CN104447980A - 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物 - Google Patents
在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物 Download PDFInfo
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- CN104447980A CN104447980A CN201410562514.6A CN201410562514A CN104447980A CN 104447980 A CN104447980 A CN 104447980A CN 201410562514 A CN201410562514 A CN 201410562514A CN 104447980 A CN104447980 A CN 104447980A
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- Prior art keywords
- glucagon
- peptide
- amino acid
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- acid
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- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
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- XDWXRAYGALQIFG-UHFFFAOYSA-L zinc;propanoate Chemical compound [Zn+2].CCC([O-])=O.CCC([O-])=O XDWXRAYGALQIFG-UHFFFAOYSA-L 0.000 description 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 1
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- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7319308P | 2008-06-17 | 2008-06-17 | |
| US61/073193 | 2008-06-17 | ||
| US7816508P | 2008-07-03 | 2008-07-03 | |
| US61/078165 | 2008-07-03 | ||
| US9041508P | 2008-08-20 | 2008-08-20 | |
| US61/090415 | 2008-08-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980127066.4A Division CN102088989B (zh) | 2008-06-17 | 2009-06-16 | 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物 |
Publications (1)
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-
2009
- 2009-06-16 KR KR1020117000019A patent/KR20110039230A/ko not_active Ceased
- 2009-06-16 AU AU2009260301A patent/AU2009260301B2/en not_active Ceased
- 2009-06-16 JP JP2011514733A patent/JP5753779B2/ja not_active Expired - Fee Related
- 2009-06-16 US US12/999,284 patent/US8450270B2/en not_active Expired - Fee Related
- 2009-06-16 EP EP09767567A patent/EP2307037A4/en not_active Withdrawn
- 2009-06-16 CA CA2727161A patent/CA2727161A1/en not_active Abandoned
- 2009-06-16 CN CN200980127066.4A patent/CN102088989B/zh not_active Expired - Fee Related
- 2009-06-16 WO PCT/US2009/047437 patent/WO2009155257A1/en not_active Ceased
- 2009-06-16 CN CN201410562514.6A patent/CN104447980A/zh active Pending
- 2009-06-16 MX MX2010012695A patent/MX2010012695A/es active IP Right Grant
- 2009-06-16 TW TW098120168A patent/TWI541023B/zh not_active IP Right Cessation
- 2009-06-16 RU RU2010151656/10A patent/RU2560254C2/ru not_active IP Right Cessation
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| CN109310743A (zh) * | 2016-05-16 | 2019-02-05 | 因塔西亚制药公司 | 胰高血糖素受体选择性多肽及其使用方法 |
| US11840559B2 (en) | 2016-05-16 | 2023-12-12 | I2O Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| CN106986924A (zh) * | 2017-03-23 | 2017-07-28 | 中国药科大学 | 胃泌酸调节素（oxm）类似物及其应用 |
| WO2022228498A1 (zh) * | 2021-04-30 | 2022-11-03 | 信达生物制药(苏州)有限公司 | 一种oxm3储存剂、oxm3制剂及制备方法 |
| WO2023001186A1 (zh) * | 2021-07-20 | 2023-01-26 | 派格生物医药(苏州)股份有限公司 | 多肽缀合物在制备治疗糖代谢相关疾病的药物中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL209287A0 (en) | 2011-01-31 |
| RU2560254C2 (ru) | 2015-08-20 |
| EP2307037A1 (en) | 2011-04-13 |
| EP2307037A4 (en) | 2011-08-03 |
| IL209287A (en) | 2016-09-29 |
| JP2011524418A (ja) | 2011-09-01 |
| CA2727161A1 (en) | 2009-12-23 |
| CN102088989B (zh) | 2014-11-26 |
| WO2009155257A8 (en) | 2010-03-25 |
| WO2009155257A1 (en) | 2009-12-23 |
| JP5753779B2 (ja) | 2015-07-22 |
| MX2010012695A (es) | 2011-03-15 |
| CN102088989A (zh) | 2011-06-08 |
| AU2009260301B2 (en) | 2015-09-03 |
| TWI541023B (zh) | 2016-07-11 |
| RU2010151656A (ru) | 2012-07-27 |
| AU2009260301A1 (en) | 2009-12-23 |
| JP2015147791A (ja) | 2015-08-20 |
| US20110190200A1 (en) | 2011-08-04 |
| KR20110039230A (ko) | 2011-04-15 |
| US8450270B2 (en) | 2013-05-28 |
| TW201010730A (en) | 2010-03-16 |
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