
- 2003-10-23 UA UAA200504854A patent/UA83645C2/ru unknown
- 2003-10-23 TW TW092129457A patent/TW200418446A/zh unknown
- 2003-10-23 AU AU2003274353A patent/AU2003274353B2/en not_active Ceased
- 2003-10-23 EP EP03758338A patent/EP1556019A2/en not_active Withdrawn
- 2003-10-23 US US10/691,895 patent/US20040087658A1/en not_active Abandoned
- 2003-10-23 JP JP2004546158A patent/JP2006506378A/ja active Pending
- 2003-10-23 EP EP10181505A patent/EP2260839A3/en not_active Withdrawn
- 2003-10-23 GE GEAP20038812A patent/GEP20094759B/en unknown
- 2003-10-23 PL PL03376476A patent/PL376476A1/xx not_active Application Discontinuation
- 2003-10-23 MX MXPA04006900A patent/MXPA04006900A/es active IP Right Grant
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2005
- 2005-04-20 ZA ZA200503204A patent/ZA200503204B/en unknown
- 2005-05-23 NO NO20052462A patent/NO20052462L/no not_active Application Discontinuation
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2008
- 2008-02-27 US US12/072,539 patent/US20090124659A1/en not_active Abandoned
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2010
- 2010-03-22 US US12/661,639 patent/US20100227852A1/en not_active Abandoned
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2011
- 2011-09-07 JP JP2011195242A patent/JP2011246491A/ja active Pending
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2014
- 2014-05-16 US US14/280,405 patent/US20140371260A1/en not_active Abandoned
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2016
- 2016-01-28 US US15/008,646 patent/US20160136144A1/en not_active Abandoned
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2021
- 2021-02-18 US US17/178,606 patent/US20210169864A1/en not_active Abandoned
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