MX2018015463A - Co-cristales de benzoato de litio y sus usos. - Google Patents
Co-cristales de benzoato de litio y sus usos.Info
- Publication number
- MX2018015463A MX2018015463A MX2018015463A MX2018015463A MX2018015463A MX 2018015463 A MX2018015463 A MX 2018015463A MX 2018015463 A MX2018015463 A MX 2018015463A MX 2018015463 A MX2018015463 A MX 2018015463A MX 2018015463 A MX2018015463 A MX 2018015463A
- Authority
- MX
- Mexico
- Prior art keywords
- crystals
- disorders
- lithium benzoate
- lithium
- benzoatecompound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
- C07C57/10—Sorbic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
- C07C57/44—Cinnamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
- C07C63/06—Benzoic acid
- C07C63/08—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La presente descripción provee co-cristales de un compuesto de benzoato de litio y un compuesto co-formador de Formula (I) (ver formula) ; tambien se proveen en la presente métodos para preparar los co-cristales y usos de los mismos para tratar y/o reducir el riesgo de un trastorno neuropsiquiatrico (por ejemplo, esquizofrenia, trastornos psicóticos, trastornos depresivos, trastornos bipolares o trastornos neurodegenerativos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662349582P | 2016-06-13 | 2016-06-13 | |
PCT/CN2017/088044 WO2017215592A1 (en) | 2016-06-13 | 2017-06-13 | Co-crystals of lithium benzoate and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018015463A true MX2018015463A (es) | 2019-05-27 |
Family
ID=60663075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018015463A MX2018015463A (es) | 2016-06-13 | 2017-06-13 | Co-cristales de benzoato de litio y sus usos. |
Country Status (11)
Country | Link |
---|---|
US (2) | US10815184B2 (es) |
EP (1) | EP3468946A4 (es) |
JP (1) | JP6958923B2 (es) |
KR (2) | KR102338171B1 (es) |
CN (1) | CN109563024B (es) |
CA (1) | CA3027300C (es) |
IL (1) | IL263486B (es) |
MX (1) | MX2018015463A (es) |
RU (2) | RU2765625C2 (es) |
TW (1) | TWI736635B (es) |
WO (1) | WO2017215592A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102403048B1 (ko) * | 2016-06-13 | 2022-05-26 | 신유알엑스 인터내셔널 (타이완) 코포레이션 | 벤조산나트륨의 공-결정 및 그의 용도 |
MY197760A (en) | 2020-06-01 | 2023-07-13 | Celagenex Res India Pvt Ltd | Novel synergistic medicinal compositions for treating dysfunctional d-serine signaling |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3498989A (en) | 1969-04-16 | 1970-03-03 | American Home Prod | Certain 8-substituted-2-alkyl-3-benzoyl esters of ecgonine and derivatives thereof |
US3870715A (en) | 1972-03-09 | 1975-03-11 | Nikolaus R Hansl | Substituted amino ethyl meta benzoic acid esters |
US4041174A (en) | 1974-08-16 | 1977-08-09 | Rom-Amer Pharmaceuticals, Ltd. | Method of treating depression |
US5204356A (en) | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
US6150354A (en) | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
GB8819494D0 (en) | 1988-08-16 | 1988-09-21 | Ucb Sa | Use of 2-amino-4-morpholino-6-propyl-1 3 5-triazines for preparation of psychotropic medicaments |
US6746678B1 (en) | 1991-02-22 | 2004-06-08 | Howard K. Shapiro | Method of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with medicaments |
WO1992014456A1 (en) | 1991-02-22 | 1992-09-03 | Shapiro Howard K | Use of pharmaceutical compounds in the treatment of symptoms of disorders related to neurological diseases and etiologically related symptomology |
FR2700117B1 (fr) | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens. |
DE4340273A1 (de) | 1993-11-26 | 1995-06-01 | Karla Dr Lehmann | Arzneimittel zur Prophylaxe des Morbus Alzheimer und zur Verhütung des Fortschreitens dieser Erkrankung |
US5453425A (en) | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
WO2001041707A2 (en) | 1999-12-08 | 2001-06-14 | Vanderbilt University | Modulation of in vivo glutamine and glycine levels in the treatment of autism |
HUP0302874A2 (hu) | 2000-08-14 | 2003-12-29 | Teva Pharmaceutical Industries Ltd. | Eljárás risperidon előállítására |
US20030185754A1 (en) | 2001-01-16 | 2003-10-02 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
WO2002066672A2 (en) | 2001-01-16 | 2002-08-29 | Genset S.A. | Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase antagonists |
US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US20070053976A1 (en) | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
US7053122B2 (en) | 2002-08-09 | 2006-05-30 | Pfizer Inc | Therapeutic use of aryl amino acid derivatives |
US7273889B2 (en) | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
US20040087658A1 (en) | 2002-10-24 | 2004-05-06 | Hans-Joerg Moebius | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
WO2004065348A1 (en) | 2003-01-23 | 2004-08-05 | Pfizer Products Inc. | Pharmaceutically acceptable salts of sertraline and pharmaceutical compositions thereof |
EP1628660A4 (en) | 2003-06-02 | 2010-06-02 | Samaritan Pharmaceuticals Inc | METHOD AND COMPOSITIONS FOR MODULATING THE CORTISOL SERUM MIRRORS |
CZ2006426A3 (cs) | 2003-12-29 | 2006-10-11 | Sepracor Inc. | Benzo [d]isoxazol-3-olové inhibitory DAAO |
WO2005070938A1 (en) | 2004-01-27 | 2005-08-04 | Synthon B.V. | Stable salts of olanzapine |
AU2005215376B2 (en) | 2004-02-18 | 2011-01-20 | Sunovion Pharmaceuticals Inc. | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
CN1980574A (zh) | 2004-05-06 | 2007-06-13 | 锡德克斯公司 | 包含舍曲林和磺基烷基醚环糊精的掩味的制剂 |
WO2006007448A2 (en) | 2004-06-17 | 2006-01-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
WO2006096439A2 (en) | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
CA2505808A1 (en) * | 2005-05-02 | 2006-11-02 | Julie Danielle Globus | Niacin used as oral supplementation for the treatment of psychosis and/or schizophrenia in humans |
WO2006129160A2 (en) | 2005-06-01 | 2006-12-07 | Aurobindo Pharma Limited | Stable aqueous oral solution of risperidone |
US20110045065A1 (en) | 2005-07-11 | 2011-02-24 | Ashok Vasantray Vyas | Substance having antioxidant, geroprotective and anti-ischemic activity and method for the preparation thereof |
US7811604B1 (en) | 2005-11-14 | 2010-10-12 | Barr Laboratories, Inc. | Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same |
GB0603181D0 (en) | 2006-02-17 | 2006-03-29 | Merck Sharp & Dohme | Treatment of neurodegenerative and psychiatric diseases |
US20080045512A1 (en) | 2006-08-09 | 2008-02-21 | Pfizer Inc. | Benzoate salt of 4-(5-methyl-oxazolo[4,5-b]-pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane |
WO2008034087A2 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Treating schizophrenia with combinations of levodopa and an antipsychotic agent |
US8071143B2 (en) | 2008-04-02 | 2011-12-06 | Brandeis University | Methods for the treatment or prevention of diabetes mellitus and other metabolic imbalances |
US20130338199A1 (en) * | 2008-07-11 | 2013-12-19 | Uday Saxena | Novel Niacin Compositions for Reduction of Amyloid Beta Peptide 42 (AB42) Production and for Treatment of Alzheimer's Disease |
EP2310004A1 (en) * | 2008-07-11 | 2011-04-20 | Kareus Therapeutics SA | Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of alzheimer's disease (ad) |
GB0813709D0 (en) * | 2008-07-26 | 2008-09-03 | Univ Dundee | Method and product |
JP2010106001A (ja) * | 2008-10-31 | 2010-05-13 | Theravalues Corp | Ppar活性化剤 |
CA3037010A1 (en) | 2009-01-20 | 2010-07-29 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Cente | Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical |
EP3650439B1 (en) * | 2010-07-23 | 2021-02-24 | Grünenthal GmbH | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
CA2831086A1 (en) * | 2011-03-24 | 2012-09-27 | University Of South Florida | Lithium compositions |
US9035044B2 (en) * | 2011-05-09 | 2015-05-19 | Janssen Pharmaceutica Nv | L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
US9120766B2 (en) | 2011-10-21 | 2015-09-01 | Amri Ssci, Llc | Methods of making cocrystals |
ES2910003T3 (es) * | 2013-04-19 | 2022-05-11 | Univ South Florida | Compuestos y composiciones de cocristal iónico de litio de anión orgánico |
EP2991999B1 (en) | 2013-04-29 | 2019-05-08 | Mapi Pharma Limited | Dapagliflozin lactose co-crystal |
WO2015086843A2 (en) * | 2013-12-13 | 2015-06-18 | Conaris Research Institute Ag | A pharmaceutical composition containing nicotinic acid and/or nicotinamide for beneficially influencing blood lipid levels by modifying the intestinal microbiota |
CA2902498C (en) * | 2014-03-24 | 2017-03-28 | Kaohsiung Chang Gung Memorial Hospital | Use of benzoic acid salt in the manufactue of a composition for preventing or treating dementia or mild cognitive impairment |
CN103992320A (zh) * | 2014-05-26 | 2014-08-20 | 南京工业大学 | 一种混悬结晶制备药物共晶的方法 |
CA3176253A1 (en) * | 2014-11-19 | 2016-05-26 | Rush University Medical Center | Use of cinnamic acid or sodium benzoate for treating lysosomal disorders |
RU2582962C1 (ru) * | 2014-12-23 | 2016-04-27 | Ольга Алексеевна Громова | Средство для профилактики и лечения нейродегенеративной патологии и сосудистой деменции (варианты) |
KR102403048B1 (ko) | 2016-06-13 | 2022-05-26 | 신유알엑스 인터내셔널 (타이완) 코포레이션 | 벤조산나트륨의 공-결정 및 그의 용도 |
-
2017
- 2017-06-13 CN CN201780047178.3A patent/CN109563024B/zh active Active
- 2017-06-13 RU RU2018146423A patent/RU2765625C2/ru active
- 2017-06-13 CA CA3027300A patent/CA3027300C/en active Active
- 2017-06-13 MX MX2018015463A patent/MX2018015463A/es unknown
- 2017-06-13 KR KR1020197000865A patent/KR102338171B1/ko active IP Right Grant
- 2017-06-13 TW TW106119578A patent/TWI736635B/zh active
- 2017-06-13 EP EP17812703.1A patent/EP3468946A4/en active Pending
- 2017-06-13 WO PCT/CN2017/088044 patent/WO2017215592A1/en unknown
- 2017-06-13 RU RU2022101542A patent/RU2022101542A/ru unknown
- 2017-06-13 US US16/309,370 patent/US10815184B2/en active Active
- 2017-06-13 JP JP2018564930A patent/JP6958923B2/ja active Active
- 2017-06-13 KR KR1020217037292A patent/KR102488927B1/ko active IP Right Grant
-
2018
- 2018-12-04 IL IL263486A patent/IL263486B/en unknown
-
2020
- 2020-09-23 US US17/030,222 patent/US11739046B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3468946A1 (en) | 2019-04-17 |
RU2765625C2 (ru) | 2022-02-01 |
WO2017215592A1 (en) | 2017-12-21 |
RU2018146423A3 (es) | 2020-10-06 |
EP3468946A4 (en) | 2020-02-12 |
KR102488927B1 (ko) | 2023-01-13 |
US20190177261A1 (en) | 2019-06-13 |
IL263486B (en) | 2021-08-31 |
JP6958923B2 (ja) | 2021-11-02 |
KR20190017939A (ko) | 2019-02-20 |
KR20210142769A (ko) | 2021-11-25 |
KR102338171B1 (ko) | 2021-12-09 |
US20210107856A1 (en) | 2021-04-15 |
TWI736635B (zh) | 2021-08-21 |
CA3027300C (en) | 2023-08-08 |
TW201811321A (zh) | 2018-04-01 |
CA3027300A1 (en) | 2017-12-21 |
IL263486A (en) | 2019-01-31 |
US11739046B2 (en) | 2023-08-29 |
JP2019518757A (ja) | 2019-07-04 |
US10815184B2 (en) | 2020-10-27 |
CN109563024B (zh) | 2023-06-06 |
RU2022101542A (ru) | 2022-02-03 |
CN109563024A (zh) | 2019-04-02 |
RU2018146423A (ru) | 2020-07-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL246875A0 (en) | 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines as bace1 inhibitors for the treatment of Alzheimer's disease | |
MX2019003623A (es) | Composiciones y metodos para el tratamiento de afecciones oftalmicas. | |
MX2021008281A (es) | Estimuladores de guanilato ciclasa soluble (sgc). | |
CL2018000375A1 (es) | 2-amino-3-fluoro-3-(fluorometil)-6-meti-6-fenil-3,4,5,6-tetrahidropiridinas como inhibidores de bace1. | |
TW201613872A (en) | IRAK4 inhibiting agents | |
JO3466B1 (ar) | مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6 | |
MX2020001757A (es) | Compuestos, sales de los mismos y metodos para el tratamiento de enfermedades. | |
SG11201703177WA (en) | 2-amino-3,5-difluoro-3,6-dimethyl-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors for treating alzheimer's disease | |
MX2021015102A (es) | Inhibidores del receptor del factor estimulante de colonias 1 (csf-1r). | |
MY186271A (en) | Ophthalmic compositions and methods of use therefor | |
PH12017500920A1 (en) | 4-oxo-3,4-dihydro-1,2,3-benzotriazine as modulators of gpr139 | |
NZ738672A (en) | Therapeutic compounds and compositions for treating social disorders and substance use disorders | |
PH12017501028A1 (en) | Treatment of retinal degeneration using progenitor cells | |
MX2023004969A (es) | Metodos para tratar y prevenir infeccion por c. difficile. | |
EA201790687A1 (ru) | Хинолинкарбоксамиды для применения в лечении множественной миеломы | |
PH12016501613A1 (en) | Pyrazines modulators of gpr6 | |
MX2018005987A (es) | Compuestos heterociclicos para el tratamiento de enfermedades. | |
MX2022001801A (es) | Secuencias recombinantes de cromosoma b de maiz y sus usos. | |
MX2016010877A (es) | Amidas antimitoticas para el tratamiento del cancer y desordenes proliferativos. | |
MX2018015463A (es) | Co-cristales de benzoato de litio y sus usos. | |
MX2018001592A (es) | Composiciones y metodos para el tratamiento y la prevencion de trastornos neurodegenerativos. | |
GEP20207127B (en) | 2-homopiperazine-1-yl-4h-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides | |
PH12016502477A1 (en) | Novel polymorphic form of n-[2-(6-fluoro-lh-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride for the treatment of alzheimer`s | |
SG10201903630UA (en) | Iminosugars useful for the treatment of viral diseases |