JP2020536098A - グリシン脳症を治療するためのベンゾエート含有組成物の使用 - Google Patents
グリシン脳症を治療するためのベンゾエート含有組成物の使用 Download PDFInfo
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- 235000012239 silicon dioxide Nutrition 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Abstract
Description
本発明は、一般に疾患及び障害の治療に有用な医薬組成物及び/又は製剤に関する。より具体的には、本発明は、グリセリルトリベンゾエート及び/又はグリセリルジベンゾエートを含む、グリシン脳症の治療のための医薬組成物及び/又は製剤に関する。
ニッケイの茶色の樹皮であるシナモンは、デザート、キャンディ、チョコレート等に一般的に用いられる香辛料及び調味料である。それにはまた、薬として用いられてきた長い歴史がある。中世の医師は、関節炎、咳嗽、嗄声、咽頭炎等を含む種々の障害を治療するために、薬にシナモンを用いた。シナモンは、マンガン、食物繊維、鉄、及びカルシウムを含有することに加えて、3つの主要な化合物、シンナムアルデヒド、シンナミルアセテート及びシンナミルアルコールを含有する。摂取後、これらの3つの活性化合物は、酸化及び加水分解によって、それぞれケイ皮酸に変換される。次いで、ケイ皮酸は肝臓でβ酸化されてベンゾエートになる。このベンゾエートは、ナトリウム塩(安息香酸ナトリウム)又はベンゾイル-CoAとして存在する。
Claims (16)
- グリシン脳症の進行を阻害する方法であって、グリセリルトリベンゾエートを含む有効量の医薬組成物をそれを必要とする患者に投与することを含む方法。
- 医薬組成物が1日1回患者に投与される、請求項1に記載の方法。
- 有効量が、50kgの患者に基づいた場合、1日約1.25グラム〜約15グラムである、請求項1又は2に記載の方法。
- 医薬組成物が、薬学的に許容される担体又は賦形剤と共に製剤化される、請求項1〜3のいずれか1項に記載の方法。
- 医薬組成物が経口投与される、請求項1〜4のいずれか1項に記載の方法。
- 組成物がグリセリルジベンゾエートを含む、請求項1〜5のいずれか1項に記載の方法。
- グリシン脳症の進行を阻害する方法であって、グリセリルジベンゾエートを含む有効量の医薬組成物をそれを必要とする患者に投与することを含む方法。
- 組成物がグリセリルトリベンゾエートを含む、請求項7に記載の方法。
- 医薬組成物が1日1回患者に投与される、請求項7又は8に記載の方法。
- 有効量が、50kgの患者に基づいた場合、1日約1.25グラム〜約15グラムである、請求項7〜9のいずれか1項に記載の方法。
- 医薬組成物が、薬学的に許容される担体又は賦形剤と共に製剤化される、請求項7〜10のいずれか1項に記載の方法。
- 医薬組成物が経口投与される、請求項7〜11のいずれか1項に記載の方法。
- グリシン脳症の進行を阻害するための製剤を使用する方法であって、有効量の製剤をそれを必要とする患者に投与することを含み、製剤が約1グラム/1mlのグリセリルトリベンゾエートを含む、方法。
- 製剤が持続放出製剤及び遅延放出製剤からなる群から選択される、請求項13に記載の方法。
- 製剤が患者に経口投与される、請求項13又は14に記載の方法。
- 50kgの患者に基づいた場合、1日約1.25グラム〜約15グラムのグリセリルトリベンゾエートが患者に投与される、請求項13〜15のいずれか1項に記載の方法。
Applications Claiming Priority (3)
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US201762569251P | 2017-10-06 | 2017-10-06 | |
US62/569,251 | 2017-10-06 | ||
PCT/US2018/052879 WO2019070478A1 (en) | 2017-10-06 | 2018-09-26 | USE OF A BENZOATE-CONTAINING COMPOSITION FOR TREATING GLYCINIC ENCEPHALOPATHY |
Publications (2)
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JP2020536098A true JP2020536098A (ja) | 2020-12-10 |
JP2020536098A5 JP2020536098A5 (ja) | 2021-08-12 |
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JP2020519254A Pending JP2020536098A (ja) | 2017-10-06 | 2018-09-26 | グリシン脳症を治療するためのベンゾエート含有組成物の使用 |
Country Status (10)
Country | Link |
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US (1) | US11304923B2 (ja) |
EP (1) | EP3691630A4 (ja) |
JP (1) | JP2020536098A (ja) |
KR (1) | KR20200065012A (ja) |
CN (1) | CN111212637A (ja) |
AU (2) | AU2018345244A1 (ja) |
BR (1) | BR112020005856A2 (ja) |
CA (1) | CA3078609A1 (ja) |
EA (1) | EA202090666A1 (ja) |
WO (1) | WO2019070478A1 (ja) |
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EP3930704A4 (en) * | 2019-02-25 | 2022-11-16 | Rush University Medical Center | COMPOSITIONS WITH CINNANIC ACID AND PROCESS FOR THE PREPARATION THEREOF |
WO2021011500A2 (en) * | 2019-07-16 | 2021-01-21 | Rush University Medical Center | Use of a benzoate containing composition to treat neurodegenerative disorders |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2015509489A (ja) * | 2012-02-10 | 2015-03-30 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | がんの処置のためのグリシン開裂系の阻害 |
JP2017505811A (ja) * | 2014-01-17 | 2017-02-23 | ラッシュ・ユニバーシティ・メディカル・センター | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
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2018
- 2018-09-26 AU AU2018345244A patent/AU2018345244A1/en not_active Abandoned
- 2018-09-26 WO PCT/US2018/052879 patent/WO2019070478A1/en unknown
- 2018-09-26 BR BR112020005856-4A patent/BR112020005856A2/pt unknown
- 2018-09-26 US US16/648,422 patent/US11304923B2/en active Active
- 2018-09-26 JP JP2020519254A patent/JP2020536098A/ja active Pending
- 2018-09-26 KR KR1020207011606A patent/KR20200065012A/ko not_active Application Discontinuation
- 2018-09-26 CA CA3078609A patent/CA3078609A1/en active Pending
- 2018-09-26 EA EA202090666A patent/EA202090666A1/ru unknown
- 2018-09-26 CN CN201880063022.9A patent/CN111212637A/zh active Pending
- 2018-09-26 EP EP18865150.9A patent/EP3691630A4/en active Pending
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2022
- 2022-01-17 AU AU2022200277A patent/AU2022200277A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015509489A (ja) * | 2012-02-10 | 2015-03-30 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | がんの処置のためのグリシン開裂系の阻害 |
JP2017505811A (ja) * | 2014-01-17 | 2017-02-23 | ラッシュ・ユニバーシティ・メディカル・センター | 尿素サイクル障害及び神経変性障害におけるベンゾエート含有組成物の使用 |
Non-Patent Citations (2)
Title |
---|
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, vol. 16, JPN6022029402, 2017, pages 868 - 880, ISSN: 0004995495 * |
J. INHERIT. METAB. DIS., vol. 28, JPN6022029400, 2005, pages 651 - 663, ISSN: 0004995496 * |
Also Published As
Publication number | Publication date |
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CN111212637A (zh) | 2020-05-29 |
EP3691630A4 (en) | 2021-10-27 |
US11304923B2 (en) | 2022-04-19 |
AU2022200277A1 (en) | 2022-02-03 |
EP3691630A1 (en) | 2020-08-12 |
EA202090666A1 (ru) | 2020-08-05 |
CA3078609A1 (en) | 2019-04-11 |
AU2018345244A1 (en) | 2020-04-02 |
KR20200065012A (ko) | 2020-06-08 |
BR112020005856A2 (pt) | 2020-09-29 |
WO2019070478A1 (en) | 2019-04-11 |
US20200281884A1 (en) | 2020-09-10 |
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