JP2011524418A5 - - Google Patents

Info

Publication number

JP2011524418A5

JP2011524418A5 JP2011514733A JP2011514733A JP2011524418A5 JP 2011524418 A5 JP2011524418 A5 JP 2011524418A5 JP 2011514733 A JP2011514733 A JP 2011514733A JP 2011514733 A JP2011514733 A JP 2011514733A JP 2011524418 A5 JP2011524418 A5 JP 2011524418A5

Authority

JP

Japan

Prior art keywords

amino acid

substitution

group

analog

glu

Prior art date

2009-06-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001413 amino acids Chemical group 0.000 claims 40
• 238000006467 substitution reaction Methods 0.000 claims 27
• 108060003199 Glucagon Proteins 0.000 claims 23
• 125000000217 alkyl group Chemical group 0.000 claims 13
• 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 8
• 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 8
• XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical compound OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 claims 8
• 238000012986 modification Methods 0.000 claims 7
• 230000004048 modification Effects 0.000 claims 7
• 238000012217 deletion Methods 0.000 claims 6
• 230000037430 deletion Effects 0.000 claims 6
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 6
• 102000051325 Glucagon Human genes 0.000 claims 5
• 229960004666 glucagon Drugs 0.000 claims 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
• 208000013016 Hypoglycemia Diseases 0.000 claims 4
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
• VBOQYPQEPHKASR-VKHMYHEASA-N L-homocysteic acid Chemical compound OC(=O)[C@@H](N)CCS(O)(=O)=O VBOQYPQEPHKASR-VKHMYHEASA-N 0.000 claims 4
• 125000002252 acyl group Chemical group 0.000 claims 4
• 239000000556 agonist Substances 0.000 claims 4
• 239000008280 blood Substances 0.000 claims 4
• 210000004369 blood Anatomy 0.000 claims 4
• 238000003776 cleavage reaction Methods 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 239000008103 glucose Substances 0.000 claims 4
• 230000002218 hypoglycaemic effect Effects 0.000 claims 4
• 238000003780 insertion Methods 0.000 claims 4
• 230000037431 insertion Effects 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 230000007017 scission Effects 0.000 claims 4
• 230000035945 sensitivity Effects 0.000 claims 4
• 230000002265 prevention Effects 0.000 claims 3
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
• WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims 2
• 239000000539 dimer Substances 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 230000004927 fusion Effects 0.000 claims 2
• 125000004404 heteroalkyl group Chemical group 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 230000006641 stabilisation Effects 0.000 claims 2
• 238000011105 stabilization Methods 0.000 claims 2
• 230000000087 stabilizing effect Effects 0.000 claims 2
• BBBXWRGITSUJPB-YUMQZZPRSA-N Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O BBBXWRGITSUJPB-YUMQZZPRSA-N 0.000 claims 1
• 108010063919 Glucagon Receptors Proteins 0.000 claims 1
• 102100040890 Glucagon receptor Human genes 0.000 claims 1
• 102100023915 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 claims 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
• 239000004202 carbamide Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001924 fatty-acyl group Chemical group 0.000 claims 1
• 239000000710 homodimer Substances 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 108010054155 lysyllysine Proteins 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1