AU2009260301B2 - Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers - Google Patents

Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers Download PDF

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Publication number
AU2009260301B2
AU2009260301B2 AU2009260301A AU2009260301A AU2009260301B2 AU 2009260301 B2 AU2009260301 B2 AU 2009260301B2 AU 2009260301 A AU2009260301 A AU 2009260301A AU 2009260301 A AU2009260301 A AU 2009260301A AU 2009260301 B2 AU2009260301 B2 AU 2009260301B2
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Prior art keywords
glucagon
amino acid
peptide
seq
acid
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AU2009260301A
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AU2009260301A1 (en
Inventor
Joseph Chabenne
Jonathan Day
Maria Dimarchi
Richard D. Dimarchi
David L. Smiley
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Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009260301A 2008-06-17 2009-06-16 Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers Ceased AU2009260301B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2015264817A AU2015264817A1 (en) 2008-06-17 2015-12-02 Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US7319308P 2008-06-17 2008-06-17
US61/073,193 2008-06-17
US7816508P 2008-07-03 2008-07-03
US61/078,165 2008-07-03
US9041508P 2008-08-20 2008-08-20
US61/090,415 2008-08-20
PCT/US2009/047437 WO2009155257A1 (en) 2008-06-17 2009-06-16 Glucagon analogs exhibiting enhanced solubility and stability physiological ph buffers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015264817A Division AU2015264817A1 (en) 2008-06-17 2015-12-02 Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers

Publications (2)

Publication Number Publication Date
AU2009260301A1 AU2009260301A1 (en) 2009-12-23
AU2009260301B2 true AU2009260301B2 (en) 2015-09-03

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AU2009260301A Ceased AU2009260301B2 (en) 2008-06-17 2009-06-16 Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers

Country Status (12)

Country Link
US (1) US8450270B2 (enExample)
EP (1) EP2307037A4 (enExample)
JP (2) JP5753779B2 (enExample)
KR (1) KR20110039230A (enExample)
CN (2) CN104447980A (enExample)
AU (1) AU2009260301B2 (enExample)
CA (1) CA2727161A1 (enExample)
IL (1) IL209287A (enExample)
MX (1) MX2010012695A (enExample)
RU (1) RU2560254C2 (enExample)
TW (1) TWI541023B (enExample)
WO (1) WO2009155257A1 (enExample)

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* Cited by examiner, † Cited by third party
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